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c19early.org COVID-19 treatment researchUrsodeoxycholic acidUDCA (more..)
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Ursodeoxycholic acid and COVID-19 outcomes: a cohort study and data synthesis of state-of-art evidence

Yu et al., Expert Review of Anti-infective Therapy, doi:10.1080/14787210.2024.2376153, PROSPERO CRD42023495522
Jul 2024  
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Mortality 3% Improvement Relative Risk Severe case 32% UDCA for COVID-19  Yu et al.  META ANALYSIS c19early.org FavorsUDCA Favorscontrol 0 0.5 1 1.5 2+
Meta analysis of 9 studies showing lower risk of severe/critical COVID-19 with UDCA. There was no significant difference for mortality.
Authors also perform a retrospective study which is listed separately1.
Currently there are 21 ursodeoxycholic acid studies and meta analysis shows:
OutcomeImprovement
Mortality7% lower [-27‑33%]
Ventilation6% lower [-293‑78%]
ICU admission27% lower [-52‑65%]
Hospitalization10% lower [-7‑24%]
Cases17% fewer [11‑23%]
risk of death, 3.0% lower, OR 0.97, p = 0.50, RR approximated with OR.
risk of severe case, 32.0% lower, OR 0.68, p = 0.02, RR approximated with OR.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Yu et al., 8 Jul 2024, peer-reviewed, 12 authors, trial PROSPERO CRD42023495522.
This PaperUDCAAll
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"Publication History", "name": "publication_history" }, "label": "Published", "name": "published", "order": 2, "value": "2024-07-08" } ], "author": [ { "affiliation": [ { "name": "National Key Laboratory for Novel Software Technology, Nanjing University, China" }, { "name": "Polixir.ai" } ], "family": "Yu", "given": "Yang", "sequence": "first" }, { "affiliation": [ { "name": "School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, China" } ], "family": "Li", "given": "Guo-Fu", "sequence": "additional" }, { "affiliation": [ { "name": "Hospital of Nanjing University, Nanjing University, China" } ], "family": "Li", "given": "Jian", "sequence": "additional" }, { "affiliation": [ { "name": "School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, China" } ], "family": "Han", "given": "Lu-Yao", "sequence": "additional" }, { "affiliation": [ { "name": "National Key Laboratory for Novel Software Technology, Nanjing University, China" }, { "name": "Polixir.ai" } ], "family": "Zhang", "given": "Zhi-Long", "sequence": "additional" }, { "affiliation": [ { "name": "National Key Laboratory for Novel Software Technology, Nanjing University, China" }, { "name": "Polixir.ai" } ], "family": "Liu", "given": "Tian-Shuo", "sequence": "additional" }, { "affiliation": [ { "name": "School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, China" } ], "family": "Jiao", "given": "Shu-Xin", "sequence": "additional" }, { "affiliation": [ { "name": "School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, China" } ], "family": "Qiao", "given": "Yu-Wei", "sequence": "additional" }, { "affiliation": [ { "name": "School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, China" } ], "family": "Zhang", "given": "Na", "sequence": "additional" }, { "affiliation": [ { "name": "National Key Laboratory for Novel Software Technology, Nanjing University, China" } ], "family": "Zhan", "given": "De-Chuan", "sequence": "additional" }, { "affiliation": [ { "name": "Hospital of Nanjing University, Nanjing University, China" } ], "family": "Tang", "given": "Shao-Qiu", "sequence": "additional" }, { "affiliation": [ { "name": "School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, China" } ], "family": "Yu", "given": "Guo", "sequence": "additional" } ], "container-title": "Expert Review of Anti-infective Therapy", "container-title-short": "Expert Review of Anti-infective Therapy", "content-domain": { "crossmark-restriction": true, "domain": [ "www.tandfonline.com" ] }, "created": { "date-parts": [ [ 2024, 7, 8 ] ], "date-time": "2024-07-08T11:53:11Z", "timestamp": 1720439591000 }, "deposited": { "date-parts": [ [ 2024, 7, 8 ] ], "date-time": "2024-07-08T11:53:24Z", "timestamp": 1720439604000 }, "funder": [ { "DOI": "10.13039/501100004608", "doi-asserted-by": "publisher", "name": "Natural Science Foundation of Jiangsu Province" }, { "DOI": 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