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A retrospective analysis of clinical outcomes between hospitalized patients with COVID‐19 who received famotidine or pantoprazole

Wagner et al., JGH Open, doi:10.1002/jgh3.12905 (abstract 10/31/2021)

Oct 2021

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Famotidine for COVID-19

25th treatment shown to reduce risk in October 2021

^*, now known with p = 0.00026 from 30 studies.

Lower risk for mortality, hospitalization, recovery, and viral clearance.

No treatment is 100% effective. Protocols combine complementary and synergistic treatments. ^* >10% efficacy in meta analysis with ≥3 clinical studies.

4,100+ studies for 60+ treatments. c19early.org

Retrospective 2,184 hospitalized patients in the USA, 638 treated with famotidine, showing lower mortality with treatment.

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risk of death, 64.5% lower, RR 0.36, p < 0.001, treatment 82 of 638 (12.9%), control 182 of 819 (22.2%), adjusted per study, odds ratio converted to relative risk, multivariable.

risk of mechanical ventilation, 6.4% lower, RR 0.94, p = 0.77, treatment 48 of 638 (7.5%), control 75 of 819 (9.2%), adjusted per study, odds ratio converted to relative risk, multivariable.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates

Wagner et al., 31 Oct 2021, retrospective, USA, peer-reviewed, 5 authors, study period 1 March, 2020 - 1 March, 2021. Contact: jj.wagner5492@gmail.com.

This Paper Famotidine All

Gastrointestinal Symptoms and Association With Respiratory Symptoms in Patients Diagnosed With SARS-CoV 2 (COVID-19)

MD Ernesto Robalino Gonzaga, MD Irene Riestra Guiance, MD Richard Henriquez, MD Mahmoud Ibrahim, MD Yuya Nway, DO Minh Ho, Jane Ha, MD, PhD Yeongkeun Kwon, BS Dohyang Kim, PhD Jinseub Hwang, PhD Jin-Won Kwon, MD, PhD Sungsoo Park

Figure 1. Panel a: Hospitalized COVID-19 patients with GI Symptoms on Admission demographic characteristics and ICU or non ICU admissions comparing with presence or no of respiratory symptoms. Panel b: Odds Ratio Estimates for ICU Admission in Patients with COVID-19 presenting with GI symptoms.

Late treatment
is less effective

Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.

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