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All Studies   Meta Analysis       

A Randomised Phase II Trial in Early COVID-19, Assessing Use of Camostat by Blocking SARS-CoV-2 Spike Protein-initiated Membrane Fusion

Dhaliwal et al., NCT04455815, SPIKE-1, NCT04455815
Mar 2022  
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Hospitalization 14% Improvement Relative Risk Camostat  SPIKE-1  EARLY TREATMENT  RCT Is early treatment with camostat beneficial for COVID-19? RCT 34 patients in the United Kingdom Trial underpowered to detect differences c19early.org Dhaliwal et al., NCT04455815, March 2022 Favorscamostat Favorscontrol 0 0.5 1 1.5 2+
Early terminated RCT with 34 patients showing no significant differences with camostat treatment.
risk of hospitalization, 14.3% lower, RR 0.86, p = 1.00, treatment 2 of 14 (14.3%), control 3 of 18 (16.7%), NNT 42.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Dhaliwal et al., 3 Mar 2022, Randomized Controlled Trial, United Kingdom, preprint, 1 author, trial NCT04455815 (history) (SPIKE-1).
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