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Investigating efficacy of colchicine plus phenolic monoterpenes fraction as a potential treatment for patients diagnosed with COVID-19: A randomized controlled parallel clinical trial

Vaziri et al., Heliyon, doi:10.1016/j.heliyon.2024.e27373, NCT04392141

Mar 2024

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Nigella Sativa

11th treatment shown to reduce risk in January 2021

^*, now known with p = 0.00016 from 14 studies.

Lower risk for ventilation, hospitalization, recovery, cases, and viral clearance.

No treatment is 100% effective. Protocols combine complementary and synergistic treatments. ^* >10% efficacy in meta analysis with ≥3 clinical studies.

4,100+ studies for 60+ treatments. c19early.org

RCT 179 hospitalized COVID-19 patients showing lower mortality, ICU admission, and hospitalization duration with colchicine plus phenolic monoterpenes compared to standard care alone. The intervention group received 0.8 mg/day colchicine and 45 mg/day phenolic monoterpenes extracted from nigella sativa and Trachyspermum ammi in addition to standard care (lopinavir/ritonavir). No serious side effects were reported. Baseline SpO₂ was significantly lower in the control group, although there was no significant difference in severity according to NIH guidelines.

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Study covers nigella sativa and colchicine.

risk of death, 81.2% lower, RR 0.19, p = 0.03, treatment 2 of 108 (1.9%), control 7 of 71 (9.9%), NNT 12, after 14 day followup.

risk of death, 89.0% lower, RR 0.11, p = 0.02, treatment 1 of 108 (0.9%), control 6 of 71 (8.5%), NNT 13, in hospital.

risk of ICU admission, 86.9% lower, RR 0.13, p = 0.002, treatment 2 of 108 (1.9%), control 10 of 71 (14.1%), NNT 8.2.

hospitalization time, 34.7% lower, relative time 0.65, p < 0.001, treatment mean 4.17 (±1.34) n=108, control mean 6.39 (±2.59) n=71.

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Vaziri et al., 6 Mar 2024, Randomized Controlled Trial, Iran, peer-reviewed, mean age 54.2, 11 authors, study period April 2020 - December 2020, this trial uses multiple treatments in the treatment arm (combined with colchicine and phenolic monoterpenes from nigella sativa and Trachyspermum ammi) - results of individual treatments may vary, trial NCT04392141 (history). Contact: amostafaie@kums.ac.ir.

This Paper Nigella Sativa All

Late treatment
is less effective

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