Effect of Acid Suppressants on the Risk of COVID-19: A Propensity Score-Matched Study Using UK Biobank
Xiude Fan, Zhengwen Liu, Tatsunori Miyata, Srinivasan Dasarathy, Daniel M Rotroff, Xiaoqin Wu, Kyle L Poulsen, PhD Laura E Nagy
Gastroenterology, doi:10.1053/j.gastro.2020.09.028
C oronavirus disease 2019 (COVID-19) is a highly contagious and life-threatening infection caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). 1 Identifying modifiable risk factors for COVID-19 would be of substantial public health benefit. To date, several studies exploring the association between use of acid suppressants and COVID-19 have produced conflicting results, 2-6 which makes it difficult to determine whether there is indeed an increased risk of SARS-CoV-2 infection and death for users of acid suppressants. Thus, we aimed to clarify the potential impact of acidsuppressant treatment on the risk of SARS-CoV-2 infection and death in patients with COVID-19.
Supplementary Material Note: To access the supplementary material accompanying this article, visit the online version of Gastroenterology at www.gastrojournal.org, and at https://doi.org/10. 1053
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