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COVID-19 Humic/Fulvic Acid Plus Epigallocatechin Gallate Treatment: A Retrospective Chart Review

Williams, R., Cureus, doi:10.7759/cureus.77188
Jan 2025  
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Mortality 97% Improvement Relative Risk Vitamin C  Williams et al.  EARLY TREATMENT Is early treatment with vitamin C + combined treatments beneficial for COVID-19? Retrospective 60 patients in the USA (October - December 2020) Lower mortality with vitamin C + combined treatments (p=0.0000039) c19early.org Williams, R., Cureus, January 2025 Favorsvitamin C Favorscontrol 0 0.5 1 1.5 2+
Vitamin C for COVID-19
6th treatment shown to reduce risk in September 2020, now with p = 0.00000004 from 74 studies, recognized in 12 countries.
Lower risk for mortality, ICU, hospitalization, and recovery.
No treatment is 100% effective. Protocols combine treatments.
5,300+ studies for 116 treatments. c19early.org
Retrospective 60 COVID-19 patients in a nursing home facility showing no mortality with EGCG (from green tea extract), humic/fulvic acid, and vitamin C treatment, compared to 55% mortality in the control group not receiving treatment.
Standard of Care (SOC): SOC for COVID-19 in the study country, the USA, is very poor with very low average efficacy for approved treatments1. Only expensive, high-profit treatments were approved. Low-cost treatments were excluded, reducing the probability of treatment—especially early—due to access and cost barriers, and eliminating complementary and synergistic benefits seen with many low-cost treatments. This may explain in part the very high mortality seen in this study. Results may differ in countries with improved SOC.
This study is excluded in meta analysis: combined treatments may contribute significantly to the effect seen.
risk of death, 97.1% lower, RR 0.03, p < 0.001, treatment 0 of 22 (0.0%), control 21 of 38 (55.3%), NNT 1.8, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Williams et al., 9 Jan 2025, retrospective, USA, peer-reviewed, 1 author, study period 17 October, 2020 - 30 December, 2020, this trial uses multiple treatments in the treatment arm (combined with EGCG and humic/fulvic acid) - results of individual treatments may vary. Contact: rickwill@vt.vcom.edu.
This PaperVitamin CAll
COVID-19 Humic/Fulvic Acid Plus Epigallocatechin Gallate Treatment: A Retrospective Chart Review
Richard Williams, Edward Geriatrics
Cureus, doi:10.7759/cureus.77188
Introduction: The initial COVID-19 infection caused significant mortality in the nursing home setting. The mortality in our facility was approximately 50% and occurred in the later phase of the initial infection. In the nursing home setting, there were no approved treatment regimes. Specific treatment was left to the treating physician in concert with the administrative medical officials; immunizations were approved in December 2020. Concurrent publications indicated that epigallocatechin gallate (EGCG) and humic/fulvic acid with vitamin C possess the ability to interfere with the SARS-CoV-2 virus; both can inhibit viral attachment and reproduction, along with providing significant anti-inflammatory activity. They also exhibit good safety profiles and were previously utilized in our facility. With the high mortality and significant published data on inhibitory aspects of EGCG, humic/fulvic acid, and vitamin C, our facility utilized these supplements to treat COVID-19-positive patients. Methods: This retrospective chart review analyzes the effectiveness of an integrative treatment consisting of EGCG and humic/fulvic acid with vitamin C provided to COVID-19 patients in a long-term care facility between October and December 2020. Nursing home patients with COVID-19 infections were either provided integrative treatment utilizing EGCG, humic/fulvic acid, and vitamin C or provided care without integrative support. All EGCG patients were informed, and, when needed, the first line of authority, power of attorney (POA) was contacted and informed that the integrative approach was not standard treatment (but was reviewed and approved by Pulaski Health and Rehabilitation Medical Facility directors and the patient's physician). Patients were informed of the safety literature and compounds' utilization in viral infections prior to accepting treatment. Results: A review of 60 records indicates that among 22 patients receiving treatment with the integrative combination, there were no mortalities. Among 38 patients treated without this integrative support, there were 21 deaths. Conclusions: In a retrospective review of the treatment data, treatment of COVID-19 in the nursing home setting with EGCG, humic/fulvic acid, and vitamin C resulted in a significant reduction in overall mortality.
Additional Information Author Contributions All authors have reviewed the final version to be published and agreed to be accountable for all aspects of the work. Concept and design: Richard Williams
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