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A retrospective analysis of clinical outcomes between hospitalized patients with COVID‐19 who received famotidine or pantoprazole

Wagner et al., JGH Open, doi:10.1002/jgh3.12905 (abstract 10/31/2021)
Oct 2021  
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Mortality 64% Improvement Relative Risk Ventilation 6% Famotidine for COVID-19  Wagner et al.  LATE TREATMENT Is late treatment with famotidine beneficial for COVID-19? Retrospective 1,457 patients in the USA (March 2020 - March 2021) Lower mortality with famotidine (p<0.000001) c19early.org Wagner et al., JGH Open, October 2021 Favorsfamotidine Favorscontrol 0 0.5 1 1.5 2+
Famotidine for COVID-19
26th treatment shown to reduce risk in October 2021, now with p = 0.00028 from 30 studies, recognized in 2 countries.
No treatment is 100% effective. Protocols combine treatments.
5,100+ studies for 112 treatments. c19early.org
Retrospective 2,184 hospitalized patients in the USA, 638 treated with famotidine, showing lower mortality with treatment.
risk of death, 64.5% lower, RR 0.36, p < 0.001, treatment 82 of 638 (12.9%), control 182 of 819 (22.2%), adjusted per study, odds ratio converted to relative risk, multivariable.
risk of mechanical ventilation, 6.4% lower, RR 0.94, p = 0.77, treatment 48 of 638 (7.5%), control 75 of 819 (9.2%), adjusted per study, odds ratio converted to relative risk, multivariable.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Wagner et al., 31 Oct 2021, retrospective, USA, peer-reviewed, 5 authors, study period 1 March, 2020 - 1 March, 2021. Contact: jj.wagner5492@gmail.com.
This PaperFamotidineAll
Gastrointestinal Symptoms and Association With Respiratory Symptoms in Patients Diagnosed With SARS-CoV 2 (COVID-19)
MD Ernesto Robalino Gonzaga, MD Irene Riestra Guiance, MD Richard Henriquez, MD Mahmoud Ibrahim, MD Yuya Nway, DO Minh Ho, Jane Ha, MD, PhD Yeongkeun Kwon, BS Dohyang Kim, PhD Jinseub Hwang, PhD Jin-Won Kwon, MD, PhD Sungsoo Park
Figure 1. Panel a: Hospitalized COVID-19 patients with GI Symptoms on Admission demographic characteristics and ICU or non ICU admissions comparing with presence or no of respiratory symptoms. Panel b: Odds Ratio Estimates for ICU Admission in Patients with COVID-19 presenting with GI symptoms.
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(2023).WHO Coronavirus Disease (COVID‐19) ' 'dashboard. Available from:https://covid19.who.int/Accessed 16 Jan 2023.'}, { 'key': 'e_1_2_6_3_1', 'first-page': '1', 'article-title': 'Clinical characteristics of COVID‐19 patients with digestive symptoms ' 'in Hubei, China', 'volume': '115', 'author': 'Pan L', 'year': '2020', 'journal-title': 'Am. J. Gastroenterol.'}, { 'key': 'e_1_2_6_4_1', 'doi-asserted-by': 'crossref', 'first-page': '766', 'DOI': '10.1016/j.apsb.2020.02.008', 'article-title': 'Analysis of therapeutic targets for SARS‐CoV‐2 and discovery of ' 'potential drugs by computational methods', 'volume': '10', 'author': 'Wu C', 'year': '2020', 'journal-title': 'Acta Pharm Sin. B.'}, { 'key': 'e_1_2_6_5_1', 'first-page': '9', 'article-title': 'Mast cells contribute to coronavirus‐induced inflammation: new ' 'anti‐inflammatory strategy', 'volume': '34', 'author': 'Kritas SK', 'year': '2020', 'journal-title': 'J. Biol. Regul. Homeost. Agents'}, { 'key': 'e_1_2_6_6_1', 'first-page': '10.21203/rs.3.r', 'article-title': 'Broad‐spectrum inhibition of coronavirus main and papain‐like proteases ' 'by HCV drugs', 'author': 'Anson BJ', 'year': '2020', 'journal-title': 'Res. Sq.'}, { 'key': 'e_1_2_6_7_1', 'doi-asserted-by': 'crossref', 'unstructured': 'BorrellB.New York clinical trial quietly tests heartburn remedy against ' 'coronavirus. Available ' 'from:https://www.science.org/content/article/new-york-clinical-trial-quietly-tests-heartburn-remedy-against-coronavirus. ' 'Accessed 7 Nov 2021.', 'DOI': '10.1126/science.abc4739'}, { 'key': 'e_1_2_6_8_1', 'doi-asserted-by': 'crossref', 'first-page': '1129', 'DOI': '10.1053/j.gastro.2020.05.053', 'article-title': 'Famotidine use is associated with improved clinical outcomes in ' 'hospitalized COVID‐19 patients: a propensity score matched ' 'retrospective cohort study', 'volume': '159', 'author': 'Freedberg DE', 'year': '2020', 'journal-title': 'Gastroenterology'}, { 'key': 'e_1_2_6_9_1', 'doi-asserted-by': 'crossref', 'first-page': '1617', 'DOI': '10.14309/ajg.0000000000000832', 'article-title': 'Impact of famotidine use on clinical outcomes of hospitalized patients ' 'with COVID‐19', 'volume': '115', 'author': 'Mather JF', 'year': '2020', 'journal-title': 'Am. J. Gastroenterol.'}, { 'key': 'e_1_2_6_10_1', 'first-page': '34940', 'article-title': 'Association between famotidine use and COVID‐19 severity in Hong Kong: ' 'a territory‐wide study', 'volume': '0016', 'author': 'Cheung KS', 'year': '2020', 'journal-title': 'Gastroenterology'}, { 'key': 'e_1_2_6_11_1', 'doi-asserted-by': 'crossref', 'first-page': '692', 'DOI': '10.14309/ajg.0000000000001153', 'article-title': 'Comparative effectiveness of famotidine in hospitalized COVID‐19 ' 'patients', 'volume': '116', 'author': 'Shoaibi A', 'year': '2021', 'journal-title': 'Am. J. Gastroenterol.'}, { 'key': 'e_1_2_6_12_1', 'doi-asserted-by': 'crossref', 'first-page': '919', 'DOI': '10.1053/j.gastro.2020.10.011', 'article-title': 'Famotidine use is not associated with 30‐day mortality: a coarsened ' 'exact match study in 7158 hospitalized patients with coronavirus ' 'disease 2019 from a large healthcare system', 'volume': '160', 'author': 'Yeramaneni S', 'year': '2021', 'journal-title': 'Gastroenterology'}, { 'key': 'e_1_2_6_13_1', 'doi-asserted-by': 'crossref', 'first-page': '3929', 'DOI': '10.1007/s10620-021-06872-z', 'article-title': 'Does famotidine reduce the risk of progression to severe disease, ' 'death, and intubation for COVID‐19 patients? A systemic review and ' 'meta‐analysis', 'volume': '66', 'author': 'Sun C', 'year': '2023', 'journal-title': 'Dig. Dis. Sci.'}, { 'key': 'e_1_2_6_14_1', 'doi-asserted-by': 'crossref', 'DOI': '10.1038/cddis.2016.218', 'article-title': 'Proton pump inhibitors protect mice from acute systemic inflammation ' 'and induce long‐term cross‐tolerance', 'volume': '7', 'author': 'Balza E', 'year': '2016', 'journal-title': 'Cell Death Dis.'}, { 'key': 'e_1_2_6_15_1', 'doi-asserted-by': 'crossref', 'first-page': '310', 'DOI': '10.1503/cmaj.092129', 'article-title': 'Use of acid‐suppressive drugs and risk of pneumonia: a systematic ' 'review and meta‐analysis', 'volume': '183', 'author': 'Eom CS', 'year': '2011', 'journal-title': 'CMAJ'}, { 'key': 'e_1_2_6_16_1', 'doi-asserted-by': 'crossref', 'first-page': '51', 'DOI': '10.1186/s12916-021-01907-8', 'article-title': 'Relation of severe COVID‐19 to polypharmacy and prescribing of ' 'psychotropic drugs: the REACT‐SCOT case‐control study', 'volume': '19', 'author': 'McKeigue PM', 'year': '2021', 'journal-title': 'BMC Med.'}, { 'key': 'e_1_2_6_17_1', 'doi-asserted-by': 'crossref', 'first-page': '137', 'DOI': '10.1097/MEG.0000000000002013', 'article-title': 'Pre‐hospitalization proton pump inhibitor use and clinical outcomes in ' 'COVID‐19', 'volume': '34', 'author': 'Ramachandran P', 'year': '2022', 'journal-title': 'Eur. J. Gastroenterol. Hepatol.'}, { 'key': 'e_1_2_6_18_1', 'first-page': '76', 'article-title': 'Severe clinical outcomes of COVID‐19 associated with proton pump ' 'inhibitors: a nationwide cohort study with propensity score matching', 'volume': '70', 'author': 'Lee SW', 'year': '2020', 'journal-title': 'Gut'}, { 'key': 'e_1_2_6_19_1', 'doi-asserted-by': 'crossref', 'first-page': '125', 'DOI': '10.1111/joim.13183', 'article-title': 'Use of proton pump inhibitors and risk of adverse clinical outcomes ' 'from COVID‐19: a meta‐analysis', 'volume': '289', 'author': 'Kow CS', 'year': '2021', 'journal-title': 'J. Intern. Med.'}, { 'key': 'e_1_2_6_20_1', 'doi-asserted-by': 'crossref', 'first-page': '879', 'DOI': '10.1136/gutjnl-2022-326952', 'article-title': 'Oral famotidine versus placebo in non‐hospitalised patients with ' 'COVID‐19: a randomised, double‐blind, data‐intense, phase 2 clinical ' 'trial', 'volume': '71', 'author': 'Brennan CM', 'year': '2022', 'journal-title': 'Gut'}, { 'key': 'e_1_2_6_21_1', 'doi-asserted-by': 'crossref', 'DOI': '10.3389/fphar.2021.633680', 'article-title': 'COVID‐19: famotidine, histamine, mast cells, and mechanisms', 'volume': '12', 'author': 'Malone RW', 'year': '2021', 'journal-title': 'Front. Pharmacol.'}, { 'key': 'e_1_2_6_22_1', 'doi-asserted-by': 'crossref', 'first-page': '54', 'DOI': '10.1001/archinte.158.1.54', 'article-title': 'A prospective randomized comparative trial showing that omeprazole ' 'prevents rebleeding in patients with bleeding peptic ulcer after ' 'successful endoscopic therapy', 'volume': '158', 'author': 'Lin HJ', 'year': '1998', 'journal-title': 'Arch. Intern. Med.'}, { 'key': 'e_1_2_6_23_1', 'doi-asserted-by': 'crossref', 'first-page': '568', 'DOI': '10.1136/bmj.38356.641134.8F', 'article-title': 'Systematic review and meta‐analysis of proton pump inhibitor therapy in ' 'peptic ulcer bleeding', 'volume': '330', 'author': 'Leontiadis GI', 'year': '2005', 'journal-title': 'BMJ'}, { 'key': 'e_1_2_6_24_1', 'doi-asserted-by': 'crossref', 'DOI': '10.1016/j.transci.2020.102926', 'article-title': 'Anemia is associated with severe coronavirus disease 2019 (COVID‐19) ' 'infection', 'volume': '59', 'author': 'Hariyanto TI', 'year': '2020', 'journal-title': 'Transfus. Apher. Sci.'}, { 'key': 'e_1_2_6_25_1', 'doi-asserted-by': 'crossref', 'first-page': '616', 'DOI': '10.1001/jama.2019.22190', 'article-title': 'Effect of stress ulcer prophylaxis with proton pump inhibitors vs ' 'histamine‐2 receptor blockers on in‐hospital mortality among ICU ' 'patients receiving invasive mechanical ventilation', 'volume': '323', 'author': 'PEPTIC Investigators for the Australian and New Zealand Intensive Care Society ' 'Clinical Trials Group, Alberta Health Services Critical Care Strategic ' 'Clinical Network, and the Irish Critical Care Trials Group', 'year': '2020', 'journal-title': 'JAMA'}, { 'key': 'e_1_2_6_26_1', 'doi-asserted-by': 'crossref', 'first-page': '65', 'DOI': '10.5414/CNP68065', 'article-title': 'Proton pump inhibitors and the kidney: critical review', 'volume': '68', 'author': 'Brewster UC', 'year': '2007', 'journal-title': 'Clin. Nephrol.'}, { 'key': 'e_1_2_6_27_1', 'doi-asserted-by': 'crossref', 'first-page': '199', 'DOI': '10.1159/000514940', 'article-title': 'Incidence and outcomes of acute kidney injury in COVID‐19: a systematic ' 'review', 'volume': '51', 'author': 'Raina R', 'year': '2022', 'journal-title': 'Blood Purif.'}, { 'key': 'e_1_2_6_28_1', 'doi-asserted-by': 'crossref', 'first-page': 'S1723', 'DOI': '10.14309/01.ajg.0000715272.88349.c2', 'article-title': 'H2‐blocker use is associated with acute kidney injury among COVID‐19 ' 'patients', 'volume': '115', 'author': 'Trieu JA', 'year': '2020', 'journal-title': 'Am. J. Gastroenter.'}, { 'key': 'e_1_2_6_29_1', 'doi-asserted-by': 'crossref', 'first-page': '833', 'DOI': '10.1007/s00134-015-3725-1', 'article-title': 'Prevalence and outcome of gastrointestinal bleeding and use of acid ' 'suppressants in acutely ill adult intensive care patients', 'volume': '41', 'author': 'Krag M', 'year': '2015', 'journal-title': 'Intens. 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Late treatment
is less effective
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