A Randomized, Double-Blind, Placebo-Controlled, Multicenter Study to Evaluate the Safety and Efficacy of ThymoQuinone Formula (TQF) for Treating Outpatient SARS-CoV-2
Bencheqroun et al.
, A Randomized, Double-Blind, Placebo-Controlled, Multicenter Study to Evaluate the Safety and Efficacy of..
, Pathogens, doi:10.3390/pathogens11050551
52 patient RCT in the USA with nigella sativa component thymoquinone, showing improved recovery with treatment. There was a significantly faster decline in the total symptom burden, and a significant increase in CD8+ and helper CD4+ central memory T lymphocytes. The treatment group contained 5 more vaccinated patients and 7 more overweight patients. Authors also present in vitro results showing an inhibitory effect with five SARS-CoV-2 variants including omicron.
risk of hospitalization, 69.3% lower, RR 0.31, p = 0.44, treatment 0 of 29 (0.0%), control 1 of 23 (4.3%), NNT 23, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
time to sustained clinical response, 9.1% lower, HR 0.91, p = 0.78, treatment 28, control 23, inverted to make HR<1 favor treatment, Kaplan–Meier.
time to sustained clinical response, 35.5% lower, HR 0.65, p = 0.25, treatment 28, control 23, inverted to make HR<1 favor treatment, Kaplan–Meier, high-risk patients.
risk of no viral clearance, 43.5% lower, RR 0.57, p = 0.31, treatment 5 of 21 (23.8%), control 8 of 19 (42.1%), NNT 5.5, day 14.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Bencheqroun et al., 7 May 2022, Double Blind Randomized Controlled Trial, placebo-controlled, USA, peer-reviewed, mean age 45.0, 25 authors, study period 27 May, 2021 - 27 September, 2021.
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A Randomized, Double-Blind, Placebo-Controlled, Multicenter
Study to Evaluate the Safety and Efficacy of ThymoQuinone
Formula (TQF) for Treating Outpatient SARS-CoV-2
Hassan Bencheqroun 1, *, Yasir Ahmed 2 , Mehmet Kocak 3 , Enrique Villa 4 , Cesar Barrera 2 ,
Mariya Mohiuddin 2 , Raul Fortunet 1 , Emmanuel Iyoha 5 , Deborah Bates 5 , Chinedu Okpalor 5 , Ola Agbosasa 5 ,
Karim Mohammed 5 , Steven Pondell 6 , Amr Mohamed 7 , Yehia I. Mohamed 8 , Betul Gok Yavuz 8 ,
Mohamed O. Kaseb 9 , Osama O. Kasseb 9 , Michelle York Gocio 9 , Peter Tsu-Man Tu 10 , Dan Li 11 , Jianming Lu 12,13 ,
Abdelhafez Selim 14 , Qing Ma 11 and Ahmed O. Kaseb 8, *
Citation: Bencheqroun, H.; Ahmed,
Y.; Kocak, M.; Villa, E.; Barrera, C.;
Mohiuddin, M.; Fortunet, R.; Iyoha,
E.; Bates, D.; Okpalor, C.; et al. A
Study to Evaluate the Safety and
Efficacy of ThymoQuinone Formula
(TQF) for Treating Outpatient
SARS-CoV-2. Pathogens 2022, 11, 551.
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Received: 22 April 2022
Accepted: 6 May 2022
Published: 7 May 2022
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