Efficacy of a Persian herbal medicine compound on coronavirus disease 2019 (COVID-19): a randomized clinical trial

DOI record: { "DOI": "10.1016/j.imr.2022.100869", "ISSN": [ "2213-4220" ], "URL": "http://dx.doi.org/10.1016/j.imr.2022.100869", "alternative-id": [ "S2213422022000373" ], "article-number": "100869", "author": [ { "affiliation": [], "family": "Setayesh", "given": "Mohammad", "sequence": "first" }, { "affiliation": [], "family": "Karimi", "given": "Mehrdad", "sequence": "additional" }, { "affiliation": [], "family": "Zargaran", "given": "Arman", "sequence": "additional" }, { "affiliation": [], "family": "Abousaidi", "given": "Hamid", "sequence": "additional" }, { "affiliation": [], "family": "Shahesmaeili", "given": "Armita", "sequence": "additional" }, { "affiliation": [], "family": "Amiri", "given": "Fatemeh", "sequence": "additional" }, { "affiliation": [], "family": "Hasheminasab", "given": "Fatemeh Sadat", "sequence": "additional" } ], "container-title": "Integrative Medicine Research", "container-title-short": "Integrative Medicine Research", "content-domain": { "crossmark-restriction": false, "domain": [] }, "created": { "date-parts": [ [ 2022, 6, 4 ] ], "date-time": "2022-06-04T01:02:52Z", "timestamp": 1654304572000 }, "deposited": { "date-parts": [ [ 2022, 6, 4 ] ], "date-time": "2022-06-04T01:03:33Z", "timestamp": 1654304613000 }, "indexed": { "date-parts": [ [ 2022, 6, 4 ] ], "date-time": "2022-06-04T01:41:29Z", "timestamp": 1654306889954 }, "is-referenced-by-count": 0, "issued": { "date-parts": [ [ 2022, 6 ] ] }, "language": "en", "license": [ { "URL": "https://www.elsevier.com/tdm/userlicense/1.0/", "content-version": "tdm", "delay-in-days": 0, "start": { "date-parts": [ [ 2022, 6, 1 ] ], "date-time": "2022-06-01T00:00:00Z", "timestamp": 1654041600000 } }, { "URL": "http://creativecommons.org/licenses/by-nc-nd/4.0/", "content-version": "vor", "delay-in-days": 2, "start": { "date-parts": [ [ 2022, 6, 3 ] ], "date-time": "2022-06-03T00:00:00Z", "timestamp": 1654214400000 } } ], "link": [ { "URL": "https://api.elsevier.com/content/article/PII:S2213422022000373?httpAccept=text/xml", "content-type": "text/xml", "content-version": "vor", "intended-application": "text-mining" }, { "URL": "https://api.elsevier.com/content/article/PII:S2213422022000373?httpAccept=text/plain", "content-type": "text/plain", "content-version": "vor", "intended-application": "text-mining" } ], "member": "78", "original-title": [], "page": "100869", "prefix": "10.1016", "published": { "date-parts": [ [ 2022, 6 ] ] }, "published-print": { "date-parts": [ [ 2022, 6 ] ] }, "publisher": "Elsevier BV", "reference": [ { "article-title": "Effectiveness of Chinese Herbal Medicine and Persian Medicine against Viral Infections: A systematic Review", "author": "Walsh", "first-page": "65", "issue": "2", "journal-title": "Systematic Reviews in Pharmacy", "key": "10.1016/j.imr.2022.100869_bib0001", "volume": "12", "year": "2020" }, { "author": "Guarner", "key": "10.1016/j.imr.2022.100869_bib0002", "series-title": "Three emerging coronaviruses in two decades: the story of SARS, MERS, and now COVID-19", "year": "2020" }, { "article-title": "Severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2): An update", "author": "Pal", "issue": "3", "journal-title": "Cureus", "key": "10.1016/j.imr.2022.100869_bib0003", "volume": "12", "year": "2020" }, { "DOI": "10.1186/s40779-020-0233-6", "article-title": "A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus (2019-nCoV) infected pneumonia (standard version)", "author": "Jin", "doi-asserted-by": "crossref", "first-page": "4", "issue": "1", "journal-title": "Military Medical Research", "key": "10.1016/j.imr.2022.100869_bib0004", "volume": "7", "year": "2020" }, { "DOI": "10.3389/fmed.2020.00526", "article-title": "Pulmonary and extra-pulmonary clinical manifestations of COVID-19", "author": "Johnson", "doi-asserted-by": "crossref", "first-page": "526", "journal-title": "Frontiers in Medicine", "key": "10.1016/j.imr.2022.100869_bib0005", "volume": "7", "year": "2020" }, { "article-title": "Defining a ‘Risk Group'and Ageism in the Era of COVID-19", "author": "Rahman", "first-page": "1", "journal-title": "Journal of Loss and Trauma", "key": "10.1016/j.imr.2022.100869_bib0006", "year": "2020" }, { "DOI": "10.1186/s13063-020-04915-w", "article-title": "Evaluating the efficacy and safety of the myrtle (Myrtus communis) in treatment and prognosis of patients suspected to novel coronavirus disease (COVID-19): study protocol for a randomized controlled trial", "author": "Azimi", "doi-asserted-by": "crossref", "first-page": "1", "issue": "1", "journal-title": "Trials", "key": "10.1016/j.imr.2022.100869_bib0007", "volume": "21", "year": "2020" }, { "article-title": "Outcome reporting from protocols of clinical trials of Coronavirus Disease 2019 (COVID-19): a review", "author": "Qiu", "journal-title": "medRxiv", "key": "10.1016/j.imr.2022.100869_bib0008", "year": "2020" }, { "DOI": "10.1016/j.ijantimicag.2020.106143", "article-title": "Safety and effectiveness of azithromycin in patients with COVID-19: An open-label randomised trial", "author": "Sekhavati", "doi-asserted-by": "crossref", "issue": "4", "journal-title": "International journal of antimicrobial agents", "key": "10.1016/j.imr.2022.100869_bib0009", "volume": "56", "year": "2020" }, { "article-title": "The Prevention and Complementary Therapy in Acute Distress Syndrome of COVID-19 in the Viewpoint of Persian Medicine: A Narrative Review", "author": "Azimi", "journal-title": "Journal of Babol University of Medical Sciences", "key": "10.1016/j.imr.2022.100869_bib0010", "year": "2022" }, { "DOI": "10.30699/jambs.29.135.238", "article-title": "Ethnomedicine Knowledge of Iranian Traditional Healers and the Novel Coronavirus Disease 2019 (COVID-19)", "author": "Azimi", "doi-asserted-by": "crossref", "first-page": "238", "issue": "135", "journal-title": "Journal of Advances in Medical and Biomedical Research", "key": "10.1016/j.imr.2022.100869_bib0011", "volume": "29", "year": "2021" }, { "article-title": "Efficacy and Safety of Integrated Traditional Chinese and Western Medicine for Corona Virus Disease 2019 (COVID-19): a systematic review and meta-analysis", "author": "Liu", "journal-title": "Pharmacological Research", "key": "10.1016/j.imr.2022.100869_bib0012", "year": "2020" }, { "DOI": "10.1080/10826084.2018.1432648", "article-title": "A Historical Report on Preparing Sustained Release Dosage Forms for Addicts in Medieval Persia, 16th Century AD", "author": "Soleymani", "doi-asserted-by": "crossref", "first-page": "1726", "issue": "10", "journal-title": "Substance Use & Misuse", "key": "10.1016/j.imr.2022.100869_bib0013", "volume": "53", "year": "2018" }, { "article-title": "Strategies in traditional Persian medicine to maintain a healthy life in the elderly", "author": "Shakeri", "issue": "ahead-of-print", "journal-title": "Journal of Complementary and Integrative Medicine", "key": "10.1016/j.imr.2022.100869_bib0014", "volume": "1", "year": "2020" }, { "article-title": "Persian medicine recommendations for the prevention of pandemics related to the respiratory system: a narrative literature review", "author": "Iranzadasl", "journal-title": "Integrative Medicine Research", "key": "10.1016/j.imr.2022.100869_bib0015", "year": "2020" }, { "key": "10.1016/j.imr.2022.100869_bib0016", "unstructured": "Siahpoosh MB. How Can Persian Medicine (Traditional Iranian Medicine) Be Effective to Control COVID-19? Traditional and Integrative Medicine 2020." }, { "DOI": "10.1016/j.imr.2020.100482", "article-title": "A cross-sectional study of Persian medicine and the COVID-19 pandemic in Iran: Rumors and recommendations", "author": "Vardanjani", "doi-asserted-by": "crossref", "issue": "3", "journal-title": "Integrative medicine research", "key": "10.1016/j.imr.2022.100869_bib0017", "volume": "9", "year": "2020" }, { "DOI": "10.1001/jamadermatol.2016.0144", "article-title": "Rhazes—his life and contributions to the field of dermatology", "author": "Hashempur", "doi-asserted-by": "crossref", "issue": "1", "journal-title": "JAMA dermatology", "key": "10.1016/j.imr.2022.100869_bib0018", "volume": "153", "year": "2017" }, { "DOI": "10.1080/01443615.2018.1431210", "article-title": "A comparative study of ranitidine and quince (Cydonia oblonga mill) sauce on gastroesophageal reflux disease (GERD) in pregnancy: a randomised, open-label, active-controlled clinical trial", "author": "Shakeri", "doi-asserted-by": "crossref", "first-page": "899", "issue": "7", "journal-title": "Journal of Obstetrics and Gynaecology", "key": "10.1016/j.imr.2022.100869_bib0019", "volume": "38", "year": "2018" }, { "DOI": "10.1007/s10787-016-0262-7", "article-title": "Chemical composition of Nigella sativa Linn: part 2 recent advances", "author": "Khan", "doi-asserted-by": "crossref", "first-page": "67", "issue": "2-3", "journal-title": "Inflammopharmacology", "key": "10.1016/j.imr.2022.100869_bib0020", "volume": "24", "year": "2016" }, { "article-title": "Black cumin (Nigella sativa) and its constituent (thymoquinone): a review on antimicrobial effects", "author": "Forouzanfar", "first-page": "929", "issue": "12", "journal-title": "Iranian journal of basic medical sciences", "key": "10.1016/j.imr.2022.100869_bib0021", "volume": "17", "year": "2014" }, { "article-title": "Antitussive effect of thymoquinone, a constituent of Nigella sativa seeds, in guinea pigs", "author": "Hosseinzadeh", "first-page": "480", "journal-title": "Pharmacologyonline", "key": "10.1016/j.imr.2022.100869_bib0022", "volume": "2", "year": "2008" }, { "article-title": "Antibacterial activity of total extracts and essential oil of Nigella sativa L. seeds in mice", "author": "Hosseinzadeh", "first-page": "429", "journal-title": "Pharmacologyonline", "key": "10.1016/j.imr.2022.100869_bib0023", "volume": "2", "year": "2007" }, { "DOI": "10.1016/S0192-0561(00)00036-9", "article-title": "Protective effect of black seed oil from Nigella sativa against murine cytomegalovirus infection", "author": "Salem", "doi-asserted-by": "crossref", "first-page": "729", "issue": "9", "journal-title": "International journal of immunopharmacology", "key": "10.1016/j.imr.2022.100869_bib0024", "volume": "22", "year": "2000" }, { "article-title": "A review: Medicinal importance of Glycyrrhiza glabra L.(Fabaceae family)", "author": "Parvaiz", "first-page": "8", "issue": "1", "journal-title": "Global J Pharmacol", "key": "10.1016/j.imr.2022.100869_bib0025", "volume": "8", "year": "2014" }, { "DOI": "10.1016/S0140-6736(03)13615-X", "article-title": "Glycyrrhizin, an active component of liquorice roots, and replication of SARS-associated coronavirus", "author": "Cinatl", "doi-asserted-by": "crossref", "first-page": "2045", "issue": "9374", "journal-title": "The Lancet", "key": "10.1016/j.imr.2022.100869_bib0026", "volume": "361", "year": "2003" }, { "DOI": "10.1021/jm0493008", "article-title": "Antiviral Activity of Glycyrrhizic Acid Derivatives against SARS− Coronavirus", "author": "Hoever", "doi-asserted-by": "crossref", "first-page": "1256", "issue": "4", "journal-title": "Journal of medicinal chemistry", "key": "10.1016/j.imr.2022.100869_bib0027", "volume": "48", "year": "2005" }, { "DOI": "10.1016/S0166-3542(03)00030-5", "article-title": "Mechanism of action of glycyrrhizic acid in inhibition of Epstein-Barr virus replication in vitro", "author": "Lin", "doi-asserted-by": "crossref", "first-page": "41", "issue": "1", "journal-title": "Antiviral research", "key": "10.1016/j.imr.2022.100869_bib0028", "volume": "59", "year": "2003" }, { "DOI": "10.1046/j.1440-1746.2002.02876.x", "article-title": "Efficacy of Stronger Neo-Minophagen C compared between two doses administered three times a week on patients with chronic viral hepatitis", "author": "Miyake", "doi-asserted-by": "crossref", "first-page": "1198", "issue": "11", "journal-title": "Journal of gastroenterology and hepatology", "key": "10.1016/j.imr.2022.100869_bib0029", "volume": "17", "year": "2002" }, { "article-title": "The effect of aqueous extract of Glycyrrhiza glabra on herpes simplex virus 1", "author": "Ghannad", "issue": "7", "journal-title": "Jundishapur journal of microbiology", "key": "10.1016/j.imr.2022.100869_bib0030", "volume": "7", "year": "2014" }, { "DOI": "10.1080/10408398.2011.633249", "article-title": "Immunity: plants as effective mediators", "author": "Sultan", "doi-asserted-by": "crossref", "first-page": "1298", "issue": "10", "journal-title": "Critical reviews in food science and nutrition", "key": "10.1016/j.imr.2022.100869_bib0031", "volume": "54", "year": "2014" }, { "DOI": "10.1177/2156587215598039", "article-title": "A review study on Punica granatum L", "author": "Shaygannia", "doi-asserted-by": "crossref", "first-page": "221", "issue": "3", "journal-title": "Journal of evidence-based complementary & alternative medicine", "key": "10.1016/j.imr.2022.100869_bib0032", "volume": "21", "year": "2016" }, { "DOI": "10.1155/2013/576479", "article-title": "Potential effects of medicinal plants and secondary metabolites on acute lung injury", "author": "Cornélio Favarin", "doi-asserted-by": "crossref", "journal-title": "BioMed research international 2013", "key": "10.1016/j.imr.2022.100869_bib0033", "year": "2013" }, { "DOI": "10.1016/S0378-8741(98)00222-0", "article-title": "Antioxidant and eicosanoid enzyme inhibition properties of pomegranate seed oil and fermented juice flavonoids", "author": "Schubert", "doi-asserted-by": "crossref", "first-page": "11", "issue": "1", "journal-title": "Journal of ethnopharmacology", "key": "10.1016/j.imr.2022.100869_bib0034", "volume": "66", "year": "1999" }, { "DOI": "10.1016/j.phymed.2009.06.002", "article-title": "Pomegranate (Punica granatum) purified polyphenol extract inhibits influenza virus and has a synergistic effect with oseltamivir", "author": "Haidari", "doi-asserted-by": "crossref", "first-page": "1127", "issue": "12", "journal-title": "Phytomedicine", "key": "10.1016/j.imr.2022.100869_bib0035", "volume": "16", "year": "2009" }, { "article-title": "Antiviral activity of tannin from the pericarp of Punica granatum L. against genital Herpes virus in vitro. Zhongguo Zhong yao za zhi= Zhongguo zhongyao zazhi=", "author": "Zhang", "first-page": "556", "issue": "9", "journal-title": "China journal of Chinese materia medica", "key": "10.1016/j.imr.2022.100869_bib0036", "volume": "20", "year": "1995" }, { "article-title": "Anti-SARS coronavirus 3C-like protease effects of Rheum palmatum L. extracts", "author": "Luo", "issue": "4", "journal-title": "Bioscience trends", "key": "10.1016/j.imr.2022.100869_bib0037", "volume": "3", "year": "2009" }, { "DOI": "10.1016/j.antiviral.2006.04.014", "article-title": "Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 interaction", "author": "Ho", "doi-asserted-by": "crossref", "first-page": "92", "issue": "2", "journal-title": "Antiviral research", "key": "10.1016/j.imr.2022.100869_bib0038", "volume": "74", "year": "2007" }, { "DOI": "10.1038/aps.2017.147", "article-title": "Emodin alleviates alternatively activated macrophage and asthmatic airway inflammation in a murine asthma model", "author": "Song", "doi-asserted-by": "crossref", "first-page": "1317", "issue": "8", "journal-title": "Acta Pharmacologica Sinica", "key": "10.1016/j.imr.2022.100869_bib0039", "volume": "39", "year": "2018" }, { "article-title": "Total phenolics and total flavonoids in Bulgarian fruits and vegetables", "author": "Marinova", "first-page": "255", "issue": "3", "journal-title": "Journal of the university of chemical technology and metallurgy", "key": "10.1016/j.imr.2022.100869_bib0040", "volume": "40", "year": "2005" }, { "DOI": "10.1007/s11094-005-0143-7", "article-title": "Improved method of flavonoid extraction from bird cherry fruits", "author": "Beketov", "doi-asserted-by": "crossref", "first-page": "316", "issue": "6", "journal-title": "Pharmaceutical Chemistry Journal", "key": "10.1016/j.imr.2022.100869_bib0041", "volume": "39", "year": "2005" }, { "DOI": "10.1016/j.phymed.2010.08.001", "article-title": "Dual inhibitory effect of Glycyrrhiza glabra (GutGard™) on COX and LOX products", "author": "Chandrasekaran", "doi-asserted-by": "crossref", "first-page": "278", "issue": "4", "journal-title": "Phytomedicine", "key": "10.1016/j.imr.2022.100869_bib0042", "volume": "18", "year": "2011" }, { "DOI": "10.3390/antiox8060186", "article-title": "Antioxidant and anti-inflammatory activities of flavanones from Glycyrrhiza glabra L.(licorice) leaf phytocomplexes: Identification of licoflavanone as a modulator of NF-kB/MAPK pathway", "author": "Frattaruolo", "doi-asserted-by": "crossref", "first-page": "186", "issue": "6", "journal-title": "Antioxidants", "key": "10.1016/j.imr.2022.100869_bib0043", "volume": "8", "year": "2019" }, { "DOI": "10.3390/molecules16075720", "article-title": "Licocalchone-C extracted from Glycyrrhiza glabra inhibits lipopolysaccharide-interferon-γ inflammation by improving antioxidant conditions and regulating inducible nitric oxide synthase expression", "author": "Franceschelli", "doi-asserted-by": "crossref", "first-page": "5720", "issue": "7", "journal-title": "Molecules", "key": "10.1016/j.imr.2022.100869_bib0044", "volume": "16", "year": "2011" }, { "DOI": "10.1007/s10787-011-0080-x", "article-title": "Modulation of lipopolysaccharide-induced pro-inflammatory mediators by an extract of Glycyrrhiza glabra and its phytoconstituents", "author": "Thiyagarajan", "doi-asserted-by": "crossref", "first-page": "235", "issue": "4", "journal-title": "Inflammopharmacology", "key": "10.1016/j.imr.2022.100869_bib0045", "volume": "19", "year": "2011" }, { "DOI": "10.1016/j.apjtm.2015.09.011", "article-title": "Effect of Rheum palmatum L. on NF-κB signaling pathway of mice with acute liver failure", "author": "Zhang", "doi-asserted-by": "crossref", "first-page": "841", "issue": "10", "journal-title": "Asian Pacific journal of tropical medicine", "key": "10.1016/j.imr.2022.100869_bib0046", "volume": "8", "year": "2015" }, { "article-title": "Investigation of urinary interleukin-6 level in chronic renal failure patients and the influence of Rheum palmatum in treating it", "author": "Song", "first-page": "107", "issue": "2", "journal-title": "Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi Jiehe Zazhi= Chinese Journal of Integrated Traditional and Western Medicine", "key": "10.1016/j.imr.2022.100869_bib0047", "volume": "20", "year": "2000" }, { "DOI": "10.1186/s12906-017-1555-0", "article-title": "Anti-inflammatory potential of ellagic acid, gallic acid and punicalagin A&B isolated from Punica granatum", "author": "BenSaad", "doi-asserted-by": "crossref", "first-page": "47", "issue": "1", "journal-title": "BMC complementary and alternative medicine", "key": "10.1016/j.imr.2022.100869_bib0048", "volume": "17", "year": "2017" }, { "DOI": "10.1016/j.ctim.2020.102535", "article-title": "Effect of Nigella sativa L. supplementation on inflammatory and oxidative stress indicators: A systematic review and meta-analysis of controlled clinical trials", "author": "Mohit", "doi-asserted-by": "crossref", "journal-title": "Complementary Therapies in Medicine", "key": "10.1016/j.imr.2022.100869_bib0049", "year": "2020" }, { "DOI": "10.1016/j.eujim.2016.03.003", "article-title": "Nigella Sativa treatment and serum concentrations of thyroid hormones, transforming growth factor β (TGF-β) and interleukin 23 (IL-23) in patients with Hashimoto's Thyroiditis", "author": "Tajmiri", "doi-asserted-by": "crossref", "first-page": "576", "issue": "4", "journal-title": "European Journal of Integrative Medicine", "key": "10.1016/j.imr.2022.100869_bib0050", "volume": "8", "year": "2016" }, { "DOI": "10.1055/s-2005-871288", "article-title": "In vitro inhibitory effects of thymol and quinones of Nigella sativa seeds on cyclooxygenase-1-and-2-catalyzed prostaglandin E2 biosyntheses", "author": "Marsik", "doi-asserted-by": "crossref", "first-page": "739", "issue": "08", "journal-title": "Planta medica", "key": "10.1016/j.imr.2022.100869_bib0051", "volume": "71", "year": "2005" }, { "article-title": "Nigella sativa l. as a potential phytotherapy for covid-19: A mini-review of in-silico studies", "author": "Koshak", "journal-title": "Current Therapeutic Research", "key": "10.1016/j.imr.2022.100869_bib0052", "year": "2020" }, { "author": "Aghili Khorasani", "key": "10.1016/j.imr.2022.100869_bib0053", "series-title": "Makhzan ul-Advia", "year": "2001" } ], "reference-count": 53, "references-count": 53, "relation": {}, "resource": { "primary": { "URL": "https://linkinghub.elsevier.com/retrieve/pii/S2213422022000373" } }, "score": 1, "short-title": [], "source": "Crossref", "subject": [ "Complementary and alternative medicine" ], "subtitle": [], "title": "Efficacy of a Persian herbal medicine compound on coronavirus disease 2019 (COVID-19): a randomized clinical trial", "type": "journal-article" }