Ursodeoxycholic acid administration did not reduce susceptibility to SARS‐CoV‐2 infection in children

{ 'indexed': {'date-parts': [[2023, 8, 15]], 'date-time': '2023-08-15T16:30:14Z', 'timestamp': 1692117014062}, 'reference-count': 12, 'publisher': 'Wiley', 'issue': '9', 'license': [ { 'start': { 'date-parts': [[2023, 6, 29]], 'date-time': '2023-06-29T00:00:00Z', 'timestamp': 1687996800000}, 'content-version': 'vor', 'delay-in-days': 0, 'URL': 'http://onlinelibrary.wiley.com/termsAndConditions#vor'}], 'funder': [ { 'DOI': '10.13039/501100001809', 'name': 'National Natural Science Foundation of China', 'doi-asserted-by': 'publisher', 'award': ['82201898']}], 'content-domain': {'domain': ['onlinelibrary.wiley.com'], 'crossmark-restriction': True}, 'published-print': {'date-parts': [[2023, 9]]}, 'abstract': '<jats:title>Abstract</jats:title><jats:sec><jats:title>Background and ' 'Aims</jats:title><jats:p>A recent study suggested that administration of ursodeoxycholic acid ' '(UDCA) at dosages usually employed clinically may reduce rates of severe acute respiratory ' 'syndrome coronavirus 2 (SARS‐CoV‐2) infection. A recent surge of SARS‐CoV‐2 omicron infection ' 'in China allowed study of whether UDCA administration reduced susceptibility to SARS‐CoV‐2 ' 'infection in children with liver ' 'disease.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Through WeChat ' 'groups, a questionnaire was distributed to families (<jats:italic>n</jats:italic>\u2009=\u2009' '300) in which a child had been admitted to our liver service in the past 5\u2009years. Among ' 'the families/households in which someone was infected with SARS‐CoV‐2, the proportion in ' 'which a child taking UDCA was infected was compared with the proportion in which a child not ' 'taking UDCA was ' 'infected.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Of the 300 ' 'questionnaire answers, 280 (93.3%) were valid. SARS‐CoV‐2 infection was confirmed in 226 ' 'families (80.7%): 146 children were taking UDCA (10‐20\u2009mg/kg/day) and 80 children were ' 'not taking UDCA. SARS‐CoV‐2 infection was confirmed in 95 children taking UDCA (65.1%) and in ' '51 children not taking UDCA (63.8%) (<jats:italic>p</jats:italic>\u2009=\u20090.843); ' 'SARS‐CoV‐2 infection was suspected in 23 children taking UDCA (15.8%) and in 11 children not ' 'taking UDCA (13.8%) (<jats:italic>p</jats:italic>\u2009=\u2009' '0.687).</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>These ' 'results indicate that UDCA administration does not reduce susceptibility to SARS‐CoV‐2 ' 'infection in children with liver disease.</jats:p></jats:sec>', 'DOI': '10.1111/liv.15660', 'type': 'journal-article', 'created': {'date-parts': [[2023, 6, 29]], 'date-time': '2023-06-29T07:35:17Z', 'timestamp': 1688024117000}, 'page': '1950-1954', 'update-policy': 'http://dx.doi.org/10.1002/crossmark_policy', 'source': 'Crossref', 'is-referenced-by-count': 1, 'title': 'Ursodeoxycholic acid administration did not reduce susceptibility to <scp>SARS‐CoV</scp>‐2 ' 'infection in children', 'prefix': '10.1111', 'volume': '43', 'author': [ { 'ORCID': 'http://orcid.org/0000-0002-0858-2151', 'authenticated-orcid': False, 'given': 'Teng', 'family': 'Liu', 'sequence': 'first', 'affiliation': [ { 'name': "The Center for Pediatric Liver Diseases Children's Hospital of " 'Fudan University Shanghai China'}, { 'name': 'Department of Pediatrics Shanghai Medical College, Fudan ' 'University Shanghai China'}]}, { 'ORCID': 'http://orcid.org/0000-0003-0823-586X', 'authenticated-orcid': False, 'given': 'Jian‐She', 'family': 'Wang', 'sequence': 'additional', 'affiliation': [ { 'name': "The Center for Pediatric Liver Diseases Children's Hospital of " 'Fudan University Shanghai China'}, { 'name': 'Department of Pediatrics Shanghai Medical College, Fudan ' 'University Shanghai China'}]}], 'member': '311', 'published-online': {'date-parts': [[2023, 6, 29]]}, 'reference': [ {'key': 'e_1_2_14_2_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1038/s41586-021-04385-3'}, {'key': 'e_1_2_14_3_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1038/s41591-021-01310-z'}, {'key': 'e_1_2_14_4_1', 'doi-asserted-by': 'publisher', 'DOI': '10.3762/bjoc.14.33'}, {'key': 'e_1_2_14_5_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1038/s41586-022-05594-0'}, { 'key': 'e_1_2_14_6_1', 'unstructured': 'YanL.https://www.ecns.cn/news/society/2022‐12‐28/detail‐ihciertf7993989.shtml. 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