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Clinical Characteristics and Risk Factors for Mortality in Critical COVID-19 Patients Aged 50 Years or Younger During Omicron Wave in Korea: Comparison With Patients Older Than 50 Years of Age

Shi et al., Journal of Korean Medical Science, doi:10.3346/jkms.2023.38.e217
Jun 2023  
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Retrospective 213 critical COVID-19 patients in South Korea, reporting no significant difference in mortality with remdesivir treatment (results not provided).
Gérard, Wu, Zhou show significantly increased risk of acute kidney injury with remdesivir.
Shi et al., 14 Jun 2023, retrospective, South Korea, peer-reviewed, 20 authors, study period 1 February, 2022 - 30 April, 2022.
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Clinical Characteristics and Risk Factors for Mortality in Critical COVID-19 Patients Aged 50 Years or Younger During Omicron Wave in Korea: Comparison With Patients Older Than 50 Years of Age
Hye Jin Shi, Jinyoung Yang, Joong Sik Eom, Jae-Hoon Ko, Kyong Ran Peck, Uh Jin Kim, Sook In Jung, Seulki Kim, Hyeri Seok, Miri Hyun, Hyun Ah Kim, Bomi Kim, Eun-Jeong Joo, Hae Suk Cheong, Cheon Hoo Jun, Yu Mi Wi, Jungok Kim, Sungmin Kym, MD Seungjin Lim, MD Yoonseon Park
Journal of Korean Medical Science, doi:10.3346/jkms.2023.38.e217
Background: The coronavirus disease 2019 (COVID-19) pandemic has caused the death of thousands of patients worldwide. Although age is known to be a risk factor for morbidity and mortality in COVID-19 patients, critical illness or death is occurring even in the younger age group as the epidemic spreads. In early 2022, omicron became the dominant variant of the COVID-19 virus in South Korea, and the epidemic proceeded on a large scale. Accordingly, this study aimed to determine whether young adults (aged ≤ 50 years) with critical COVID-19 infection during the omicron period had different characteristics from older patients and to determine the risk factors for mortality in this specific age group. Methods: We evaluated 213 critical adult patients (high flow nasal cannula or higher respiratory support) hospitalized for polymerase chain reaction-confirmed COVID-19 in nine hospitals in South Korea between February 1, 2022 and April 30, 2022. Demographic characteristics, including body mass index (BMI) and vaccination status; underlying diseases; clinical features
Ethics statement The present study protocol was reviewed and approved by the Institutional Review Board of Gil Medical Center (approval No. GCIRB2021-462). This study adhered to the principles embodied in the Declaration of Helsinki. The requirement for written informed consent was waived because de-identified data were collected retrospectively. SUPPLEMENTARY MATERIALS Supplementary Table 1 Clinicodemographic patient characteristics by variant period Click here to view Supplementary Table 2 Clinicodemographic characteristics by variant period in patients aged ≤ 50 years Click here to view Supplementary Table 3 Predictors of mortality (univariate and multivariate analysis) Click here to view Supplementary Table 4 Risk factors for mortality in patients aged >50 years (N = 142, univariate analysis) Click here to view Supplementary Table 5 Clinical characteristics of patients aged ≤ 50 years who died Click here to view
Aleem, Samad, Vaqar, Emerging Variants of SARS-CoV-2 And Novel Therapeutics Against Coronavirus (COVID-19)
Anjan, Khatri, Viotti, Cheung, Garcia et al., Is the Omicron variant truly less virulent in solid organ transplant recipients?, Transpl Infect Dis, doi:10.1111/tid.13923
Bhattacharyya, Hanage, Challenges in inferring intrinsic severity of the SARS-CoV-2 omicron variant, N Engl J Med, doi:10.1056/NEJMp2119682
Bienvenu, Noonan, Wang, Peter, Higher mortality of COVID-19 in males: sex differences in immune response and cardiovascular comorbidities, Cardiovasc Res, doi:10.1093/cvr/cvaa284
Bouzid, Visseaux, Kassasseya, Daoud, Fémy et al., Comparison of patients infected with delta versus omicron COVID-19 variants presenting to Paris emergency departments : a retrospective cohort study, Ann Intern Med
Capuzzo, Amaral, Liu, Assess COVID-19 prognosis … but be aware of your instrument's accuracy! Intensive, Care Med
Chen, Yan, Sun, Zheng, Sun et al., Estimation of disease burden and clinical severity of COVID-19 caused by omicron BA.2 in Shanghai, Emerg Microbes Infect, doi:10.1080/22221751.2022.2128435
Drożdżal, Rosik, Lechowicz, Machaj, Szostak et al., An update on drugs with therapeutic potential for SARS-CoV-2 (COVID-19) treatment, Drug Resist Updat, doi:10.1016/j.drup.2021.100794
Forchette, Sebastian, Liu, A comprehensive review of COVID-19 virology, vaccines, variants, and therapeutics, Curr Med Sci
He, Page, Weinberg, Mishra, The development and validation of simplified machine learning algorithms to predict prognosis of hospitalized patients with COVID-19: multicenter, retrospective study, J Med Internet Res, doi:10.2196/31549
Heald-Sargent, Muller, Zheng, Rippe, Patel et al., Age-related differences in nasopharyngeal severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) levels in patients with mild to moderate coronavirus disease 2019 (COVID-19), JAMA Pediatr, doi:10.1001/jamapediatrics.2020.3651
Jang, Hur, Choi, Hong, Lee et al., Prognostic factors for severe coronavirus disease 2019 in Daegu, Korea, J Korean Med Sci, doi:10.3346/jkms.2020.35.e209
Jeon, COVID-19] Paxlovid was introduced in Korea about two month ago... but still perscribed only 47000 patients
Kang, Jung, Age-related morbidity and mortality among patients with COVID-19, Infect Chemother
Kim, Lee, Choi, Um, Lee et al., Clinical characteristics of 40 patients infected with the SARS-CoV-2 omicron variant in Korea, J Korean Med Sci, doi:10.3346/jkms.2022.37.e31
Lauring, Tenforde, Chappell, Gaglani, Ginde et al., Clinical severity of, and effectiveness of mRNA vaccines against, covid-19 from omicron, delta, and alpha SARS-CoV-2 variants in the United States: prospective observational study, BMJ, doi:10.1136/bmj-2021-069761
Lee, Choe, Jeong, Kim, Kim et al., Importation and transmission of SARS-CoV-2 B.1.1.529 (omicron) variant of concern in Korea, J Korean Med Sci, doi:10.3346/jkms.2021.36.e346
Lee, Choi, Park, Jo, Choi et al., Analysis of critical COVID-19 cases among children in Korea, J Korean Med Sci, doi:10.3346/jkms.2022.37.e13
Lee, Kim, Huh, Hyun, Rhee et al., Risk factors for mortality and respiratory support in elderly patients hospitalized with COVID-19 in Korea, J Korean Med Sci, doi:10.3346/jkms.2020.35.e223
Lim, Shin, Nam, Jung, Koo, Proper management of people with obesity during the COVID-19 pandemic, J Obes Metab Syndr
Liu, Liu, Ye, Yu, Luo et al., Predictors of mortality for hospitalized young adults aged less than 60 years old with severe COVID-19: a retrospective study, J Thorac Dis, doi:10.21037/jtd-21-120
Lu, Huang, Wang, Tang, Wang et al., Clinical characteristics and predictors of mortality in young adults with severe COVID-19: a retrospective observational study, Ann Clin Microbiol Antimicrob, doi:10.1186/s12941-020-00412-9
Malik, Ahmed, Shinde, Almermesh, Alghamdi et al., The impact of COVID-19 on comorbidities: a review of recent updates for combating it, Saudi J Biol Sci, doi:10.1016/j.sjbs.2022.02.006
Martins-Filho, De Souza Araújo, Quintans-Júnior, Soares, Barboza et al., Dynamics of hospitalizations and in-hospital deaths from COVID-19 in northeast Brazil: a retrospective analysis based on the circulation of SARS-CoV-2 variants and vaccination coverage, Epidemiol Health, doi:10.4178/epih.e2022036
Murillo-Zamora, Aguilar-Sollano, Delgado-Enciso, Hernandez-Suarez, Predictors of laboratorypositive COVID-19 in children and teenagers, Public Health, doi:10.1016/j.puhe.2020.10.012
Nyberg, Ferguson, Nash, Webster, Flaxman et al., Comparative analysis of the risks of hospitalisation and death associated with SARS-CoV-2 omicron (B.1.1.529) and delta (B.1.617.2) variants in England: a cohort study, Lancet, doi:10.1016/S0140-6736(22)00462-7
Pinato, Aguilar-Company, Ferrante, Hanbury, Bower et al., Outcomes of the SARS-CoV-2 omicron (B.1.1.529) variant outbreak among vaccinated and unvaccinated patients with cancer in Europe: results from the retrospective, multicentre, OnCovid registry study, Lancet Oncol, doi:10.1016/S1470-2045(22)00273-X
Pubmed | Crossref, None, doi:10.1001/jamainternmed.2020.0994
Pubmed | Crossref, None, doi:10.1007/s00134-021-06539-3
Pubmed | Crossref, None, doi:10.1007/s11596-021-2395-1
Pubmed | Crossref, None, doi:10.1080/07853890.2022.2034936
Pubmed | Crossref, None, doi:10.15585/mmwr.mm7115e1
Pubmed | Crossref, None, doi:10.3947/ic.2020.52.2.154
Pubmed | Crossref, None, doi:10.5811/westjem.2020.5.47972
Pubmed | Crossref, None, doi:10.7326/M22-0308
Pubmed | Crossref, None, doi:10.7570/jomes20056
Shi, Nham, Kim, Joo, Cheong et al., Clinical characteristics and risk factors for mortality in critical coronavirus disease 2019 patients 50 years of age or younger during the delta wave: comparison with patients > 50 years in Korea, J Korean Med Sci, doi:10.3346/jkms.2022.37.e175
Shim, Choi, Kwon, Kim, Song, Transmission potential of the omicron variant of severe acute respiratory syndrome coronavirus 2 in South Korea, Open Forum Infect Dis, doi:10.1093/ofid/ofac248
Singanayagam, Hakki, Dunning, Madon, Crone et al., Community transmission and viral load kinetics of the SARS-CoV-2 delta (B.1.617.2) variant in vaccinated and unvaccinated individuals in the UK: a prospective, longitudinal, cohort study, Lancet Infect Dis, doi:10.1016/S1473-3099(21)00648-4
Smith, Hakim, Leung, Xu, Schluter et al., COVID-19 mortality and vaccine coverage, MMWR Morb Mortal Wkly Rep
Steinberg, Wright, Kushner, In young adults with COVID-19, obesity is associated with adverse outcomes, West J Emerg Med
Ward, Bermingham, Ayoubkhani, Gethings, Pouwels et al., Risk of covid-19 related deaths for SARS-CoV-2 omicron (B.1.1.529) compared with delta (B.1.617.2): retrospective cohort study, BMJ, doi:10.1136/bmj-2022-070695
Wen, Chen, Tang, Wang, Zhou et al., Efficacy and safety of three new oral antiviral treatment (molnupiravir, fluvoxamine and Paxlovid) for COVID-19: a meta-analysis, Ann Med
Wu, Chen, Cai, Xia, Zhou et al., Risk factors associated with acute respiratory distress syndrome and death in patients with coronavirus disease, JAMA Intern Med
Xavier, Oliveira, Da, Vieira, Lobosco et al., Characterisation of Omicron Variant during COVID-19 Pandemic and the Impact of Vaccination, Transmission Rate, Mortality, and Reinfection in South Africa, Germany, and Brazil. BioTech (Basel), doi:10.3390/biotech11020012
Late treatment
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