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All Studies   Meta Analysis    Recent:   
0 0.5 1 1.5 2+ Mortality 73% Improvement Relative Risk Hospitalization 74% Recovery 52% Viral clearance 38% Nigella Sativa  Umer et al.  META ANALYSIS Favors nigella sativa Favors control

Nigella sativa for the treatment of COVID-19 patients: A rapid systematic review and meta-analysis of randomized controlled trials

Umer et al., Food Science & Nutrition, doi:10.1002/fsn3.3906
Dec 2023  
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11th treatment shown to reduce risk in January 2021
*, now known with p = 0.00016 from 14 studies.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
3,800+ studies for 60+ treatments.
Systematic review and meta analysis of seven RCTs showing significantly lower mortality (RR 0.27) and improved viral clearance (RR 0.62) with nigella sativa treatment in COVID-19 patients. The mortality benefit was greater with early treatment within 5 days of symptom onset.
2 meta analyses show significant improvements with nigella sativa for mortality Kow, Umer and viral clearance Umer.
Currently there are 14 nigella sativa for COVID-19 studies, showing 57% lower mortality [-20‑85%], 62% lower ventilation [19‑82%], 40% lower ICU admission [-61‑78%], 34% lower hospitalization [16‑47%], and 51% fewer cases [21‑69%].
risk of death, 73.0% lower, RR 0.27, p = 0.009.
risk of hospitalization, 74.0% lower, RR 0.26, p = 0.15.
risk of no recovery, 52.0% lower, OR 0.48, p = 0.10, RR approximated with OR.
risk of no viral clearance, 38.0% lower, RR 0.62, p = 0.04.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Umer et al., 27 Dec 2023, peer-reviewed, 9 authors.
This PaperNigella SativaAll
Nigella sativa for the treatment of COVID-19 patients: A rapid systematic review and meta-analysis of randomized controlled trials
Mohammad Umer, Aiman Naveed, | Qanita, | Huzaifa, Ahmad Cheema, Abia Shahid, Alaa Hamza Hermis, Sampath Chinnam, | Sarya Swed, Syeda Sahra, Sarya Swed, Huzaifa Ahmad Cheema
Nigella sativa is an herbal therapy for various afflictions. It has some potential to be a promising option as an efficacious treatment for COVID-19 patients that can contribute to global healthcare as a relatively cheap therapy but evidence of its use from randomized controlled trials (RCTs) is limited. Therefore, to explore the effect of N. sativa in combating COVID-19, we undertook this meta-analysis. We searched several databases to retrieve all RCTs investigating N. sativa for the treatment of COVID-19 as compared to placebo or standard care. We used RevMan 5.4 for all analyses with risk ratio (RR) or odds ratio (OR) as the effect measures. We included a total of seven RCTs in this review. N. sativa significantly reduced the risk of allcause mortality in patients with COVID-19 compared to the control group (RR 0.27, 95% CI: 0.10 to 0.72; I 2 = 0%). N. sativa significantly reduced the rate of viral PCR positivity (RR 0.62, 95% CI: 0.39 to 0.97; I 2 = 0%). We did not find any significant difference in the risk of hospitalization (RR 0.26, 95% CI: 0.04 to 1.54; I 2 = 0%) and the rate of no recovery (OR 0.48, 95% CI: 0.20 to 1.15; I 2 = 84%) between the two groups. N. sativa is an easily available herbal medicine that may decrease the risk of mortality and improve virological clearance in COVID-19 patients. However, our results are limited by the small number of RCTs available. Further large-scale RCTs are needed to better understand the anti-inflammatory and antiviral effects of N. sativa in COVID-19 patients.
S U PP O RTI N G I N FO R M ATI O N Additional supporting information can be found online in the Supporting Information section at the end of this article.
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