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0 0.5 1 1.5 2+ Mortality 42% Improvement Relative Risk Fluvoxamine for COVID-19  Calusic et al.  ICU PATIENTS Is very late treatment with fluvoxamine beneficial for COVID-19? PSM prospective study of 102 patients in Croatia (Apr - May 2021) Lower mortality with fluvoxamine (p=0.027) Calusic et al., British J. Clinical Ph.., Nov 2021 Favors fluvoxamine Favors control

Safety and efficacy of fluvoxamine in COVID-19 ICU patients: an open label, prospective cohort trial with matched controls

Calusic et al., British Journal of Clinical Pharmacology, doi:10.1111/bcp.15126
Nov 2021  
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Prospective PSM study of 51 COVID-19 ICU patients in Croatia and 51 matched controls, showing significantly lower mortality with treatment.
risk of death, 42.0% lower, HR 0.58, p = 0.03, treatment 30 of 51 (58.8%), control 39 of 51 (76.5%), NNT 5.7, adjusted per study, propensity score matching.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Calusic et al., 1 Nov 2021, prospective, propensity score matching, Croatia, peer-reviewed, 7 authors, study period 1 April, 2021 - 31 May, 2021.
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Safety and efficacy of fluvoxamine in COVID‐19 ICU patients: An open label, prospective cohort trial with matched controls
Martina Calusic, Robert Marcec, Lea Luksa, Ivan Jurkovic, Natasa Kovac, Slobodan Mihaljevic, MD Robert Likic
British Journal of Clinical Pharmacology, doi:10.1111/bcp.15126
Background: Fluvoxamine, an SSRI and sigma-1 receptor agonist, has so far shown promise in the prevention of COVID-19 progression as an early treatment option in 3 conducted trials. The aim of this study was to evaluate the safety and efficacy of fluvoxamine in COVID-19 patients if administered later in the disease's course. Methods: The study was designed as an open label, prospective cohort trial with matched controls. In April and May 2021, 51 ICU COVID-19 patients hospitalised in the
Anderson, Fluvoxamine , melatonin and COVID
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Who, COVID-19 Weekly Epidemiological Update 55
Late treatment
is less effective
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