Mechanisms of action of fluvoxamine for COVID-19: a historical review
Hashimoto et al.
, Mechanisms of action of fluvoxamine for COVID-19: a historical review
, Molecular Psychiatry, doi:10.1038/s41380-021-01432-3 (Review)
Review of the potential mechanisms of action of fluvoxamine for COVID-19.
Hashimoto et al., 7 Jan 2022, peer-reviewed, 3 authors.
Abstract: Molecular Psychiatry
Mechanisms of action of ﬂuvoxamine for COVID-19: a historical
Yaeko Hashimoto1,2, Takuji Suzuki1 and Kenji Hashimoto
© The Author(s), under exclusive licence to Springer Nature Limited 2021
The ongoing coronavirus disease 2019 (COVID-19) pandemic caused by the novel severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) accelerates the discovery of prophylactic and therapeutic drugs for persons infected with the virus. Drug repurposing
for the COVID-19 pandemic has received particular attention. Increasing clinical data suggest that antidepressant use in early-stage
subjects with COVID-19 might be associated with a reduced risk of intubation or death. Among the antidepressants, ﬂuvoxamine is
the most attractive drug for mild to moderate subjects with COVID-19. In this article, we review the mechanisms of action (i.e.,
serotonin transporter, sigma-1 receptor, and acid sphingomyelinase) of ﬂuvoxamine for COVID-19. Furthermore, we discuss a
possible link between maternal COVID-19 infection and a risk for neuropsychiatric disorders (i.e., autism spectrum disorder and
schizophrenia) in offspring.
Molecular Psychiatry; https://doi.org/10.1038/s41380-021-01432-3
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