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0 0.5 1 1.5 2+ Mortality, 10ng/mL 33% Improvement Relative Risk Mortality, 20ng/mL 16% Severe case, 10ng/mL 0% Severe case, 20ng/mL 12% Vitamin D for COVID-19  Dana et al.  Sufficiency Are vitamin D levels associated with COVID-19 outcomes? Retrospective 831 patients in Iran (March - November 2020) Lower mortality with higher vitamin D levels (not stat. sig., p=0.29) Dana et al., The Eurasian J. Medicine, Aug 2022 Favors vitamin D Favors control

Vitamin D Level in Laboratory Confirmed COVID-19 and Disease Progression

Dana et al., The Eurasian Journal of Medicine, doi:10.5152/eurasianjmed.2022.21088
Aug 2022  
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Analysis of 831 hospitalized patients in Iran, showing higher mortality with severe vitamin D deficiency, without statistical significance.
This is the 144th of 187 COVID-19 sufficiency studies for vitamin D, which collectively show higher levels reduce risk with p<0.0000000001 (1 in 11 vigintillion).
risk of death, 33.1% lower, RR 0.67, p = 0.29, high D levels (≥10ng/mL) 49 of 376 (13.0%), low D levels (<10ng/mL) 8 of 46 (17.4%), NNT 23, adjusted per study, inverted to make RR<1 favor high D levels (≥10ng/mL), odds ratio converted to relative risk, sufficiency vs. severe deficiency, multivariable.
risk of death, 15.7% lower, RR 0.84, p = 0.44, high D levels (≥20ng/mL) 49 of 376 (13.0%), low D levels (<20ng/mL) 30 of 197 (15.2%), NNT 46, adjusted per study, inverted to make RR<1 favor high D levels (≥20ng/mL), odds ratio converted to relative risk, sufficiency vs. deficiency, multivariable.
risk of severe case, no change, RR 1.00, p = 1.00, high D levels (≥10ng/mL) 59 of 376 (15.7%), low D levels (<10ng/mL) 7 of 46 (15.2%), adjusted per study, inverted to make RR<1 favor high D levels (≥10ng/mL), odds ratio converted to relative risk, sufficiency vs. severe deficiency, multivariable.
risk of severe case, 11.6% lower, RR 0.88, p = 0.45, high D levels (≥20ng/mL) 59 of 376 (15.7%), low D levels (<20ng/mL) 35 of 197 (17.8%), NNT 48, adjusted per study, inverted to make RR<1 favor high D levels (≥20ng/mL), odds ratio converted to relative risk, sufficiency vs. deficiency, multivariable.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Dana et al., 11 Aug 2022, retrospective, Iran, peer-reviewed, 16 authors, study period March 2020 - November 2020.
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Vitamin D Level in Laboratory Confirmed COVID-19 and Disease Progression
Nasim Dana, Maryam Nasirian, Golnaz Vaseghi, Kiyan Heshmat-Ghahdarijani, Behrooz Ataei, Azam Mosayebi, Amirreza Manteghinejad, Shaghayegh Haghjooy Javanmard
The Eurasian Journal of Medicine, doi:10.5152/eurasianjmed.2022.21088
Objective: There is no conclusive evidence to suggest vitamin D level can prevent or treat infection with the new coronavirus disease 2019. This study aimed to investigate the effects of serum level of vitamin D in patients with coronavirus disease 2019 on death, severity, and hospitalization duration. Materials and Methods: Baseline characteristic of patients was extracted from the Isfahan coronavirus disease 2019 registry database (I-CORE). Blood samples were taken from all patients to measure the level of vitamin D (25-hydroxyvitamin D) and categorized. The effect of 25(OH) D on death, severity, and hospitalization duration was analyzed by logistic regression. Results: Among our study patients, 5.5% had a severe deficiency of vitamin D, 23.7% deficiency, and 24.8% insufficiency. Of the 107 patients who died, 7.5% were severely deficient in vitamin D. We found that vitamin D deficiency had no significant effect on death, disease severity, and hospitalization (P > .05). However, having at least one comorbidity increased the odds of death five times after adjusting age > 60 years and gender (P < .0001). The results showed that among all comorbidities, diabetes has the greatest impact on the outcomes as it raised the odds of death, disease severity, and length of hospital stay by 2.23,1.72, and 1.48, respectively, after controlling the age > 60 and gender (P = .0002, P = .08, P = .012). Conclusions: The mortality, disease severity, and hospitalization of coronavirus disease 2019 patients seem to be not affected by the low levels of 25(OH)D. However, the synergy between vitamin D levels and comorbidities, age, and gender could affect the outcome of coronavirus disease 2019 patients.
@ Severe deficiency (0-10), Deficiency (1-20), Insufficiency (20-30), Sufficiency (30-100), Toxicity (upper than 100). ^Sufficiency category with the highest case number was considered as reference group. & Days between admission to discharge (just for alive patients; n = 724). # Adjusted for have at least one underlying disease. *Estimated crude or adjusted odds ratio using binary logistic regression was significant if P value <.05.
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