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All Studies   Meta Analysis    Recent:   
0 0.5 1 1.5 2+ Mortality, after 14 day foll.. 81% Improvement Relative Risk Mortality, in hospital 89% ICU admission 87% Hospitalization time 35% Nigella Sativa  Vaziri et al.  LATE TREATMENT  RCT Is late treatment with nigella sativa + combined treatments beneficial for COVID-19? RCT 179 patients in Iran (April - December 2020) Lower mortality (p=0.03) and ICU admission (p=0.0019) c19early.org Vaziri et al., Heliyon, March 2024 Favors nigella sativa Favors control

Investigating efficacy of colchicine plus phenolic monoterpenes fraction as a potential treatment for patients diagnosed with COVID-19: A randomized controlled parallel clinical trial

Mar 2024  
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11th treatment shown to reduce risk in January 2021
 
*, now known with p = 0.00016 from 14 studies.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,000+ studies for 60+ treatments. c19early.org
RCT 179 hospitalized COVID-19 patients showing lower mortality, ICU admission, and hospitalization duration with colchicine plus phenolic monoterpenes compared to standard care alone. The intervention group received 0.8 mg/day colchicine and 45 mg/day phenolic monoterpenes extracted from nigella sativa and Trachyspermum ammi in addition to standard care (lopinavir/ritonavir). No serious side effects were reported. Baseline SpO2 was significantly lower in the control group, although there was no significant difference in severity according to NIH guidelines.
Study covers nigella sativa and colchicine.
risk of death, 81.2% lower, RR 0.19, p = 0.03, treatment 2 of 108 (1.9%), control 7 of 71 (9.9%), NNT 12, after 14 day followup.
risk of death, 89.0% lower, RR 0.11, p = 0.02, treatment 1 of 108 (0.9%), control 6 of 71 (8.5%), NNT 13, in hospital.
risk of ICU admission, 86.9% lower, RR 0.13, p = 0.002, treatment 2 of 108 (1.9%), control 10 of 71 (14.1%), NNT 8.2.
hospitalization time, 34.7% lower, relative time 0.65, p < 0.001, treatment mean 4.17 (±1.34) n=108, control mean 6.39 (±2.59) n=71.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Vaziri et al., 6 Mar 2024, Randomized Controlled Trial, Iran, peer-reviewed, mean age 54.2, 11 authors, study period April 2020 - December 2020, this trial uses multiple treatments in the treatment arm (combined with colchicine and phenolic monoterpenes from nigella sativa and Trachyspermum ammi) - results of individual treatments may vary, trial NCT04392141 (history). Contact: amostafaie@kums.ac.ir.
This PaperNigella SativaAll
Late treatment
is less effective
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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