Combination of spironolactone and sitagliptin improves clinical outcomes of outpatients with COVID-19: a prospective cohort study

DOI record: { "DOI": "10.1007/s40618-023-02141-0", "ISSN": [ "1720-8386" ], "URL": "http://dx.doi.org/10.1007/s40618-023-02141-0", "alternative-id": [ "2141" ], "assertion": [ { "group": { "label": "Article History", "name": "ArticleHistory" }, "label": "Received", "name": "received", "order": 1, "value": "6 February 2023" }, { "group": { "label": "Article History", "name": "ArticleHistory" }, "label": "Accepted", "name": "accepted", "order": 2, "value": "16 June 2023" }, { "group": { "label": "Article History", "name": "ArticleHistory" }, "label": "First Online", "name": "first_online", "order": 3, "value": "24 June 2023" }, { "group": { "label": "Declarations", "name": "EthicsHeading" }, "name": "Ethics", "order": 1 }, { "group": { "label": "Conflict of interest", "name": "EthicsHeading" }, "name": "Ethics", "order": 2, "value": "The authors have declared that no conflict of interest exists." }, { "group": { "label": "Iranian registry of clinical trial", "name": "EthicsHeading" }, "name": "Ethics", "order": 3, "value": "IRCT registration number: IRCT20201003048904N2, Registration date: December 10, 2020." } ], "author": [ { "affiliation": [], "family": "Davarpanah", "given": "M. A.", "sequence": "first" }, { "affiliation": [], "family": "Adatorwovor", "given": "R.", "sequence": "additional" }, { "affiliation": [], "family": "Mansoori", "given": "Y.", "sequence": "additional" }, { "affiliation": [], "family": "Ramsheh", "given": "F. S. R.", "sequence": "additional" }, { "affiliation": [], "family": "Parsa", "given": "A.", "sequence": "additional" }, { "affiliation": [], "family": "Hajiani", "given": "M.", "sequence": "additional" }, { "affiliation": [], "family": "Faramarzi", "given": "H.", "sequence": "additional" }, { "affiliation": [], "family": "Kavuluru", "given": "R.", "sequence": "additional" }, { "ORCID": "http://orcid.org/0000-0003-4484-1971", "affiliation": [], "authenticated-orcid": false, "family": "Asadipooya", "given": "K.", "sequence": "additional" } ], "container-title": "Journal of Endocrinological Investigation", "container-title-short": "J Endocrinol Invest", "content-domain": { "crossmark-restriction": false, "domain": [ "link.springer.com" ] }, "created": { "date-parts": [ [ 2023, 6, 24 ] ], "date-time": "2023-06-24T11:59:54Z", "timestamp": 1687607994000 }, "deposited": { "date-parts": [ [ 2024, 1, 9 ] ], "date-time": "2024-01-09T19:14:07Z", "timestamp": 1704827647000 }, "funder": [ { "DOI": "10.13039/501100013041", "award": [ "IR.SUMS.MED.REC.1399.550" ], "doi-asserted-by": "publisher", "name": "Vice-Chancellor for Research, Shiraz University of Medical Sciences" } ], "indexed": { "date-parts": [ [ 2024, 6, 12 ] ], "date-time": "2024-06-12T05:17:46Z", "timestamp": 1718169466802 }, "is-referenced-by-count": 2, "issue": "1", "issued": { "date-parts": [ [ 2023, 6, 24 ] ] }, "journal-issue": { "issue": "1", "published-online": { "date-parts": [ [ 2024, 1 ] ] } }, "language": "en", "license": [ { "URL": "https://www.springernature.com/gp/researchers/text-and-data-mining", "content-version": "tdm", "delay-in-days": 0, "start": { "date-parts": [ [ 2023, 6, 24 ] ], "date-time": "2023-06-24T00:00:00Z", "timestamp": 1687564800000 } }, { "URL": "https://www.springernature.com/gp/researchers/text-and-data-mining", "content-version": "vor", "delay-in-days": 0, "start": { "date-parts": [ [ 2023, 6, 24 ] ], "date-time": "2023-06-24T00:00:00Z", "timestamp": 1687564800000 } } ], "link": [ { "URL": "https://link.springer.com/content/pdf/10.1007/s40618-023-02141-0.pdf", "content-type": "application/pdf", "content-version": "vor", "intended-application": "text-mining" }, { "URL": "https://link.springer.com/article/10.1007/s40618-023-02141-0/fulltext.html", "content-type": "text/html", "content-version": "vor", "intended-application": "text-mining" }, { "URL": "https://link.springer.com/content/pdf/10.1007/s40618-023-02141-0.pdf", "content-type": "application/pdf", "content-version": "vor", "intended-application": "similarity-checking" } ], "member": "297", "original-title": [], "page": "235-243", "prefix": "10.1007", "published": { "date-parts": [ [ 2023, 6, 24 ] ] }, "published-online": { "date-parts": [ [ 2023, 6, 24 ] ] }, "publisher": "Springer Science and Business Media LLC", "reference": [ { "key": "2141_CR1", "unstructured": "Hopkins J (2020) Coronavirus resource center. Im Internet (Stand: 1904 2020). https://coronavirus.jhu.edu/map.html" }, { "DOI": "10.1111/all.14657", "author": "YD Gao", "doi-asserted-by": "publisher", "first-page": "428", "issue": "2", "journal-title": "Allergy", "key": "2141_CR2", "unstructured": "Gao YD, Ding M, Dong X, Zhang JJ, KursatAzkur A, Azkur D, Gan H, Sun YL, Fu W, Li W, Liang HL, Cao YY, Yan Q, Cao C, Gao HY, Brüggen MC, van de Veen W, Sokolowska M, Akdis M, Akdis CA (2021) Risk factors for severe and critically ill COVID-19 patients: a review. Allergy 76(2):428–455", "volume": "76", "year": "2021" }, { "DOI": "10.15585/mmwr.mm7023e2", "author": "A Christie", "doi-asserted-by": "publisher", "first-page": "858", "issue": "23", "journal-title": "MMWR Morb Mortal Wkly Rep", "key": "2141_CR3", "unstructured": "Christie A, Henley SJ, Mattocks L, Fernando R, Lansky A, Ahmad FB, Adjemian J, Anderson RN, Binder AM, Carey K, Dee DL, Dias T, Duck WM, Gaughan DM, Lyons BC, McNaghten AD, Park MM, Reses H, Rodgers L, Van Santen K, Walker D, Beach MJ (2021) Decreases in COVID-19 cases, emergency department visits, hospital admissions, and deaths among older adults following the introduction of COVID-19 vaccine—United States, September 6, 2020-May 1, 2021. MMWR Morb Mortal Wkly Rep 70(23):858–864", "volume": "70", "year": "2021" }, { "author": "T Kustin", "first-page": "236", "issue": "1", "journal-title": "Nat Med", "key": "2141_CR4", "unstructured": "Kustin T, Harel N, Finkel U, Perchik S, Harari S, Tahor M, Caspi I, Levy R, Leshchinsky M, Ken Dror S, Bergerzon G, Gadban H, Gadban F, Eliassian E, Shimron O, Saleh L, Ben-Zvi H, Keren Taraday E, Amichay D, Ben-Dor A, Sagas D, Strauss M, Shemer Avni Y, Huppert A, Kepten E, Balicer RD, Netzer D, Ben-Shachar S, Stern A (2021) Evidence for increased breakthrough rates of SARS-CoV-2 variants of concern in BNT162b2-mRNA-vaccinated individuals. Nat Med 20(1):236", "volume": "20", "year": "2021" }, { "DOI": "10.1093/ofid/ofab376", "author": "J Xie", "doi-asserted-by": "publisher", "issue": "8", "journal-title": "Open Forum Infect Dis", "key": "2141_CR5", "unstructured": "Xie J, Wang Z, Liang J, Lin H, Yang Z, Wang Y, Liang H, Wu H, Chen R, Ou Y, Wang F, Wang Y, Wang Y, Luo W, Zhang J, Li N, Li Z, Jiang M, Li S, Li J (2021) Critical review of the scientific evidence and recommendations in COVID-19 management guidelines. Open Forum Infect Dis 8(8):ofab376", "volume": "8", "year": "2021" }, { "DOI": "10.1056/NEJMoa2108163", "doi-asserted-by": "crossref", "key": "2141_CR6", "unstructured": "Weinreich DM, Sivapalasingam S, Norton T, Ali S, Gao H, Bhore R, Xiao J, Hooper AT, Hamilton JD, Musser BJ, Rofail D, Hussein M, Im J, Atmodjo DY, Perry C, Pan C, Mahmood A, Hosain R, Davis JD, Turner KC, Baum A, Kyratsous CA, Kim Y, Cook A, Kampman W, Roque-Guerrero L, Acloque G, Aazami H, Cannon K, Simón-Campos JA, Bocchini JA, Kowal B, DiCioccio AT, Soo Y, Geba GP, Stahl N, Lipsich L, Braunstein N, Herman G, Yancopoulos GD (2021) REGEN-COV antibody combination and outcomes in outpatients with Covid-19. New Eng J Med" }, { "DOI": "10.1038/s41579-021-00573-0", "author": "WT Harvey", "doi-asserted-by": "publisher", "first-page": "409", "issue": "7", "journal-title": "Nat Rev Microbiol", "key": "2141_CR7", "unstructured": "Harvey WT, Carabelli AM, Jackson B, Gupta RK, Thomson EC, Harrison EM, Ludden C, Reeve R, Rambaut A, Peacock SJ, Robertson DL (2021) SARS-CoV-2 variants, spike mutations and immune escape. Nat Rev Microbiol 19(7):409–424", "volume": "19", "year": "2021" }, { "DOI": "10.1038/s41591-021-01294-w", "author": "RE Chen", "doi-asserted-by": "publisher", "first-page": "717", "issue": "4", "journal-title": "Nat Med", "key": "2141_CR8", "unstructured": "Chen RE, Zhang X, Case JB, Winkler ES, Liu Y, VanBlargan LA, Liu J, Errico JM, Xie X, Suryadevara N, Gilchuk P, Zost SJ, Tahan S, Droit L, Turner JS, Kim W, Schmitz AJ, Thapa M, Wang D, Boon ACM, Presti RM, O’Halloran JA, Kim AHJ, Deepak P, Pinto D, Fremont DH, Crowe JE Jr, Corti D, Virgin HW, Ellebedy AH, Shi PY, Diamond MS (2021) Resistance of SARS-CoV-2 variants to neutralization by monoclonal and serum-derived polyclonal antibodies. Nat Med 27(4):717–726", "volume": "27", "year": "2021" }, { "DOI": "10.1101/2020.02.19.956581", "doi-asserted-by": "crossref", "key": "2141_CR9", "unstructured": "Walls AC, Park YJ, Tortorici MA, Wall A, McGuire AT, Veesler D (2020) Structure, function, and antigenicity of the SARS-CoV-2 spike glycoprotein. Cell" }, { "DOI": "10.1080/22221751.2020.1739565", "author": "N Vankadari", "doi-asserted-by": "publisher", "first-page": "601", "issue": "1", "journal-title": "Emerg Microbes Infect", "key": "2141_CR10", "unstructured": "Vankadari N, Wilce JA (2020) Emerging WuHan (COVID-19) coronavirus: glycan shield and structure prediction of spike glycoprotein and its interaction with human CD26. Emerg Microbes Infect 9(1):601–604", "volume": "9", "year": "2020" }, { "DOI": "10.1126/science.abb2507", "author": "D Wrapp", "doi-asserted-by": "publisher", "first-page": "1260", "issue": "6483", "journal-title": "Science (New York, NY)", "key": "2141_CR11", "unstructured": "Wrapp D, Wang N, Corbett KS, Goldsmith JA, Hsieh CL, Abiona O, Graham BS, McLellan JS (2020) Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation. Science (New York, NY) 367(6483):1260–1263", "volume": "367", "year": "2020" }, { "DOI": "10.3389/fimmu.2020.576745", "author": "D Zipeto", "doi-asserted-by": "publisher", "journal-title": "Front Immunol", "key": "2141_CR12", "unstructured": "Zipeto D, Palmeira JDF, Argañaraz GA, Argañaraz ER (2020) ACE2/ADAM17/TMPRSS2 interplay may be the main risk factor for COVID-19. Front Immunol 11:576745", "volume": "11", "year": "2020" }, { "DOI": "10.1016/j.cell.2021.02.053", "author": "ML Yeung", "doi-asserted-by": "publisher", "first-page": "2212", "issue": "8", "journal-title": "Cell", "key": "2141_CR13", "unstructured": "Yeung ML, Teng JLL, Jia L, Zhang C, Huang C, Cai JP, Zhou R, Chan KH, Zhao H, Zhu L, Siu KL, Fung SY, Yung S, Chan TM, To KK, Chan JF, Cai Z, Lau SKP, Chen Z, Jin DY, Woo PCY, Yuen KY (2021) Soluble ACE2-mediated cell entry of SARS-CoV-2 via interaction with proteins related to the renin-angiotensin system. Cell 184(8):2212-2228.e2212", "volume": "184", "year": "2021" }, { "DOI": "10.1097/FJC.0000000000000960", "author": "CS Wilcox", "doi-asserted-by": "publisher", "first-page": "323", "issue": "3", "journal-title": "J Cardiovasc Pharmacol", "key": "2141_CR14", "unstructured": "Wilcox CS, Pitt B (2020) Is spironolactone the preferred renin-angiotensin-aldosterone inhibitor for protection against COVID-19? J Cardiovasc Pharmacol 77(3):323–331", "volume": "77", "year": "2020" }, { "DOI": "10.1136/hrt.2005.071829", "author": "M Satoh", "doi-asserted-by": "publisher", "first-page": "979", "issue": "7", "journal-title": "Heart", "key": "2141_CR15", "unstructured": "Satoh M, Ishikawa Y, Minami Y, Akatsu T, Nakamura M (2006) Eplerenone inhibits tumour necrosis factor alpha shedding process by tumour necrosis factor alpha converting enzyme in monocytes from patients with congestive heart failure. Heart 92(7):979–980", "volume": "92", "year": "2006" }, { "DOI": "10.1007/s11255-019-02074-9", "author": "D Dong", "doi-asserted-by": "publisher", "first-page": "755", "issue": "4", "journal-title": "Int Urol Nephrol", "key": "2141_CR16", "unstructured": "Dong D, Fan TT, Ji YS, Yu JY, Wu S, Zhang L (2019) Spironolactone alleviates diabetic nephropathy through promoting autophagy in podocytes. Int Urol Nephrol 51(4):755–764", "volume": "51", "year": "2019" }, { "DOI": "10.1161/01.RES.0000187500.24964.7A", "author": "S Keidar", "doi-asserted-by": "publisher", "first-page": "946", "issue": "9", "journal-title": "Circ Res", "key": "2141_CR17", "unstructured": "Keidar S, Gamliel-Lazarovich A, Kaplan M, Pavlotzky E, Hamoud S, Hayek T, Karry R, Abassi Z (2005) Mineralocorticoid receptor blocker increases angiotensin-converting enzyme 2 activity in congestive heart failure patients. Circ Res 97(9):946–953", "volume": "97", "year": "2005" }, { "DOI": "10.1016/j.dsx.2021.03.027", "author": "II Rakhmat", "doi-asserted-by": "publisher", "first-page": "777", "issue": "3", "journal-title": "Diabet Metab Syndrome", "key": "2141_CR18", "unstructured": "Rakhmat II, Kusmala YY, Handayani DR, Juliastuti H, Nawangsih EN, Wibowo A, Lim MA, Pranata R (2021) Dipeptidyl peptidase-4 (DPP-4) inhibitor and mortality in coronavirus disease 2019 (COVID-19)—a systematic review, meta-analysis, and meta-regression. Diabet Metab Syndrome 15(3):777–782", "volume": "15", "year": "2021" }, { "DOI": "10.1210/jendso/bvac017", "author": "F Abbasi", "doi-asserted-by": "publisher", "issue": "4", "journal-title": "J Endocr Soc", "key": "2141_CR19", "unstructured": "Abbasi F, Adatorwovor R, Davarpanah MA, Mansoori Y, Hajiani M, Azodi F, Sefidbakht S, Davoudi S, Rezaei F, Mohammadmoradi S, Asadipooya K (2022) A randomized trial of sitagliptin and spironolactone with combination therapy in hospitalized adults with COVID-19. J Endocr Soc 6(4):bvac017", "volume": "6", "year": "2022" }, { "DOI": "10.1016/j.genrep.2021.101341", "author": "F Rahimi", "doi-asserted-by": "publisher", "journal-title": "Gene Reports", "key": "2141_CR20", "unstructured": "Rahimi F, TalebiBezmin Abadi A (2021) Emergence of the delta plus variant of SARS-CoV-2 in Iran. Gene Reports 25:101341", "volume": "25", "year": "2021" }, { "DOI": "10.1093/jamia/ocaa141", "author": "M Garcia", "doi-asserted-by": "publisher", "first-page": "1476", "issue": "9", "journal-title": "J Am Med Inform Assoc", "key": "2141_CR21", "unstructured": "Garcia M, Lipskiy N, Tyson J, Watkins R, Esser ES, Kinley T (2020) Centers for Disease Control and Prevention 2019 novel coronavirus disease (COVID-19) information management: addressing national health-care and public health needs for standardized data definitions and codified vocabulary for data exchange. J Am Med Inform Assoc 27(9):1476–1487", "volume": "27", "year": "2020" }, { "DOI": "10.1097/MD.0000000000026371", "author": "JE Blair", "doi-asserted-by": "publisher", "issue": "24", "journal-title": "Medicine", "key": "2141_CR22", "unstructured": "Blair JE, Gotimukul A, Wang F, Mina SA, Bartels HC, Burns MW, Kole AE, Vikram HR, Gea-Banacloche JC, Seville MT, Petty SAB, Vikram A, Orenstein R (2021) Mild to moderate COVID-19 illness in adult outpatients: characteristics, symptoms, and outcomes in the first 4 weeks of illness. Medicine 100(24):e26371", "volume": "100", "year": "2021" }, { "DOI": "10.3389/fpubh.2020.551889", "author": "R Rahmanzade", "doi-asserted-by": "publisher", "journal-title": "Front Public Health", "key": "2141_CR23", "unstructured": "Rahmanzade R, Rahmanzadeh R, Hashemian SM, Tabarsi P (2020) Iran’s approach to COVID-19: evolving treatment protocols and ongoing clinical trials. Front Public Health 8:551889", "volume": "8", "year": "2020" }, { "DOI": "10.1371/journal.pone.0245840", "author": "S Goodacre", "doi-asserted-by": "publisher", "issue": "1", "journal-title": "PLoS One", "key": "2141_CR24", "unstructured": "Goodacre S, Thomas B, Sutton L, Burnsall M, Lee E, Bradburn M, Loban A, Waterhouse S, Simmonds R, Biggs K, Marincowitz C, Schutter J, Connelly S, Sheldon E, Hall J, Young E, Bentley A, Challen K, Fitzsimmons C, Harris T, Lecky F, Lee A, Maconochie I, Walter D (2021) Derivation and validation of a clinical severity score for acutely ill adults with suspected COVID-19: the PRIEST observational cohort study. PLoS One 16(1):e0245840", "volume": "16", "year": "2021" }, { "DOI": "10.1080/14787210.2021.1863146", "author": "HF Tsang", "doi-asserted-by": "publisher", "first-page": "877", "issue": "7", "journal-title": "Expert Rev Anti Infect Ther", "key": "2141_CR25", "unstructured": "Tsang HF, Chan LWC, Cho WCS, Yu ACS, Yim AKY, Chan AKC, Ng LPW, Wong YKE, Pei XM, Li MJW, Wong SC (2021) An update on COVID-19 pandemic: the epidemiology, pathogenesis, prevention and treatment strategies. Expert Rev Anti Infect Ther 19(7):877–888", "volume": "19", "year": "2021" }, { "DOI": "10.1136/bmjopen-2021-049505", "author": "EF Peacocke", "doi-asserted-by": "publisher", "issue": "9", "journal-title": "BMJ Open", "key": "2141_CR26", "unstructured": "Peacocke EF, Heupink LF, Frønsdal K, Dahl EH, Chola L (2021) Global access to COVID-19 vaccines: a scoping review of factors that may influence equitable access for low and middle-income countries. BMJ Open 11(9):e049505", "volume": "11", "year": "2021" }, { "DOI": "10.1016/j.amjmed.2020.07.003", "author": "PA McCullough", "doi-asserted-by": "publisher", "first-page": "16", "issue": "1", "journal-title": "Am J Med", "key": "2141_CR27", "unstructured": "McCullough PA, Kelly RJ, Ruocco G, Lerma E, Tumlin J, Wheelan KR, Katz N, Lepor NE, Vijay K, Carter H, Singh B, McCullough SP, Bhambi BK, Palazzuoli A, De Ferrari GM, Milligan GP, Safder T, Tecson KM, Wang DD, McKinnon JE, O’Neill WW, Zervos M, Risch HA (2021) Pathophysiological basis and rationale for early outpatient treatment of SARS-CoV-2 (COVID-19) infection. Am J Med 134(1):16–22", "volume": "134", "year": "2021" }, { "author": "TC Lee", "first-page": "763", "journal-title": "Eur Respir J", "key": "2141_CR28", "unstructured": "Lee TC, Bortolussi-Courval É, Belga S, Daneman N, Chan AK, Hanula R, Ezer N, McDonald EG (2022) Inhaled corticosteroids for outpatients with Covid-19: a meta-analysis. Eur Respir J 9:763", "volume": "9", "year": "2022" }, { "DOI": "10.1056/NEJMoa2116044", "author": "A Jayk Bernal", "doi-asserted-by": "publisher", "first-page": "509", "issue": "6", "journal-title": "New Eng J Med", "key": "2141_CR29", "unstructured": "Jayk Bernal A, Gomes da Silva MM, Musungaie DB, Kovalchuk E, Gonzalez A, Delos Reyes V, Martín-Quirós A, Caraco Y, Williams-Diaz A, Brown ML, Du J, Pedley A, Assaid C, Strizki J, Grobler JA, Shamsuddin HH, Tipping R, Wan H, Paschke A, Butterton JR, Johnson MG, De Anda C (2022) Molnupiravir for oral treatment of Covid-19 in nonhospitalized patients. New Eng J Med 386(6):509–520", "volume": "386", "year": "2022" }, { "DOI": "10.1056/NEJMoa2118542", "author": "J Hammond", "doi-asserted-by": "publisher", "first-page": "1397", "issue": "15", "journal-title": "N Engl J Med", "key": "2141_CR30", "unstructured": "Hammond J, Leister-Tebbe H, Gardner A, Abreu P, Bao W, Wisemandle W, Baniecki M, Hendrick VM, Damle B, Simón-Campos A, Pypstra R, Rusnak JM (2022) Oral Nirmatrelvir for high-risk, nonhospitalized adults with Covid-19. N Engl J Med 386(15):1397–1408", "volume": "386", "year": "2022" }, { "DOI": "10.1056/NEJMoa2116846", "author": "RL Gottlieb", "doi-asserted-by": "publisher", "first-page": "305", "issue": "4", "journal-title": "N Engl J Med", "key": "2141_CR31", "unstructured": "Gottlieb RL, Vaca CE, Paredes R, Mera J, Webb BJ, Perez G, Oguchi G, Ryan P, Nielsen BU, Brown M, Hidalgo A, Sachdeva Y, Mittal S, Osiyemi O, Skarbinski J, Juneja K, Hyland RH, Osinusi A, Chen S, Camus G, Abdelghany M, Davies S, Behenna-Renton N, Duff F, Marty FM, Katz MJ, Ginde AA, Brown SM, Schiffer JT, Hill JA (2022) Early remdesivir to prevent progression to severe Covid-19 in outpatients. N Engl J Med 386(4):305–315", "volume": "386", "year": "2022" }, { "author": "E Mahase", "key": "2141_CR32", "unstructured": "Mahase E (2021) Covid-19: Pfizer’s paxlovid is 89% effective in patients at risk of serious illness, company reports. British Medical Journal Publishing Group", "volume-title": "Covid-19: Pfizer’s paxlovid is 89% effective in patients at risk of serious illness, company reports", "year": "2021" }, { "DOI": "10.1002/jmv.27623", "author": "WT Lin", "doi-asserted-by": "publisher", "first-page": "2222", "issue": "5", "journal-title": "J Med Virol", "key": "2141_CR33", "unstructured": "Lin WT, Hung SH, Lai CC, Wang CY, Chen CH (2022) The impact of neutralizing monoclonal antibodies on the outcomes of COVID-19 outpatients: a systematic review and meta-analysis of randomized controlled trials. J Med Virol 94(5):2222–2229", "volume": "94", "year": "2022" }, { "DOI": "10.1016/j.jinf.2022.06.011", "doi-asserted-by": "crossref", "key": "2141_CR34", "unstructured": "Coulson JM, Adams A, Gray LA, Evans A (2022) COVID-19 \"Rebound\" associated with nirmatrelvir/ritonavir pre-hospital therapy. J Infect 85(4):436–480" }, { "DOI": "10.1007/s11845-021-02820-y", "author": "A Vitiello", "doi-asserted-by": "publisher", "first-page": "2367", "issue": "5", "journal-title": "Ir J Med Sci", "key": "2141_CR35", "unstructured": "Vitiello A (2022) Sars-Cov-2 and risk of antiviral drug resistance. Ir J Med Sci 191(5):2367–2368", "volume": "191", "year": "2022" }, { "author": "A Komorowski", "first-page": "57", "journal-title": "Sci Brief Ontario COVID-19 Sci Advisory Table", "key": "2141_CR36", "unstructured": "Komorowski A, Tseng A, Vandersluis S (2022) Evidence-based recommendations on the use of nirmatrelvir/ritonavir (Paxlovid) for adults in Ontario. Sci Brief Ontario COVID-19 Sci Advisory Table 3:57", "volume": "3", "year": "2022" }, { "DOI": "10.1016/S0140-6736(22)00372-5", "author": "AD Usher", "doi-asserted-by": "publisher", "first-page": "779", "issue": "10327", "journal-title": "Lancet (London, England)", "key": "2141_CR37", "unstructured": "Usher AD (2022) The global COVID-19 treatment divide. Lancet (London, England) 399(10327):779–782", "volume": "399", "year": "2022" }, { "DOI": "10.1093/cid/ciac180", "author": "LD Saravolatz", "doi-asserted-by": "publisher", "first-page": "165", "issue": "1", "journal-title": "Clin Infect Dis", "key": "2141_CR38", "unstructured": "Saravolatz LD, Depcinski S, Sharma M (2023) Molnupiravir and nirmatrelvir-ritonavir: oral coronavirus disease 2019 antiviral drugs. Clin Infect Dis 76(1):165–171", "volume": "76", "year": "2023" }, { "DOI": "10.1016/j.cell.2020.04.004", "author": "V Monteil", "doi-asserted-by": "publisher", "first-page": "905", "issue": "4", "journal-title": "Cell", "key": "2141_CR39", "unstructured": "Monteil V, Kwon H, Prado P, Hagelkrüys A, Wimmer RA, Stahl M, Leopoldi A, Garreta E, Hurtado Del Pozo C, Prosper F, Romero JP, Wirnsberger G, Zhang H, Slutsky AS, Conder R, Montserrat N, Mirazimi A, Penninger JM (2020) Inhibition of SARS-CoV-2 infections in engineered human tissues using clinical-grade soluble human ACE2. Cell 181(4):905-913.e907", "volume": "181", "year": "2020" }, { "DOI": "10.1681/ASN.2020101537", "author": "J Wysocki", "doi-asserted-by": "publisher", "first-page": "795", "issue": "4", "journal-title": "J Am Soc Nephrol", "key": "2141_CR40", "unstructured": "Wysocki J, Ye M, Hassler L, Gupta AK, Wang Y, Nicoleascu V, Randall G, Wertheim JA, Batlle D (2021) A novel soluble ACE2 variant with prolonged duration of action neutralizes SARS-CoV-2 infection in human kidney organoids. J Am Soc Nephrol 32(4):795–803", "volume": "32", "year": "2021" }, { "DOI": "10.1186/s12931-020-01445-6", "author": "J Xu", "doi-asserted-by": "publisher", "first-page": "182", "issue": "1", "journal-title": "Respir Res", "key": "2141_CR41", "unstructured": "Xu J, Xu X, Jiang L, Dua K, Hansbro PM, Liu G (2020) SARS-CoV-2 induces transcriptional signatures in human lung epithelial cells that promote lung fibrosis. Respir Res 21(1):182", "volume": "21", "year": "2020" }, { "DOI": "10.1016/j.ejim.2021.09.007", "doi-asserted-by": "crossref", "key": "2141_CR42", "unstructured": "Angeli F, Zappa M, Reboldi G, Trapasso M, Cavallini C, Spanevello A, Verdecchia P (2021) The pivotal link between ACE2 deficiency and SARS-CoV-2 infection: one year later. Eur J Intern Med 93:28–34" }, { "DOI": "10.3389/fmed.2021.629176", "author": "D Jeon", "doi-asserted-by": "publisher", "journal-title": "Front Med", "key": "2141_CR43", "unstructured": "Jeon D, Son M, Choi J (2021) Effect of spironolactone on COVID-19 in patients with underlying liver cirrhosis: a nationwide case-control study in South Korea. Front Med 8:629176", "volume": "8", "year": "2021" }, { "DOI": "10.18087/cardio.2020.11.n1440", "author": "VY Mareev", "doi-asserted-by": "publisher", "first-page": "4", "issue": "11", "journal-title": "Kardiologiia", "key": "2141_CR44", "unstructured": "Mareev VY, Orlova YA, Plisyk AG, Pavlikova EP, Matskeplishvili ST, Akopyan ZA, Seredenina EM, Potapenko AV, Agapov MA, Asratyan DA, Dyachuk LI, Samokhodskaya LM, Mershina E, Sinitsyn VE, Pakhomov PV, Bulanova MM, Fuks AA, Mareev YV, Begrambekova YL, Kamalov A (2020) results of open-label non-randomized comparative clinical trial: “bromhexine and spironolactone for coronavirus infection requiring hospitalization” (BISCUIT). Kardiologiia 60(11):4–15", "volume": "60", "year": "2020" }, { "DOI": "10.1038/s41580-021-00418-x", "author": "CB Jackson", "doi-asserted-by": "publisher", "first-page": "3", "issue": "1", "journal-title": "Nat Rev Mol Cell Biol", "key": "2141_CR45", "unstructured": "Jackson CB, Farzan M, Chen B, Choe H (2022) Mechanisms of SARS-CoV-2 entry into cells. Nat Rev Mol Cell Biol 23(1):3–20", "volume": "23", "year": "2022" }, { "DOI": "10.1128/CMR.00133-20", "doi-asserted-by": "crossref", "key": "2141_CR46", "unstructured": "Synowiec A, Szczepański A, Barreto-Duran E, Lie LK, Pyrc K (2021) Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): a systemic infection. Clin Microbiol Rev 34(2):e00133–e00120" }, { "DOI": "10.1007/s00592-020-01539-z", "author": "SB Solerte", "doi-asserted-by": "publisher", "first-page": "779", "issue": "7", "journal-title": "Acta Diabetol", "key": "2141_CR47", "unstructured": "Solerte SB, Di Sabatino A, Galli M, Fiorina P (2020) Dipeptidyl peptidase-4 (DPP4) inhibition in COVID-19. Acta Diabetol 57(7):779–783", "volume": "57", "year": "2020" }, { "DOI": "10.2174/1871530322666220104103325", "doi-asserted-by": "crossref", "key": "2141_CR48", "unstructured": "Bakhtiari M, Asadipooya K (2022) Metainflammation in COVID-19. Endocr Metab Immune Disord Drug Targets 22(12):1154–1166" }, { "DOI": "10.2337/db21-0926", "author": "M Ben Nasr", "doi-asserted-by": "publisher", "first-page": "1579", "issue": "7", "journal-title": "Diabetes", "key": "2141_CR49", "unstructured": "Ben Nasr M, D’Addio F, Montefusco L, Usuelli V, Loretelli C, Rossi A, Pastore I, Abdelsalam A, Maestroni A, Dell’Acqua M, Ippolito E, Assi E, Seelam AJ, Fiorina RM, Chebat E, Morpurgo P, Lunati ME, Bolla AM, Abdi R, Bonventre JV, Rusconi S, Riva A, Corradi D, Santus P, Clark P, Nebuloni M, Baldi G, Finzi G, Folli F, Zuccotti GV, Galli M, Herold KC, Fiorina P (2022) Indirect and direct effects of SARS-CoV-2 on human pancreatic islets. Diabetes 71(7):1579–1590", "volume": "71", "year": "2022" }, { "DOI": "10.1038/s42255-021-00347-1", "author": "JA Müller", "doi-asserted-by": "publisher", "first-page": "149", "issue": "2", "journal-title": "Nat Metab", "key": "2141_CR50", "unstructured": "Müller JA, Groß R, Conzelmann C, Krüger J, Merle U, Steinhart J, Weil T, Koepke L, Bozzo CP, Read C, Fois G, Eiseler T, Gehrmann J, van Vuuren J, Wessbecher IM, Frick M, Costa IG, Breunig M, Grüner B, Peters L, Schuster M, Liebau S, Seufferlein T, Stenger S, Stenzinger A, MacDonald PE, Kirchhoff F, Sparrer KMJ, Walther P, Lickert H, Barth TFE, Wagner M, Münch J, Heller S, Kleger A (2021) SARS-CoV-2 infects and replicates in cells of the human endocrine and exocrine pancreas. Nat Metab 3(2):149–165", "volume": "3", "year": "2021" }, { "DOI": "10.1038/s42255-021-00407-6", "author": "L Montefusco", "doi-asserted-by": "publisher", "first-page": "774", "issue": "6", "journal-title": "Nat Metab", "key": "2141_CR51", "unstructured": "Montefusco L, Ben Nasr M, D’Addio F, Loretelli C, Rossi A, Pastore I, Daniele G, Abdelsalam A, Maestroni A, Dell’Acqua M, Ippolito E, Assi E, Usuelli V, Seelam AJ, Fiorina RM, Chebat E, Morpurgo P, Lunati ME, Bolla AM, Finzi G, Abdi R, Bonventre JV, Rusconi S, Riva A, Corradi D, Santus P, Nebuloni M, Folli F, Zuccotti GV, Galli M, Fiorina P (2021) Acute and long-term disruption of glycometabolic control after SARS-CoV-2 infection. Nat Metab 3(6):774–785", "volume": "3", "year": "2021" }, { "DOI": "10.1172/jci.insight.146701", "doi-asserted-by": "crossref", "key": "2141_CR52", "unstructured": "Loretelli C, Abdelsalam A, D'Addio F, Ben Nasr M, Assi E, Usuelli V, Maestroni A, Seelam AJ, Ippolito E, Di Maggio S, Loreggian L, Radovanovic D, Vanetti C, Yang J, El Essawy B, Rossi A, Pastore I, Montefusco L, Lunati ME, Bolla AM, Biasin M, Antinori S, Santus P, Riva A, Zuccotti GV, Galli M, Rusconi S, Fiorina P (2021) PD-1 blockade counteracts post-COVID-19 immune abnormalities and stimulates the anti-SARS-CoV-2 immune response. JCI Insight 6(24):e146701" }, { "DOI": "10.1210/clinem/dgac450", "doi-asserted-by": "crossref", "key": "2141_CR53", "unstructured": "Asadipooya K (2022) Letter to the editor from Asadipooya: “obesity and COVID-19: mechanistic insights from adipose tissue”. J Clin Endocrinol Metab 107(10):e4269" }, { "DOI": "10.22541/au.165403085.53671439/v1", "doi-asserted-by": "crossref", "key": "2141_CR54", "unstructured": "Davarpanah MA, Adatorwovor R, Mansoori Y, Ramsheh FSR, Parsa A, Hajiani M, Faramarzi H, Kavuluru R, Asadipooya K (2022) Combination of spironolactone and sitagliptin improves clinical outcomes of outpatients with COVID-19: a prospective cohort study. medRxiv. 2022.2001.2021.22269322" }, { "DOI": "10.1038/s41574-020-0399-8", "author": "CF Deacon", "doi-asserted-by": "publisher", "first-page": "642", "issue": "11", "journal-title": "Nat Rev Endocrinol", "key": "2141_CR55", "unstructured": "Deacon CF (2020) Dipeptidyl peptidase 4 inhibitors in the treatment of type 2 diabetes mellitus. Nat Rev Endocrinol 16(11):642–653", "volume": "16", "year": "2020" }, { "DOI": "10.1016/j.metabol.2020.154295", "author": "AP Stoian", "doi-asserted-by": "publisher", "journal-title": "Metabolism", "key": "2141_CR56", "unstructured": "Stoian AP, Sachinidis A, Stoica RA, Nikolic D, Patti AM, Rizvi AA (2020) The efficacy and safety of dipeptidyl peptidase-4 inhibitors compared to other oral glucose-lowering medications in the treatment of type 2 diabetes. Metabolism 109:154295", "volume": "109", "year": "2020" }, { "DOI": "10.1210/jc.2018-00241", "author": "KA Martin", "doi-asserted-by": "publisher", "first-page": "1233", "issue": "4", "journal-title": "J Clin Endocrinol Metab", "key": "2141_CR57", "unstructured": "Martin KA, Anderson RR, Chang RJ, Ehrmann DA, Lobo RA, Murad MH, Pugeat MM, Rosenfield RL (2018) Evaluation and treatment of hirsutism in premenopausal women: an endocrine society clinical practice guideline. J Clin Endocrinol Metab 103(4):1233–1257", "volume": "103", "year": "2018" } ], "reference-count": 57, "references-count": 57, "relation": { "has-preprint": [ { "asserted-by": "object", "id": "10.1101/2022.01.21.22269322", "id-type": "doi" } ] }, "resource": { "primary": { "URL": "https://link.springer.com/10.1007/s40618-023-02141-0" } }, "score": 1, "short-title": [], "source": "Crossref", "subject": [], "subtitle": [], "title": "Combination of spironolactone and sitagliptin improves clinical outcomes of outpatients with COVID-19: a prospective cohort study", "type": "journal-article", "update-policy": "http://dx.doi.org/10.1007/springer_crossmark_policy", "volume": "47" }