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0 0.5 1 1.5 2+ Mortality 75% Improvement Relative Risk ICU admission 0% c19early.org/aa Zarehoseinzade et al. Finasteride for COVID-19 RCT LATE Is late treatment with antiandrogens beneficial for COVID-19? RCT 80 patients in Iran Lower mortality with antiandrogens (not stat. sig., p=0.36) Zarehoseinzade et al., Medical J. The Islamic Re.., doi:10.47176/mjiri.35.30 Favors finasteride Favors control

Finasteride in hospitalized adult males with COVID-19: A risk factor for severity of the disease or an adjunct treatment: A randomized controlled clinical trial

Zarehoseinzade et al., Medical Journal of The Islamic Republic of Iran, doi:10.47176/mjiri.35.30
Zarehoseinzade et al., Finasteride in hospitalized adult males with COVID-19: A risk factor for severity of the disease or an adjunct.., Medical Journal of The Islamic Republic of Iran, doi:10.47176/mjiri.35.30
Apr 2021   Source   PDF  
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RCT 80 hospitalized COVID-19 patients in Iran, 40 treated with finasteride, showing no significant differences other than improved oxygen saturation on the 5th day with treatment. There was significantly more patients with diabetes in the control group. 5mg finasteride for 7 days. IRCT20200505047318N1.
risk of death, 75.0% lower, RR 0.25, p = 0.36, treatment 1 of 40 (2.5%), control 4 of 40 (10.0%), NNT 13.
risk of ICU admission, no change, RR 1.00, p = 1.00, treatment 1 of 40 (2.5%), control 1 of 40 (2.5%).
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Zarehoseinzade et al., 30 Apr 2021, Randomized Controlled Trial, Iran, peer-reviewed, 5 authors.
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This PaperAntiandrogensAll
Finasteride in hospitalized adult males with COVID-19: A risk factor for severity of the disease or an adjunct treatment: A randomized controlled clinical trial
Elham Zarehoseinzade, Abbas Allami, Mehrnoosh Ahmadi, Behzad Bijani, Navid Mohammadi
Medical Journal of The Islamic Republic of Iran, doi:10.47176/mjiri.35.30
Background finasteride mig COVID-19 infe Methods: W patients aged ≥ patients were r drug therapy an and secondary protocol was IR.QUMS.REC significant. Results: We (p= 0.018). Th patients in the f Conclusion: hospitalized m required to help
staff at the B in the study. Conflict of I The authors d
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Late treatment
is less effective
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