Alkalinization
Analgesics..
Antiandrogens..
Bromhexine
Budesonide
Cannabidiol
Colchicine
Conv. Plasma
Curcumin
Ensovibep
Famotidine
Favipiravir
Fluvoxamine
Hydroxychlor..
Iota-carragee..
Ivermectin
Lactoferrin
Lifestyle..
Melatonin
Metformin
Molnupiravir
Monoclonals..
Nigella Sativa
Nitazoxanide
Nitric Oxide
Paxlovid
Peg.. Lambda
Povidone-Iod..
Quercetin
Remdesivir
Vitamins..
Zinc

Other
Feedback
Home
Home   COVID-19 treatment studies for N-acetylcysteine  COVID-19 treatment studies for N-acetylcys..  C19 studies: N-acetylcys..  N-acetylcys..   Select treatmentSelect treatmentTreatmentsTreatments
Alkalinization Meta Lactoferrin Meta
Melatonin Meta
Bromhexine Meta Metformin Meta
Budesonide Meta Molnupiravir Meta
Cannabidiol Meta
Colchicine Meta Nigella Sativa Meta
Conv. Plasma Meta Nitazoxanide Meta
Curcumin Meta Nitric Oxide Meta
Ensovibep Meta Paxlovid Meta
Famotidine Meta Peg.. Lambda Meta
Favipiravir Meta Povidone-Iod.. Meta
Fluvoxamine Meta Quercetin Meta
Hydroxychlor.. Meta Remdesivir Meta
Iota-carragee.. Meta
Ivermectin Meta Zinc Meta

Other Treatments Global Adoption
All Studies   All Outcomes   Recent:  
0 0.5 1 1.5 2+ Mortality -135% unadjusted Improvement Relative Risk c19early.org/na Ramadhan et al. N-acetylcysteine for COVID-19 LATE Is late treatment with N-acetylcysteine beneficial for COVID-19? Prospective study of 91 patients in Indonesia (Jun 2020 - Jul 2021) Study underpowered to detect differences Ramadhan et al., Indonesian J. Tropical and Infectious Disease, 9:3 Favors N-acetylcysteine Favors control
The Effects of N-Acetylcysteine as Adjuvant Therapy To Reduce TNF-Α Level And Increase SPO2/FIO2 Ratio In Improving Hypoxemia In COVID-19 Patients
Ramadhan et al., Indonesian Journal of Tropical and Infectious Disease, 9:3
Ramadhan et al., The Effects of N-Acetylcysteine as Adjuvant Therapy To Reduce TNF-Α Level And Increase SPO2/FIO2 Ratio In.., Indonesian Journal of Tropical and Infectious Disease, 9:3
Dec 2021   Source   PDF  
  Twitter
  Facebook
Share
  All Studies   Meta
Prospective study with 75 NAC patients and 16 control patients, showing no significant difference in mortality. This study is excluded in the after exclusion results of meta analysis: excessive unadjusted differences between groups.
risk of death, 134.7% higher, RR 2.35, p = 0.68, treatment 11 of 75 (14.7%), control 1 of 16 (6.2%), unadjusted.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Ramadhan et al., 27 Dec 2021, prospective, Indonesia, peer-reviewed, 6 authors, study period June 2020 - July 2021.
All Studies   All Outcomes   Submit Updates or Corrections
This PaperN-acetylcys..All
Abstract: Available online at IJTID Website: https://e-journal.unair.ac.id/IJTID/ Vol. 9 No. 3 September–December 2021 The Effects of N-Acetylcysteine as Adjuvant Therapy To Reduce TNF-Α Level And Increase SPO2/FIO2 Ratio In Improving Hypoxemia In COVID-19 Patients 1 1 1 1 Fitratul Ramadhan , Ngakan Putu Parsama Putra , Ungky Agus Setyawan , Susanthy Djajalaksana , Aditya Sri 1 2 Listyoko , Harun al Rasyid 1 Department of Pulmonology and Medical Respiration, Faculty of Medicine, Universitas Brawijaya-RSUD Dr Saiful Anwar, Malang Indonesia 2 Department of Public Health and Preventive Medicine, Faculty of Medicine, Universitas Brawijaya, Malang Indonesia Received: 22 stOctober 2021; Revised: 28 th November 2021; Accepted: 23 thDecember 2021 ABSTRACT Tumor Necrosis Factor Alpha (TNF-α) is a pro-inflammatory cytokine that plays a crucial role in COVID-19 disease progression. N-acetylcysteine (NAC) works throughout several GSH-mediated mechanisms and is known to eliminate oxidative stress in acute respiratory distress syndrome (ARDS) in COVID-19. This study aims to analyze the e ect of the N-Acetylcysteine as Adjuvant Therapy to reduce TNF-α levels and Increase SpO2/FiO2 ratio in Improving hypoxemia in COVID-19 Patients. This is a quasi-experimental, non-equivalent control group design study. There were 91 subjects selected using non-random sampling, which consisted of 75 patients in the NAC group and 16 patients in the control group. The TNF-α level was measured using the ELISA method, and SpO2/FiO2 ratio was calculated on day 1 (on admission) and day eight after NAC 5000mg/ 72 hours was given. Statistical analysis was conducted using Wilcoxon and Mann-Whitney U Test. There is a significant decrease in TNF-α level in the treatment group (median 1.49±5.22) (p=0.016) compared with the control group (median 1.64±1.99) (p=0.005). The Median SpO2/FiO2 ratio on day 1 is 163.70±69.64 in the control group and 121.49±40.41 in the treatment group (p=0.005). The Median SpO2/FiO2 ratio on day 8 is 249.69±132.26 in the control group and 151.29±59.18 in the treatment group (p=0.001). There is a positive correlation between serum TNF-α level and SpO2/FiO2 ratio after administration of adjuvant therapy NAC (r=0.240, p=0.038). There is a positive correlation and significant decrease of serum TNF-α and SpO2/FiO2 ratio after adjuvant NAC therapy, which improves hypoxemia in COVID-19 patients. Keywords: N-acetylcysteine, TNF-α, SpO2/FiO2 ratio ABSTRAK Tumor Necrosis Factor Alpha (TNF-α) merupakan sitokin proinflamasi yang berperan penting dalam perkembangan penyakit COVID-19. N-acetylcysteine (NAC) bekerja melalui beberapa mekanisme yang dimediasi GSH dan diketahui menghilangkan stres oksidatif pada acute respiratory distress syndrome (ARDS) pada COVID-19. Penelitian ini bertujuan untuk menganalisis pengaruh NAC sebagai terapi Adjuvant untuk menurunkan kadar TNF-α dan Meningkatkan rasio SpO2/FiO2 dalam Memperbaiki Hipoksemia pada Pasien COVID-19. Penelitian ini merupakan quasi-experimental, non-equivalent control group designed study. Subyek yang dipilih sebanyak 91 orang dengan non random sampling, yang terdiri dari 75 pasien pada kelompok NAC dan 16 pasien pada kelompok kontrol. Kadar TNFα diukur menggunakan metode ELISA dan Rasio SpO2/FiO2 diukur pada hari ke-1 (saat masuk) dan hari ke-8 setelah pemberian NAC 5000mg/72 jam. Analisis statistik dilakukan dengan menggunakan Wilcoxon dan Mann-Whitney U Test. Terdapat penurunan kadar TNF-α yang signifikan pada..
Late treatment
is less effective
Please send us corrections, updates, or comments. Vaccines and treatments are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment, vaccine, or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop   
Submit