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Mechanisms of action of fluvoxamine for COVID-19: a historical review

Hashimoto et al., Molecular Psychiatry, doi:10.1038/s41380-021-01432-3
Jan 2022  
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Review of the potential mechanisms of action of fluvoxamine for COVID-19.
Reviews covering fluvoxamine for COVID-19 include Hashimoto, Hashimoto (B), Hashimoto (C), Hoertel, Kirsch, Sukhatme.
Hashimoto et al., 7 Jan 2022, peer-reviewed, 3 authors.
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Mechanisms of action of fluvoxamine for COVID-19: a historical review
Yaeko Hashimoto, Takuji Suzuki, Kenji Hashimoto
Molecular Psychiatry, doi:10.1038/s41380-021-01432-3
The ongoing coronavirus disease 2019 (COVID-19) pandemic caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) accelerates the discovery of prophylactic and therapeutic drugs for persons infected with the virus. Drug repurposing for the COVID-19 pandemic has received particular attention. Increasing clinical data suggest that antidepressant use in early-stage subjects with COVID-19 might be associated with a reduced risk of intubation or death. Among the antidepressants, fluvoxamine is the most attractive drug for mild to moderate subjects with COVID-19. In this article, we review the mechanisms of action (i.e., serotonin transporter, sigma-1 receptor, and acid sphingomyelinase) of fluvoxamine for COVID-19. Furthermore, we discuss a possible link between maternal COVID-19 infection and a risk for neuropsychiatric disorders (i.e., autism spectrum disorder and schizophrenia) in offspring.
AUTHOR CONTRIBUTIONS Y.H., T.S., and K.H. did the reference search and wrote the manuscript. Y.H. and K.H. prepared the figures and table. All authors approved the final manuscript. CONFLICT OF INTEREST Dr. Y. Hashimoto and Dr. T. Suzuki have no conflict of interest. Dr. K. Hashimoto is the inventor of filed patent applications on "The use of R-Ketamine in the treatment of psychiatric diseases", "(S)-norketamine and salt thereof as pharmaceutical", "R-Ketamine and derivative thereof as a prophylactic or therapeutic agent for neurodegeneration disease or recognition function disorder", "Preventive or therapeutic agent and pharmaceutical composition for inflammatory diseases or bone diseases", and "R-Ketamine and its derivatives as a preventive or therapeutic agent for a neurodevelopmental disorder" by the Chiba University. Dr. K. Hashimoto has also received speakers' honoraria, consultant fees, or research support from Abbott, Meiji Seika Pharma, Dainippon-Sumitomo, Taisho, Otsuka, Murakami Farm, and Perception Neuroscience. ADDITIONAL INFORMATION Correspondence and requests for materials should be addressed to Kenji Hashimoto. Reprints and permission information is available at Publisher's note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
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