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All Studies   Meta Analysis       

A Retrospective Analysis of Outcomes Amongst COVID-19 Infected Patients with Acute Hepatitis Receiving N-Acetylcysteine Therapy in a Safety Net Hospital

Pellegrini et al., Gastroenterology, doi:10.1016/S0016-5085(21)02756-6
May 2021  
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Mortality 52% Improvement Relative Risk N-acetylcysteine  Pellegrini et al.  LATE TREATMENT Is late treatment with N-acetylcysteine beneficial for COVID-19? Retrospective 864 patients in the USA (March - May 2020) Lower mortality with N-acetylcysteine (p=0.00014) c19early.org Pellegrini et al., Gastroenterology, May 2021 FavorsN-acetylcysteine Favorscontrol 0 0.5 1 1.5 2+
14th treatment shown to reduce risk in February 2021, now with p = 0.000028 from 24 studies, recognized in 3 countries.
Lower risk for mortality, hospitalization, and cases.
No treatment is 100% effective. Protocols combine treatments.
5,100+ studies for 109 treatments. c19early.org
Retrospective 864 hospitalized late stage COVID-19 patients in the USA, 138 receiving NAC treatment for acute hepatitis, showing lower mortality with treatment. Results are adjusted for confounders, however details are not provided.
risk of death, 51.7% lower, OR 0.48, p < 0.001, treatment 138, control 726, adjusted per study, inverted to make OR<1 favor treatment, multivariable, RR approximated with OR.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Pellegrini et al., 23 May 2021, retrospective, USA, peer-reviewed, 10 authors, study period March 2020 - May 2020.
This PaperN-acetylcys..All
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Late treatment
is less effective
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