Low pH Hypromellose (Taffix) nasal powder spray could reduce SARS-CoV-2 infection rate post mass-gathering event at a highly endemic community: an observational prospective open label user survey

DOI record: { "DOI": "10.1080/14787210.2021.1908127", "ISSN": [ "1478-7210", "1744-8336" ], "URL": "http://dx.doi.org/10.1080/14787210.2021.1908127", "alternative-id": [ "10.1080/14787210.2021.1908127" ], "assertion": [ { "label": "Peer Review Statement", "name": "peerreview_statement", "order": 1, "value": "The publishing and review policy for this title is described in its Aims & Scope." }, { "URL": "http://www.tandfonline.com/action/journalInformation?show=aimsScope&journalCode=ierz20", "label": "Aim & Scope", "name": "aims_and_scope_url", "order": 2, "value": "http://www.tandfonline.com/action/journalInformation?show=aimsScope&journalCode=ierz20" }, { "group": { "label": "Publication History", "name": "publication_history" }, "label": "Received", "name": "received", "order": 0, "value": "2021-02-05" }, { "group": { "label": "Publication History", "name": "publication_history" }, "label": "Accepted", "name": "accepted", "order": 2, "value": "2021-03-18" }, { "group": { "label": "Publication History", "name": "publication_history" }, "label": "Published", "name": "published", "order": 3, "value": "2021-04-01" } ], "author": [ { "affiliation": [ { "name": "University of Haifa", "place": [ "Haifa, Israel" ] } ], "family": "Shmuel", "given": "Klang", "sequence": "first" }, { "affiliation": [ { "name": "Nasus Pharma", "place": [ "Tel Aviv, Israel" ] } ], "family": "Dalia", "given": "Megiddo", "sequence": "additional" }, { "affiliation": [ { "name": "Nasus Pharma", "place": [ "Tel Aviv, Israel" ] } ], "family": "Tair", "given": "Lapidot", "sequence": "additional" }, { "affiliation": [ { "name": "Jerusalem Israel, and the Scientific Director of Meuhedet HMO Research Institute", "place": [ "Jerusalem, Israel" ] } ], "family": "Yaakov", "given": "Naparstek", "sequence": "additional" } ], "container-title": "Expert Review of Anti-infective Therapy", "container-title-short": "Expert Review of Anti-infective Therapy", "content-domain": { "crossmark-restriction": true, "domain": [ "www.tandfonline.com" ] }, "created": { "date-parts": [ [ 2021, 3, 24 ] ], "date-time": "2021-03-24T09:12:53Z", "timestamp": 1616577173000 }, "deposited": { "date-parts": [ [ 2025, 12, 23 ] ], "date-time": "2025-12-23T09:55:33Z", "timestamp": 1766483733000 }, "funder": [ { "name": "Taffix and has donated the product for the survey and paid for statistical and data analysis performed by independent company" } ], "indexed": { "date-parts": [ [ 2025, 12, 23 ] ], "date-time": "2025-12-23T09:59:09Z", "timestamp": 1766483949413, "version": "3.48.0" }, "is-referenced-by-count": 19, "issue": "10", "issued": { "date-parts": [ [ 2021, 4 ] ] }, "journal-issue": { "issue": "10", "published-print": { "date-parts": [ [ 2021, 10, 3 ] ] } }, "language": "en", "license": [ { "URL": "http://creativecommons.org/licenses/by-nc-nd/4.0/", "content-version": "unspecified", "delay-in-days": 175, "start": { "date-parts": [ [ 2021, 9, 23 ] ], "date-time": "2021-09-23T00:00:00Z", "timestamp": 1632355200000 } } ], "link": [ { "URL": "https://www.tandfonline.com/doi/pdf/10.1080/14787210.2021.1908127", "content-type": "unspecified", "content-version": "vor", "intended-application": "similarity-checking" } ], "member": "301", "original-title": [], "page": "1325-1330", "prefix": "10.1080", "published": { "date-parts": [ [ 2021, 4 ] ] }, "published-online": { "date-parts": [ [ 2021, 4 ] ] }, "published-print": { "date-parts": [ [ 2021, 10, 3 ] ] }, "publisher": "Informa UK Limited", "reference": [ { "key": "e_1_3_5_2_1", "unstructured": "[cited 2021 Mar 1]. Available from: https://datadashboard.health.gov.il/COVID-19/general" }, { "key": "e_1_3_5_3_1", "unstructured": "[cited 2021 Mar 1]. https://www1.nyc.gov/site/doh/covid/covid-19-data-recent.page. Available from: https://www.wsj.com/articles/new-york-citys-daily-coronavirus-infection-rate-hits-highest-level-in-months-11601395229" }, { "DOI": "10.1038/s41591-020-0868-6", "article-title": "SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes", "author": "Sungnak W", "doi-asserted-by": "crossref", "issue": "5", "journal-title": "Nat Med", "key": "e_1_3_5_4_1", "unstructured": "Sungnak W, Huang N, Bécavin C, et al. SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes. Nat Med. 2020;26(5):681‐7.", "volume": "26", "year": "2020" }, { "article-title": "In vitro and in vivo evaluation of the efficacy and safety of powder hydroxypropylmethylcellulose as nasal mucosal barrier", "author": "Popov TA", "first-page": "107", "journal-title": "Med Devices (Auckl)", "key": "e_1_3_5_5_1", "unstructured": "Popov TA, Emberlin J, Josling P, et al. In vitro and in vivo evaluation of the efficacy and safety of powder hydroxypropylmethylcellulose as nasal mucosal barrier. Med Devices (Auckl). 2020;13:107–113.", "volume": "13", "year": "2020" }, { "article-title": "Effects of creating a non-specific, virus-hostile environment in the nasopharynx on symptoms and duration of common cold", "author": "Hull D", "first-page": "73", "issue": "2", "journal-title": "Acta Otorhinolaryngol Ital", "key": "e_1_3_5_6_1", "unstructured": "Hull D, Rennie P, Noronha A, et al. Effects of creating a non-specific, virus-hostile environment in the nasopharynx on symptoms and duration of common cold. Acta Otorhinolaryngol Ital. 2007;27(2):73–77.", "volume": "27", "year": "2007" }, { "article-title": "TaffiX nasal powder forms an effective barrier against SARS-CoV-2", "author": "Mann B", "first-page": "25483", "issue": "3", "journal-title": "Biomed J Sci Tech Res", "key": "e_1_3_5_7_1", "unstructured": "Mann B, Moreau BG, Lapidot T, et al. TaffiX nasal powder forms an effective barrier against SARS-CoV-2. Biomed J Sci Tech Res. 2021;33(3).25483–5", "volume": "33", "year": "2021" }, { "key": "e_1_3_5_8_1", "unstructured": "CDC. [cited 2021 Mar 1]. Available from: https://www.cdc.gov/quarantine/historyquarantine.html#:~:text=Quarantine%20Now- The%20Middle%20Ages for%2040%20days%20before%20landing" }, { "DOI": "10.1016/S0140-6736(20)31207-1", "article-title": "A history of the medical mask and the rise of throwaway culture", "author": "Strasser BJ", "doi-asserted-by": "crossref", "first-page": "19", "issue": "10243", "journal-title": "Lancet", "key": "e_1_3_5_9_1", "unstructured": "Strasser BJ, Schlich T. A history of the medical mask and the rise of throwaway culture. Lancet. 2020 Jul 4;396(10243):19–20.", "volume": "396", "year": "2020" }, { "key": "e_1_3_5_10_1", "unstructured": "FDA. [cited 2021 Mar 1]. Available from: https://www.fda.gov/emergency-preparedness-and-response/mcm-legal-regulatory-and-policy-framework/emergency-use-authorization#coviddrugs" }, { "DOI": "10.1007/s40520-020-01570-8", "article-title": "The role of vitamin D in the prevention of coronavirus disease 2019 infection and mortality", "author": "Ilie PC", "doi-asserted-by": "crossref", "first-page": "1195", "issue": "7", "journal-title": "Aging Clin Exp Res", "key": "e_1_3_5_11_1", "unstructured": "Ilie PC, Stefanescu S, Smith L. The role of vitamin D in the prevention of coronavirus disease 2019 infection and mortality. Aging Clin Exp Res. 2020;32(7):1195–1198.", "volume": "32", "year": "2020" }, { "DOI": "10.1186/s12948-020-00139-0", "article-title": "Vitamin D and Covid-19: an update on evidence and potential therapeutic implications", "author": "Murdaca G", "doi-asserted-by": "crossref", "first-page": "23", "issue": "1", "journal-title": "Clin Mol Allergy", "key": "e_1_3_5_12_1", "unstructured": "Murdaca G, Pioggia G, Negrini S. Vitamin D and Covid-19: an update on evidence and potential therapeutic implications. Clin Mol Allergy. 2020 Nov 19;18(1):23.", "volume": "18", "year": "2020" }, { "key": "e_1_3_5_13_1", "unstructured": "NICE. [cited 2021 Mar 1]. Available from: https://www.nice.org.uk/guidance/ng187" }, { "DOI": "10.1007/s00253-021-11094-4", "article-title": "Chloroquine and hydroxychloroquine in the treatment of COVID-19: the never-ending story", "author": "Gasmi A", "doi-asserted-by": "crossref", "first-page": "1333", "issue": "4", "journal-title": "Appl Microbiol Biotechnol", "key": "e_1_3_5_14_1", "unstructured": "Gasmi A, Peana M, Noor S, et al. Chloroquine and hydroxychloroquine in the treatment of COVID-19: the never-ending story. Appl Microbiol Biotechnol. 2021 Feb;105(4):1333–1343. .", "volume": "105", "year": "2021" }, { "DOI": "10.1371/journal.pone.0244778", "article-title": "The efficacy and safety of hydroxychloroquine for COVID-19 prophylaxis: a systematic review and meta-analysis of randomized trials", "author": "Lewis K", "doi-asserted-by": "crossref", "first-page": "e0244778", "issue": "1", "journal-title": "PLoS One", "key": "e_1_3_5_15_1", "unstructured": "Lewis K, Chaudhuri D, Alshamsi F, et al. The efficacy and safety of hydroxychloroquine for COVID-19 prophylaxis: a systematic review and meta-analysis of randomized trials. PLoS One. 2021 Jan 6;16(1):e0244778.", "volume": "16", "year": "2021" }, { "DOI": "10.3390/ijms22031213", "article-title": "Mediterranean diet for the prevention of gestational diabetes in the Covid-19 era: implications of Il-6 in diabesity", "author": "Fedullo AL", "doi-asserted-by": "crossref", "first-page": "1213", "journal-title": "Int J Mol Sci", "key": "e_1_3_5_16_1", "unstructured": "Fedullo AL, Schiattarella A, Morlando M, et al. Mediterranean diet for the prevention of gestational diabetes in the Covid-19 era: implications of Il-6 in diabesity. Int J Mol Sci. 2021;22:1213.", "volume": "22", "year": "2021" }, { "DOI": "10.1073/pnas.2010217118", "article-title": "The hygiene hypothesis, the COVID pandemic, and consequences for the human microbiome", "author": "Finlay BB", "doi-asserted-by": "crossref", "first-page": "e2010217118", "issue": "6", "journal-title": "Proc Natl Acad Sci U S A", "key": "e_1_3_5_17_1", "unstructured": "Finlay BB, Amato KR, Azad M, et al. The hygiene hypothesis, the COVID pandemic, and consequences for the human microbiome. Proc Natl Acad Sci U S A. 2021 Feb 9;118(6):e2010217118.", "volume": "118", "year": "2021" }, { "key": "e_1_3_5_18_1", "unstructured": "[cited 2021 Mar 1]. Available from: https://www.idi.org.il/media/15500/haredi-2020.pdf" }, { "key": "e_1_3_5_19_1", "unstructured": "[cited 2021 Mar 1]. Available from: https://www.cbs.gov.il/en/mediarelease/Pages/2020/Serological-Survey-in-Bene-Beraq.aspx" }, { "key": "e_1_3_5_20_1", "unstructured": "[cited 2021 Mar 1]. 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