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0 0.5 1 1.5 2+ Mortality 25% Improvement Relative Risk Zinc for COVID-19  Kyagambiddwa et al.  LATE TREATMENT Is late treatment with zinc beneficial for COVID-19? Retrospective 246 patients in Uganda (May 2020 - August 2022) Lower mortality with zinc (not stat. sig., p=0.28) c19early.org Kyagambiddwa et al., Infection and Dru.., May 2023 Favors zinc Favors control

Thirty-Day Outcomes of Young and Middle-Aged Adults Admitted with Severe COVID-19 in Uganda: A Retrospective Cohort Study

Kyagambiddwa et al., Infection and Drug Resistance, doi:10.2147/idr.s405256
May 2023  
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Zinc for COVID-19
2nd treatment shown to reduce risk in July 2020
 
*, now known with p = 0.0000013 from 44 studies, recognized in 11 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,200+ studies for 70+ treatments. c19early.org
Retrospective 246 severe COVID-19 patients in Uganda, showing lower mortality with zinc treatment in unadjusted results, without statistical significance.
Although the 25% lower mortality is not statistically significant, it is consistent with the significant 29% lower mortality [10‑44%] from meta analysis of the 20 mortality results to date.
This study is excluded in the after exclusion results of meta analysis: unadjusted results with no group details.
Study covers zinc and vitamin C.
risk of death, 25.4% lower, RR 0.75, p = 0.28, treatment 20 of 89 (22.5%), control 22 of 73 (30.1%), NNT 13.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Kyagambiddwa et al., 11 May 2023, retrospective, Uganda, peer-reviewed, mean age 39.0, 15 authors, study period May 2020 - August 2022. Contact: tonnykyagambiddwa97@gmail.com, enuwagira@must.ac.ug.
This PaperZincAll
Thirty-Day Outcomes of Young and Middle-Aged Adults Admitted with Severe COVID-19 in Uganda: A Retrospective Cohort Study
Tonny Kyagambiddwa, Timothy Mwanje Kintu, Emmanuel Miiro, Franchesca Nabalamba, Gloria Suubi Asiimwe, Anne Marion Namutebi, Fardous C Abeya, Boniface A Lumori, Isaac Ijuka, Rose K Muhindo, Andrew Mutekanga, Richard Musinguzi, Francis Natuhwera, Joseph Ngonzi, Edwin Nuwagira
Infection and Drug Resistance, doi:10.2147/idr.s405256
Background: There is scarcity of data regarding young and middle-aged adults hospitalized with severe Corona Virus Disease 2019 (COVID-19) in Africa. In this study, we describe the clinical characteristics and 30-day survival among adults aged 18 to 49 years admitted with severe COVID-19 in Uganda. Methods: We reviewed treatment records of patients admitted with severe COVID-19 across five COVID-19 treatment units (CTU) in Uganda. We included individuals aged 18 to 49 years, who had a positive test or met the clinical criteria for COVID-19. We defined severe COVID-19 as having an oxygen saturation <94%, lung infiltrates >50% on imaging and presence of a co-morbidity that required admission in the CTU. Our main outcome was the 30-day survival from the time of admission. We used a Cox proportional hazards model to determine the factors associated with 30-day survival at a 5% level of significance. Results: Of the 246 patient files reviewed, 50.8% (n = 125) were male, the mean ± (standard deviation) age was 39 ± 8 years, majority presented with cough, 85.8% (n = 211) and median C-reactive protein (interquartile range) was 48 (47.5, 178.8) mg/L. The 30-day mortality was 23.9% (59/246). At admission, anemia (hazard ratio (HR): 3.00, 95% confidence interval (CI), 1.32-6.82; p = 0.009) and altered mental state (GCS <15) (HR: 6.89, 95% CI: 1.48-32.08, p = 0.014) were significant predictors of 30-day mortality. Conclusion: There was a high 30-day mortality among young and middle-aged adults with severe COVID-19 in Uganda. Early recognition and targeted management of anemia and altered consciousness are needed to improve clinical outcomes.
Abbreviations Ethics Approval and Informed Consent The study was approved by the Research Ethics Committee of Mbarara University of Science and Technology under reference number MUST-2022-435. The ethics committee waived the requirement for consent. Permission for access to medical records was granted by the necessary boards at respective hospitals. Study codes were used to ensure the anonymity of participants' data. Data generated from the study shall be used for research purposes only and shall be private and confidential at all times. All principles of data transfer and principles of protection of human research participants outlined in the Declaration of Helsinki were observed. Disclosure The authors declare that they have no competing interests.
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Late treatment
is less effective
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