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All Studies   Meta Analysis   Recent: 
Inhibition of acid sphingomyelinase by ambroxol prevents SARS-CoV-2 entry into epithelial cells
Carpinteiro et al., Journal of Biological Chemistry, doi:10.1016/j.jbc.2021.100701 (In Vitro)
31 Jan 2021    Source   PDF   Share   Tweet
In Vitro study showing that ambroxol (a metabolite of bromhexine) inhibits SARS-CoV-2 infection.
Bromhexine may be less effective for omicron due to the entry process moving towards TMPRSS2-independent fusion.
2 In Vitro studies support the efficacy of bromhexine [Carpinteiro, Hoffman].
Carpinteiro et al., 31 Jan 2021, peer-reviewed, 10 authors.
In Vitro studies are an important part of preclinical research, however results may be very different in vivo.
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