Abstract: HHS Public Access
Author manuscript
Author Manuscript
Adv Ther. Author manuscript; available in PMC 2024 May 01.
Published in final edited form as:
Adv Ther. 2023 November ; 40(11): 4805–4816. doi:10.1007/s12325-023-02618-7.
Ramipril for the Treatment of COVID-19: RAMIC, a Randomized,
Double-Blind, Placebo-Controlled Clinical Trial
Daniel Q. Huang,
NAFLD Research Center, Division of Gastroenterology, University of California at San Diego, La
Jolla, CA, USA
Author Manuscript
Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore,
Singapore, Singapore
Division of Gastroenterology and Hepatology, Department of Medicine, National University Health
System, Singapore, Singapore
Veeral Ajmera,
NAFLD Research Center, Division of Gastroenterology, University of California at San Diego, La
Jolla, CA, USA
Division of Gastroenterology, Department of Medicine, University of California San Diego, La
Jolla, CA, USA
Author Manuscript
Christian Tomaszewski,
Department of Emergency Medicine, University of California, San Diego and the El Centro
Regional, Medical Center, San Diego, CA, USA
Andrew LaFree,
Department of Emergency Medicine, University of California, San Diego and the El Centro
Regional, Medical Center, San Diego, CA, USA
Ricki Bettencourt,
NAFLD Research Center, Division of Gastroenterology, University of California at San Diego, La
Jolla, CA, USA
Wesley K. Thompson,
Author Manuscript
roloomba@ucsd.edu .
Author Contributions. Study design: Rohit Loomba, Veeral Ajmera, Daniel Huang. Data acquisition: Veeral Ajmera, Daniel Huang,
Christian Tomaszewski, Andrew LaFree, Jinho Jung, Maral Amangurbanova, Michelle S. Harkins, Wesley K Thompson, Davey M
Smith, Atul Malhotra, Ravindra L Mehta, Vaishal Tolia, Jeffery Yin, Paul A Insel, Stone Leachman, Summer Collier, Lissa Richards,
Kristin Woods, Archana Bhatt, Xinlian Zhang, Oana M Penciu, Stuart Zarich, Tamrat Retta, J Pedro Teixeira, Brian Chinnock,
Netanya S Utay, Jordan Lake, Rohit Loomba. Data analysis: Ricki Bettencourt, Daniel Huang, Rohit Loomba. Data interpretation and
review/revision of the manuscript: All authors. Study concept and study supervision: Rohit Loomba. All authors approved the final
draft of the manuscript as well as the authorship list.
Daniel Q. Huang and Veeral Ajmera share co-first authorship.
Compliance with Ethics Guidelines. This study was approved by the institutional review board for all sites (Advarra IRB approved
Apr 2020, A Randomized, Double-blind, Placebo Controlled Trial to Evaluate the Efficacy of Ramipril to Prevent ICU Admission,
Mechanical Ventilation or Death in Persons with COVID-19 [Pro00043364]). Consent was obtained from each patient, and was
received either in-person, or by videoconference or telephone, which occurred in the presence of a co-signing witness. All authors
agree with the manuscript and consent for its publication.
Supplementary Information The online version contains supplementary material available at https://doi.org/10.1007/
s12325-023-02618-7.
Huang et al.
Page 2
Author Manuscript
Division of Biostatistics and Bioinformatics, Department of Family Medicine and Public Health,
University of California San Diego, La Jolla, CA, USA
Davey M. Smith,
Division of Infectious Diseases and Global Public Health, Department of Medicine, University of
California San Diego, La Jolla, CA, USA
Veteran Affairs Medical Center, San Diego, CA, USA
Atul Malhotra,
Division of Pulmonary, Critical Care and Sleep..
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