Efficacy of Nigella sativa in COVID-19 patients: a systematic review and meta-analysis

Elrosasy et al., Journal of Emergency and Disaster Medicine, doi:10.1007/s44467-025-00004-7, PROSPERO CRD42023449783, Jan 2026
14th treatment shown to reduce risk in January 2021, now with p = 0.00016 from 14 studies.
No treatment is 100% effective. Protocols combine treatments.
6,400+ studies for 210+ treatments. c19early.org
Systematic review and meta-analysis of 6 RCTs showing significantly lower mortality and symptom severity with nigella sativa treatment in 1,595 COVID-19 patients.
3 meta-analyses show significant improvements with nigella sativa for mortality1-3, progression3, and viral clearance2.
Currently there are 14 nigella sativa for COVID-19 studies, showing 57% lower mortality [-20‑85%], 62% lower ventilation [19‑82%], 40% lower ICU admission [-61‑78%], 34% lower hospitalization [16‑47%], and 51% fewer cases [21‑69%].
Elrosasy et al., 28 Jan 2026, Egypt, peer-reviewed, 10 authors, trial PROSPERO CRD42023449783. Contact: moaz_s_sayed@students.kasralainy.edu.eg.
Efficacy of Nigella sativa in COVID-19 patients: a systematic review and meta-analysis
Amr Elrosasy, Amira Mohamed Taha, Rashad G Mohamed, Fatmaelzahraa Yasser Ali, Dang Nguyen, Nouran Ahmed Taha, Shirin Cadri, Islam Omar, Mohamed Elbanna, Moaz Elsayed Abouelmagd
Journal of Emergency and Disaster Medicine, doi:10.1007/s44467-025-00004-7
Background The COVID-19 pandemic has necessitated the investigation of potential treatment options to alleviate symptoms, reduce severe infection rates, and reduce mortality rates. Previous research on Nigella sativa, a phytomedicine with various therapeutic properties, has shown promise. This study aims to determine the efficacy of Nigella sativa as a treatment option for COVID-19 patients. Methods We carried out a thorough systematic review of relevant literature from multiple databases until May 2024. Eligible studies were randomized controlled trials (RCTs) that investigated the efficacy of Nigella sativa as a treatment for COVID-19. We utilized the Cochrane Revised Risk of Bias 2 (ROB 2.0) to assess the quality of each included study. We carried out statistical analysis using RevMan version 5.4. Results The meta-analysis included a total of six studies with a total of 1595 COVID-19 patients. The use of Nigella sativa significantly reduced the severity of infection symptoms (OR = 0.08, 95% CI [0.02 to 0.25], P < 0.0001) and demonstrated a significant reduction in mortality rates (P = 0.383). Also, it significantly reduced CRP levels (MD = -3.287, 95% CI [-4.620 to -1.955], P < 0.00001) and the overall likelihood of patients experiencing headache (OR = 0.82, 95% CI [0.76 to 0.89], P < 0.00001). Furthermore, in contrast, our study found no statistically significant effect of Nigella sativa on common COVID-19 symptoms such as fever, cough, fatigue, and ferritin levels, a key inflammatory marker. Similarly, it had no effect on the occurrence of rhinorrhea or shortness of breath among patients. Conclusion This meta-analysis provides evidence that Nigella sativa is effective as a potential treatment option for COVID-19 patients. The use of this phytomedicine significantly reduces the likelihood of patients experiencing headaches and severe infection symptoms.
Supplementary Information The online version contains supplementary material available at h t t p s : / / d o i . o r g / 1 0 . 1 0 0 7 / s 4 4 4 6 7 -0 2 5 -0 0 0 0 4 -7. Supplementary Material 1. Authors' contributions Conceptualization, Methodology: Amr Elrosasy; Project administration: Amira Mohamed Taha, Amr Elrosasy; Formal analysis and investigation: Amr Elrosasy; Data Curation: Rashad G. Mohamed, Islam Omar, Fatmaelzahraa Yasser Ali, Mohamed Elbanna; Writing-original draft preparation: Amira Mohamed Taha, Dang Nguyen, Nouran Ahmed Taha, Shirin Cadri,; Writing-review and editing: Amira Mohamed Taha, Moaz Elsayed Abouelmagd. Funding None. Data availability All data were extracted from published articles included in this review. The complete extraction sheet and analysis files (RevMan) are available from the corresponding author upon reasonable request. Declarations Ethics approval and consent to participate Not applicable. Competing interests The authors declare no competing interests. Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
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