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All Studies   Meta Analysis    Recent:   
0 0.5 1 1.5 2+ Case -51% Improvement Relative Risk Acetaminophen for COVID-19  Blanc et al.  Prophylaxis Does acetaminophen reduce COVID-19 infections? Retrospective 179 patients in France (March - April 2020) More cases with acetaminophen (not stat. sig., p=0.19) c19early.org Blanc et al., MDPI AG, May 2020 Favors acetaminophen Favors control

Interest of Proton Pump Inhibitors in Reducing the Occurrence of COVID-19: A Case-Control Study

May 2020  
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1st treatment shown to increase risk in November 2020
 
*, now known with p = 0.00000029 from 28 studies, but still recommended in 46 countries.
* From meta analysis with ≥3 clinical studies.
4,100+ studies for 60+ treatments. c19early.org
Retrospective 179 elderly patients in France, showing higher risk of COVID-19 cases with acetaminophen use, without statistical significance.
Acetaminophen is also known as paracetamol, Tylenol, Panadol, Calpol, Tempra, Calprofen, Doliprane, Efferalgan, Grippostad C, Dolo, Acamol, Fevadol, Crocin, and Perfalgan.
risk of case, 51.4% higher, OR 1.51, p = 0.19, treatment 60, control 119, RR approximated with OR.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Blanc et al., 2 May 2020, retrospective, France, preprint, mean age 84.1, 22 authors, study period 2 March, 2020 - 8 April, 2020.
This PaperAcetaminophenAll
Interest of Proton Pump Inhibitors in Reducing the Occurrence of COVID-19: A Case-Control Study
Frederic Blanc, Cedric Waechter, Thomas Vogel, Benoît Schorr, Catherine Demuynck, Catherine Martin-Hunyadi, Maxence Meyer, Denata Mutelica, Nadjiba Bougaa, Samira Fafi-Kremer, Lidia Calabrese, Elise Schmitt, Delphine Imperiale, Catherine Jehl, Alexandre Boussuge, Carmen Suna, François Weill, Alexia Matzinger, Candice Muller, Patrick Karcher, Georges Kaltenbach, Erik Sauleau
doi:10.20944/preprints202005.0016.v1
Background: COVID-19 is a disease of the elderly as 95% of deaths related to COVID-19 occur in people over 60 years of age. Despite the urgent need for a preventive treatment there are currently no serious leads, other than the vaccination. Objective: To find a preventive treatment of COVID-19 in elderly patients.
References
Amanat, Krammer, SARS-CoV-2 Vaccines: Status Report, Immunity
Bloch, Shoham, Casadevall, Deployment of convalescent plasma for the prevention and treatment of COVID-19, The Journal of Clinical Investigation
Caruso, Zerunian, Polici, Chest CT Features of COVID-19 in Rome, Radiology
Cetin, Wurm, Reichardt, Increased risk of death associated with the use of proton pump inhibitors in dementia patients and controls -a pharmacoepidemiological claims data analysis, European Journal of Neurology
Chang, Letter: Suppression of herpetic recurrence by chlorpromazine, N Engl J Med
Chen, Dai, Mo, Clinical characteristics and outcomes of older patients with coronavirus disease 2019 (COVID-19), The Journals of Gerontology: Series A
Europe, COVID-19 weekly surveillance report
Geerlings, Hoepelman, Immune dysfunction in patients with diabetes mellitus (DM)
Gomm, Holt, Thomé, Association of Proton Pump Inhibitors With Risk of Dementia: A Pharmacoepidemiological Claims Data Analysis, JAMA Neurology
Gordon, Jang, Bouhaddou, A SARS-CoV-2-human protein-protein interaction map reveals drug targets and potential drug-repurposing, BioRxiv
Grasselli, Zangrillo, Zanella, Baseline Characteristics and Outcomes of
Gurwitz, Angiotensin receptor blockers as tentative SARS-CoV-2 therapeutics, Drug Dev Res
Homolak, Kodvanj, Widely Available Lysosome Targeting Agents Should Be Considered as a Potential Therapy for COVID-19
Hreinsson, Palsdóttir, Bjornsson, The Association of Drugs With Severity and Specific Causes of Acute Lower Gastrointestinal Bleeding, Journal of clinical gastroenterology
Hálfdánarson, Pottegård, Björnsson, Proton-pump inhibitors among adults: a nationwide drug-utilization study, Therapeutic Advances in Gastroenterology
Jones-Brando, Buthod, Holland, Yolken, Torrey, Metabolites of the antipsychotic agent clozapine inhibit the replication of human immunodeficiency virus type 1, Schizophr Res
Klompas, Coronavirus Disease 2019 (COVID-19): Protecting Hospitals From the Invisible, Annals of Internal Medicine
Lee, Jeon, Hong, Proton pump inhibitors enhance the effects of cytotoxic agents in chemoresistant epithelial ovarian carcinoma, Oncotarget
Mehta, Yeligar, Elon, Brown, Guidot, Alcoholism causes alveolar macrophage zinc deficiency and immune dysfunction, American journal of respiratory and critical care medicine
Moatti, The French response to COVID-19: intrinsic difficulties at the interface of science, public health, and policy, The Lancet Public Health
Richardson, Hirsch, Narasimhan, Presenting Characteristics, Comorbidities, and Outcomes Among 5700 Patients Hospitalized With COVID-19 in the New York City Area, JAMA
Simmons, Reeves, Rennekamp, Amberg, Piefer et al., Characterization of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) spike glycoprotein-mediated viral entry, Proc Natl Acad Sci U S A
Spugnini, Baldi, Buglioni, Lansoprazole as a rescue agent in chemoresistant tumors: a phase I/II study in companion animals with spontaneously occurring tumors, Journal of Translational Medicine
Team, Vital Surveillances: The Epidemiological Characteristics of an Outbreak of 2019 Novel Coronavirus Diseases (COVID-19)-China, 2020, China CDC Weekly
Vaduganathan, Vardeny, Michel, Mcmurray, Pfeffer et al., Renin-Angiotensin-Aldosterone System Inhibitors in Patients with Covid-19, N Engl J Med
Wunderlich, Fey, Sydow, Antiviral effect of haloperidol on Rauscher murine leukemia virus, Archiv fur Geschwulstforschung
Yang, Shen, Targeting the Endocytic Pathway and Autophagy Process as a Novel Therapeutic Strategy in COVID-19, Int J Biol Sci
Zhu, Zhang, Wang, A Novel Coronavirus from Patients with Pneumonia in China, 2019, New England Journal of Medicine
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Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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