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All Studies   Meta Analysis    Recent:   
0 0.5 1 1.5 2+ Case 46% Improvement Relative Risk UDCA for COVID-19  John et al.  Prophylaxis Does ursodeoxycholic acid reduce COVID-19 infections? Retrospective 3,214 patients in the USA Fewer cases with ursodeoxycholic acid (p=0.000014) c19early.org John et al., J. Internal Medicine, Apr 2023 Favors ursodeoxycholic acid Favors control

Ursodeoxycholic acid is associated with a reduction in SARS‐CoV‐2 infection and reduced severity of COVID‐19 in patients with cirrhosis

John et al., Journal of Internal Medicine, doi:10.1111/joim.13630
Apr 2023  
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Retrospective 3,214 veterans with cirrhosis comparing 1,607 participants taking ursodeoxycholic acid (UDCA) to 1,607 propensity score matched controls not taking UDCA. UDCA use was associated with significantly lower odds of SARS-CoV-2 infection (aOR 0.54), symptomatic COVID-19 (aOR 0.54), moderate or worse COVID-19 (aOR 0.51), and severe/critical COVID-19 (aOR 0.48). While retrospective, the results suggest UDCA may reduce COVID-19 susceptibility and severity in patients with cirrhosis through downregulation of ACE2 receptors.
risk of case, 46.0% lower, OR 0.54, p < 0.001, treatment 1,607, control 1,607, RR approximated with OR.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
John et al., 5 Apr 2023, retrospective, USA, peer-reviewed, 15 authors.
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