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All Studies   Meta Analysis       

A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial of the Efficacy of Camostat Mesilate for Treatment of COVID-19 in Outpatients

Sagent Pharmaceuticals, NCT04583592, NCT04583592
Mar 2021  
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Mortality -152% Improvement Relative Risk ER, hospitalization, death 13% Viral clearance 16% Camostat  Sagent Pharmaceuticals et al.  EARLY TREATMENT  RCT Is early treatment with camostat beneficial for COVID-19? Double-blind RCT 295 patients in the USA Improved viral clearance with camostat (not stat. sig., p=0.36) c19early.org Sagent Pharmaceuticals, NCT04583592, Mar 2021 Favorscamostat Favorscontrol 0 0.5 1 1.5 2+
RCT 295 outpatients in the USA, showing no significant differences with camostat.
risk of death, 152.1% higher, RR 2.52, p = 1.00, treatment 1 of 194 (0.5%), control 0 of 101 (0.0%), continuity correction due to zero event (with reciprocal of the contrasting arm), day 28.
ER, hospitalization, death, 13.2% lower, RR 0.87, p = 0.79, treatment 10 of 194 (5.2%), control 6 of 101 (5.9%), NNT 127.
risk of no viral clearance, 16.1% lower, RR 0.84, p = 0.36, treatment 58 of 194 (29.9%), control 36 of 101 (35.6%), NNT 17, day 15.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Sagent Pharmaceuticals et al., 31 Mar 2021, Double Blind Randomized Controlled Trial, placebo-controlled, USA, preprint, 1 author, trial NCT04583592 (history). Contact: ctinkoff@sagentpharma.com.
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