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All Studies   Meta Analysis       

Ursodeoxycholic acid and COVID-19 outcomes: a cohort study and data synthesis of state-of-art evidence

Yu et al., Expert Review of Anti-infective Therapy, doi:10.1080/14787210.2024.2376153, PROSPERO CRD42023495522
Jul 2024  
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Mortality 3% Improvement Relative Risk Severe case 32% UDCA for COVID-19  Yu et al.  META ANALYSIS c19early.org FavorsUDCA Favorscontrol 0 0.5 1 1.5 2+
Meta analysis of 9 studies showing lower risk of severe/critical COVID-19 with UDCA. There was no significant difference for mortality.
Authors also perform a retrospective study which is listed separately1.
Currently there are 19 ursodeoxycholic acid studies and meta analysis shows:
OutcomeImprovement
Mortality16% lower [-14‑39%]
Ventilation67% lower [-143‑95%]
ICU admission27% lower [-52‑65%]
Hospitalization17% lower [-4‑34%]
Cases16% fewer [9‑22%]
risk of death, 3.0% lower, OR 0.97, p = 0.50, RR approximated with OR.
risk of severe case, 32.0% lower, OR 0.68, p = 0.02, RR approximated with OR.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Yu et al., 8 Jul 2024, peer-reviewed, 12 authors, trial PROSPERO CRD42023495522.
This PaperUDCAAll
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