Investigating efficacy of colchicine plus phenolic monoterpenes fraction as a potential treatment for patients diagnosed with COVID-19: A randomized controlled parallel clinical trial

DOI record: { "DOI": "10.1016/j.heliyon.2024.e27373", "ISSN": [ "2405-8440" ], "URL": "http://dx.doi.org/10.1016/j.heliyon.2024.e27373", "alternative-id": [ "S2405844024034042" ], "article-number": "e27373", "assertion": [ { "label": "This article is maintained by", "name": "publisher", "value": "Elsevier" }, { "label": "Article Title", "name": "articletitle", "value": "Investigating efficacy of colchicine plus phenolic monoterpenes fraction as a potential treatment for patients diagnosed with COVID-19: A randomized controlled parallel clinical trial" }, { "label": "Journal Title", "name": "journaltitle", "value": "Heliyon" }, { "label": "CrossRef DOI link to publisher maintained version", "name": "articlelink", "value": "https://doi.org/10.1016/j.heliyon.2024.e27373" }, { "label": "Content Type", "name": "content_type", "value": "article" }, { "label": "Copyright", "name": "copyright", "value": "© 2024 The Authors. Published by Elsevier Ltd." } ], "author": [ { "affiliation": [], "family": "Vaziri", "given": "Siavash", "sequence": "first" }, { "affiliation": [], "family": "Janbakhsh", "given": "Alireza", "sequence": "additional" }, { "affiliation": [], "family": "Zamanian", "given": "Mohammad Hossein", "sequence": "additional" }, { "affiliation": [], "family": "Shakiba", "given": "Yadollah", "sequence": "additional" }, { "affiliation": [], "family": "Mostafaei", "given": "Shayan", "sequence": "additional" }, { "affiliation": [], "family": "Norooznezhad", "given": "Amir Hossein", "sequence": "additional" }, { "affiliation": [], "family": "Mansouri", "given": "Kamran", "sequence": "additional" }, { "affiliation": [], "family": "Bagheri", "given": "Ahmad", "sequence": "additional" }, { "affiliation": [], "family": "Abdali", "given": "Farhad", "sequence": "additional" }, { "affiliation": [], "family": "Fatahpour", "given": "Kavyan", "sequence": "additional" }, { "affiliation": [], "family": "Mostafaie", "given": "Ali", "sequence": "additional" } ], "container-title": "Heliyon", "container-title-short": "Heliyon", "content-domain": { "crossmark-restriction": true, "domain": [ "cell.com", "elsevier.com", "sciencedirect.com" ] }, "created": { "date-parts": [ [ 2024, 3, 6 ] ], "date-time": "2024-03-06T08:28:28Z", "timestamp": 1709713708000 }, "deposited": { "date-parts": [ [ 2024, 3, 6 ] ], "date-time": "2024-03-06T08:28:35Z", "timestamp": 1709713715000 }, "indexed": { "date-parts": [ [ 2024, 3, 7 ] ], "date-time": "2024-03-07T00:33:10Z", "timestamp": 1709771590804 }, "is-referenced-by-count": 0, "issued": { "date-parts": [ [ 2024, 3 ] ] }, "language": "en", "license": [ { "URL": "https://www.elsevier.com/tdm/userlicense/1.0/", "content-version": "tdm", "delay-in-days": 0, "start": { "date-parts": [ [ 2024, 3, 1 ] ], "date-time": "2024-03-01T00:00:00Z", "timestamp": 1709251200000 } }, { "URL": "http://creativecommons.org/licenses/by/4.0/", "content-version": "vor", "delay-in-days": 0, "start": { "date-parts": [ [ 2024, 2, 28 ] ], "date-time": "2024-02-28T00:00:00Z", "timestamp": 1709078400000 } } ], "link": [ { "URL": "https://api.elsevier.com/content/article/PII:S2405844024034042?httpAccept=text/xml", "content-type": "text/xml", "content-version": "vor", "intended-application": "text-mining" }, { "URL": "https://api.elsevier.com/content/article/PII:S2405844024034042?httpAccept=text/plain", "content-type": "text/plain", "content-version": "vor", "intended-application": "text-mining" } ], "member": "78", "original-title": [], "page": "e27373", "prefix": "10.1016", "published": { "date-parts": [ [ 2024, 3 ] ] }, "published-print": { "date-parts": [ [ 2024, 3 ] ] }, "publisher": "Elsevier BV", "reference": [ { "DOI": "10.4269/ajtmh.20-0512", "article-title": "Primary symptoms, comorbidities, and outcomes of 431 hospitalized patients with confirmative RT-PCR results for COVID-19", "author": "Norooznezhad", "doi-asserted-by": "crossref", "first-page": "834", "journal-title": "Am. J. Trop. Med. Hyg.", "key": "10.1016/j.heliyon.2024.e27373_bib1", "volume": "103", "year": "2020" }, { "DOI": "10.1016/j.arcmed.2020.03.015", "article-title": "Inappropriate antibiotic consumption as a possible cause of inflammatory storm and septic shock in patients diagnosed with coronavirus-19 disease (COVID-19)", "author": "Hantoushzadeh", "doi-asserted-by": "crossref", "first-page": "347", "journal-title": "Arch. Med. Res.", "key": "10.1016/j.heliyon.2024.e27373_bib2", "volume": "51", "year": "2020" }, { "DOI": "10.1016/S0140-6736(20)30566-3", "article-title": "Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study", "author": "Zhou", "doi-asserted-by": "crossref", "first-page": "1054", "journal-title": "Lancet", "key": "10.1016/j.heliyon.2024.e27373_bib3", "volume": "395", "year": "2020" }, { "DOI": "10.1002/jmv.26525", "article-title": "Changes of leukocytes, neutrophils, and lymphocytes count and dependent variables in pregnant women with coronavirus disease 2019 (COVID-19) before and after cesarean delivery", "author": "Norooznezhad", "doi-asserted-by": "crossref", "first-page": "664", "journal-title": "J. Med. Virol.", "key": "10.1016/j.heliyon.2024.e27373_bib4", "volume": "2", "year": "2021" }, { "DOI": "10.3390/jcm9051583", "article-title": "Herbal medicine for the treatment of coronavirus disease 2019 (COVID-19): a systematic review and meta-analysis of randomized controlled trials", "author": "Ang", "doi-asserted-by": "crossref", "first-page": "1583", "journal-title": "J. Clin. Med.", "key": "10.1016/j.heliyon.2024.e27373_bib5", "volume": "9", "year": "2020" }, { "key": "10.1016/j.heliyon.2024.e27373_bib6", "series-title": "Definitions of Symptoms for Reportable Illnesses", "year": "2020" }, { "key": "10.1016/j.heliyon.2024.e27373_bib8", "series-title": "Management of Persons with COVID-19", "year": "2020" }, { "article-title": "Effect of colchicine vs standard care on cardiac and inflammatory biomarkers and clinical outcomes in patients hospitalized with coronavirus disease 2019: the GRECCO-19 randomized clinical trial", "author": "Deftereos", "journal-title": "JAMA New Open", "key": "10.1016/j.heliyon.2024.e27373_bib9", "volume": "3", "year": "2020" }, { "DOI": "10.1136/rmdopen-2020-001455", "article-title": "Beneficial effects of colchicine for moderate to severe COVID-19: a randomised, double-blinded, placebo-controlled clinical trial", "author": "Lopes", "doi-asserted-by": "crossref", "journal-title": "RMD Open", "key": "10.1016/j.heliyon.2024.e27373_bib10", "volume": "7", "year": "2021" }, { "DOI": "10.1186/s13063-020-04647-x", "article-title": "Nigella sativa supplementation to treat symptomatic mild COVID-19: a structured summary of a protocol for a randomised, controlled, clinical trial", "author": "Koshak", "doi-asserted-by": "crossref", "first-page": "703", "journal-title": "Trials", "key": "10.1016/j.heliyon.2024.e27373_bib11", "volume": "21", "year": "2020" }, { "DOI": "10.1016/j.semarthrit.2015.06.013", "article-title": "Colchicine--Update on mechanisms of action and therapeutic uses", "author": "Leung", "doi-asserted-by": "crossref", "first-page": "341", "journal-title": "Semin. Arthritis Rheum.", "key": "10.1016/j.heliyon.2024.e27373_bib12", "volume": "45", "year": "2015" }, { "DOI": "10.2174/1871529X18666180212114816", "article-title": "Immunomodulatory and anti-inflammatory effects of thymoquinone", "author": "Shaterzadeh-Yazdi", "doi-asserted-by": "crossref", "first-page": "52", "journal-title": "Cardiovasc. Hematol. Disord.: Drug Targets", "key": "10.1016/j.heliyon.2024.e27373_bib13", "volume": "18", "year": "2018" }, { "DOI": "10.3390/antiox9090897", "article-title": "Implications of oxidative stress and potential role of mitochondrial dysfunction in COVID-19: therapeutic effects of vitamin D", "author": "de Las Heras", "doi-asserted-by": "crossref", "first-page": "897", "journal-title": "Antioxidants", "key": "10.1016/j.heliyon.2024.e27373_bib14", "volume": "9", "year": "2020" }, { "DOI": "10.1093/eurheartj/ehaa623", "article-title": "COVID-19 is, in the end, an endothelial disease", "author": "Libby", "doi-asserted-by": "crossref", "first-page": "3038", "journal-title": "Eur. Heart J.", "key": "10.1016/j.heliyon.2024.e27373_bib15", "volume": "41", "year": "2020" } ], "reference-count": 14, "references-count": 14, "relation": {}, "resource": { "primary": { "URL": "https://linkinghub.elsevier.com/retrieve/pii/S2405844024034042" } }, "score": 1, "short-title": [], "source": "Crossref", "subject": [ "Multidisciplinary" ], "subtitle": [], "title": "Investigating efficacy of colchicine plus phenolic monoterpenes fraction as a potential treatment for patients diagnosed with COVID-19: A randomized controlled parallel clinical trial", "type": "journal-article", "update-policy": "http://dx.doi.org/10.1016/elsevier_cm_policy" }