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All Studies   Meta Analysis    Recent:   
0 0.5 1 1.5 2+ Mortality -8% Improvement Relative Risk Oxygen time 27% Hospitalization time 29% Nigella Sativa  Setayesh et al.  LATE TREATMENT  RCT Is late treatment with nigella sativa + combined treatments beneficial for COVID-19? RCT 79 patients in Iran (June - September 2020) Lower need for oxygen therapy (p=0.007) and shorter hospitalization (p<0.0001) c19early.org Setayesh et al., Integrative Medicine .., Jun 2022 Favors nigella sativa Favors control

Efficacy of a Persian herbal medicine compound on coronavirus disease 2019 (COVID-19): a randomized clinical trial

Setayesh et al., Integrative Medicine Research, doi:10.1016/j.imr.2022.100869, IRCT20200330046899N1
Jun 2022  
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11th treatment shown to reduce risk in January 2021
 
*, now known with p = 0.00016 from 14 studies.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,100+ studies for 60+ treatments. c19early.org
Small RCT 41 patients treated with nigella sativa, glycyrrhiza glabra, punica granatum, and rheum palmatum, and 41 control patients, showing shorter hospitalization with treatment.
risk of death, 7.9% higher, RR 1.08, p = 1.00, treatment 1 of 38 (2.6%), control 1 of 41 (2.4%).
oxygen time, 26.8% lower, relative time 0.73, p = 0.007, treatment mean 3.0 (±1.6) n=38, control mean 4.1 (±1.9) n=41.
hospitalization time, 28.7% lower, relative time 0.71, p < 0.001, treatment mean 5.7 (±1.9) n=38, control mean 8.0 (±1.8) n=41.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Setayesh et al., 3 Jun 2022, Randomized Controlled Trial, Iran, peer-reviewed, mean age 59.1, 7 authors, study period June 2020 - September 2020, this trial uses multiple treatments in the treatment arm (combined with glycyrrhiza glabra, punica granatum, and rheum palmatum) - results of individual treatments may vary, trial IRCT20200330046899N1. Contact: hasheminasab@zaums.ac.ir, hashemifa67@gmail.com.
This PaperNigella SativaAll
Efficacy of a Persian herbal medicine compound on coronavirus disease 2019 (COVID-19): A randomized controlled trial
Mohammad Setayesh, Mehrdad Karimi, Arman Zargaran, Hamid Abousaidi, Armita Shahesmaeili, Fatemeh Amiri, Fatemeh Sadat Hasheminasab
Integrative Medicine Research, doi:10.1016/j.imr.2022.100869
Background: The global attention to the capacities of traditional medicine for alleviating the clinical manifestations of COVID-19 has been growing. The present trial aimed to evaluate the efficacy and safety of a Persian herbal medicine formula among patients with COVID-19. Methods: The present trial was conducted in Afzalipour hospital, Kerman, Iran, from June to September 2020. Hospitalized COVID-19 patients were randomly divided into intervention (Persian herbal medicine formula + routine treatment) or control (only routine treatment) groups. The intervention group received both capsule number 1 and 2 every 8 hours for 7 days. Capsule number 1 contained extract of the Glycyrrhiza glabra, Punica granatum , and Rheum palmatum , and the second capsule was filled by Nigella sativa powder. Participants were followed up to 7 days. The primary outcome was the number of hospitalization days, while cough, fever, and respiratory rate, days on oxygen (O 2 ) therapy, and mortality rate were considered as the secondary outcomes. Results: Eighty-two patients were enrolled to the study, while 79 cases completed the trial and their data were analyzed (mean age: 59.1 ± 17.1 years). Based on the results, the Persian medicine formula decreased the mean hospitalization days, so that the mean difference of length of hospitalization as primary outcome was 2.95 ± 0.43 days. A significant clinical improvement was observed regarding dyspnea, need for O 2 ) therapy, and respiratory rate in the intervention group. No adverse effects were reported. Conclusion: The present study supported the use of the Persian medicine formula as an adjuvant therapy for hospitalized COVID-19 patients. Study registration: Iranian Registry of Clinical Trials (www.irct.ir): IRCT2020 0330 046899N1. Study registration: Iranian Registry of Clinical Trials (www.irct.ir): IRCT2020 0330 046899N1.
Conflict of interest There was no conflict of interest in this study. CRediT authorship contribution statement
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Late treatment
is less effective
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