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"abstract": "<jats:title>Abstract</jats:title><jats:sec><jats:title>Background and Aims</jats:title><jats:p>A recent study suggested that administration of ursodeoxycholic acid (UDCA) at dosages usually employed clinically may reduce rates of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection. A recent surge of SARS‐CoV‐2 omicron infection in China allowed study of whether UDCA administration reduced susceptibility to SARS‐CoV‐2 infection in children with liver disease.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Through WeChat groups, a questionnaire was distributed to families (<jats:italic>n</jats:italic> = 300) in which a child had been admitted to our liver service in the past 5 years. Among the families/households in which someone was infected with SARS‐CoV‐2, the proportion in which a child taking UDCA was infected was compared with the proportion in which a child not taking UDCA was infected.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Of the 300 questionnaire answers, 280 (93.3%) were valid. SARS‐CoV‐2 infection was confirmed in 226 families (80.7%): 146 children were taking UDCA (10‐20 mg/kg/day) and 80 children were not taking UDCA. SARS‐CoV‐2 infection was confirmed in 95 children taking UDCA (65.1%) and in 51 children not taking UDCA (63.8%) (<jats:italic>p</jats:italic> = 0.843); SARS‐CoV‐2 infection was suspected in 23 children taking UDCA (15.8%) and in 11 children not taking UDCA (13.8%) (<jats:italic>p</jats:italic> = 0.687).</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>These results indicate that UDCA administration does not reduce susceptibility to SARS‐CoV‐2 infection in children with liver disease.</jats:p></jats:sec>",
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