Clinical and laboratory characteristics of patients hospitalized with severe COVID-19 in New Orleans, August 2020 to September 2021

{ 'indexed': {'date-parts': [[2024, 3, 26]], 'date-time': '2024-03-26T02:28:13Z', 'timestamp': 1711420093774}, 'reference-count': 44, 'publisher': 'Springer Science and Business Media LLC', 'issue': '1', 'license': [ { 'start': { 'date-parts': [[2024, 3, 19]], 'date-time': '2024-03-19T00:00:00Z', 'timestamp': 1710806400000}, 'content-version': 'tdm', 'delay-in-days': 0, 'URL': 'https://creativecommons.org/licenses/by/4.0'}, { 'start': { 'date-parts': [[2024, 3, 19]], 'date-time': '2024-03-19T00:00:00Z', 'timestamp': 1710806400000}, 'content-version': 'vor', 'delay-in-days': 0, 'URL': 'https://creativecommons.org/licenses/by/4.0'}], 'funder': [ { 'DOI': '10.13039/100000030', 'name': 'Centers for Disease Control and Prevention', 'doi-asserted-by': 'publisher', 'award': ['U01CK000480']}], 'content-domain': {'domain': ['link.springer.com'], 'crossmark-restriction': False}, 'abstract': '<jats:title>Abstract</jats:title><jats:p>Louisiana experienced high morbidity and mortality ' 'from COVID-19. To assess possible explanatory factors, we conducted a cohort study ' '(ClinSeqSer) of patients hospitalized with COVID-19 in New Orleans during August ' '2020–September 2021. Following enrollment, we reviewed medical charts, and performed ' 'SARS-CoV-2 RT-PCR testing on nasal and saliva specimens. We used multivariable logistic ' 'regression to assess associations between patient characteristics and severe illness, defined ' 'as\u2009≥\u20096\xa0L/min oxygen or intubation. Among 456 patients, median age was 56\xa0' 'years, 277 (60.5%) were Black non-Hispanic, 436 (95.2%) had underlying health conditions, and ' '358 were unvaccinated (92.0% of 389 verified). Overall, 187 patients (40.1%) had severe ' 'illness; 60 (13.1%) died during admission. In multivariable models, severe illness was ' 'associated with age\u2009≥\u200965\xa0years (OR 2.08, 95% CI 1.22–3.56), hospitalization\u2009' '&gt;\u20095\xa0days after illness onset (OR 1.49, 95% CI 1.01–2.21), and SARS CoV-2 cycle ' 'threshold (Ct) result of\u2009&lt;\u200932 in saliva (OR 4.79, 95% CI 1.22–18.77). Among ' 'patients who were predominantly Black non-Hispanic, unvaccinated and with underlying health ' 'conditions, approximately 1 in 3 patients had severe COVID-19. Older age and delayed time to ' 'admission might have contributed to high case-severity. An association between case-severity ' 'and low Ct value in saliva warrants further investigation.</jats:p>', 'DOI': '10.1038/s41598-024-57306-5', 'type': 'journal-article', 'created': {'date-parts': [[2024, 3, 19]], 'date-time': '2024-03-19T06:50:29Z', 'timestamp': 1710831029000}, 'update-policy': 'http://dx.doi.org/10.1007/springer_crossmark_policy', 'source': 'Crossref', 'is-referenced-by-count': 0, 'title': 'Clinical and laboratory characteristics of patients hospitalized with severe COVID-19 in New ' 'Orleans, August 2020 to September 2021', 'prefix': '10.1038', 'volume': '14', 'author': [ {'given': 'Arnaud', 'family': 'Drouin', 'sequence': 'first', 'affiliation': []}, {'given': 'Ian D.', 'family': 'Plumb', 'sequence': 'additional', 'affiliation': []}, {'given': 'Matthew', 'family': 'McCullough', 'sequence': 'additional', 'affiliation': []}, {'given': 'Jade', 'family': 'James Gist', 'sequence': 'additional', 'affiliation': []}, {'given': 'Sharon', 'family': 'Liu', 'sequence': 'additional', 'affiliation': []}, {'given': 'Marc', 'family': 'Theberge', 'sequence': 'additional', 'affiliation': []}, {'given': 'Joshua', 'family': 'Katz', 'sequence': 'additional', 'affiliation': []}, {'given': 'Matthew', 'family': 'Moreida', 'sequence': 'additional', 'affiliation': []}, {'given': 'Shelby', 'family': 'Flaherty', 'sequence': 'additional', 'affiliation': []}, {'given': 'Bhoomija', 'family': 'Chatwani', 'sequence': 'additional', 'affiliation': []}, {'given': 'Melissa', 'family': 'Briggs Hagen', 'sequence': 'additional', 'affiliation': []}, {'given': 'Claire M.', 'family': 'Midgley', 'sequence': 'additional', 'affiliation': []}, {'given': 'Dahlene', 'family': 'Fusco', 'sequence': 'additional', 'affiliation': []}], 'member': '297', 'published-online': {'date-parts': [[2024, 3, 19]]}, 'reference': [ { 'issue': '3', 'key': '57306_CR1', 'doi-asserted-by': 'publisher', 'first-page': '133', 'DOI': '10.1038/s41579-022-00846-2', 'volume': '21', 'author': 'HE Davis', 'year': '2023', 'unstructured': 'Davis, H. 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AD has served as co site-PI on ' 'clinical trials sponsored by Gilead Sciences, Regeneron, MetroBiotech LLC, and ' 'the NIH (DMID COVAIL). Other authors declare that they have no conflict of ' 'interest.', 'order': 1, 'name': 'Ethics', 'group': {'name': 'EthicsHeading', 'label': 'Competing interests'}}], 'article-number': '6539'}