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Assessment of toxicological effects of favipiravir (T‐705) on the lung tissue of rats: An experimental study

Erbaş et al., Journal of Biochemical and Molecular Toxicology, doi:10.1002/jbt.23536
Nov 2023  
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Analysis of the toxicological effects of favipiravir on healthy lung tissue in rats. Authors found that favipiravir treatment increased oxidative stress, apoptosis, and inflammation in the lung tissue as evidenced by changes in antioxidant parameters, increased expression of pro-apoptotic markers like Bax and caspase-3, and higher levels of inflammatory markers like NF-κB, IL-6, and P2X7R. The histopathological analysis also showed unfavorable changes like thickening in the alveolar regions, hemorrhage, and infiltration of inflammatory cells after favipiravir administration. The results suggest that favipiravir causes toxic side effects in lung tissue even in healthy rats, implying potential pulmonary adverse effects that should be considered when using this drug therapeutically.
Erbaş et al., 9 Nov 2023, Turkey, peer-reviewed, 5 authors. Contact: eliferbas4154@gmail.com.
This PaperFavipiravirAll
Assessment of toxicological effects of favipiravir (T‐705) on the lung tissue of rats: An experimental study
Elif Erbaş, Nevra Aydemir Celep, Deniz Tekiner, Aydın Genç, Semin Gedikli
Journal of Biochemical and Molecular Toxicology, doi:10.1002/jbt.23536
This study aimed to present new data on the side effects of favipiravir on healthy lung tissue and the respiratory system. In the study, two different durations (5 and 10 days) were preferred to determine the effect of favipiravir treatment due to clinical improvement rates of approximately 5 and 10 days during the use of favipiravir in COVID-19 patients. In addition, after 10 days of favipiravir treatment, animals were kept for 5 days without any treatment to determine the regeneration of lung tissues. Favipiravir was administered to rats by oral gavage at a daily dose of 200 mg/kg for 5 and 10 days, as in previous studies. At the end of the experiment, the histopathological and biochemical effects of favipiravir in the lung tissue were investigated. The data obtained from the study showed that favipiravir increased oxidative stress parameters, expression of apoptotic markers, and pro-inflammatory markers in lung tissue. Since malondialdehydes is an oxidant parameter, it increased in favipiravir-administered groups; It was determined that the antioxidant parameters glutathione, superoxide dismutase, glutathione peroxidase, and catalase decreased. Other markers used in the analysis are Bcl-2, Bax, NF-κB, interleukin (IL)-6, Muc1, iNOS, P2X7R, IL-6 and caspase-3. The levels of Bax, caspase-3, NF-κB, IL-6, Muc1, and P2X7R were increased in the Fav-treated groups compared with the control. However, the levels of Bcl-2 decreased in the Fav-treated groups. The present study proves that favipiravir, widely used today, causes side effects in lung tissue.
CONFLICT OF INTEREST STATEMENT The authors declare no conflict of interest.
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