Analgesics
Antiandrogens
Antihistamines
Azvudine
Bromhexine
Budesonide
Colchicine
Conv. Plasma
Curcumin
Famotidine
Favipiravir
Fluvoxamine
Hydroxychlor..
Ivermectin
Lifestyle
Melatonin
Metformin
Minerals
Molnupiravir
Monoclonals
Naso/orophar..
Nigella Sativa
Nitazoxanide
PPIs
Paxlovid
Quercetin
Remdesivir
Thermotherapy
Vitamins
More

Other
Feedback
Home
Top
Results
Abstract
All losartan studies
Meta analysis
 
Feedback
Home
next
study
previous
study
c19early.org COVID-19 treatment researchLosartanLosartan (more..)
Melatonin Meta
Metformin Meta
Antihistamines Meta
Azvudine Meta Molnupiravir Meta
Bromhexine Meta
Budesonide Meta
Colchicine Meta Nigella Sativa Meta
Conv. Plasma Meta Nitazoxanide Meta
Curcumin Meta PPIs Meta
Famotidine Meta Paxlovid Meta
Favipiravir Meta Quercetin Meta
Fluvoxamine Meta Remdesivir Meta
Hydroxychlor.. Meta Thermotherapy Meta
Ivermectin Meta

All Studies   Meta Analysis       

COVIDMED – An early pandemic randomized clinical trial of losartan treatment for hospitalized COVID-19 patients

Freilich et al., Contemporary Clinical Trials Communications, doi:10.1016/j.conctc.2022.100968, COVIDMED, NCT04340557
Oct 2022  
  Post
  Facebook
Share
  Source   PDF   All Studies   Meta AnalysisMeta
Mortality -533% Improvement Relative Risk Hospitalization time -160% Losartan  COVIDMED  LATE TREATMENT  RCT Is late treatment with losartan beneficial for COVID-19? RCT 12 patients in the USA Higher mortality (p=0.49) and longer hospitalization (p=0.3), not sig. c19early.org Freilich et al., Contemporary Clinical.., Oct 2022 Favorslosartan Favorscontrol 0 0.5 1 1.5 2+
RCT 15 hospitalized COVID-19 patients showing no significant differences with losartan treatment. The study was terminated early due to low enrollment.
risk of death, 533.3% higher, RR 6.33, p = 0.49, treatment 4 of 9 (44.4%), control 0 of 3 (0.0%), continuity correction due to zero event (with reciprocal of the contrasting arm).
hospitalization time, 160.3% higher, relative time 2.60, p = 0.30, treatment 9, control 3.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Freilich et al., 31 Oct 2022, Randomized Controlled Trial, placebo-controlled, USA, peer-reviewed, mean age 69.8, 4 authors, trial NCT04340557 (history) (COVIDMED). Contact: daniel.freilich@bassett.org, jennifer.victory@bassett.org, paul.jenkins@bassett.org.
This PaperLosartanAll
COVIDMED – An early pandemic randomized clinical trial of losartan treatment for hospitalized COVID-19 patients
Daniel Freilich, Jennifer Victory, Paul Jenkins, Anne Gadomski
Contemporary Clinical Trials Communications, doi:10.1016/j.conctc.2022.100968
Losartan Angiotensin converting enzyme inhibitor (ACEi) Angiotensin II receptor Blocker (ARB) COVID
Source of funding This work was supported by a Bassett Research Institute ED Thomas Grant (which included funds to purchase study drugs) and salary support from the Bassett Research Institute and Bassett Medical Center's Department of Internal Medicine. Funders had no role in the design, execution, data analysis, or manuscript preparation or publication of this study. Authors' contributions All authors contributed to refinement of and approved the manuscript. Authorship role All authors collaborated in the writing/editing of the manuscript. Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. Appendix A. Supplementary data Supplementary data to this article can be found online at https://doi. org/10.1016/j.conctc.2022.100968.
References
Baral, Tsampasian, Debski, Moran, Garg et al., Association between renin-angiotensin-aldosterone system inhibitors and clinical outcomes in patients with COVID-19A systematic review and meta-analysis, JAMA Netw. Open
Bean, Kraljevic, Searle, Bendayan, Kevin et al., Angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers are not associated with severe COVID-19 infection in a multi-site UK acute hospital trust, Eur. J. Heart Fail
Bengtson, Montgomery, Nazir, Satterwhite, Kim et al., An open label trial to assess safety of losartan for treating worsening respiratory illness in COVID-19, Front. Med, doi:10.3389/fmed.2021.630209
Cao, Wang, Wen, Liu, Wang et al., A trial of lopinavir-ritonavir in adults hospitalized with severe covid-19, N. Engl. J. Med
Cohen, Hanff, William, Sweitzer, Rosado-Santander et al., Continuation versus discontinuation of renin-angiotensin system inhibitors in patients admitted to hospital with COVID-19: a prospective, randomised, open-label trial, Lancet Respir. Med
Duarte, Pelorosso, Nicolosi, Salgado, Vetulli et al., Telmisartan for treatment of Covid-19 patients: an open multicenter randomized clinical trial, EClinicalMedicine, doi:10.1016/j.eclinm.2021.100962
Fosbol, Butt, Østergaard, Andersson, Selmer et al., Association of angiotensin-converting enzyme inhibitor or angiotensin receptor blocker use with COVID-19 diagnosis and mortality, JAMA
Geriak, Haddad, Kullar, Greenwood, Habib et al., Randomized prospective open label study shows No impact on clinical outcome of adding losartan to hospitalized COVID-19 patients with mild hypoxemia, Infect. Dis. Ther
Hoffmann, Kleine-Weber, Schroeder, Krüger, Herrler et al., SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor, Cell
Horby, Mafham, Linsell, Bell, Staplin et al., Effect of hydroxychloroquine in hospitalized patients with covid-19. The RECOVERY collaborative group, N. Engl. J. Med
Ishiyama, Gallagher, Averill, Tallant, Brosnihan et al., Upregulation of angiotensin-converting enzyme 2 after myocardial infarction by blockade of angiotensin II receptors, Hypertension
Kuba, Imai, Rao, Gao, Guo et al., A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury, Nat. Med
Lopes, Macedo, De Barros E Silva, Moll-Bernardes, Santos et al., Effect of discontinuing vs continuing angiotensinconverting enzyme inhibitors and angiotensin II receptor blockers on days alive and out of the hospital in patients admitted with COVID-19A randomized clinical trial, JAMA
Mancia, Rea, Ludergnani, Apolone, Corrao, Renin-Angiotensin-aldosterone system blockers and the risk of covid-19, N. Engl. J. Med
Mehra, Desai, Kuy, Henry, Patel, Cardiovascular disease, drug therapy, and mortality in covid-19, N. Engl. J. Med
Mehta, Kalra, Nowacki, Anjewierden, Han et al., Association of use of angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers with testing positive for coronavirus disease 2019 (COVID-19), JAMA Cardiol
Puskarich, Cummins, Ingraham, Wacker, Reilkoff et al., A multi-center phase II randomized clinical trial of losartan on symptomatic outpatients with COVID-19, EClinicalMedicine, doi:10.1016/j.eclinm.2021.100957
Puskarich, Ingraham, Merck, Efficacy of losartan in hospitalized patients with COVID-19-induced lung injury: a randomized clinical trial, JAMA Netw. Open
Reynolds, Adhikari, Pulgarin, Troxel, Iturrate et al., Renin-Angiotensin-aldosterone system inhibitors and risk of covid-19, N. Engl. J. Med
Vaduganathan, Vardeny, Michel, Mcmurray, Pfeffer et al., Renin-Angiotensin-aldosterone system inhibitors in patients with covid-19, N. Engl. J. Med
{ 'indexed': {'date-parts': [[2024, 4, 24]], 'date-time': '2024-04-24T00:58:17Z', 'timestamp': 1713920297570}, 'reference-count': 20, 'publisher': 'Elsevier BV', 'license': [ { 'start': { 'date-parts': [[2022, 10, 1]], 'date-time': '2022-10-01T00:00:00Z', 'timestamp': 1664582400000}, 'content-version': 'tdm', 'delay-in-days': 0, 'URL': 'https://www.elsevier.com/tdm/userlicense/1.0/'}, { 'start': { 'date-parts': [[2022, 7, 14]], 'date-time': '2022-07-14T00:00:00Z', 'timestamp': 1657756800000}, 'content-version': 'vor', 'delay-in-days': 0, 'URL': 'http://creativecommons.org/licenses/by/4.0/'}], 'content-domain': { 'domain': [ 'clinicalkey.fr', 'clinicalkey.jp', 'clinicalkey.com.au', 'clinicalkey.es', 'clinicalkey.com', 'elsevier.com', 'sciencedirect.com'], 'crossmark-restriction': True}, 'published-print': {'date-parts': [[2022, 10]]}, 'DOI': '10.1016/j.conctc.2022.100968', 'type': 'journal-article', 'created': {'date-parts': [[2022, 7, 20]], 'date-time': '2022-07-20T06:12:27Z', 'timestamp': 1658297547000}, 'page': '100968', 'update-policy': 'http://dx.doi.org/10.1016/elsevier_cm_policy', 'source': 'Crossref', 'is-referenced-by-count': 5, 'title': 'COVIDMED – An early pandemic randomized clinical trial of losartan treatment for hospitalized ' 'COVID-19 patients', 'prefix': '10.1016', 'volume': '29', 'author': [ { 'ORCID': 'http://orcid.org/0000-0002-2219-6900', 'authenticated-orcid': False, 'given': 'Daniel', 'family': 'Freilich', 'sequence': 'first', 'affiliation': []}, {'given': 'Jennifer', 'family': 'Victory', 'sequence': 'additional', 'affiliation': []}, {'given': 'Paul', 'family': 'Jenkins', 'sequence': 'additional', 'affiliation': []}, {'given': 'Anne', 'family': 'Gadomski', 'sequence': 'additional', 'affiliation': []}], 'member': '78', 'reference': [ { 'issue': '2', 'key': '10.1016/j.conctc.2022.100968_bib1', 'doi-asserted-by': 'crossref', 'first-page': '271', 'DOI': '10.1016/j.cell.2020.02.052', 'article-title': 'SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a ' 'clinically proven protease inhibitor', 'volume': '181', 'author': 'Hoffmann', 'year': '2020', 'journal-title': 'Cell'}, { 'key': '10.1016/j.conctc.2022.100968_bib2', 'doi-asserted-by': 'crossref', 'first-page': '875', 'DOI': '10.1038/nm1267', 'article-title': 'A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS ' 'coronavirus–induced lung injury. Letter', 'volume': '11', 'author': 'Kuba', 'year': '2005', 'journal-title': 'Nat. Med.'}, { 'issue': '5', 'key': '10.1016/j.conctc.2022.100968_bib3', 'doi-asserted-by': 'crossref', 'first-page': '970', 'DOI': '10.1161/01.HYP.0000124667.34652.1a', 'article-title': 'Upregulation of angiotensin-converting enzyme 2 after myocardial ' 'infarction by blockade of angiotensin II receptors', 'volume': '43', 'author': 'Ishiyama', 'year': '2004', 'journal-title': 'Hypertension'}, { 'key': '10.1016/j.conctc.2022.100968_bib4', 'doi-asserted-by': 'crossref', 'first-page': '1653', 'DOI': '10.1056/NEJMsr2005760', 'article-title': 'Renin–Angiotensin–aldosterone system inhibitors in patients with ' 'covid-19', 'volume': '382', 'author': 'Vaduganathan', 'year': '2020', 'journal-title': 'N. Engl. J. Med.'}, { 'key': '10.1016/j.conctc.2022.100968_bib5', 'doi-asserted-by': 'crossref', 'first-page': 'e102', 'DOI': '10.1056/NEJMoa2007621', 'article-title': 'Cardiovascular disease, drug therapy, and mortality in covid-19', 'volume': '382', 'author': 'Mehra', 'year': '2020', 'journal-title': 'N. Engl. J. Med.'}, { 'key': '10.1016/j.conctc.2022.100968_bib6', 'doi-asserted-by': 'crossref', 'first-page': '2441', 'DOI': '10.1056/NEJMoa2008975', 'article-title': 'Renin–Angiotensin–aldosterone system inhibitors and risk of covid-19', 'volume': '382', 'author': 'Reynolds', 'year': '2020', 'journal-title': 'N. Engl. J. Med.'}, { 'key': '10.1016/j.conctc.2022.100968_bib7', 'doi-asserted-by': 'crossref', 'first-page': '2431', 'DOI': '10.1056/NEJMoa2006923', 'article-title': 'Renin–Angiotensin–aldosterone system blockers and the risk of covid-19', 'volume': '382', 'author': 'Mancia', 'year': '2020', 'journal-title': 'N. Engl. J. Med.'}, { 'issue': '6', 'key': '10.1016/j.conctc.2022.100968_bib8', 'doi-asserted-by': 'crossref', 'first-page': '967', 'DOI': '10.1002/ejhf.1924', 'article-title': 'Angiotensin-converting enzyme inhibitors and angiotensin II receptor ' 'blockers are not associated with severe COVID-19 infection in a ' 'multi-site UK acute hospital trust', 'volume': '22', 'author': 'Bean', 'year': '2020', 'journal-title': 'Eur. J. Heart Fail.'}, { 'issue': '2', 'key': '10.1016/j.conctc.2022.100968_bib9', 'doi-asserted-by': 'crossref', 'first-page': '168', 'DOI': '10.1001/jama.2020.11301', 'article-title': 'Association of angiotensin-converting enzyme inhibitor or angiotensin ' 'receptor blocker use with COVID-19 diagnosis and mortality', 'volume': '324', 'author': 'Fosbol', 'year': '2020', 'journal-title': 'JAMA'}, { 'issue': '9', 'key': '10.1016/j.conctc.2022.100968_bib10', 'doi-asserted-by': 'crossref', 'first-page': '1020', 'DOI': '10.1001/jamacardio.2020.1855', 'article-title': 'Association of use of angiotensin-converting enzyme inhibitors and ' 'angiotensin II receptor blockers with testing positive for coronavirus ' 'disease 2019 (COVID-19)', 'volume': '5', 'author': 'Mehta', 'year': '2020', 'journal-title': 'JAMA Cardiol.'}, { 'issue': '3', 'key': '10.1016/j.conctc.2022.100968_bib11', 'doi-asserted-by': 'crossref', 'first-page': '254', 'DOI': '10.1001/jama.2020.25864', 'article-title': 'Effect of discontinuing vs continuing angiotensin-converting enzyme ' 'inhibitors and angiotensin II receptor blockers on days alive and out ' 'of the hospital in patients admitted with COVID-19A randomized clinical ' 'trial', 'volume': '325', 'author': 'Lopes', 'year': '2021', 'journal-title': 'JAMA'}, { 'issue': '3', 'key': '10.1016/j.conctc.2022.100968_bib12', 'doi-asserted-by': 'crossref', 'first-page': '275', 'DOI': '10.1016/S2213-2600(20)30558-0', 'article-title': 'Continuation versus discontinuation of renin–angiotensin system ' 'inhibitors in patients admitted to hospital with COVID-19: a ' 'prospective, randomised, open-label trial', 'volume': '9', 'author': 'Cohen', 'year': '2021', 'journal-title': 'Lancet Respir. Med.'}, { 'key': '10.1016/j.conctc.2022.100968_bib13', 'doi-asserted-by': 'crossref', 'DOI': '10.3389/fmed.2021.630209', 'article-title': 'An open label trial to assess safety of losartan for treating worsening ' 'respiratory illness in COVID-19', 'author': 'Bengtson', 'year': '2021', 'journal-title': 'Front. Med. (Lausanne)'}, { 'key': '10.1016/j.conctc.2022.100968_bib14', 'doi-asserted-by': 'crossref', 'DOI': '10.1016/j.eclinm.2021.100962', 'article-title': 'Telmisartan for treatment of Covid-19 patients: an open multicenter ' 'randomized clinical trial', 'author': 'Duarte', 'year': '2021', 'journal-title': 'EClinicalMedicine'}, { 'issue': '3', 'key': '10.1016/j.conctc.2022.100968_bib15', 'doi-asserted-by': 'crossref', 'first-page': '1323', 'DOI': '10.1007/s40121-021-00453-3', 'article-title': 'Randomized prospective open label study shows No impact on clinical ' 'outcome of adding losartan to hospitalized COVID-19 patients with mild ' 'hypoxemia', 'volume': '10', 'author': 'Geriak', 'year': '2021', 'journal-title': 'Infect. Dis. Ther.'}, { 'issue': '3', 'key': '10.1016/j.conctc.2022.100968_bib16', 'doi-asserted-by': 'crossref', 'DOI': '10.1001/jamanetworkopen.2021.3594', 'article-title': 'Association between renin-angiotensin-aldosterone system inhibitors and ' 'clinical outcomes in patients with COVID-19A systematic review and ' 'meta-analysis', 'volume': '4', 'author': 'Baral', 'year': '2021', 'journal-title': 'JAMA Netw. Open'}, { 'key': '10.1016/j.conctc.2022.100968_bib17', 'doi-asserted-by': 'crossref', 'DOI': '10.1016/j.eclinm.2021.100957', 'article-title': 'A multi-center phase II randomized clinical trial of losartan on ' 'symptomatic outpatients with COVID-19', 'author': 'Puskarich', 'year': '2021', 'journal-title': 'EClinicalMedicine'}, { 'issue': '3', 'key': '10.1016/j.conctc.2022.100968_bib18', 'doi-asserted-by': 'crossref', 'DOI': '10.1001/jamanetworkopen.2022.2735', 'article-title': 'Efficacy of losartan in hospitalized patients with COVID-19–induced ' 'lung injury: a randomized clinical trial', 'volume': '5', 'author': 'Puskarich', 'year': '2022', 'journal-title': 'JAMA Netw. Open'}, { 'issue': '21', 'key': '10.1016/j.conctc.2022.100968_bib19', 'doi-asserted-by': 'crossref', 'first-page': '2030', 'DOI': '10.1056/NEJMoa2022926', 'article-title': 'Effect of hydroxychloroquine in hospitalized patients with covid-19. ' 'The RECOVERY collaborative group', 'volume': '383', 'author': 'Horby', 'year': '2020', 'journal-title': 'N. Engl. J. Med.'}, { 'issue': '19', 'key': '10.1016/j.conctc.2022.100968_bib20', 'doi-asserted-by': 'crossref', 'first-page': '1787', 'DOI': '10.1056/NEJMoa2001282', 'article-title': 'A trial of lopinavir–ritonavir in adults hospitalized with severe ' 'covid-19', 'volume': '382', 'author': 'Cao', 'year': '2020', 'journal-title': 'N. Engl. J. Med.'}], 'container-title': 'Contemporary Clinical Trials Communications', 'original-title': [], 'language': 'en', 'link': [ { 'URL': 'https://api.elsevier.com/content/article/PII:S2451865422000850?httpAccept=text/xml', 'content-type': 'text/xml', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': 'https://api.elsevier.com/content/article/PII:S2451865422000850?httpAccept=text/plain', 'content-type': 'text/plain', 'content-version': 'vor', 'intended-application': 'text-mining'}], 'deposited': { 'date-parts': [[2024, 2, 4]], 'date-time': '2024-02-04T14:01:11Z', 'timestamp': 1707055271000}, 'score': 1, 'resource': {'primary': {'URL': 'https://linkinghub.elsevier.com/retrieve/pii/S2451865422000850'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2022, 10]]}, 'references-count': 20, 'alternative-id': ['S2451865422000850'], 'URL': 'http://dx.doi.org/10.1016/j.conctc.2022.100968', 'relation': { 'has-preprint': [ { 'id-type': 'doi', 'id': '10.1101/2022.01.12.22269095', 'asserted-by': 'object'}]}, 'ISSN': ['2451-8654'], 'subject': [], 'container-title-short': 'Contemporary Clinical Trials Communications', 'published': {'date-parts': [[2022, 10]]}, 'assertion': [ {'value': 'Elsevier', 'name': 'publisher', 'label': 'This article is maintained by'}, { 'value': 'COVIDMED – An early pandemic randomized clinical trial of losartan treatment ' 'for hospitalized COVID-19 patients', 'name': 'articletitle', 'label': 'Article Title'}, { 'value': 'Contemporary Clinical Trials Communications', 'name': 'journaltitle', 'label': 'Journal Title'}, { 'value': 'https://doi.org/10.1016/j.conctc.2022.100968', 'name': 'articlelink', 'label': 'CrossRef DOI link to publisher maintained version'}, {'value': 'article', 'name': 'content_type', 'label': 'Content Type'}, { 'value': '© 2022 The Authors. Published by Elsevier Inc.', 'name': 'copyright', 'label': 'Copyright'}], 'article-number': '100968'}
Late treatment
is less effective
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop   
Submit