COVID-19 in Individuals Treated With Long-Term Hydroxychloroquine: A Propensity Score-Matched Analysis of Cicatricial Alopecia Patients
et al., Journal of Drugs in Dermatology, doi:10.36849/JDD.5843, Jul 2021
HCQ for COVID-19
1st treatment shown to reduce risk in
March 2020, now with p < 0.00000000001 from 424 studies, used in 59 countries.
No treatment is 100% effective. Protocols
combine treatments.
6,200+ studies for
200+ treatments. c19early.org
|
PSM retrospective 144 alopecia patients in the USA, showing lower risk of COVID-19 with HCQ prophylaxis. The supplemental appendix is not available.
Standard of Care (SOC) for COVID-19 in the study country,
the USA, is very poor with very low average efficacy for approved treatments1.
Only expensive, high-profit treatments were approved for early treatment. Low-cost treatments were excluded, reducing the probability of early treatment due to access and cost barriers, and eliminating complementary and synergistic benefits seen with many low-cost treatments.
|
risk of case, 13.0% lower, OR 0.87, p = 0.006, treatment 45, control 99, adjusted per study, propensity score matching, multivariable, RR approximated with OR.
|
| Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates |
Shaw et al., 1 Jul 2021, retrospective, USA, peer-reviewed, 10 authors, study period 1 March, 2020 - 15 May, 2020.
Contact: Kristen.LoSicco@nyulangone.org.
Abstract: doi:10.36849/JDD.5843
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August 2021
914
Volume 20 • Issue 8
Copyright © 2021
LETTERS TO THE EDITOR
Journal of Drugs in Dermatology
COVID-19 in Individuals Treated With Long-Term
Hydroxychloroquine: A Propensity Score-Matched
Analysis of Cicatricial Alopecia Patients
Katharina S. Shaw,a Lu Yin,a Jinal K. Shah,b Rachel A. Sally,a Katerina S. Svigos,a Prince U. Adotama,a
Hsiao Han Tuan,a Jerry Shapiro MD,a Rebecca A. Betensky,b* and Kristen I. Lo Sicco MDa*
The Ronald O. Perelman Department of Dermatology, New York University Grossman School of Medicine, New York, NY
b
Department of Biostatistics, New York University School of Global Public Health, New York, NY
a
Both authors contributed equally to this work as co-first authors
*
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