Efficacy of Persian medicine herbal formulations (capsules and decoction) compared to standard care in patients with COVID-19, a multicenter open-labeled, randomized, controlled clinical trial
RCT 358 hospitalized patients in Iran, 184 receiving treatment with a combination of nigella sativa and several other herbal medicines, showing shorter hospitalization time and improved recovery with treatment. IR.TUMS.VCR.REC.1399.024.
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risk of death, 50.8% lower, RR 0.49, p = 0.45, treatment 2 of 192 (1.0%), control 4 of 189 (2.1%), NNT 93.
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risk of ICU admission, 60.6% lower, RR 0.39, p = 0.28, treatment 2 of 192 (1.0%), control 5 of 189 (2.6%), NNT 62.
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hospitalization time, 70.0% lower, HR 0.30, p < 0.001, treatment 184, control 174, Cox proportional hazards, primary outcome.
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fever, 66.5% lower, OR 0.33, p = 0.001, treatment 184, control 174, inverted to make OR<1 favor treatment, RR approximated with OR.
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dyspnea, 13.7% lower, OR 0.86, p < 0.001, treatment 184, control 174, inverted to make OR<1 favor treatment, RR approximated with OR.
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Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
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Karimi et al., 4 Oct 2021, Randomized Controlled Trial, Iran, peer-reviewed, 37 authors, study period March 2020 - July 2020, this trial uses multiple treatments in the treatment arm (combined with several herbal medicines) - results of individual treatments may vary.
Abstract: Received: 6 December 2020
Revised: 12 August 2021
Accepted: 26 August 2021
DOI: 10.1002/ptr.7277
RESEARCH ARTICLE
Efficacy of Persian medicine herbal formulations (capsules
and decoction) compared to standard care in patients with
COVID-19, a multicenter open-labeled, randomized, controlled
clinical trial
Mehrdad Karimi1
| Azadeh Zarei1 | Samaneh Soleymani2
|
3
4
Saeidreza Jamalimoghadamsiahkali | Asmaa Asadi | Mohsen Shati5
6
Mohieddin Jafari
Ayeh Naghizadeh1
|
|
7
Hassan Rezadoost | Gholamreza Kordafshar
Raefeh Mardi1 | Parva Namiranian1
|
1
|
|
Seyed Peyman Khamechi1,8 | Narges Ansari9 | Mohammad Sadegh Adel Mehraban1
Hananeh Aliakbarzadeh1 | Mahnaz Khanavi10 | Niusha Esmaealzadeh2 |
|
Alireza Moravveji11 | Mehrdad Salahi12 | Maryam Khoi12 | Reza Razzaghi13 |
Hamid Reza Banafshe14 | Mostafa Alizadeh8,15 | Marzieh Akhbari1,8 |
Mina Atharizadeh8,16 | Akram Izadikhah17 | Mahin Elsagh18 |
Mahdi Hossein Zade Ghahnavieh17 | Fatemeh Eghbalian19 | Azam Vanai20 |
Hossein Izadi21 | Seyed Ali Al-hadi Moravej18,19 | Seyede Ferdos Jazayeri18,19 |
Houman Bayat22 | Hamid Emadi Koochak23 | Arman Zargaran2
1
Department of Traditional Medicine, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran
2
Department of Traditional Pharmacy, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran
3
Ziaeian Hospital, Tehran University of Medical Sciences, Tehran, Iran
4
Department of Infectious Diseases, Pakdasht Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
5
Mental Health Research Center, Iran University of Medical Sciences, Tehran, Iran
6
Faculty of Medicine, University of Helsinki, Helsinki, Finland
7
Department of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, Tehran, Iran
8
Evidence Based Integrative Medicine Research Center, Kashan University of Medical Sciences, Kashan, Iran
9
Department of Internal Medicine, School of Medicine, Al-Zahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran
10
Department of Pharmacognosy, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
11
Social Determinants of Health Research Center, Kashan University of Medical Sciences, Kashan, Iran
12
Department of Infectious Disease, Isabn-e-Maryam Hospital, Isfahan, Iran
13
Department of Infectious Disease, School of Medicine, Shahid Beheshti Hospital, Kashan University of Medical Sciences, Kashan, Iran
14
Department of Pharmacology, School of Medicine, Kashan University of Medical Sciences, Kashan, Iran
15
Department of Persian Medicine, School of Persian Medicine, Babol University of Medical Sciences, Babol, Iran
16
Department of Persian Medicine, School of Persian Medicine, Qom University of Medical Sciences, Qom, Iran
17
Department of Persian Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
18
Department of Persian Medicine, School of Persian Medicine, Iran University of Medical Sciences, Tehran, Iran
19
Research Institute for Islamic and Complementary Medicine, School of Persian Medicine, Iran University of Medical Sciences, Tehran, Iran
20
Department of Nephrology, Shahid Beheshti University of Medical Sciences, Tehran, Iran
21
Department of Internal Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Phytotherapy Research. 2021;35:6295–6309.
wileyonlinelibrary.com/journal/ptr
© 2021 John Wiley & Sons..
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