Patient Characteristics and Outcomes of 11,721 Patients with COVID19 Hospitalized Across the United States

DOI record: { "DOI": "10.1093/cid/ciaa1268", "ISSN": [ "1058-4838", "1537-6591" ], "URL": "http://dx.doi.org/10.1093/cid/ciaa1268", "abstract": "<jats:title>Abstract</jats:title>\n <jats:sec>\n <jats:title>Background</jats:title>\n <jats:p>As coronavirus disease 2019 (COVID-19) disseminates throughout the United States, a better understanding of the patient characteristics associated with hospitalization, morbidity, and mortality in diverse geographic regions is essential.</jats:p>\n </jats:sec>\n <jats:sec>\n <jats:title>Methods</jats:title>\n <jats:p>Hospital chargemaster data on adult patients with COVID-19 admitted to 245 hospitals across 38 states between 15 February and 20 April 2020 were assessed. The clinical course from admission, through hospitalization, and to discharge or death was analyzed.</jats:p>\n </jats:sec>\n <jats:sec>\n <jats:title>Results</jats:title>\n <jats:p>A total of 11 721 patients were included (majority were &amp;gt;60 years of age [59.9%] and male [53.4%]). Comorbidities included hypertension (46.7%), diabetes (27.8%), cardiovascular disease (18.6%), obesity (16.1%), and chronic kidney disease (12.2%). Mechanical ventilation was required by 1967 patients (16.8%). Mortality among hospitalized patients was 21.4% and increased to 70.5% among those on mechanical ventilation. Male sex, older age, obesity, geographic region, and the presence of chronic kidney disease or a preexisting cardiovascular disease were associated with increased odds of mechanical ventilation. All aforementioned risk factors, with the exception of obesity, were associated with increased odds of death (all P values &amp;lt; .001). Many patients received investigational medications for treatment of COVID-19, including 48 patients on remdesivir and 4232 on hydroxychloroquine.</jats:p>\n </jats:sec>\n <jats:sec>\n <jats:title>Conclusions</jats:title>\n <jats:p>This large observational cohort describes the clinical course and identifies factors associated with the outcomes of hospitalized patients with COVID-19 across the United States. These data can inform strategies to prioritize prevention and treatment for this disease.</jats:p>\n </jats:sec>", "author": [ { "affiliation": [ { "name": "TARGET PharmaSolutions Inc., Durham, North Carolina, USA" } ], "family": "Fried", "given": "Michael W", "sequence": "first" }, { "affiliation": [ { "name": "TARGET PharmaSolutions Inc., Durham, North Carolina, USA" } ], "family": "Crawford", "given": "Julie M", "sequence": "additional" }, { "affiliation": [ { "name": "TARGET PharmaSolutions Inc., Durham, North Carolina, USA" } ], "family": "Mospan", "given": "Andrea R", "sequence": "additional" }, { "affiliation": [ { "name": "TARGET PharmaSolutions Inc., Durham, North Carolina, USA" } ], "family": "Watkins", "given": "Stephanie E", "sequence": "additional" }, { "affiliation": [ { "name": "TARGET PharmaSolutions Inc., Durham, North Carolina, USA" } ], "family": "Munoz", "given": "Breda", "sequence": "additional" }, { "affiliation": [ { "name": "TARGET PharmaSolutions Inc., Durham, North Carolina, USA" } ], "family": "Zink", "given": "Richard C", "sequence": "additional" }, { "affiliation": [ { "name": "Elliott Health Information Pros Inc., Cary, North Carolina, USA" } ], "family": "Elliott", "given": "Sherry", "sequence": "additional" }, { "affiliation": [ { "name": "TARGET PharmaSolutions Inc., Durham, North Carolina, USA" } ], "family": "Burleson", "given": "Kyle", "sequence": "additional" }, { "affiliation": [ { "name": "Liver Care and Transplantation Services at University of Washington Medical Center, Seattle, Washington, USA" } ], "family": "Landis", "given": "Charles", "sequence": "additional" }, { "affiliation": [ { "name": "Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA" } ], "family": "Reddy", "given": "K Rajender", "sequence": "additional" }, { "affiliation": [ { "name": "Department of Medicine, Division of Gastroenterology and Hepatology, Weill Cornell Medicine Center for Liver Disease, New York, New York, USA" } 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