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0 0.5 1 1.5 2+ ICU admission 23% Improvement Relative Risk Recovery 88% Hospitalization time -2% Discharge -3% Favipiravir for COVID-19  Delen et al.  LATE TREATMENT Is late treatment with favipiravir beneficial for COVID-19? Retrospective 69 patients in Turkey (March - July 2020) Improved recovery with favipiravir (p=0.02) Delen et al., Acta Clinica Croatica, Dec 2022 Favors favipiravir Favors control

Effects of Hydroxychloroquine Plus Favipiravir Treatment on the Clinical Course and Biomarkers in Hospitalized COVID-19 Patients with Pneumonia

Delen et al., Acta Clinica Croatica, doi:10.20471/acc.2022.61.03.05
Dec 2022  
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Retrospective 69 COVID-19 patients in Turkey, showing improved fever recovery with the addition of favipiravir to HCQ, but no significant difference in discharge, ICU admission, or hospitalization time.
risk of ICU admission, 22.8% lower, RR 0.77, p = 1.00, treatment 3 of 34 (8.8%), control 4 of 35 (11.4%), NNT 38.
risk of no recovery, 87.5% lower, RR 0.12, p = 0.02, treatment 1 of 21 (4.8%), control 8 of 21 (38.1%), NNT 3.0, day 5, fever.
hospitalization time, 2.2% higher, relative time 1.02, p = 0.74, treatment 34, control 35.
risk of no hospital discharge, 2.9% higher, RR 1.03, p = 1.00, treatment 31 of 34 (91.2%), control 31 of 35 (88.6%).
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Delen et al., 31 Dec 2022, retrospective, Turkey, peer-reviewed, mean age 60.1, 8 authors, study period March 2020 - July 2020. Contact:
This PaperFavipiravirAll
Effects of Hydroxychloroquine Plus Favipiravir Treatment on the Clinical Course and Biomarkers in Hospitalized COVID-19 Patients with Pneumonia
Acun Leman, Abdullah Delen¹, Umut Sabri Gok¹, Ozlem Kasapoglu², Zarife Cagasar³, Nurcan Gok⁴, Serdar Berber⁵, Bora Derya⁶, Tetik⁷, MD. Umut Sabri Kasapoglu
Acta clinica croatica, doi:10.20471/acc.2022.61.03.05
Background: The novel coronavirus disease 2019 (COVID-19) has a broad spectrum of clinical manifestations, the most common serious clinical manifestation of the coronavirus infection being pneumonia. Unfortunately, the optimal treatment approach is still uncertain. However, many studies have been conducted on the effectiveness of several medications in the treatment of COVID-19 infection. The aim of this study was to evaluate the effectiveness of the hydroxychloroquine (HCQ) + favipiravir (FAV) treatment regimen and HCQ alone by comparing the patient's clinical response and laboratory results on the fifth day of treatment in patients hospitalized due to COVID-19 infection. Patients and methods: This retrospective cohort study was conducted in Malatya Training and Research Hospital between March 2020 and July 2020. The study included 69 patients with confirmed COVID-19 with pneumonia. The patients were divided into 2 groups, those receiving HCQ alone and those receiving the HCQ + FAV combination. Results: A total of 69 patients were included in the study, and the mean age was 60.09±15.56 years. A statistically significant decrease was observed in C-reactive protein (CRP) levels, at the end of the fifth day, in patients who received HCQ + FAV treatment (p=0.002), whereas there was no decrease in CRP levels in patients who received HCQ treatment alone. In addition, an increase in lymphocyte count and a better fever response was observed at the end of the fifth day in patients who received HCQ + FAV (p=0.008). However, there was no statistical difference between both treatment regimens in terms of hospital stay and treatment results (p=0.008, p=0.744, p=0.517). Conclusion: Although the combination of HCQ + FAV treatment was observed to be effective on CRP levels and fever response in patients with COVID-19 pneumonia, there was no difference in terms of hospital stay and discharge.
Conflict of interest: The authors have stated explicitly that there are no conflicts of interest in connection with this article. Financial disclosure: None declared.
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Late treatment
is less effective
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