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c19early.org COVID-19 treatment researchUrsodeoxycholic acidUDCA (more..)
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Ursodeoxycholic acid and COVID-19 outcomes: a cohort study and data synthesis of state-of-art evidence

Yu et al., Expert Review of Anti-infective Therapy, doi:10.1080/14787210.2024.2376153
Jul 2024  
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Time to recovery 39% Improvement Relative Risk UDCA for COVID-19  Yu et al.  LATE TREATMENT Is late treatment with ursodeoxycholic acid beneficial for COVID-19? Retrospective 115 patients in China (December - December 2022) Faster recovery with ursodeoxycholic acid (p=0.044) c19early.org Yu et al., Expert Review of Anti-infec.., Jul 2024 FavorsUDCA Favorscontrol 0 0.5 1 1.5 2+
Retrospective 115 hospitalized COVID-19 patients in China showing faster time to body temperature recovery with ursodeoxycholic acid (UDCA) treatment. Results were better for higher dose treatment (300mg vs. 150mg).
Authors also perform a meta analysis showing lower risk of severe/critical COVID-19 with UDCA, which is listed separately1.
time to recovery, 38.7% lower, HR 0.61, p = 0.04, treatment 65, control 50, adjusted per study, inverted to make HR<1 favor treatment, multivariable, Cox proportional hazards.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Yu et al., 8 Jul 2024, retrospective, China, peer-reviewed, 12 authors, study period 10 December, 2022 - 30 December, 2022. Contact: zhandc@nju.edu.cn, tangshaoqiu@nju.edu.cn, guoyu@cpu.edu.cn.
This PaperUDCAAll
Ursodeoxycholic acid and COVID-19 outcomes: a cohort study and data synthesis of state-of-art evidence
Yang Yu, Guo-Fu Li, Jian Li, Lu-Yao Han, Zhi-Long Zhang, Tian-Shuo Liu, Shu-Xin Jiao, Yu-Wei Qiao, Na Zhang, De-Chuan Zhan, Shao-Qiu Tang, Guo Yu
Expert Review of Anti-infective Therapy, doi:10.1080/14787210.2024.2376153
Background: The potential of ursodeoxycholic acid (UDCA) in inhibiting angiotensin-converting enzyme 2 was demonstrated. However, conflicting evidence emerged regarding the association between UDCA and COVID-19 outcomes, prompting the need for a comprehensive investigation. Research design and methods: Patients diagnosed with COVID-19 infection were retrospectively analyzed and divided into two groups: the UDCA-treated group and the control group. Kaplan-Meier recovery analysis and Cox proportional hazards models were used to evaluate the recovery time and hazard ratios. Additionally, study-level pooled analyses for multiple clinical outcomes were performed. Results: In the 115-patient cohort, UDCA treatment was significantly associated with a reduced recovery time. The subgroup analysis suggests that the 300 mg subgroup had a significant (adjusted hazard ratio: 1.63 [95% CI, 1.01 to 2.60]) benefit with a shorter duration of fever. The results of pooled analyses also show that UDCA treatment can significantly reduce the incidence of severe/critical diseases in COVID-19 (adjusted odds ratio: 0.68 [95% CI, 0.50 to 0.94]). Conclusions: UDCA treatment notably improves the recovery time following an Omicron strain infection without observed safety concerns. These promising results advocate for UDCA as a viable treatment for COVID-19, paving the way for further large-scale and prospective research to explore the full potential of UDCA.
Abbreviations Author contributions Guo YU, Yang Yu, De-Chuan Zhan: conception of cohort study; Guo YU, Guo-Fu Li: design of the study; Jian Li, Shao-Qiu Tang, Lu-Yao Han: Resources and data curation for cohort study; Yang Yu, Guo Yu, Lu-Yao Han, Zhi-Long Zhang, Tian-Shuo Liu: Investigation of cohort study; Guo-Fu Li: Conception of evidence synthesis and meta-analytical methodology; Lu-Yao Han, Shu-Xin Jiao, Yu-Wei Qiao, Na Zhang: Systematic review and meta-analysis; Lu-Yao Han, Guo-Fu Li, Guo Yu: interpretation of the results; Lu-Yao Han, Guo-Fu Li, Guo Yu: drafting of the manuscript; Guo-Fu Li, Guo Yu: critical revision of the manuscript for important intellectual content. Declaration of interest The following financial interests may be considered potential competing interests: Y. Yu is the controlling shareholder of Polixir Technologies Co., Ltd. Zhi-Long Zhang and T.S. Liu declare receipt of employment by Polixir Technologies Co., Ltd. The research sponsor, Polixir Technologies Co., Ltd., did not play any role in research design, data collection, analysis and interpretation, report writing, and the decision to submit this paper for publication. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. Reviewer disclosures Peer reviewers on this manuscript have no relevant..
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Late treatment
is less effective
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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