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Prevalence, Outcomes, and Predictors of Prolonged Corrected QT Interval in Hydroxychloroquine-Naïve Hospitalized COVID-19 Patients

Gupta et al., Cardiovascular Toxicology, doi:10.1007/s12012-024-09886-x
Jul 2024  
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Retrospective 295 hospitalized COVID-19 patients showing increased risk of prolonged QTc with remdesivir use, without statistical significance, OR 1.84 [0.69 - 4.9]. Azithromycin had no effect on prolonged QTc.
Gérard, Zhou, Wu, Kamo, Choi show significantly increased risk of acute kidney injury with remdesivir.
Gupta et al., 2 Jul 2024, retrospective, peer-reviewed, 6 authors.
This PaperRemdesivirAll
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An improved method for adjusting the QT interval for heart rate ' '(the framingham heart study). American Journal of Cardiology, 70(7), ' '797–801. https://doi.org/10.1016/0002-9149(92)90562-d', 'journal-title': 'American Journal of Cardiology'}, { 'issue': '1', 'key': '9886_CR31', 'doi-asserted-by': 'publisher', 'first-page': '15', 'DOI': '10.1016/s0022-0736(82)80040-x', 'volume': '15', 'author': 'PE Puddu', 'year': '1982', 'unstructured': 'Puddu, P. E., Bernard, P. M., Chaitman, B. R., & Bourassa, M. G. (1982). ' 'QT interval measurement by a computer assisted program: A potentially ' 'useful clinical parameter. Journal of Electrocardiology, 15(1), 15–21. ' 'https://doi.org/10.1016/s0022-0736(82)80040-x', 'journal-title': 'Journal of Electrocardiology'}, { 'issue': '1', 'key': '9886_CR32', 'doi-asserted-by': 'publisher', 'first-page': '82', 'DOI': '10.1111/anec.12277', 'volume': '21', 'author': 'JT Barbey', 'year': '2016', 'unstructured': 'Barbey, J. T., Connolly, M., Beaty, B., & Krantz, M. J. (2016). Man ' 'versus Machine: Comparison of automated and manual methodologies for ' 'measuring the QTc interval: A prospective study. Annals of Noninvasive ' 'Electrocardiology, 21(1), 82–90. https://doi.org/10.1111/anec.12277', 'journal-title': 'Annals of Noninvasive Electrocardiology'}, { 'issue': '6', 'key': '9886_CR33', 'doi-asserted-by': 'publisher', 'first-page': '569', 'DOI': '10.1016/j.hrthm.2005.02.011', 'volume': '2', 'author': 'S Viskin', 'year': '2005', 'unstructured': 'Viskin, S., Rosovski, U., Sands, A. J., Chen, E., Kistler, P. M., ' 'Kalman, J. M., Chavez, L. R., Torres, P. I., Centurión, O. A., Fujiki, ' 'A., & Maury, P. (2005). Inaccurate electrocardiographic interpretation ' 'of long QT: the majority of physicians cannot recognize a long QT when ' 'they see one. Heart Rhythm, 2(6), 569–574. ' 'https://doi.org/10.1016/j.hrthm.2005.02.011', 'journal-title': 'Heart Rhythm'}, { 'key': '9886_CR34', 'unstructured': 'Alldredge BK, Corelli RL, Ernst ME, Guglielmo BJ, Jacobson PA, Williams ' 'BR (2013). Koda-kimble and Young’s applied therapeutics: the clinical ' 'use of drugs. Wolters Kluwer/Lippincott Williams & Wilkins'}], 'container-title': 'Cardiovascular Toxicology', 'original-title': [], 'language': 'en', 'link': [ { 'URL': 'https://link.springer.com/content/pdf/10.1007/s12012-024-09886-x.pdf', 'content-type': 'application/pdf', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': 'https://link.springer.com/article/10.1007/s12012-024-09886-x/fulltext.html', 'content-type': 'text/html', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': 'https://link.springer.com/content/pdf/10.1007/s12012-024-09886-x.pdf', 'content-type': 'application/pdf', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'deposited': { 'date-parts': [[2024, 7, 2]], 'date-time': '2024-07-02T05:40:36Z', 'timestamp': 1719898836000}, 'score': 1, 'resource': {'primary': {'URL': 'https://link.springer.com/10.1007/s12012-024-09886-x'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2024, 7, 2]]}, 'references-count': 34, 'alternative-id': ['9886'], 'URL': 'http://dx.doi.org/10.1007/s12012-024-09886-x', 'relation': {}, 'ISSN': ['1530-7905', '1559-0259'], 'subject': [], 'container-title-short': 'Cardiovasc Toxicol', 'published': {'date-parts': [[2024, 7, 2]]}, 'assertion': [ { 'value': '26 December 2023', 'order': 1, 'name': 'received', 'label': 'Received', 'group': {'name': 'ArticleHistory', 'label': 'Article History'}}, { 'value': '19 June 2024', 'order': 2, 'name': 'accepted', 'label': 'Accepted', 'group': {'name': 'ArticleHistory', 'label': 'Article History'}}, { 'value': '2 July 2024', 'order': 3, 'name': 'first_online', 'label': 'First Online', 'group': {'name': 'ArticleHistory', 'label': 'Article History'}}, {'order': 1, 'name': 'Ethics', 'group': {'name': 'EthicsHeading', 'label': 'Declarations'}}, { 'value': 'All authors have completed the International Committee of Medical Journal ' 'Editors uniform disclosure form at . None of the author has any competing ' 'interest.', 'order': 2, 'name': 'Ethics', 'group': {'name': 'EthicsHeading', 'label': 'Competing Interest'}}, { 'value': 'The study was approved by Institutional Ethics Committee, Vardhman Mahavir ' 'Medical College & Safdarjung Hospital, New Delhi ' '(IEC/VMMC/SJH/Project/2020-12/CC-92).', 'order': 3, 'name': 'Ethics', 'group': {'name': 'EthicsHeading', 'label': 'Ethical Approval'}}]}
Late treatment
is less effective
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