Abstract: U.S. Department of Veterans Affairs
Public Access Author manuscript
Gut. Author manuscript; available in PMC 2023 July 01.
Published in final edited form as:
Gut. 2022 July ; 71(7): 1447–1450. doi:10.1136/gutjnl-2021-325701.
VA Author Manuscript
Proton pump inhibitor use is not associated with severe
COVID-19 related outcomes: A propensity score weighted
analysis of a national veteran cohort
Shailja C. Shah, MD, MPH*,1,2, Alese E. Halvorson, MS3, Brandon McBay, BA4, Chad Dorn,
MS5, Otis Wilson, BA6,7, Jason Denton, BS5, Sony Tuteja, PharmD, MS6,7, Kyong-Mi Chang,
MD6,7, Kelly Cho, PhD, MPH8, Richard L. Hauger, MD9,10, Ayako Suzuki, MD, PhD, MSc11,12,
Christine M. Hunt, MD, MPH11,12, Edward Siew, MD, MSCI13,14, Michael E. Matheny, MD,
MS, MPH5,13,14, Adriana Hung, MD, MPH13,15, Robert A. Greevy Jr., PhD3,15, Christianne L.
Roumie, MD, MPH15,16,17
1Gastroenterology Section, VA San Diego Healthcare System, San Diego, CA
VA Author Manuscript
2Division of Gastroenterology, University of California, San Diego, San Diego, CA
3Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN
4Department of Public Health, Harvard T.H. Chan School of Public Health, Boston, MA
5Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN
6The Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA
7University of Pennsylvania Perelman School of Medicine, Philadelphia PA
8VA Boston Healthcare System & Brigham and Women’s Hospital, Harvard Medical School,
Boston, MA
9Department of Psychiatry, University of California San Diego, La Jolla, CA
10Center of Excellence for Stress & Mental Health, VA San Diego Healthcare System, San Diego,
VA Author Manuscript
CA
11Division of Gastroenterology, Duke University Medical Center, Durham, NC
12Gastroenterology Section, Durham VA Health Care System, Durham, NC
13Division of Nephrology & Hypertension, Vanderbilt University Medical Center, Nashville, TN
14VA Tennessee Valley, Health Services Research and Development
*
Corresponding Author: Shailja C Shah, MD MPH, 3350 La Jolla Village Drive, 3-South (GI Section), Mail Code 111D, San Diego,
CA 92161, Phone: 619-854-9550 / Fax: None, s6shah@health.ucsd.edu.
Author Contributions: SCS: Study concept, study design, dataset verification, interpretation of data and statistical analysis, drafting
of initial manuscript, critical revision of manuscript; AEH, RAG: study design, primary statistical analysis, dataset verification,
interpretation of data and statistical analysis, critical revision of manuscript, methodological oversight; CD, OW, JD: dataset creation
and stewardship; BM, ST, KC, AS, CMH, ES, MEM, AH: manuscript revision; CLR: study design, interpretation of data and
statistical analysis, methodological and study oversight, critical revision of manuscript. All authors approved the final version of the
manuscript.
Disclosures/conflicts of interest: The authors report no conflicts of interest that are relevant to this article. Dr. Shah is an ad hoc
consultant for Phathom Pharmaceuticals.
Shah et al.
Page 2
15VA Tennessee Valley, Clinical Services Research and Development
16Department of Medicine, Vanderbilt University Medical Center, Nashville, TN
17VA Geriatrics Research Education and Clinical Center (GRECC), VA Tennessee Valley Health
System, Nashville, TN
VA Author Manuscript
Keywords
coronavirus; gastric acid suppression; antihistamine-2 receptor antagonists; population-based
analysis
Dear..
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