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All Studies   Meta Analysis   Recent: 
0 0.5 1 1.5 2+ Time to improvement 37% Improvement Relative Risk Time to improvement (b) 59% c19early.org/a Shinkai et al. Favipiravir for COVID-19 RCT LATE Favors favipiravir Favors control
Efficacy and Safety of Favipiravir in Moderate COVID-19 Pneumonia Patients without Oxygen Therapy: A Randomized, Phase III Clinical Trial
Shinkai et al., Infectious Diseases and Therapy, doi:10.1007/s40121-021-00517-4
27 Aug 2021    Source   PDF   Share   Tweet
RCT 156 patients in Japan, 107 treated with favipiravir, showing significant improvement in a composite outcome defined as the time to improvement in temperature, SpO2, CT findings, and recovery to PCR-.
time to improvement, 37.1% lower, HR 0.63, p = 0.01, treatment 107, control 49, adjusted per study, inverted to make HR<1 favor treatment, Cox proportional hazards, composite time to improvement in temperature, SpO2, CT findings, and recovery to PCR-.
time to improvement, 58.5% lower, HR 0.41, p = 0.01, treatment 47, control 13, adjusted per study, inverted to make HR<1 favor treatment, <5 days from onset of fever, Cox proportional hazards, composite time to improvement in temperature, SpO2, CT findings, and recovery to PCR-.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Shinkai et al., 27 Aug 2021, Single Blind Randomized Controlled Trial, Japan, peer-reviewed, 39 authors, average treatment delay 4.8 days.
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This PaperFavipiravirAll
Late treatment
is less effective
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