Back to the Basics of SARS-CoV-2 Biochemistry: Microvascular Occlusive Glycan Bindings Govern Its Morbidities and Inform Therapeutic Responses

{ 'indexed': {'date-parts': [[2024, 4, 23]], 'date-time': '2024-04-23T00:37:09Z', 'timestamp': 1713832629606}, 'reference-count': 203, 'publisher': 'MDPI AG', 'issue': '4', 'license': [ { 'start': { 'date-parts': [[2024, 4, 22]], 'date-time': '2024-04-22T00:00:00Z', 'timestamp': 1713744000000}, 'content-version': 'vor', 'delay-in-days': 0, 'URL': 'https://creativecommons.org/licenses/by/4.0/'}], 'content-domain': {'domain': [], 'crossmark-restriction': False}, 'abstract': '<jats:p>Consistent with the biochemistry of coronaviruses as well established over decades, ' 'SARS-CoV-2 makes its initial attachment to host cells through the binding of its spike ' 'protein (SP) to sialylated glycans (containing the monosaccharide sialic acid) on the cell ' 'surface. The virus can then slide over and enter via ACE2. SARS-CoV-2 SP attaches ' 'particularly tightly to the trillions of red blood cells (RBCs), platelets and endothelial ' 'cells in the human body, each cell very densely coated with sialic acid surface molecules but ' 'having no ACE2 or minimal ACE2. These interlaced attachments trigger the blood cell ' 'aggregation, microvascular occlusion and vascular damage that underlie the hypoxia, blood ' 'clotting and related morbidities of severe COVID-19. Notably, the two human betacoronaviruses ' 'that express a sialic acid-cleaving enzyme are benign, while the other three—SARS, SARS-CoV-2 ' 'and MERS—are virulent. RBC aggregation experimentally induced in several animal species using ' 'an injected polysaccharide caused most of the same morbidities of severe COVID-19. This ' 'glycan biochemistry is key to disentangling controversies that have arisen over the efficacy ' 'of certain generic COVID-19 treatment agents and the safety of SP-based COVID-19 vaccines. ' 'More broadly, disregard for the active physiological role of RBCs yields unreliable or ' 'erroneous reporting of pharmacokinetic parameters as routinely obtained for most drugs and ' 'other bioactive agents using detection in plasma, with whole-blood levels being up to 30-fold ' 'higher. Appreciation of the active role of RBCs can elucidate the microvascular underpinnings ' 'of other health conditions, including cardiovascular disease, and therapeutic opportunities ' 'to address them.</jats:p>', 'DOI': '10.3390/v16040647', 'type': 'journal-article', 'created': {'date-parts': [[2024, 4, 22]], 'date-time': '2024-04-22T13:53:52Z', 'timestamp': 1713794032000}, 'page': '647', 'source': 'Crossref', 'is-referenced-by-count': 0, 'title': 'Back to the Basics of SARS-CoV-2 Biochemistry: Microvascular Occlusive Glycan Bindings Govern ' 'Its Morbidities and Inform Therapeutic Responses', 'prefix': '10.3390', 'volume': '16', 'author': [ { 'ORCID': 'http://orcid.org/0000-0001-6841-7054', 'authenticated-orcid': False, 'given': 'David E.', 'family': 'Scheim', 'sequence': 'first', 'affiliation': [ { 'name': 'US Public Health Service, Commissioned Corps, Inactive Reserve, ' 'Blacksburg, VA 24060, USA'}]}, { 'ORCID': 'http://orcid.org/0000-0003-1086-0138', 'authenticated-orcid': False, 'given': 'Peter I.', 'family': 'Parry', 'sequence': 'additional', 'affiliation': [ { 'name': 'Children’s Health Research Clinical Unit, Faculty of Medicine, ' 'The University of Queensland, South Brisbane, QLD 4101, ' 'Australia'}, { 'name': 'Department of Psychiatry, Flinders University, Bedford Park, SA ' '5042, Australia'}]}, { 'given': 'David J.', 'family': 'Rabbolini', 'sequence': 'additional', 'affiliation': [ { 'name': 'Kolling Institute, Faculty of Medicine and Health, The ' 'University of Sydney, St Leonards, NSW 2064, Australia'}]}, { 'given': 'Colleen', 'family': 'Aldous', 'sequence': 'additional', 'affiliation': [ { 'name': 'College of Health Sciences, University of KwaZulu-Natal, Durban ' '4041, South Africa'}]}, { 'ORCID': 'http://orcid.org/0009-0009-9427-1947', 'authenticated-orcid': False, 'given': 'Morimasa', 'family': 'Yagisawa', 'sequence': 'additional', 'affiliation': [ { 'name': 'Satoshi Omura Memorial Research Institute, Kitasato University, ' 'Tokyo 108-8641, Japan'}, { 'name': 'Louis Pasteur Center for Medical Research, Kyoto 606-8225, ' 'Japan'}]}, { 'given': 'Robert', 'family': 'Clancy', 'sequence': 'additional', 'affiliation': [ { 'name': 'Emeritus Professor, School of Medicine and Public Health, ' 'University of Newcastle, Newcastle, NE1 7RU, Australia'}]}, { 'ORCID': 'http://orcid.org/0000-0002-0519-4698', 'authenticated-orcid': False, 'given': 'Thomas J.', 'family': 'Borody', 'sequence': 'additional', 'affiliation': [{'name': 'Centre for Digestive Diseases, Five Dock, NSW 2046, Australia'}]}, { 'given': 'Wendy E.', 'family': 'Hoy', 'sequence': 'additional', 'affiliation': [ { 'name': 'Emeritus Professor of Medicine, University of Queensland, ' 'Herston, QLD 4029, Australia'}]}], 'member': '1968', 'published-online': {'date-parts': [[2024, 4, 22]]}, 'reference': [ { 'key': 'ref_1', 'doi-asserted-by': 'crossref', 'unstructured': 'Scheim, D.E., Vottero, P., Santin, A.D., and Hirsh, A.G. (2023). ' 'Sialylated Glycan Bindings from SARS-CoV-2 Spike Protein to Blood and ' 'Endothelial Cells Govern the Severe Morbidities of COVID-19. Int. J. ' 'Mol. Sci., 24.', 'DOI': '10.3390/ijms242317039'}, { 'key': 'ref_2', 'doi-asserted-by': 'crossref', 'unstructured': 'Parry, P.I., Lefringhausen, A., Turni, C., Neil, C.J., Cosford, R., ' 'Hudson, N.J., and Gillespie, J. (2023). ‘Spikeopathy’: COVID-19 Spike ' 'Protein Is Pathogenic, from Both Virus and Vaccine mRNA. Biomedicines, ' '11.', 'DOI': '10.3390/biomedicines11082287'}, { 'key': 'ref_3', 'doi-asserted-by': 'crossref', 'unstructured': 'Robson, B. (2020). Bioinformatics studies on a function of the ' 'SARS-CoV-2 spike glycoprotein as the binding of host sialic acid ' 'glycans. Comput. Biol. Med., 122.', 'DOI': '10.1016/j.compbiomed.2020.103849'}, { 'key': 'ref_4', 'doi-asserted-by': 'crossref', 'unstructured': 'Scheim, D.E. (2022). A Deadly Embrace: Hemagglutination Mediated by ' 'SARS-CoV-2 Spike Protein at its 22 N-Glycosylation Sites, Red Blood Cell ' 'Surface Sialoglycoproteins, and Antibody. Int. J. Mol. Sci., 23.', 'DOI': '10.3390/ijms23052558'}, { 'key': 'ref_5', 'doi-asserted-by': 'crossref', 'first-page': '154497', 'DOI': '10.1016/j.prp.2023.154497', 'article-title': 'COVID-19, post-acute COVID-19 syndrome (PACS, “long COVID”) and ' 'post-COVID-19 vaccination syndrome (PCVS, “post-COVIDvac-syndrome”): ' 'Similarities and differences', 'volume': '246', 'author': 'Scholkmann', 'year': '2023', 'journal-title': 'Pathol.—Res. Pract.'}, { 'key': 'ref_6', 'doi-asserted-by': 'crossref', 'first-page': '610', 'DOI': '10.1016/j.sbi.2011.08.009', 'article-title': 'Viruses and sialic acids: Rules of engagement', 'volume': '21', 'author': 'Neu', 'year': '2011', 'journal-title': 'Curr. Opin. Struct. Biol.'}, { 'key': 'ref_7', 'doi-asserted-by': 'crossref', 'first-page': '16', 'DOI': '10.1111/j.1749-6632.2012.06517.x', 'article-title': 'Multifarious roles of sialic acids in immunity', 'volume': '1253', 'author': 'Varki', 'year': '2012', 'journal-title': 'Ann. N. Y. Acad. Sci.'}, { 'key': 'ref_8', 'doi-asserted-by': 'crossref', 'first-page': '1155', 'DOI': '10.1002/cbic.201700077', 'article-title': 'Biochemical, Cellular, Physiological, and Pathological Consequences of ' 'Human Loss of N-Glycolylneuraminic Acid', 'volume': '18', 'author': 'Okerblom', 'year': '2017', 'journal-title': 'ChemBioChem'}, { 'key': 'ref_9', 'doi-asserted-by': 'crossref', 'unstructured': 'Cosic, I., Cosic, D., and Loncarevic, I. (2020). RRM Prediction of ' 'Erythrocyte Band3 Protein as Alternative Receptor for SARS-CoV-2 Virus. ' 'Appl. Sci., 10.', 'DOI': '10.3390/app10114053'}, { 'key': 'ref_10', 'doi-asserted-by': 'crossref', 'first-page': '1317', 'DOI': '10.1182/blood.2020007214', 'article-title': 'Platelet Gene Expression and Function in COVID-19 Patients', 'volume': '136', 'author': 'Manne', 'year': '2020', 'journal-title': 'Blood'}, { 'key': 'ref_11', 'doi-asserted-by': 'crossref', 'first-page': '46', 'DOI': '10.1111/jth.15156', 'article-title': 'Is there a role for the ACE2 receptor in SARS-CoV-2 interactions with ' 'platelets?', 'volume': '19', 'author': 'Campbell', 'year': '2021', 'journal-title': 'J. Thromb. Haemost.'}, { 'key': 'ref_12', 'doi-asserted-by': 'crossref', 'first-page': '1111', 'DOI': '10.1016/j.jacbts.2020.09.010', 'article-title': 'Cardiorenal Tissues Express SARS-CoV-2 Entry Genes and Basigin ' '(BSG/CD147) Increases with Age in Endothelial Cells', 'volume': '5', 'author': 'Vaja', 'year': '2020', 'journal-title': 'JACC Basic Transl. Sci.'}, { 'key': 'ref_13', 'doi-asserted-by': 'crossref', 'unstructured': 'Ganier, C., Du-Harpur, X., Harun, N., Wan, B., Arthurs, C., Luscombe, ' 'N., Watt, F., and Lynch, M. (2020). CD147 (BSG) but not ACE2 expression ' 'is detectable in vascular endothelial cells within single cell RNA ' 'sequencing datasets derived from multiple tissues in healthy ' 'individuals. bioRxiv.', 'DOI': '10.1101/2020.05.29.123513'}, { 'key': 'ref_14', 'doi-asserted-by': 'crossref', 'first-page': '865', 'DOI': '10.1161/CIRCULATIONAHA.120.052824', 'article-title': 'Lack of Evidence of Angiotensin-Converting Enzyme 2 Expression and ' 'Replicative Infection by SARS-CoV-2 in Human Endothelial Cells', 'volume': '143', 'author': 'McCracken', 'year': '2021', 'journal-title': 'Circulation'}, { 'key': 'ref_15', 'doi-asserted-by': 'crossref', 'first-page': '1089', 'DOI': '10.1016/j.stemcr.2022.03.016', 'article-title': 'The SARS-CoV-2 receptor ACE2 is expressed in mouse pericytes but not ' 'endothelial cells: Implications for COVID-19 vascular research', 'volume': '17', 'author': 'Muhl', 'year': '2022', 'journal-title': 'Stem Cell Rep.'}, { 'key': 'ref_16', 'doi-asserted-by': 'crossref', 'first-page': '11855', 'DOI': '10.1038/s41598-022-15976-z', 'article-title': 'Senescent endothelial cells are predisposed to SARS-CoV-2 infection and ' 'subsequent endothelial dysfunction', 'volume': '12', 'author': 'Urata', 'year': '2022', 'journal-title': 'Sci. Rep.'}, { 'key': 'ref_17', 'doi-asserted-by': 'crossref', 'first-page': '1374', 'DOI': '10.1016/j.ajpath.2021.05.007', 'article-title': 'COVID-19 Vasculopathy: Mounting Evidence for an Indirect Mechanism of ' 'Endothelial Injury', 'volume': '191', 'author': 'Nicosia', 'year': '2021', 'journal-title': 'Am. J. Pathol.'}, { 'key': 'ref_18', 'doi-asserted-by': 'crossref', 'unstructured': 'Liu, F., Han, K., Blair, R., Kenst, K., Qin, Z., Upcin, B., Wörsdörfer, ' 'P., Midkiff, C.C., Mudd, J., and Belyaeva, E. (2021). SARS-CoV-2 Infects ' 'Endothelial Cells In Vivo and In Vitro. Front. Cell Infect. Microbiol., ' '11.', 'DOI': '10.3389/fcimb.2021.701278'}, { 'key': 'ref_19', 'first-page': '543', 'article-title': 'Unusually high concentrations of sialic acids on the surface of ' 'vascular endothelia', 'volume': '66', 'author': 'Born', 'year': '1985', 'journal-title': 'Br. J. Exp. Pathol.'}, { 'key': 'ref_20', 'doi-asserted-by': 'crossref', 'first-page': '481', 'DOI': '10.1111/j.1538-7836.2010.04164.x', 'article-title': 'A local increase in red blood cell aggregation can trigger deep vein ' 'thrombosis: Evidence based on quantitative cellular ultrasound imaging', 'volume': '9', 'author': 'Yu', 'year': '2011', 'journal-title': 'J. Thromb. Haemost.'}, { 'key': 'ref_21', 'doi-asserted-by': 'crossref', 'first-page': '271', 'DOI': '10.1111/jth.14360', 'article-title': 'Red blood cells: The forgotten player in hemostasis and thrombosis', 'volume': '17', 'author': 'Weisel', 'year': '2019', 'journal-title': 'J. Thromb. Haemost.'}, { 'key': 'ref_22', 'doi-asserted-by': 'crossref', 'first-page': '1795', 'DOI': '10.1182/blood-2017-03-745349', 'article-title': 'Red blood cells in thrombosis', 'volume': '130', 'author': 'Byrnes', 'year': '2017', 'journal-title': 'Blood'}, { 'key': 'ref_23', 'doi-asserted-by': 'crossref', 'first-page': '283', 'DOI': '10.1002/ajh.26440', 'article-title': 'Increased blood viscosity and red blood cell aggregation in patients ' 'with COVID-19', 'volume': '97', 'author': 'Nader', 'year': '2022', 'journal-title': 'Am. J. Hematol.'}, { 'key': 'ref_24', 'doi-asserted-by': 'crossref', 'first-page': '29', 'DOI': '10.1016/bs.aivir.2016.08.004', 'article-title': 'Chapter Two—Coronavirus Spike Protein and Tropism Changes', 'volume': 'Volume 96', 'author': 'Ziebuhr', 'year': '2016', 'journal-title': 'Advances in Virus Research'}, { 'key': 'ref_25', 'doi-asserted-by': 'crossref', 'first-page': '143', 'DOI': '10.1146/annurev-virology-122019-070025', 'article-title': 'Initial Step of Virus Entry: Virion Binding to Cell-Surface Glycans', 'volume': '7', 'author': 'Koehler', 'year': '2020', 'journal-title': 'Annu. Rev. Virol.'}, { 'key': 'ref_26', 'doi-asserted-by': 'crossref', 'first-page': 'e02764-19', 'DOI': '10.1128/mBio.02764-19', 'article-title': 'Distinct Roles for Sialoside and Protein Receptors in Coronavirus ' 'Infection', 'volume': '11', 'author': 'Qing', 'year': '2020', 'journal-title': 'mBio'}, { 'key': 'ref_27', 'doi-asserted-by': 'crossref', 'first-page': '285', 'DOI': '10.1146/annurev-virology-031413-085417', 'article-title': 'Glycan Engagement by Viruses: Receptor Switches and Specificity', 'volume': '1', 'author': 'Stehle', 'year': '2014', 'journal-title': 'Annu. Rev. Virol.'}, { 'key': 'ref_28', 'doi-asserted-by': 'crossref', 'first-page': '747', 'DOI': '10.1093/glycob/9.8.747', 'article-title': 'Evolutionary considerations in relating oligosaccharide diversity to ' 'biological function', 'volume': '9', 'author': 'Gagneux', 'year': '1999', 'journal-title': 'Glycobiology'}, { 'key': 'ref_29', 'doi-asserted-by': 'crossref', 'first-page': '2046', 'DOI': '10.1021/acscentsci.0c00855', 'article-title': 'The SARS-CoV-2 Spike Protein Binds Sialic Acids and Enables Rapid ' 'Detection in a Lateral Flow Point of Care Diagnostic Device', 'volume': '6', 'author': 'Baker', 'year': '2020', 'journal-title': 'ACS Cent. Sci.'}, { 'key': 'ref_30', 'doi-asserted-by': 'crossref', 'first-page': 'e202201432', 'DOI': '10.1002/anie.202201432', 'article-title': 'The SARS-CoV-2 Spike Glycoprotein Directly Binds Exogeneous Sialic ' 'Acids: A NMR View', 'volume': '61', 'author': 'Unione', 'year': '2022', 'journal-title': 'Angew. Chem. Int. Ed.'}, { 'key': 'ref_31', 'doi-asserted-by': 'crossref', 'first-page': '283', 'DOI': '10.1038/s41392-020-00426-x', 'article-title': 'CD147-spike protein is a novel route for SARS-CoV-2 infection to host ' 'cells', 'volume': '5', 'author': 'Wang', 'year': '2020', 'journal-title': 'Signal Transduct. Target. Ther.'}, { 'key': 'ref_32', 'doi-asserted-by': 'crossref', 'first-page': 'eabj7790', 'DOI': '10.1126/scitranslmed.abj7790', 'article-title': 'Lung epithelial and endothelial damage, loss of tissue repair, ' 'inhibition of fibrinolysis, and cellular senescence in fatal COVID-19', 'volume': '13', 'author': 'Walters', 'year': '2021', 'journal-title': 'Sci. Transl. Med.'}, { 'key': 'ref_33', 'first-page': 'e14726', 'article-title': 'SARS-CoV-2 related microvascular damage and symptoms during and after ' 'COVID-19: Consequences of capillary transit-time changes, tissue ' 'hypoxia and inflammation', 'volume': '9', 'year': '2021', 'journal-title': 'Physiol. Rep.'}, { 'key': 'ref_34', 'doi-asserted-by': 'crossref', 'first-page': '855', 'DOI': '10.1080/14789450.2018.1531710', 'article-title': 'Red blood cells as an organ? How deep omics characterization of the ' 'most abundant cell in the human body highlights other systemic ' 'metabolic functions beyond oxygen transport', 'volume': '15', 'author': 'Nemkov', 'year': '2018', 'journal-title': 'Expert Rev. Proteom.'}, { 'key': 'ref_35', 'doi-asserted-by': 'crossref', 'unstructured': 'Sender, R., Fuchs, S., and Milo, R. (2016). Revised Estimates for the ' 'Number of Human and Bacteria Cells in the Body. PLoS Biol., 14.', 'DOI': '10.1101/036103'}, { 'key': 'ref_36', 'first-page': '59', 'article-title': 'Blood platelets', 'volume': '66', 'author': 'Hilton', 'year': '1979', 'journal-title': 'Sci. Prog.'}, { 'key': 'ref_37', 'doi-asserted-by': 'crossref', 'first-page': '392', 'DOI': '10.1016/0968-0004(85)90067-2', 'article-title': 'The red cell surface revisited', 'volume': '10', 'author': 'Viitala', 'year': '1985', 'journal-title': 'Trends Biochem. Sci.'}, { 'key': 'ref_38', 'doi-asserted-by': 'crossref', 'first-page': '223', 'DOI': '10.1093/oxfordjournals.molbev.a004075', 'article-title': 'Natural selection on the erythrocyte surface', 'volume': '19', 'author': 'Baum', 'year': '2002', 'journal-title': 'Mol. Biol. Evol.'}, { 'key': 'ref_39', 'doi-asserted-by': 'crossref', 'unstructured': 'Boschi, C., Scheim, D.E., Bancod, A., Militello, M., Bideau, M.L., ' 'Colson, P., Fantini, J., and Scola, B.L. (2022). SARS-CoV-2 Spike ' 'Protein Induces Hemagglutination: Implications for COVID-19 Morbidities ' 'and Therapeutics and for Vaccine Adverse Effects. Int. J. Mol. Sci., 23.', 'DOI': '10.1101/2022.11.24.517882'}, { 'key': 'ref_40', 'doi-asserted-by': 'crossref', 'first-page': 'L485', 'DOI': '10.1152/ajplung.00231.2021', 'article-title': 'Erythrocytes identify complement activation in patients with COVID-19', 'volume': '321', 'author': 'Lam', 'year': '2021', 'journal-title': 'Am. J. Physiol. Lung Cell. Mol. Physiol.'}, { 'key': 'ref_41', 'doi-asserted-by': 'crossref', 'first-page': '1124', 'DOI': '10.1016/j.ijbiomac.2021.10.112', 'article-title': 'SARS-CoV-2 spike protein causes blood coagulation and thrombosis by ' 'competitive binding to heparan sulfate', 'volume': '193', 'author': 'Zheng', 'year': '2021', 'journal-title': 'Int. J. Biol. Macromol.'}, { 'key': 'ref_42', 'doi-asserted-by': 'crossref', 'first-page': '1205', 'DOI': '10.1016/j.scib.2021.01.010', 'article-title': 'Binding of the SARS-CoV-2 spike protein to glycans', 'volume': '66', 'author': 'Hao', 'year': '2021', 'journal-title': 'Sci. Bull.'}, { 'key': 'ref_43', 'doi-asserted-by': 'crossref', 'first-page': '413', 'DOI': '10.1038/s41598-020-80464-1', 'article-title': 'No evidence for basigin/CD147 as a direct SARS-CoV-2 spike binding ' 'receptor', 'volume': '11', 'author': 'Shilts', 'year': '2021', 'journal-title': 'Sci. Rep.'}, { 'key': 'ref_44', 'doi-asserted-by': 'crossref', 'first-page': '1609', 'DOI': '10.1161/CIRCULATIONAHA.120.050354', 'article-title': 'Severe COVID-19 Is a Microvascular Disease', 'volume': '142', 'author': 'Lowenstein', 'year': '2020', 'journal-title': 'Circulation'}, { 'key': 'ref_45', 'doi-asserted-by': 'crossref', 'first-page': '1', 'DOI': '10.1016/j.trsl.2020.04.007', 'article-title': 'Complement associated microvascular injury and thrombosis in the ' 'pathogenesis of severe COVID-19 infection: A report of five cases', 'volume': '220', 'author': 'Magro', 'year': '2020', 'journal-title': 'Transl. Res.'}, { 'key': 'ref_46', 'doi-asserted-by': 'crossref', 'unstructured': 'Grobler, C., Maphumulo, S.C., Grobbelaar, L.M., Bredenkamp, J.C., ' 'Laubscher, G.J., Lourens, P.J., Steenkamp, J., Kell, D.B., and ' 'Pretorius, E. (2020). COVID-19: The Rollercoaster of Fibrin(Ogen), ' 'D-Dimer, Von Willebrand Factor, P-Selectin and Their Interactions with ' 'Endothelial Cells, Platelets and Erythrocytes. Int. J. Mol. Sci., 21.', 'DOI': '10.20944/preprints202007.0142.v1'}, { 'key': 'ref_47', 'doi-asserted-by': 'crossref', 'first-page': '123', 'DOI': '10.1055/a-1551-9911', 'article-title': 'Mild COVID-19 and Impaired Blood Cell–Endothelial Crosstalk: ' 'Considering Long-Term Use of Antithrombotics?', 'volume': '122', 'author': 'Melkumyants', 'year': '2022', 'journal-title': 'Thromb. Haemost.'}, { 'key': 'ref_48', 'first-page': '34', 'article-title': 'Red blood cell morphology in patients with COVID-19-related anaemia', 'volume': '19', 'author': 'Berzuini', 'year': '2021', 'journal-title': 'Blood Transfus.'}, { 'key': 'ref_49', 'doi-asserted-by': 'crossref', 'first-page': '661', 'DOI': '10.1097/CCM.0000000000004862', 'article-title': 'Capillary Leukocytes, Microaggregates, and the Response to Hypoxemia in ' 'the Microcirculation of Coronavirus Disease 2019 Patients', 'volume': '49', 'author': 'Favaron', 'year': '2021', 'journal-title': 'Crit. Care Med.'}, { 'key': 'ref_50', 'doi-asserted-by': 'crossref', 'first-page': '100727', 'DOI': '10.1016/j.cegh.2021.100727', 'article-title': 'The dynamics of inflammatory markers in coronavirus disease-2019 ' '(COVID-19) patients: A systematic review and meta-analysis', 'volume': '11', 'author': 'Mahat', 'year': '2021', 'journal-title': 'Clin. Epidemiol. Glob. Health'}, { 'key': 'ref_51', 'doi-asserted-by': 'crossref', 'first-page': '1305', 'DOI': '10.1590/1806-9282.20210618', 'article-title': 'The prognostic significance of erythrocyte sedimentation rate in ' 'COVID-19', 'volume': '67', 'author': 'Kaya', 'year': '2021', 'journal-title': 'Rev. Assoc. Med. Bras.'}, { 'key': 'ref_52', 'doi-asserted-by': 'crossref', 'first-page': '1146', 'DOI': '10.1515/cclm-2020-0620', 'article-title': 'Erythrocyte sedimentation rate is associated with severe coronavirus ' 'disease 2019 (COVID-19): A pooled analysis', 'volume': '58', 'author': 'Plebani', 'year': '2020', 'journal-title': 'Clin. Chem. Lab. Med.'}, { 'key': 'ref_53', 'doi-asserted-by': 'crossref', 'unstructured': 'Kurt, C., and Altunceki, C.Y.A. (2022). Contribution of Erythrocyte ' 'Sedimentation Rate to Predict Disease Severity and Outcome in COVID-19 ' 'Patients. Can. J. Infect. Dis. Med. Microbiol., 2022.', 'DOI': '10.1155/2022/6510952'}, { 'key': 'ref_54', 'doi-asserted-by': 'crossref', 'first-page': '74', 'DOI': '10.1186/s43066-021-00144-1', 'article-title': 'Long-term clinical and biochemical residue after COVID-19 recovery', 'volume': '11', 'author': 'Gameil', 'year': '2021', 'journal-title': 'Egypt. Liver J.'}, { 'key': 'ref_55', 'doi-asserted-by': 'crossref', 'first-page': '30', 'DOI': '10.1186/s40001-020-00432-3', 'article-title': 'Laboratory features of severe vs. non-severe COVID-19 patients in Asian ' 'populations: A systematic review and meta-analysis', 'volume': '25', 'author': 'Ghahramani', 'year': '2020', 'journal-title': 'Eur. J. Med. Res.'}, { 'key': 'ref_56', 'doi-asserted-by': 'crossref', 'first-page': '1089', 'DOI': '10.1007/s00134-020-06062-x', 'article-title': 'High risk of thrombosis in patients with severe SARS-CoV-2 infection: A ' 'multicenter prospective cohort study', 'volume': '46', 'author': 'Helms', 'year': '2020', 'journal-title': 'Intensive Care Med.'}, { 'key': 'ref_57', 'doi-asserted-by': 'crossref', 'first-page': '1738', 'DOI': '10.1111/jth.14850', 'article-title': 'Hypercoagulability of COVID-19 patients in intensive care unit: A ' 'report of thromboelastography findings and other parameters of ' 'hemostasis', 'volume': '18', 'author': 'Panigada', 'year': '2020', 'journal-title': 'J. Thromb. Haemost.'}, { 'key': 'ref_58', 'doi-asserted-by': 'crossref', 'first-page': '101324', 'DOI': '10.1016/j.gore.2024.101324', 'article-title': 'Increased von Willebrand and Factor VIII plasma levels in gynecologic ' 'patients with Post-Acute-COVID-Sequela (PASC)/Long COVID', 'volume': '51', 'author': 'Bellone', 'year': '2024', 'journal-title': 'Gynecol. Oncol. Rep.'}, { 'key': 'ref_59', 'doi-asserted-by': 'crossref', 'first-page': '386', 'DOI': '10.1161/01.CIR.14.3.386', 'article-title': 'Angioscopic Changes in the Smaller Blood Vessels in Diabetes Mellitus ' 'and their Relationship to Aging', 'volume': '14', 'author': 'Ditzel', 'year': '1956', 'journal-title': 'Circulation'}, { 'key': 'ref_60', 'doi-asserted-by': 'crossref', 'first-page': '5', 'DOI': '10.1111/j.1549-8719.2011.00130.x', 'article-title': 'Microvascular Dysfunction: A Potential Mechanism in the Pathogenesis of ' 'Obesity-associated Insulin Resistance and Hypertension', 'volume': '19', 'author': 'Meijer', 'year': '2012', 'journal-title': 'Microcirculation'}, { 'key': 'ref_61', 'unstructured': 'Bicher, H.I. (1972). Blood Cell Aggregation in Thrombotic Processes, C. ' 'C. Thomas. Chapter I: Red cell aggregation in thrombotic disease, trauma ' 'and shock.'}, { 'key': 'ref_62', 'doi-asserted-by': 'crossref', 'first-page': '105', 'DOI': '10.1177/000331975600700202', 'article-title': 'Concerning the Geometric Shapes of Arteries and Arterioles: A ' 'Contribution to the Biophysics of Health, Disease, and Death', 'volume': '7', 'author': 'Knisely', 'year': '1956', 'journal-title': 'Angiology'}, { 'key': 'ref_63', 'doi-asserted-by': 'crossref', 'first-page': '1933', 'DOI': '10.1093/cid/ciab707', 'article-title': 'Intravenous Injection of Coronavirus Disease 2019 (COVID-19) mRNA ' 'Vaccine Can Induce Acute Myopericarditis in Mouse Model', 'volume': '74', 'author': 'Li', 'year': '2022', 'journal-title': 'Clin. Infect. Diseases'}, { 'key': 'ref_64', 'first-page': '211', 'article-title': 'COVID 19 m-RNA (Pfizer) vaccination impairs cardiac functions in adult ' 'male rats', 'volume': '43', 'author': 'Hassan', 'year': '2023', 'journal-title': 'Bull. Egypt. Soc. Physiol. Sci.'}, { 'key': 'ref_65', 'doi-asserted-by': 'crossref', 'first-page': '102742', 'DOI': '10.1016/j.pdpdt.2022.102742', 'article-title': 'The assesment of retina and optic disc vascular structures in people ' 'who received CoronaVac vaccine', 'volume': '38', 'author': 'Gedik', 'year': '2022', 'journal-title': 'Photodiagnosis Photodyn. Ther.'}, { 'key': 'ref_66', 'doi-asserted-by': 'crossref', 'first-page': '103702', 'DOI': '10.1016/j.pdpdt.2023.103702', 'article-title': 'Effects of Sinovac-Coronavac and Pfizer-BioNTech mRNA vaccines on ' 'choroidal and retinal vascular system', 'volume': '43', 'author': 'Saritas', 'year': '2023', 'journal-title': 'Photodiagnosis Photodyn. Ther.'}, { 'key': 'ref_67', 'doi-asserted-by': 'crossref', 'first-page': '104500', 'DOI': '10.1016/j.mvr.2023.104500', 'article-title': 'Evaluation of retinal and optic disc vascular structures in individuals ' 'before and after Pfizer-BioNTech vaccination', 'volume': '147', 'author': 'Gedik', 'year': '2023', 'journal-title': 'Microvasc. Res.'}, { 'key': 'ref_68', 'doi-asserted-by': 'crossref', 'unstructured': 'Haider, A., Bengs, S., Schade, K., Wijnen, W.J., Portmann, A., Etter, ' 'D., Fröhlich, S., Warnock, G.I., Treyer, V., and Burger, I.A. (2020). ' 'Myocardial 18F-FDG Uptake Pattern for Cardiovascular Risk Stratification ' 'in Patients Undergoing Oncologic PET/CT. J. Clin. Med., 9.', 'DOI': '10.3390/jcm9072279'}, { 'key': 'ref_69', 'first-page': '624', 'article-title': 'Likely Common Role of Hypoxia in Driving 18F-FDG Uptake in Cancer, ' 'Myocardial Ischemia, Inflammation and Infection', 'volume': '36', 'author': 'Yao', 'year': '2021', 'journal-title': 'Cancer Biother. Radiopharm.'}, { 'key': 'ref_70', 'doi-asserted-by': 'crossref', 'first-page': 'e230743', 'DOI': '10.1148/radiol.230743', 'article-title': 'Assessment of Myocardial (18)F-FDG Uptake at PET/CT in Asymptomatic ' 'SARS-CoV-2-vaccinated and Nonvaccinated Patients', 'volume': '308', 'author': 'Nakahara', 'year': '2023', 'journal-title': 'Radiology'}, { 'key': 'ref_71', 'doi-asserted-by': 'crossref', 'first-page': 'A10712', 'DOI': '10.1161/circ.144.suppl_1.10712', 'article-title': 'Abstract 10712: Observational Findings of PULS Cardiac Test Findings ' 'for Inflammatory Markers in Patients Receiving mRNA Vaccines', 'volume': '144', 'author': 'Gundry', 'year': '2021', 'journal-title': 'Circulation'}, { 'key': 'ref_72', 'doi-asserted-by': 'crossref', 'first-page': 'e2300048', 'DOI': '10.1002/prca.202300048', 'article-title': 'Detection of recombinant Spike protein in the blood of individuals ' 'vaccinated against SARS-CoV-2: Possible molecular mechanisms', 'volume': '17', 'author': 'Brogna', 'year': '2023', 'journal-title': 'PROTEOMICS—Clin. Appl.'}, { 'key': 'ref_73', 'doi-asserted-by': 'crossref', 'first-page': '867', 'DOI': '10.1161/CIRCULATIONAHA.122.061025', 'article-title': 'Circulating Spike Protein Detected in Post–COVID-19 mRNA Vaccine ' 'Myocarditis', 'volume': '147', 'author': 'Yonker', 'year': '2023', 'journal-title': 'Circulation'}, { 'key': 'ref_74', 'doi-asserted-by': 'crossref', 'first-page': '2200', 'DOI': '10.1016/j.vaccine.2024.01.100', 'article-title': 'COVID-19 vaccines and adverse events of special interest: A ' 'multinational Global Vaccine Data Network (GVDN) cohort study of 99 ' 'million vaccinated individuals', 'volume': '42', 'author': 'Faksova', 'year': '2024', 'journal-title': 'Vaccine'}, { 'key': 'ref_75', 'doi-asserted-by': 'crossref', 'unstructured': 'Krumholz, H.M., Wu, Y., Sawano, M., Shah, R., Zhou, T., Arun, A.S., ' 'Khosla, P., Kaleem, S., Anushree, V., and Bornali, B. (2023). ' 'Post-Vaccination Syndrome: A Descriptive Analysis of Reported Symptoms ' 'and Patient Experiences After COVID-19 Immunization. medRxiv.', 'DOI': '10.1101/2023.11.09.23298266'}, { 'key': 'ref_76', 'doi-asserted-by': 'crossref', 'first-page': '1155', 'DOI': '10.1007/s00431-022-04786-0', 'article-title': 'Changes of ECG parameters after BNT162b2 vaccine in the senior high ' 'school students', 'volume': '182', 'author': 'Chiu', 'year': '2023', 'journal-title': 'Eur. J. Pediatr.'}, { 'key': 'ref_77', 'doi-asserted-by': 'crossref', 'unstructured': 'Mansanguan, S., Charunwatthana, P., Piyaphanee, W., Dechkhajorn, W., ' 'Poolcharoen, A., and Mansanguan, C. (2022). Cardiovascular Manifestation ' 'of the BNT162b2 mRNA COVID-19 Vaccine in Adolescents. Trop. Med. Infect. ' 'Dis., 7.', 'DOI': '10.20944/preprints202208.0151.v1'}, { 'key': 'ref_78', 'doi-asserted-by': 'crossref', 'first-page': '853', 'DOI': '10.2174/138920112800399095', 'article-title': 'History of avermectin and ivermectin, with notes on the history of ' 'other macrocyclic lactone antiparasitic agents', 'volume': '13', 'author': 'Campbell', 'year': '2012', 'journal-title': 'Curr. Pharm. Biotechnol.'}, { 'key': 'ref_79', 'first-page': '44', 'article-title': 'Global Trends in Clinical Studies of Ivermectin in COVID-19', 'volume': '74', 'author': 'Yagisawa', 'year': '2021', 'journal-title': 'Jpn. J. Antibiot.'}, { 'key': 'ref_80', 'doi-asserted-by': 'crossref', 'first-page': '2743', 'DOI': '10.1038/s41598-024-53086-0', 'article-title': 'Binding behavior of receptor binding domain of the SARS-CoV-2 virus and ' 'ivermectin', 'volume': '14', 'author': 'Gossen', 'year': '2024', 'journal-title': 'Sci. Rep.'}, { 'key': 'ref_81', 'doi-asserted-by': 'crossref', 'unstructured': 'Aminpour, M., Cannariato, M., Safaeeardebili, M.E., Preto, J., ' 'Moracchiato, A., Doria, D., Donato, F., Zizzi, E.A., Deriu, M.A., and ' 'Scheim, D.E. (2022). In Silico Analysis of the Multi-Targeted Mode of ' 'Action of Ivermectin and Related Compounds. Computation, 10.', 'DOI': '10.3390/computation10040051'}, { 'key': 'ref_82', 'doi-asserted-by': 'crossref', 'first-page': '3023', 'DOI': '10.21873/invivo.12134', 'article-title': 'Ivermectin Docks to the SARS-CoV-2 Spike Receptor-binding Domain ' 'Attached to ACE2', 'volume': '34', 'author': 'Lehrer', 'year': '2020', 'journal-title': 'In Vivo'}, { 'key': 'ref_83', 'doi-asserted-by': 'crossref', 'first-page': '196', 'DOI': '10.3390/biologics2030015', 'article-title': 'Changes in SpO2 on Room Air for 34 Severe COVID-19 Patients after ' 'Ivermectin-Based Combination Treatment: 62% Normalization within 24 ' 'Hours', 'volume': '2', 'author': 'Stone', 'year': '2022', 'journal-title': 'Biologics'}, { 'key': 'ref_84', 'doi-asserted-by': 'crossref', 'first-page': '1', 'DOI': '10.9734/jpri/2022/v34i44A36328', 'article-title': 'A comparison of Ivermectin and Non Ivermectin based regimen for ' 'COVID-19 in Abuja: Effects on virus clearance, Days-to-Discharge and ' 'Mortality', 'volume': '34', 'author': 'Thairu', 'year': '2022', 'journal-title': 'J. Pharm. Res. Int.'}, { 'key': 'ref_85', 'unstructured': 'Babalola, O.E. (Personal communication, 2022). (Bingham University, New ' 'Karu, Nigeria), Personal communication.'}, { 'key': 'ref_86', 'doi-asserted-by': 'crossref', 'first-page': '339', 'DOI': '10.2217/fmb-2022-0014', 'article-title': 'Effectiveness of ivermectin-based multidrug therapy in severely ' 'hypoxic, ambulatory COVID-19 patients', 'volume': '17', 'author': 'Hazan', 'year': '2022', 'journal-title': 'Future Microbiol.'}, { 'key': 'ref_87', 'doi-asserted-by': 'crossref', 'first-page': '233', 'DOI': '10.23937/2474-3658/1510233', 'article-title': 'A Randomized Controlled Trial of Ivermectin Monotherapy Versus HCQ, ' 'IVM, and AZ Combination Therapy in COVID-19 Patients in Nigeria', 'volume': '7', 'author': 'Babalola', 'year': '2021', 'journal-title': 'J. Infect. Dis. Epidemiol.'}, { 'key': 'ref_88', 'unstructured': 'Statistics Kingdom (2024, January 30). Mann Whitney U Test Calculator. ' 'Available online: ' 'http://www.statskingdom.com/170median_mann_whitney.html.'}, { 'key': 'ref_89', 'unstructured': 'Borody, T.J., and Clancy, R.L. (2024, March 29). Combination Therapy For ' 'COVID-19 Based on Ivermectin in an Australian Population. Trialsite ' 'News, 19 October 2021. Available online: ' 'https://www.trialsitenews.com/a/combination-therapy-for-covid-19-based-on-ivermectin-in-an-australian-population.'}, { 'key': 'ref_90', 'doi-asserted-by': 'crossref', 'first-page': '100924', 'DOI': '10.1016/j.nmni.2021.100924', 'article-title': 'Ivermectin: A multifaceted drug of Nobel prize-honored distinction with ' 'indicated efficacy against a new global scourge, COVID-19', 'volume': '43', 'author': 'Santin', 'year': '2021', 'journal-title': 'New Microbes New Infect.'}, { 'key': 'ref_91', 'doi-asserted-by': 'crossref', 'first-page': '1426', 'DOI': '10.1001/jama.2021.3071', 'article-title': 'Effect of Ivermectin on Time to Resolution of Symptoms Among Adults ' 'with Mild COVID-19: A Randomized Clinical Trial', 'volume': '325', 'author': 'Hurtado', 'year': '2021', 'journal-title': 'JAMA'}, { 'key': 'ref_92', 'doi-asserted-by': 'crossref', 'first-page': '1721', 'DOI': '10.1056/NEJMoa2115869', 'article-title': 'Effect of Early Treatment with Ivermectin among Patients with COVID-19', 'volume': '386', 'author': 'Reis', 'year': '2022', 'journal-title': 'N. Engl. J. Med.'}, { 'key': 'ref_93', 'doi-asserted-by': 'crossref', 'unstructured': 'Scheim, D.E., Aldous, C., Osimani, B., Fordham, E.J., and Hoy, W.E. ' '(2023). When Characteristics of Clinical Trials Require Per-Protocol as ' 'Well as Intention-to-Treat Outcomes to Draw Reliable Conclusions: Three ' 'Examples. J. Clin. Med., 12.', 'DOI': '10.3390/jcm12113625'}, { 'key': 'ref_94', 'doi-asserted-by': 'crossref', 'unstructured': 'Scheim, D.E., Hibberd, J.A., and Chamie-Quintero, J.J. (2021). Protocol ' 'violations in López-Medina et al.: 38 switched ivermectin (IVM) and ' 'placebo doses, failure of blinding, ubiquitous IVM use OTC in Cali, and ' 'nearly identical AEs for the IVM and control groups. OSF Prepr.', 'DOI': '10.31219/osf.io/u7ewz'}, { 'key': 'ref_95', 'doi-asserted-by': 'crossref', 'first-page': '481', 'DOI': '10.1038/d41586-020-02958-2', 'article-title': 'Latin America’s embrace of an unproven COVID treatment is hindering ' 'drug trials', 'volume': '586', 'year': '2020', 'journal-title': 'Nature'}, { 'key': 'ref_96', 'unstructured': 'U.S. Food & Drug Administration (2023, October 30). Memorandum ' 'Explaining Basis for Declining Request for Emergency Use Authorization ' 'of Fluvoxamine Maleate, Available online: ' 'https://www.accessdata.fda.gov/drugsatfda_docs/nda/2020/EUA%20110%20Fluvoxamine%20Decisional%20Memo_Redacted.pdf.'}, { 'key': 'ref_97', 'unstructured': 'NIH COVID-19 Treatment Guidelines (2023, October 30). NIH COVID-19 ' 'Treatment Guidelines. Fluvoxamine: Selected Clinical Data, Limitations ' 'and Interpretation. Table 4c. 16 December 2021, Available online: ' 'https://www.covid19treatmentguidelines.nih.gov/tables/fluvoxamine-data/.'}, { 'key': 'ref_98', 'unstructured': 'TOGETHER Trial DSS and Data Repository Screenshots (2023, October 30). ' 'Date-Time Stamped Screenshots from Publications of the TOGETHER trial ' '(NCT04727424). Available online: ' 'https://drive.google.com/file/d/1pBZ1GihxW_ROB3Aid6tFMplqAyMYOGDl/preview.'}, { 'key': 'ref_99', 'unstructured': '(2023, October 30). Email from Sarah Fullegar, Sent June 7, 2022, to ' 'Edmund Fordham, Screenshot, Email Addresses Redacted. Available online: ' 'https://drive.google.com/file/d/1lUsSRf1KX-pa9T5EX4HbegdK8mYNQ_Ty/preview.'}, { 'key': 'ref_100', 'unstructured': 'Letter from 66 Scientists and Physicians to the Coauthors of Reis et al ' '(2023, October 30). 2022 and to others as Identified in the ' 'Correspondence, as Emailed on May 10, 2022, Together with the Email ' 'Thread of Follow-up Correspondence through July 19, 2022, with All But ' 'Certain Publicly Available Email Addresses Redacted. Available online: ' 'https://drive.google.com/file/d/1eSez1YNIf26PHAPX6oHpw-UFg-QY1cfd/preview.'}, { 'key': 'ref_101', 'doi-asserted-by': 'crossref', 'first-page': 'e42', 'DOI': '10.1016/S2214-109X(21)00448-4', 'article-title': 'Effect of early treatment with fluvoxamine on risk of emergency care ' 'and hospitalisation among patients with COVID-19: The TOGETHER ' 'randomised, platform clinical trial', 'volume': '10', 'author': 'Reis', 'year': '2022', 'journal-title': 'Lancet Glob. Health'}, { 'key': 'ref_102', 'first-page': '100142', 'article-title': 'Effect of early treatment with metformin on risk of emergency care and ' 'hospitalization among patients with COVID-19: The TOGETHER randomized ' 'platform clinical trial', 'volume': '6', 'author': 'Reis', 'year': '2022', 'journal-title': 'Lancet Reg. Health Am.'}, { 'key': 'ref_103', 'doi-asserted-by': 'crossref', 'first-page': '106130', 'DOI': '10.1016/j.jinf.2024.106130', 'article-title': 'Ivermectin for COVID-19 in adults in the community (PRINCIPLE): An ' 'open, randomised, controlled, adaptive platform trial of short- and ' 'longer-term outcomes', 'volume': '88', 'author': 'Hayward', 'year': '2024', 'journal-title': 'J. Infect.'}, { 'key': 'ref_104', 'unstructured': 'c19ivm.org (2024, March 04). PRINCIPLE: Significantly Improved Recovery ' 'and Lower Long COVID with Ivermectin. Available online: ' 'https://c19ivm.org/principleivm.html.'}, { 'key': 'ref_105', 'doi-asserted-by': 'crossref', 'first-page': '1380', 'DOI': '10.1016/S0140-6736(15)60696-1', 'article-title': 'Offline: What is medicine’s 5 sigma?', 'volume': '385', 'author': 'Horton', 'year': '2015', 'journal-title': 'Lancet'}, { 'key': 'ref_106', 'doi-asserted-by': 'crossref', 'first-page': '82', 'DOI': '10.1016/j.jclinepi.2016.02.012', 'article-title': 'Evidence-based medicine has been hijacked: A report to David Sackett', 'volume': '73', 'author': 'Ioannidis', 'year': '2016', 'journal-title': 'J. Clin. Epidemiol.'}, { 'key': 'ref_107', 'unstructured': 'Gotzsche, P. (2013). Deadly Medicines and Organised Crime: How Big ' 'Pharma Has Corrupted Healthcare, CRC Press. [1st ed.]. Chapter 19.'}, { 'key': 'ref_108', 'doi-asserted-by': 'crossref', 'first-page': '472', 'DOI': '10.1111/anae.15263', 'article-title': 'False individual patient data and zombie randomised controlled trials ' 'submitted to Anaesthesia', 'volume': '76', 'author': 'Carlisle', 'year': '2021', 'journal-title': 'Anaesthesia'}, { 'key': 'ref_109', 'doi-asserted-by': 'crossref', 'first-page': '102860', 'DOI': '10.1016/j.futures.2021.102860', 'article-title': 'Science, the endless frontier of regulatory capture', 'volume': '135', 'author': 'Saltelli', 'year': '2022', 'journal-title': 'Futures'}, { 'key': 'ref_110', 'doi-asserted-by': 'crossref', 'first-page': 'h2942', 'DOI': '10.1136/bmj.h2942', 'article-title': 'Justifying conflicts of interest in medical journals: A very bad idea', 'volume': '350', 'author': 'Steinbrook', 'year': '2015', 'journal-title': 'BMJ'}, { 'key': 'ref_111', 'doi-asserted-by': 'crossref', 'first-page': '1069', 'DOI': '10.1001/jama.300.9.1069', 'article-title': 'Industry-Sponsored Clinical Research: A Broken System', 'volume': '300', 'author': 'Angell', 'year': '2008', 'journal-title': 'JAMA'}, { 'key': 'ref_112', 'doi-asserted-by': 'crossref', 'first-page': '377', 'DOI': '10.1017/S0963180107070478', 'article-title': 'Commercialism and Medicine: An Overview', 'volume': '16', 'author': 'Kassirer', 'year': '2007', 'journal-title': 'Camb. Q. Healthc. Ethics'}, { 'key': 'ref_113', 'doi-asserted-by': 'crossref', 'first-page': '120', 'DOI': '10.1136/bmj.39024.487720.68', 'article-title': 'What have we learnt from Vioxx?', 'volume': '334', 'author': 'Krumholz', 'year': '2007', 'journal-title': 'BMJ'}, { 'key': 'ref_114', 'doi-asserted-by': 'crossref', 'first-page': '145', 'DOI': '10.5694/j.1326-5377.1990.tb136833.x', 'article-title': 'Cure of duodenal ulcer after eradication of Helicobacter pylori', 'volume': '153', 'author': 'George', 'year': '1990', 'journal-title': 'Med. J. Aust.'}, { 'key': 'ref_115', 'doi-asserted-by': 'crossref', 'first-page': 'e12751', 'DOI': '10.1111/hel.12751', 'article-title': 'Clinical and economic impact of “triple therapy” for Helicobacter ' 'pylori eradication on peptic ulcer disease in Australia', 'volume': '25', 'author': 'Eslick', 'year': '2020', 'journal-title': 'Helicobacter'}, { 'key': 'ref_116', 'doi-asserted-by': 'crossref', 'unstructured': 'Feenstra, R.C., and Shapiro, M.D. (2003). Scanner Data and Price ' 'Indexes, University of Chicago Press.', 'DOI': '10.7208/chicago/9780226239668.001.0001'}, { 'key': 'ref_117', 'unstructured': 'Wemple, E. (2023, October 30). Opinion: Bogus Oklahoma ivermectin story ' 'was just too good to check. Washington Post, 9 September 2021. Available ' 'online: ' 'https://www.washingtonpost.com/opinions/2021/09/09/bogus-oklahoma-ivermectin-story-was-just-too-good-check/.'}, { 'key': 'ref_118', 'unstructured': 'McCarthy, J., Kory, P.D., and Bigtree, D. (2023). War on Ivermectin: The ' 'Medicine that Saved Millions and Could Have Ended the Pandemic, ' 'Skyhorse. Chapter 33.'}, { 'key': 'ref_119', 'unstructured': 'Pfeiffer, M.B., and Bonvie, L. (2023, October 30). Horse-Bleep: How 4 ' 'Calls on Animal Ivermectin Launched a False FDA-Media Attack on a ' 'Life-Saving Human Medicine. rescue.substack.com, 16 October 2021. ' 'Available online: ' 'https://rescue.substack.com/p/horse-bleep-how-4-calls-on-animal.'}, { 'key': 'ref_120', 'doi-asserted-by': 'crossref', 'unstructured': 'Scheim, D.E. (2023). “Discredit,” “Neutralize,” “Destroy”: The targeting ' 'of doctors and scientists who reported the deadly toxicities of a ' 'painkilling drug. OSF Prepr.', 'DOI': '10.31219/osf.io/bxk7d'}, { 'key': 'ref_121', 'first-page': 'e43168', 'article-title': 'COVID-19 Excess Deaths in Peru’s 25 States in 2020: Nationwide Trends, ' 'Confounding Factors, and Correlations with the Extent of Ivermectin ' 'Treatment by State', 'volume': '15', 'author': 'Chamie', 'year': '2023', 'journal-title': 'Cureus'}, { 'key': 'ref_122', 'doi-asserted-by': 'crossref', 'first-page': '626', 'DOI': '10.1111/bcp.13840', 'article-title': 'Population pharmacokinetics of oral ivermectin in venous plasma and ' 'dried blood spots in healthy volunteers', 'volume': '85', 'author': 'Duthaler', 'year': '2019', 'journal-title': 'Br. J. Clin. Pharmacol.'}, { 'key': 'ref_123', 'doi-asserted-by': 'crossref', 'first-page': '1202', 'DOI': '10.1097/00007890-199311000-00029', 'article-title': 'Blood distribution of rapamycin', 'volume': '56', 'author': 'Yatscoff', 'year': '1993', 'journal-title': 'Transplantation'}, { 'key': 'ref_124', 'doi-asserted-by': 'crossref', 'first-page': '478', 'DOI': '10.1097/00007691-199312000-00004', 'article-title': 'Therapeutic monitoring of rapamycin: A new immunosuppressive drug', 'volume': '15', 'author': 'Yatscoff', 'year': '1993', 'journal-title': 'Ther. Drug Monit.'}, { 'key': 'ref_125', 'unstructured': 'U.S. Food & Drug Administration (2024, January 29). Clinical ' 'Pharmacology/Biopharmaceutics Review, NDA: 21,083; Sirolimus (Rapamune), ' 'Available online: ' 'https://www.accessdata.fda.gov/drugsatfda_docs/nda/99/21083A_Rapamune_clinphrmr.pdf.'}, { 'key': 'ref_126', 'first-page': '279', 'article-title': 'Red blood cells: A neglected compartment in pharmacokinetics and ' 'pharmacodynamics', 'volume': '49', 'author': 'Hinderling', 'year': '1997', 'journal-title': 'Pharmacol. Rev.'}, { 'key': 'ref_127', 'doi-asserted-by': 'crossref', 'first-page': '1308632', 'DOI': '10.3389/fphys.2023.1308632', 'article-title': 'Drug transport by red blood cells', 'volume': '14', 'author': 'Biagiotti', 'year': '2023', 'journal-title': 'Front. Physiol.'}, { 'key': 'ref_128', 'doi-asserted-by': 'crossref', 'first-page': '7005', 'DOI': '10.1021/acs.jafc.0c02601', 'article-title': 'Red Blood Cells and Lipoproteins: Important Reservoirs and Transporters ' 'of Polyphenols and Their Metabolites', 'volume': '68', 'author': 'Harbi', 'year': '2020', 'journal-title': 'J. Agric. Food Chem.'}, { 'key': 'ref_129', 'doi-asserted-by': 'crossref', 'first-page': '715', 'DOI': '10.1093/cid/ciab465', 'article-title': 'Circulating Severe Acute Respiratory Syndrome Coronavirus 2 ' '(SARS-CoV-2) Vaccine Antigen Detected in the Plasma of mRNA-1273 ' 'Vaccine Recipients', 'volume': '74', 'author': 'Ogata', 'year': '2022', 'journal-title': 'Clin. Infect. Dis.'}, { 'key': 'ref_130', 'doi-asserted-by': 'crossref', 'unstructured': 'Cognetti, J.S., and Miller, B.L. (2021). Monitoring Serum Spike Protein ' 'with Disposable Photonic Biosensors Following SARS-CoV-2 Vaccination. ' 'Sensors, 21.', 'DOI': '10.3390/s21175857'}, { 'key': 'ref_131', 'doi-asserted-by': 'crossref', 'first-page': '1165', 'DOI': '10.1161/01.CIR.99.9.1165', 'article-title': 'Sex, Age, Cardiovascular Risk Factors, and Coronary Heart Disease', 'volume': '99', 'author': 'Jousilahti', 'year': '1999', 'journal-title': 'Circulation'}, { 'key': 'ref_132', 'doi-asserted-by': 'crossref', 'first-page': '25', 'DOI': '10.1177/2047487319878371', 'article-title': 'Diabetes as a cardiovascular risk factor: An overview of global trends ' 'of macro and micro vascular complications', 'volume': '26', 'author': 'Ceriello', 'year': '2019', 'journal-title': 'Eur. J. Prev. Cardiol.'}, { 'key': 'ref_133', 'first-page': 'e984', 'article-title': 'Obesity and Cardiovascular Disease: A Scientific Statement From the ' 'American Heart Association', 'volume': '143', 'author': 'Poirier', 'year': '2021', 'journal-title': 'Circulation'}, { 'key': 'ref_134', 'doi-asserted-by': 'crossref', 'unstructured': 'Michel, J.-B., and Martin-Ventura, J.L. (2020). Red Blood Cells and ' 'Hemoglobin in Human Atherosclerosis and Related Arterial Diseases. Int. ' 'J. Mol. Sci., 21.', 'DOI': '10.3390/ijms21186756'}, { 'key': 'ref_135', 'doi-asserted-by': 'crossref', 'unstructured': 'Turpin, C., Catan, A., Meilhac, O., Bourdon, E., Canonne-Hergaux, F., ' 'and Rondeau, P. (2021). Erythrocytes: Central Actors in Multiple Scenes ' 'of Atherosclerosis. Int. J. Mol. Sci., 22.', 'DOI': '10.3390/ijms22115843'}, { 'key': 'ref_136', 'doi-asserted-by': 'crossref', 'first-page': '639', 'DOI': '10.1016/S0195-668X(02)00741-8', 'article-title': 'Erythrocyte sedimentation rate, coronary atherosclerosis, and cardiac ' 'mortality', 'volume': '24', 'author': 'Natali', 'year': '2003', 'journal-title': 'Eur. Heart J.'}, { 'key': 'ref_137', 'doi-asserted-by': 'crossref', 'first-page': '33', 'DOI': '10.1155/2008/184647', 'article-title': 'Erythrocyte aggregation as an early biomarker in patients with ' 'asymptomatic carotid stenosis', 'volume': '24', 'author': 'Assayag', 'year': '2008', 'journal-title': 'Dis. Markers'}, { 'key': 'ref_138', 'doi-asserted-by': 'crossref', 'first-page': '1614', 'DOI': '10.1053/euhj.2000.2148', 'article-title': 'Erythrocyte sedimentation rate: A possible marker of atherosclerosis ' 'and a strong predictor of coronary heart disease mortality', 'volume': '21', 'author': 'Erikssen', 'year': '2000', 'journal-title': 'Eur. Heart J.'}, { 'key': 'ref_139', 'doi-asserted-by': 'crossref', 'first-page': '689', 'DOI': '10.1258/ebm.2010.009370', 'article-title': 'Polyphenols enhance total oxidant-scavenging capacities of human blood ' 'by binding to red blood cells', 'volume': '235', 'author': 'Koren', 'year': '2010', 'journal-title': 'Exp. Biol. Med.'}, { 'key': 'ref_140', 'doi-asserted-by': 'crossref', 'first-page': '7262474', 'DOI': '10.1155/2020/7262474', 'article-title': 'Hemorheological Alterations in Patients with Heart Failure with Reduced ' 'Ejection Fraction Treated by Resveratrol', 'volume': '2020', 'author': 'Gal', 'year': '2020', 'journal-title': 'Cardiovasc. Ther.'}, { 'key': 'ref_141', 'doi-asserted-by': 'crossref', 'first-page': '163', 'DOI': '10.5152/eurjrheum.2023.23064', 'article-title': 'Resveratrol in Rheumatological Diseases: A Systematic Review', 'volume': '10', 'author': 'Carvalho', 'year': '2023', 'journal-title': 'Eur. J. Rheumatol.'}, { 'key': 'ref_142', 'doi-asserted-by': 'crossref', 'first-page': '164', 'DOI': '10.1016/j.imbio.2016.10.008', 'article-title': 'Resveratrol improves treatment outcome and laboratory parameters in ' 'patients with Takayasu arteritis: A randomized double-blind and ' 'placebo-controlled trial', 'volume': '222', 'author': 'Shi', 'year': '2017', 'journal-title': 'Immunobiology'}, { 'key': 'ref_143', 'doi-asserted-by': 'crossref', 'first-page': '900', 'DOI': '10.3389/neuro.24.004.2009', 'article-title': 'Resveratrol preserves cerebrovascular density and cognitive function in ' 'aging mice', 'volume': '1', 'author': 'Oomen', 'year': '2009', 'journal-title': 'Front. Aging Neurosci.'}, { 'key': 'ref_144', 'doi-asserted-by': 'crossref', 'first-page': '6570', 'DOI': '10.3390/molecules15096570', 'article-title': 'Determination of Quercetin and Resveratrol in Whole Blood—Implications ' 'for Bioavailability Studies', 'volume': '15', 'author': 'Biasutto', 'year': '2010', 'journal-title': 'Molecules'}, { 'key': 'ref_145', 'unstructured': 'Oregon State University, Linus Pauling Institute (2024, January 30). ' 'Micronutrient Information Center: Resveratrol. 11 June 2015. Available ' 'online: ' 'https://lpi.oregonstate.edu/mic/dietary-factors/phytochemicals/resveratrol.'}, { 'key': 'ref_146', 'doi-asserted-by': 'crossref', 'first-page': '360', 'DOI': '10.1002/biof.105', 'article-title': 'Resveratrol: Biological and pharmaceutical properties as anticancer ' 'molecule', 'volume': '36', 'author': 'Hsieh', 'year': '2010', 'journal-title': 'Biofactors'}, { 'key': 'ref_147', 'doi-asserted-by': 'crossref', 'first-page': '9', 'DOI': '10.1111/j.1749-6632.2010.05842.x', 'article-title': 'Bioavailability of resveratrol', 'volume': '1215', 'author': 'Walle', 'year': '2011', 'journal-title': 'Ann. N. Y. Acad. Sci.'}, { 'key': 'ref_148', 'doi-asserted-by': 'crossref', 'first-page': '137', 'DOI': '10.1016/S0378-4347(00)86110-1', 'article-title': 'Distribution of chloroquine and its metabolite desethyl-chloroquine in ' 'human blood cells and its implication for the quantitative ' 'determination of these compounds in serum and plasma', 'volume': '272', 'author': 'Bergqvist', 'year': '1983', 'journal-title': 'J. Chromatogr.'}, { 'key': 'ref_149', 'doi-asserted-by': 'crossref', 'first-page': '1630', 'DOI': '10.1001/jama.1960.03020150054010', 'article-title': 'Use of antimalarial drugs as “desludging” agents in vascular disease ' 'processes: Preliminary report', 'volume': '172', 'author': 'Madow', 'year': '1960', 'journal-title': 'JAMA'}, { 'key': 'ref_150', 'first-page': '214', 'article-title': 'Desludging Action of Hydroxychloroquine in R.A', 'volume': '8', 'author': 'Cecchi', 'year': '1962', 'journal-title': 'Acta Rheumatol. Scand.'}, { 'key': 'ref_151', 'doi-asserted-by': 'crossref', 'first-page': '4380', 'DOI': '10.1161/01.CIR.96.12.4380', 'article-title': 'Hydroxychloroquine Reverses Thrombogenic Properties of Antiphospholipid ' 'Antibodies in Mice', 'volume': '96', 'author': 'Edwards', 'year': '1997', 'journal-title': 'Circulation'}, { 'key': 'ref_152', 'doi-asserted-by': 'crossref', 'first-page': '930', 'DOI': '10.1016/j.jaad.2020.12.013', 'article-title': 'Use of hydroxychloroquine and risk of major adverse cardiovascular ' 'events in patients with lupus erythematosus: A Danish nationwide cohort ' 'study', 'volume': '84', 'author': 'Haugaard', 'year': '2021', 'journal-title': 'J. Am. Acad. Dermatol.'}, { 'key': 'ref_153', 'doi-asserted-by': 'crossref', 'first-page': '743', 'DOI': '10.1002/acr.24850', 'article-title': 'Hydroxychloroquine Use and Cardiovascular Events Among Patients with ' 'Systemic Lupus Erythematosus and Rheumatoid Arthritis', 'volume': '75', 'author': 'Jorge', 'year': '2023', 'journal-title': 'Arthritis Care Res.'}, { 'key': 'ref_154', 'doi-asserted-by': 'crossref', 'first-page': '6615', 'DOI': '10.18632/oncotarget.23570', 'article-title': 'The association between hydroxychloroquine treatment and cardiovascular ' 'morbidity among rheumatoid arthritis patients', 'volume': '9', 'author': 'Shapiro', 'year': '2017', 'journal-title': 'Oncotarget'}, { 'key': 'ref_155', 'doi-asserted-by': 'crossref', 'first-page': '141', 'DOI': '10.3389/fphar.2012.00141', 'article-title': 'Resveratrol: French paradox revisited', 'volume': '3', 'author': 'Catalgol', 'year': '2012', 'journal-title': 'Front. Pharmacol.'}, { 'key': 'ref_156', 'doi-asserted-by': 'crossref', 'first-page': '87', 'DOI': '10.3233/CH-2012-1632', 'article-title': 'Effects of ethanol on red blood cell rheological behavior', 'volume': '56', 'author': 'Rabai', 'year': '2014', 'journal-title': 'Clin. Hemorheol. Microcirc.'}, { 'key': 'ref_157', 'doi-asserted-by': 'crossref', 'first-page': '1523', 'DOI': '10.1016/0140-6736(92)91277-F', 'article-title': 'Wine, alcohol, platelets, and the French paradox for coronary heart ' 'disease', 'volume': '339', 'author': 'Renaud', 'year': '1992', 'journal-title': 'Lancet'}, { 'key': 'ref_158', 'doi-asserted-by': 'crossref', 'first-page': 'e223849', 'DOI': '10.1001/jamanetworkopen.2022.3849', 'article-title': 'Association of Habitual Alcohol Intake with Risk of Cardiovascular ' 'Disease', 'volume': '5', 'author': 'Biddinger', 'year': '2022', 'journal-title': 'JAMA Netw. Open'}, { 'key': 'ref_159', 'doi-asserted-by': 'crossref', 'first-page': '375', 'DOI': '10.15288/jsad.2017.78.375', 'article-title': 'Alcohol Consumption and Mortality From Coronary Heart Disease: An ' 'Updated Meta-Analysis of Cohort Studies', 'volume': '78', 'author': 'Zhao', 'year': '2017', 'journal-title': 'J. Stud. Alcohol. Drugs'}, { 'key': 'ref_160', 'doi-asserted-by': 'crossref', 'first-page': '10715', 'DOI': '10.1007/s11033-022-07700-x', 'article-title': 'SARS-CoV-2 cell entry beyond the ACE2 receptor', 'volume': '49', 'author': 'Alipoor', 'year': '2022', 'journal-title': 'Mol. Biol. Rep.'}, { 'key': 'ref_161', 'doi-asserted-by': 'crossref', 'first-page': '101346', 'DOI': '10.1016/j.xcrp.2023.101346', 'article-title': 'SARS-CoV-2 evolved variants optimize binding to cellular glycocalyx', 'volume': '4', 'author': 'Kim', 'year': '2023', 'journal-title': 'Cell Rep. Phys. Sci.'}, { 'key': 'ref_162', 'doi-asserted-by': 'crossref', 'unstructured': 'Nie, C., Sahoo, A.K., Netz, R.R., Herrmann, A., Ballauff, M., and Haag, ' 'R. (2022). Charge Matters: Mutations in Omicron Variant Favor Binding to ' 'Cells. ChemBioChem, 23.', 'DOI': '10.1002/cbic.202100681'}, { 'key': 'ref_163', 'doi-asserted-by': 'crossref', 'unstructured': 'Gan, H.H., Zinno, J., Piano, F., and Gunsalus, K.C. (2022). Omicron ' 'Spike Protein Has a Positive Electrostatic Surface That Promotes ACE2 ' 'Recognition and Antibody Escape. Front. Virol., 2.', 'DOI': '10.3389/fviro.2022.894531'}, { 'key': 'ref_164', 'doi-asserted-by': 'crossref', 'first-page': '75', 'DOI': '10.1016/B978-0-12-800097-7.00003-8', 'article-title': 'Chapter Three—Modulation of Glycan Recognition by Clustered Saccharide ' 'Patches', 'volume': 'Volume 308', 'author': 'Jeon', 'year': '2014', 'journal-title': 'International Review of Cell and Molecular Biology'}, { 'key': 'ref_165', 'doi-asserted-by': 'crossref', 'unstructured': 'Soares, C.O., Grosso, A.S., Ereño-Orbea, J., Coelho, H., and Marcelo, F. ' '(2021). Molecular Recognition Insights of Sialic Acid Glycans by ' 'Distinct Receptors Unveiled by NMR and Molecular Modeling. Front. Mol. ' 'Biosci., 8.', 'DOI': '10.3389/fmolb.2021.727847'}, { 'key': 'ref_166', 'doi-asserted-by': 'crossref', 'first-page': '739', 'DOI': '10.1038/nrmicro3346', 'article-title': 'The sweet spot: Defining virus–sialic acid interactions', 'volume': '12', 'author': 'Reiss', 'year': '2014', 'journal-title': 'Nat. Rev. Microbiol.'}, { 'key': 'ref_167', 'doi-asserted-by': 'crossref', 'first-page': '455', 'DOI': '10.1089/omi.2009.0148', 'article-title': 'The sialome—far more than the sum of its parts', 'volume': '14', 'author': 'Cohen', 'year': '2010', 'journal-title': 'Omics'}, { 'key': 'ref_168', 'doi-asserted-by': 'crossref', 'first-page': '1480', 'DOI': '10.1016/j.bbagen.2019.05.012', 'article-title': 'Exploitation of glycosylation in enveloped virus pathobiology', 'volume': '1863', 'author': 'Watanabe', 'year': '2019', 'journal-title': 'Biochim. Biophys. Acta (BBA)—Gen. Subj.'}, { 'key': 'ref_169', 'doi-asserted-by': 'crossref', 'first-page': '221', 'DOI': '10.1016/0042-6822(91)90026-8', 'article-title': 'Isolated HE-protein from hemagglutinating encephalomyelitis virus and ' 'bovine coronavirus has receptor-destroying and receptor-binding ' 'activity', 'volume': '180', 'author': 'Schultze', 'year': '1991', 'journal-title': 'Virology'}, { 'key': 'ref_170', 'doi-asserted-by': 'crossref', 'first-page': '117', 'DOI': '10.1016/j.coviro.2019.01.004', 'article-title': 'Virus recognition of glycan receptors', 'volume': '34', 'author': 'Thompson', 'year': '2019', 'journal-title': 'Curr. Opin. Virol.'}, { 'key': 'ref_171', 'doi-asserted-by': 'crossref', 'first-page': '10', 'DOI': '10.1128/JVI.01567-19', 'article-title': 'Modified Sialic Acids on Mucus and Erythrocytes Inhibit Influenza A ' 'Virus Hemagglutinin and Neuraminidase Functions', 'volume': '94', 'author': 'Barnard', 'year': '2020', 'journal-title': 'J. Virol.'}, { 'key': 'ref_172', 'doi-asserted-by': 'crossref', 'first-page': '715', 'DOI': '10.1038/s41586-022-04479-6', 'article-title': 'SARS-CoV-2 Omicron variant replication in human bronchus and lung ex ' 'vivo', 'volume': '603', 'author': 'Hui', 'year': '2022', 'journal-title': 'Nature'}, { 'key': 'ref_173', 'doi-asserted-by': 'crossref', 'unstructured': 'Peacock, T.P., Brown, J.C., Zhou, J., Thakur, N., Sukhova, K., Newman, ' 'J., Kugathasan, R., Yan, A.W.C., Furnon, W., and De Lorenzo, G. (2022). ' 'The altered entry pathway and antigenic distance of the SARS-CoV-2 ' 'Omicron variant map to separate domains of spike protein. bioRxiv.', 'DOI': '10.1101/2021.12.31.474653'}, { 'key': 'ref_174', 'unstructured': 'Makary, M. (2023, October 30). The Real Data Behind the New COVID ' 'Vaccines the White House is Pushing. New York Post, 14 September 2023. ' 'Available online: ' 'https://nypost.com/2023/09/14/the-real-data-behind-the-new-covid-vaccines-the-white-house-is-pushing/.'}, { 'key': 'ref_175', 'unstructured': '(2024, February 23). NIH Media Advisory, 19 July 2022. Vaccine-Induced ' 'Immune Response to Omicron Wanes Substantially Over Time, Available ' 'online: ' 'https://www.nih.gov/news-events/news-releases/vaccine-induced-immune-response-omicron-wanes-substantially-over-time.'}, { 'key': 'ref_176', 'doi-asserted-by': 'crossref', 'first-page': '100679', 'DOI': '10.1016/j.xcrm.2022.100679', 'article-title': 'Rapid decline in vaccine-boosted neutralizing antibodies against ' 'SARS-CoV-2 Omicron variant', 'volume': '3', 'author': 'Lyke', 'year': '2022', 'journal-title': 'Cell Rep. Med.'}, { 'key': 'ref_177', 'doi-asserted-by': 'crossref', 'unstructured': 'Shrestha, N.K., Burke, P.C., Nowacki, A.S., and Gordon, S.M. (2023). ' 'Risk of Coronavirus Disease 2019 (COVID-19) among those up-to-date and ' 'not up-to-date on COVID-19 vaccination by US CDC criteria. PLoS ONE, 18.', 'DOI': '10.1101/2023.06.09.23290893'}, { 'key': 'ref_178', 'doi-asserted-by': 'crossref', 'first-page': 'ofad209', 'DOI': '10.1093/ofid/ofad209', 'article-title': 'Effectiveness of the Coronavirus Disease 2019 Bivalent Vaccine', 'volume': '10', 'author': 'Shrestha', 'year': '2023', 'journal-title': 'Open Forum Infect. Dis.'}, { 'key': 'ref_179', 'doi-asserted-by': 'crossref', 'first-page': 'e487', 'DOI': '10.1093/cid/ciac722', 'article-title': 'Persistent circulating SARS-CoV-2 spike Is associated with post-acute ' 'COVID-19 sequelae', 'volume': '76', 'author': 'Swank', 'year': '2022', 'journal-title': 'Clin. Infect. Dis.'}, { 'key': 'ref_180', 'doi-asserted-by': 'crossref', 'first-page': 'e28364', 'DOI': '10.1002/jmv.28364', 'article-title': 'Liquid biomarkers of macrophage dysregulation and circulating spike ' 'protein illustrate the biological heterogeneity in patients with ' 'post-acute sequelae of COVID-19', 'volume': '95', 'author': 'Willscher', 'year': '2023', 'journal-title': 'J. Med. Virol.'}, { 'key': 'ref_181', 'doi-asserted-by': 'crossref', 'first-page': '5526', 'DOI': '10.3389/fimmu.2021.746021', 'article-title': 'Persistence of SARS-CoV-2 S1 Protein in CD16+ Monocytes in Post-Acute ' 'Sequelae of COVID-19 (PASC) up to 15 Months Post-Infection', 'volume': '12', 'author': 'Patterson', 'year': '2022', 'journal-title': 'Front. Immunol.'}, { 'key': 'ref_182', 'doi-asserted-by': 'crossref', 'first-page': 'e28568', 'DOI': '10.1002/jmv.28568', 'article-title': 'Persistent circulation of soluble and extracellular vesicle-linked ' 'Spike protein in individuals with postacute sequelae of COVID-19', 'volume': '95', 'author': 'Craddock', 'year': '2023', 'journal-title': 'J. Med. Virol.'}, { 'key': 'ref_183', 'first-page': 'OC27', 'article-title': 'Use of Ivermectin as a Prophylactic Option in Asymptomatic Family Close ' 'Contacts with Patients of COVID-19 (NCT number: 04422561)', 'volume': '15', 'author': 'Shouman', 'year': '2021', 'journal-title': 'J. Clin. Diagn. Res.'}, { 'key': 'ref_184', 'doi-asserted-by': 'crossref', 'first-page': '314', 'DOI': '10.1016/j.ijid.2021.04.035', 'article-title': 'Positive impact of oral hydroxychloroquine and povidone-iodine throat ' 'spray for COVID-19 prophylaxis: An open-label randomized trial', 'volume': '106', 'author': 'Seet', 'year': '2021', 'journal-title': 'Int. J. Infect. Dis.'}, { 'key': 'ref_185', 'doi-asserted-by': 'crossref', 'first-page': 'e601', 'DOI': '10.1097/MJT.0000000000001433', 'article-title': 'Intensive Treatment with Ivermectin and Iota-Carrageenan as ' 'Pre-exposure Prophylaxis for COVID-19 in Health Care Workers From ' 'Tucuman, Argentina', 'volume': '28', 'author': 'Chahla', 'year': '2021', 'journal-title': 'Am. J. Ther.'}, { 'key': 'ref_186', 'unstructured': 'Desort-Henin, V., Kostova, A., Babiker, E.A., Caramel, A., and Malamut, ' 'R. (2023, July 03). The SAIVE Trial, Post-Exposure use of ivermectin in ' 'COVID-19 prevention: Efficacy and Safety Results. Poster Presentation, ' 'European Congress of Clinical Microbiology and Infectious Diseases. ' 'Available online: ' 'https://www.medincell.com/wp-content/uploads/2023/04/Poster-SAIVE-April2023-OK3.pdf.'}, { 'key': 'ref_187', 'unstructured': 'The Nobel Assembly at Karolinska Institutet (2023, October 10). The 2015 ' 'Nobel Prize in Physiology or Medicine—Press release. 5 October 2015. ' 'Available online: ' 'https://www.nobelprize.org/prizes/medicine/2015/press-release/.'}, { 'key': 'ref_188', 'doi-asserted-by': 'crossref', 'first-page': '428', 'DOI': '10.1097/00000658-196403000-00017', 'article-title': 'Correlation between sludge in the bulbar conjunctiva and the mesentery', 'volume': '159', 'author': 'Bjoerk', 'year': '1964', 'journal-title': 'Ann. Surg.'}, { 'key': 'ref_189', 'doi-asserted-by': 'crossref', 'first-page': '431', 'DOI': '10.1126/science.106.2758.431', 'article-title': 'Sludged Blood', 'volume': '106', 'author': 'Knisely', 'year': '1947', 'journal-title': 'Science'}, { 'key': 'ref_190', 'doi-asserted-by': 'crossref', 'unstructured': 'Gresele, P., Born, G.V.R., Patrono, C., and Page, C.P. (2012). ' 'Antiplatelet Agents, Springer.', 'DOI': '10.1007/978-3-642-29423-5'}, { 'key': 'ref_191', 'doi-asserted-by': 'crossref', 'first-page': '234', 'DOI': '10.1016/S0046-8177(87)80005-9', 'article-title': 'Cell biology of endothelial cells', 'volume': '18', 'author': 'Jaffe', 'year': '1987', 'journal-title': 'Human. Pathol.'}, { 'key': 'ref_192', 'doi-asserted-by': 'crossref', 'first-page': '127', 'DOI': '10.1016/S0006-3495(83)84378-1', 'article-title': 'Theory of the electrokinetic behavior of human erythrocytes', 'volume': '42', 'author': 'Levine', 'year': '1983', 'journal-title': 'Biophys. J.'}, { 'key': 'ref_193', 'doi-asserted-by': 'crossref', 'first-page': '2885', 'DOI': '10.1681/ASN.2007010119', 'article-title': 'Glomerular endothelial glycocalyx constitutes a barrier to protein ' 'permeability', 'volume': '18', 'author': 'Singh', 'year': '2007', 'journal-title': 'J. Am. Soc. Nephrol.'}, { 'key': 'ref_194', 'doi-asserted-by': 'crossref', 'unstructured': 'Hikmet, F., Méar, L., Edvinsson, Å., Micke, P., Uhlén, M., and Lindskog, ' 'C. (2020). The protein expression profile of ACE2 in human tissues. Mol. ' 'Syst. Biol., 16.', 'DOI': '10.15252/msb.20209610'}, { 'key': 'ref_195', 'doi-asserted-by': 'crossref', 'first-page': 'e575', 'DOI': '10.1016/S2352-3026(20)30216-7', 'article-title': 'Endotheliopathy in COVID-19-associated coagulopathy: Evidence from a ' 'single-centre, cross-sectional study', 'volume': '7', 'author': 'Goshua', 'year': '2020', 'journal-title': 'Lancet Haematol.'}, { 'key': 'ref_196', 'doi-asserted-by': 'crossref', 'first-page': '2942', 'DOI': '10.1111/jth.15067', 'article-title': 'Coagulation biomarkers are independent predictors of increased oxygen ' 'requirements in COVID-19', 'volume': '18', 'author': 'Rauch', 'year': '2020', 'journal-title': 'J. Thromb. Haemost.'}, { 'key': 'ref_197', 'doi-asserted-by': 'crossref', 'first-page': '1258', 'DOI': '10.1021/ci700044s', 'article-title': 'Analysis of HIV Wild-Type and Mutant Structures via in Silico Docking ' 'against Diverse Ligand Libraries', 'volume': '47', 'author': 'Chang', 'year': '2007', 'journal-title': 'J. Chem. Inf. Model.'}, { 'key': 'ref_198', 'doi-asserted-by': 'crossref', 'first-page': '161', 'DOI': '10.1186/s12936-017-1801-4', 'article-title': 'Ivermectin to reduce malaria transmission I. Pharmacokinetic and ' 'pharmacodynamic considerations regarding efficacy and safety', 'volume': '16', 'author': 'Chaccour', 'year': '2017', 'journal-title': 'Malar. J.'}, { 'key': 'ref_199', 'doi-asserted-by': 'crossref', 'first-page': '1122', 'DOI': '10.1177/009127002237994', 'article-title': 'Safety, tolerability, and pharmacokinetics of escalating high doses of ' 'ivermectin in healthy adult subjects', 'volume': '42', 'author': 'Guzzo', 'year': '2002', 'journal-title': 'J. Clin. Pharmacol.'}, { 'key': 'ref_200', 'doi-asserted-by': 'crossref', 'first-page': '42', 'DOI': '10.1208/s12248-007-9000-9', 'article-title': 'The Pharmacokinetics and Interactions of Ivermectin in Humans—A ' 'Mini-review', 'volume': '10', 'year': '2008', 'journal-title': 'AAPS J.'}, { 'key': 'ref_201', 'doi-asserted-by': 'crossref', 'unstructured': 'Munoz, J., Ballester, M.R., Antonijoan, R.M., Gich, I., Rodriguez, M., ' 'Colli, E., Gold, S., and Krolewiecki, A.J. (2018). Safety and ' 'pharmacokinetic profile of fixed-dose ivermectin with an innovative 18mg ' 'tablet in healthy adult volunteers. PLoS Negl. Trop. Dis., 12.', 'DOI': '10.1371/journal.pntd.0006020'}, { 'key': 'ref_202', 'doi-asserted-by': 'crossref', 'first-page': '407', 'DOI': '10.1007/s002280050131', 'article-title': 'Ivermectin distribution in the plasma and tissues of patients infected ' 'with Onchocerca volvulus', 'volume': '50', 'author': 'Baraka', 'year': '1996', 'journal-title': 'Eur. J. Clin. Pharmacol.'}, { 'key': 'ref_203', 'doi-asserted-by': 'crossref', 'first-page': '735', 'DOI': '10.1111/j.1440-1681.1990.tb01273.x', 'article-title': 'The effect of ivermectin on some haematological indices in rabbits: ' 'Influence of vitamin K treatment', 'volume': '17', 'author': 'Ali', 'year': '1990', 'journal-title': 'Clin. Exp. Pharmacol. Physiol.'}], 'container-title': 'Viruses', 'original-title': [], 'language': 'en', 'link': [ { 'URL': 'https://www.mdpi.com/1999-4915/16/4/647/pdf', 'content-type': 'unspecified', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'deposited': { 'date-parts': [[2024, 4, 22]], 'date-time': '2024-04-22T14:05:13Z', 'timestamp': 1713794713000}, 'score': 1, 'resource': {'primary': {'URL': 'https://www.mdpi.com/1999-4915/16/4/647'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2024, 4, 22]]}, 'references-count': 203, 'journal-issue': {'issue': '4', 'published-online': {'date-parts': [[2024, 4]]}}, 'alternative-id': ['v16040647'], 'URL': 'http://dx.doi.org/10.3390/v16040647', 'relation': {}, 'ISSN': ['1999-4915'], 'subject': [], 'container-title-short': 'Viruses', 'published': {'date-parts': [[2024, 4, 22]]}}