Repurposing antidepressants inhibiting the sphingomyelinase acid/ceramide system against COVID-19: current evidence and potential mechanisms

DOI record: { "DOI": "10.1038/s41380-021-01254-3", "ISSN": [ "1359-4184", "1476-5578" ], "URL": "http://dx.doi.org/10.1038/s41380-021-01254-3", "alternative-id": [ "1254" ], "assertion": [ { "group": { "label": "Article History", "name": "ArticleHistory" }, "label": "Received", "name": "received", "order": 1, "value": "30 June 2021" }, { "group": { "label": "Article History", "name": "ArticleHistory" }, "label": "Revised", "name": "revised", "order": 2, "value": "26 July 2021" }, { "group": { "label": "Article History", "name": "ArticleHistory" }, "label": "Accepted", "name": "accepted", "order": 3, "value": "29 July 2021" }, { "group": { "label": "Article History", "name": "ArticleHistory" }, "label": "First Online", "name": "first_online", "order": 4, "value": "12 August 2021" }, { "group": { "label": "Competing interests", "name": "EthicsHeading" }, "name": "Ethics", "order": 1, "value": "NH, MS-R, EG, JK, AC, and FL are inventors on a patent application related to methods of treating COVID-19, filled by Assistance Publique —Hopitaux de Paris in France. NH has received personal fees and nonfinancial support from Lundbeck, outside the submitted work. AMR and EJL are inventors on a patent application related to methods of treating COVID-19, which was filed by Washington University in St. Louis. EJL has received consulting fees from Johnson and Johnson, and Jazz Pharmaceuticals. AMR has received grant or research support from the McDonnell Center for Systems Neuroscience, the McDonnell Center for Cellular and Molecular Neurobiology, and the Taylor Family Institute for Innovative Psychiatric Research. DS is the Chief Medical Officer and CEO of Enable Biosciences, a CLIA certified Federal clinical reference laboratory that performs COVID-19 antibody testing. CL reports personal fees and nonfinancial support from Janssen-Cilag, Lundbeck, Otsuka Pharmaceutical, and Boehringer Ingelheim, outside the submitted work. FL has received speaker and consulting fees from Janssen-Cilag, Euthérapie-Servier, and Lundbeck, outside the submitted work. 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