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The effect of remdesivir on mortality and the outcome of patients with COVID‐19 in intensive care unit: A case–control study

Amirizadeh et al., Health Science Reports, doi:10.1002/hsr2.1676
Nov 2023  
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Mortality -3% Improvement Relative Risk Ventilation time -52% ICU time -27% Hospitalization time -24% Remdesivir  Amirizadeh et al.  ICU PATIENTS Is very late treatment with remdesivir beneficial for COVID-19? Retrospective 70 patients in Iran Longer ventilation (p=0.17) and ICU admission (p=0.23), not sig. c19early.org Amirizadeh et al., Health Science Repo.., Nov 2023 Favorsremdesivir Favorscontrol 0 0.5 1 1.5 2+
Retrospective 70 COVID-19 ICU patients, 35 receiving remdesivir plus standard treatment and 35 receiving standard treatment only. No significant differences were found for mortality, hospitalization time, ICU time, or ventilation time.
Gérard, Zhou, Wu, Kamo, Choi, Kim show significantly increased risk of acute kidney injury with remdesivir.
risk of death, 3.3% higher, RR 1.03, p = 1.00, treatment 31 of 35 (88.6%), control 30 of 35 (85.7%).
ventilation time, 52.2% higher, relative time 1.52, p = 0.17, treatment mean 7.03 (±8.92) n=35, control mean 4.62 (±5.24) n=35.
ICU time, 27.0% higher, relative time 1.27, p = 0.23, treatment mean 14.03 (±11.55) n=35, control mean 11.05 (±9.1) n=35.
hospitalization time, 24.2% higher, relative time 1.24, p = 0.22, treatment mean 16.11 (±11.52) n=35, control mean 12.97 (±9.65) n=35.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Amirizadeh et al., 1 Nov 2023, retrospective, Iran, peer-reviewed, 5 authors, average treatment delay 8.04 (treatment) 7.45 (control) days. Contact: kharazmkia@lums.ac.ir, md.ghasemazimi@gmail.com.
This PaperRemdesivirAll
The effect of remdesivir on mortality and the outcome of patients with COVID‐19 in intensive care unit: A case–control study
Mehran Amirizadeh, Ali Kharazmkia, Kobra Sharifi Abdoli, Hadi Hayati Abbarik, Ghasem Azimi
Health Science Reports, doi:10.1002/hsr2.1676
In 2002, severe acute respiratory syndrome (SARS) first appeared in China. It quickly spread worldwide within 3 months, resulting in the first pandemic of the twenty-first century with a 10% mortality rate. 1 Several unexplained signs and symptoms of acute and chronic pulmonary pneumonia were recorded in Wuhan, China, in late
CONFLICT OF INTEREST STATEMENT The authors declare no conflict of interest. ETHICS STATEMENT All procedures performed in this study involving human participants were in accordance with the ethical standards of the institutional and/ or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. TRANSPARENCY STATEMENT The lead author Ali Kharazmkia, Ghasem Azimi affirms that this manuscript is an honest, accurate, and transparent account of the study being reported; that no important aspects of the study have been omitted; and that any discrepancies from the study as planned (and, if relevant, registered) have been explained. Mehran Amirizadeh 1 Ali Kharazmkia 1, 2 Kobra Sharifi abdoli 3 Hadi Hayati abbarik 4 Ghasem Azimi 5 1 Department of Clinical Pharmacy, School of Pharmacy,
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Late treatment
is less effective
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