Comparative Analysis of Serum Zinc, Copper and Magnesium Level and Their Relations in Association with Severity and Mortality in SARS-CoV-2 Patients

{ 'indexed': {'date-parts': [[2022, 1, 22]], 'date-time': '2022-01-22T14:10:10Z', 'timestamp': 1642860610006}, 'reference-count': 44, 'publisher': 'Springer Science and Business Media LLC', 'license': [ { 'start': { 'date-parts': [[2022, 1, 22]], 'date-time': '2022-01-22T00:00:00Z', 'timestamp': 1642809600000}, 'content-version': 'tdm', 'delay-in-days': 0, 'URL': 'https://www.springer.com/tdm'}, { 'start': { 'date-parts': [[2022, 1, 22]], 'date-time': '2022-01-22T00:00:00Z', 'timestamp': 1642809600000}, 'content-version': 'vor', 'delay-in-days': 0, 'URL': 'https://www.springer.com/tdm'}], 'funder': [ { 'DOI': '10.13039/501100007338', 'name': 'All-India Institute of Medical Sciences', 'doi-asserted-by': 'publisher'}], 'content-domain': {'domain': ['link.springer.com'], 'crossmark-restriction': False}, 'short-container-title': ['Biol Trace Elem Res'], 'DOI': '10.1007/s12011-022-03124-7', 'type': 'journal-article', 'created': {'date-parts': [[2022, 1, 22]], 'date-time': '2022-01-22T02:02:24Z', 'timestamp': 1642816944000}, 'update-policy': 'http://dx.doi.org/10.1007/springer_crossmark_policy', 'source': 'Crossref', 'is-referenced-by-count': 0, 'title': [ 'Comparative Analysis of Serum Zinc, Copper and Magnesium Level and Their Relations in ' 'Association with Severity and Mortality in SARS-CoV-2 Patients'], 'prefix': '10.1007', 'author': [ {'given': 'Kiran Kumar', 'family': 'PVSN', 'sequence': 'first', 'affiliation': []}, {'given': 'Sojit', 'family': 'Tomo', 'sequence': 'additional', 'affiliation': []}, {'given': 'Purvi', 'family': 'Purohit', 'sequence': 'additional', 'affiliation': []}, { 'given': 'Shrimanjunath', 'family': 'Sankanagoudar', 'sequence': 'additional', 'affiliation': []}, {'given': 'Jayakaran', 'family': 'Charan', 'sequence': 'additional', 'affiliation': []}, {'given': 'Abhishek', 'family': 'Purohit', 'sequence': 'additional', 'affiliation': []}, {'given': 'Vijaylakshami', 'family': 'Nag', 'sequence': 'additional', 'affiliation': []}, {'given': 'Pradeep', 'family': 'Bhatia', 'sequence': 'additional', 'affiliation': []}, {'given': 'Kuldeep', 'family': 'Singh', 'sequence': 'additional', 'affiliation': []}, {'given': 'Naveen', 'family': 'Dutt', 'sequence': 'additional', 'affiliation': []}, {'given': 'Mahendra Kumar', 'family': 'Garg', 'sequence': 'additional', 'affiliation': []}, {'given': 'Praveen', 'family': 'Sharma', 'sequence': 'additional', 'affiliation': []}, {'given': 'Sanjeev', 'family': 'Misra', 'sequence': 'additional', 'affiliation': []}, {'given': 'Dharamveer', 'family': 'Yadav', 'sequence': 'additional', 'affiliation': []}], 'member': '297', 'published-online': {'date-parts': [[2022, 1, 22]]}, 'reference': [ { 'key': '3124_CR1', 'doi-asserted-by': 'publisher', 'first-page': '1', 'DOI': '10.1016/j.trsl.2020.04.007', 'volume': '220', 'author': 'C Magro', 'year': '2020', 'unstructured': 'Magro C, Mulvey JJ, Berlin D et al (2020) Complement associated ' 'microvascular injury and thrombosis in the pathogenesis of severe ' 'COVID-19 infection: a report of five cases. Transl Res 220:1–13. ' 'https://doi.org/10.1016/j.trsl.2020.04.007', 'journal-title': 'Transl Res'}, { 'key': '3124_CR2', 'doi-asserted-by': 'publisher', 'first-page': '1092', 'DOI': '10.1001/jama.2020.1623', 'volume': '323', 'author': 'D Chang', 'year': '2020', 'unstructured': 'Chang D, Lin M, Wei L et al (2020) Epidemiologic and clinical ' 'characteristics of novel coronavirus infections involving 13 patients ' 'outside Wuhan, China. JAMA 323:1092–1093. ' 'https://doi.org/10.1001/jama.2020.1623', 'journal-title': 'JAMA'}, { 'key': '3124_CR3', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.virusres.2020.198043', 'volume': '286', 'author': 'J Li', 'year': '2020', 'unstructured': 'Li J, Gong X, Wang Z et al (2020) Clinical features of familial ' 'clustering in patients infected with 2019 novel coronavirus in Wuhan. ' 'China Virus Res 286:198043. ' 'https://doi.org/10.1016/j.virusres.2020.198043', 'journal-title': 'China Virus Res'}, { 'key': '3124_CR4', 'doi-asserted-by': 'publisher', 'first-page': '9', 'DOI': '10.1093/pcmedi/pbaa004', 'volume': '3', 'author': 'K Diao', 'year': '2020', 'unstructured': 'Diao K, Han P, Pang T et al (2020) HRCT imaging features in ' 'representative imported cases of 2019 novel coronavirus pneumonia. ' 'Precis Clin Med 3:9–13. https://doi.org/10.1093/pcmedi/pbaa004', 'journal-title': 'Precis Clin Med'}, { 'key': '3124_CR5', 'doi-asserted-by': 'publisher', 'first-page': '155', 'DOI': '10.1080/17474086.2021.1875813', 'volume': '14', 'author': 'S Tomo', 'year': '2021', 'unstructured': 'Tomo S, Kumar KP, Roy D et al (2021) Complement activation and ' 'coagulopathy - an ominous duo in COVID19. Expert Rev Hematol 14:155–173. ' 'https://doi.org/10.1080/17474086.2021.1875813', 'journal-title': 'Expert Rev Hematol'}, { 'key': '3124_CR6', 'doi-asserted-by': 'publisher', 'first-page': '1209', 'DOI': '10.1080/14786419.2018.1457671', 'volume': '33', 'author': 'B Stanimirovic', 'year': '2019', 'unstructured': 'Stanimirovic B, Vujovic D, Pejin B et al (2019) A contribution to the ' 'elemental profile of the leaf samples of newly developed Cabernet Franc ' 'varieties. Nat Prod Res 33:1209–1213. ' 'https://doi.org/10.1080/14786419.2018.1457671', 'journal-title': 'Nat Prod Res'}, { 'key': '3124_CR7', 'doi-asserted-by': 'publisher', 'first-page': 'E236', 'DOI': '10.3390/nu12010236', 'volume': '12', 'author': 'AF Gombart', 'year': '2020', 'unstructured': 'Gombart AF, Pierre A, Maggini S (2020) A review of micronutrients and ' 'the immune system-working in harmony to reduce the risk of infection. ' 'Nutrients 12:E236. https://doi.org/10.3390/nu12010236', 'journal-title': 'Nutrients'}, { 'key': '3124_CR8', 'doi-asserted-by': 'publisher', 'first-page': 'E1531', 'DOI': '10.3390/nu10101531', 'volume': '10', 'author': 'S Maggini', 'year': '2018', 'unstructured': 'Maggini S, Pierre A, Calder PC (2018) Immune function and micronutrient ' 'requirements change over the life course. Nutrients 10:E1531. ' 'https://doi.org/10.3390/nu10101531', 'journal-title': 'Nutrients'}, { 'key': '3124_CR9', 'doi-asserted-by': 'publisher', 'first-page': 'E5336', 'DOI': '10.1073/pnas.1513447112', 'volume': '112', 'author': 'CX Li', 'year': '2015', 'unstructured': 'Li CX, Gleason JE, Zhang SX et al (2015) Candida albicans adapts to host ' 'copper during infection by swapping metal cofactors for superoxide ' 'dismutase. Proc Natl Acad Sci U S A 112:E5336-5342. ' 'https://doi.org/10.1073/pnas.1513447112', 'journal-title': 'Proc Natl Acad Sci U S A'}, { 'key': '3124_CR10', 'doi-asserted-by': 'publisher', 'first-page': '1064S', 'DOI': '10.1093/ajcn/67.5.1064S', 'volume': '67', 'author': 'SS Percival', 'year': '1998', 'unstructured': 'Percival SS (1998) Copper and immunity. Am J Clin Nutr 67:1064S-1068S. ' 'https://doi.org/10.1093/ajcn/67.5.1064S', 'journal-title': 'Am J Clin Nutr'}, { 'key': '3124_CR11', 'doi-asserted-by': 'publisher', 'first-page': '4374', 'DOI': '10.1128/aem.59.12.4374-4376.1993', 'volume': '59', 'author': 'JL Sagripanti', 'year': '1993', 'unstructured': 'Sagripanti JL, Routson LB, Lytle CD (1993) Virus inactivation by copper ' 'or iron ions alone and in the presence of peroxide. Appl Environ ' 'Microbiol 59:4374–4376', 'journal-title': 'Appl Environ Microbiol'}, { 'key': '3124_CR12', 'first-page': '148', 'volume': '99', 'author': 'T Ishida', 'year': '2018', 'unstructured': 'Ishida T (2018) Antiviral activities of Cu2+ ions in viral prevention, ' 'replication, RNA degradation, and for antiviral efficacies of lytic ' 'virus, ROS-mediated virus, copper chelation. World Sci News 99:148–168', 'journal-title': 'World Sci News'}, { 'key': '3124_CR13', 'doi-asserted-by': 'publisher', 'first-page': '1564', 'DOI': '10.1056/NEJMc2004973', 'volume': '382', 'author': 'N van Doremalen', 'year': '2020', 'unstructured': 'van Doremalen N, Bushmaker T, Morris DH et al (2020) Aerosol and surface ' 'stability of SARS-CoV-2 as compared with SARS-CoV-1. N Engl J Med ' '382:1564–1567. https://doi.org/10.1056/NEJMc2004973', 'journal-title': 'N Engl J Med'}, { 'key': '3124_CR14', 'doi-asserted-by': 'publisher', 'first-page': '646', 'DOI': '10.1097/MCO.0b013e3283312956', 'volume': '12', 'author': 'AS Prasad', 'year': '2009', 'unstructured': 'Prasad AS (2009) Zinc: role in immunity, oxidative stress and chronic ' 'inflammation. Curr Opin Clin Nutr Metab Care 12:646–652. ' 'https://doi.org/10.1097/MCO.0b013e3283312956', 'journal-title': 'Curr Opin Clin Nutr Metab Care'}, { 'key': '3124_CR15', 'doi-asserted-by': 'publisher', 'first-page': '696', 'DOI': '10.1093/advances/nmz013', 'volume': '10', 'author': 'SA Read', 'year': '2019', 'unstructured': 'Read SA, Obeid S, Ahlenstiel C, Ahlenstiel G (2019) The role of zinc in ' 'antiviral immunity. Adv Nutr Bethesda Md 10:696–710. ' 'https://doi.org/10.1093/advances/nmz013', 'journal-title': 'Adv Nutr Bethesda Md'}, { 'key': '3124_CR16', 'doi-asserted-by': 'publisher', 'first-page': '108', 'DOI': '10.1016/j.chest.2020.06.082', 'volume': '159', 'author': 'JS Yao', 'year': '2021', 'unstructured': 'Yao JS, Paguio JA, Dee EC et al (2021) The minimal effect of zinc on the ' 'survival of hospitalized patients with COVID-19: an observational study. ' 'Chest 159:108–111. https://doi.org/10.1016/j.chest.2020.06.082', 'journal-title': 'Chest'}, { 'key': '3124_CR17', 'doi-asserted-by': 'publisher', 'DOI': '10.1371/journal.ppat.1001176', 'volume': '6', 'author': 'AJW te Velthuis', 'year': '2010', 'unstructured': 'te Velthuis AJW, van den Worm SHE, Sims AC et al (2010) Zn(2+) inhibits ' 'coronavirus and arterivirus RNA polymerase activity in vitro and zinc ' 'ionophores block the replication of these viruses in cell culture. PLoS ' 'Pathog 6:e1001176. https://doi.org/10.1371/journal.ppat.1001176', 'journal-title': 'PLoS Pathog'}, { 'key': '3124_CR18', 'doi-asserted-by': 'publisher', 'first-page': '307', 'DOI': '10.1016/j.ijid.2020.06.006', 'volume': '99', 'author': 'E Finzi', 'year': '2020', 'unstructured': 'Finzi E (2020) Treatment of SARS-CoV-2 with high dose oral zinc salts: a ' 'report on four patients. Int J Infect Dis IJID Off Publ Int Soc Infect ' 'Dis 99:307–309. https://doi.org/10.1016/j.ijid.2020.06.006', 'journal-title': 'Int J Infect Dis IJID Off Publ Int Soc Infect Dis'}, { 'key': '3124_CR19', 'doi-asserted-by': 'publisher', 'first-page': '1828', 'DOI': '10.1084/jem.20181970', 'volume': '216', 'author': 'C Kanellopoulou', 'year': '2019', 'unstructured': 'Kanellopoulou C, George AB, Masutani E et al (2019) Mg2+ regulation of ' 'kinase signaling and immune function. J Exp Med 216:1828–1842. ' 'https://doi.org/10.1084/jem.20181970', 'journal-title': 'J Exp Med'}, { 'key': '3124_CR20', 'doi-asserted-by': 'publisher', 'first-page': '1771', 'DOI': '10.1007/s12011-020-02314-5', 'volume': '199', 'author': 'M Ye', 'year': '2021', 'unstructured': 'Ye M, Li Q, Xiao L, Zheng Z (2021) Serum magnesium and fractional ' 'exhaled nitric oxide in relation to the severity in asthma-chronic ' 'obstructive pulmonary disease overlap. Biol Trace Elem Res ' '199:1771–1777. https://doi.org/10.1007/s12011-020-02314-5', 'journal-title': 'Biol Trace Elem Res'}, { 'key': '3124_CR21', 'first-page': '326', 'volume': '31', 'author': 'S Tomo', 'year': '2020', 'unstructured': 'Tomo S, Karli S, Dharmalingam K et al (2020) The clinical laboratory: a ' 'key player in diagnosis and management of COVID-19. EJIFCC 31:326–346', 'journal-title': 'EJIFCC'}, { 'key': '3124_CR22', 'doi-asserted-by': 'publisher', 'author': 'A Bahrami', 'year': '2021', 'unstructured': 'Bahrami A, Arabestani MR, Taheri M et al (2021) Exploring the role of ' 'heavy metals and their derivatives on the pathophysiology of COVID-19. ' 'Biol Trace Elem Res. https://doi.org/10.1007/s12011-021-02893-x', 'journal-title': 'Biol Trace Elem Res', 'DOI': '10.1007/s12011-021-02893-x'}, { 'key': '3124_CR23', 'doi-asserted-by': 'publisher', 'unstructured': 'Fakhrolmobasheri M, Mazaheri-Tehrani S, Kieliszek M, et al (2021) ' 'COVID-19 and selenium deficiency: a systematic review. Biol Trace Elem ' 'Res 1–12. https://doi.org/10.1007/s12011-021-02997-4', 'DOI': '10.1007/s12011-021-02997-4'}, { 'key': '3124_CR24', 'unstructured': 'Heavy metal content of a medicinal moss tea for hypertension - PubMed. ' 'https://pubmed.ncbi.nlm.nih.gov/22236074/. Accessed 11 Jan 2022'}, { 'key': '3124_CR25', 'doi-asserted-by': 'publisher', 'unstructured': 'Yadav D, Birdi A, Tomo S, et al (2021) Association of vitamin D status ' 'with COVID-19 infection and mortality in the Asia Pacific region: a ' 'cross-sectional study. Indian J Clin Biochem IJCB 1–6. ' 'https://doi.org/10.1007/s12291-020-00950-1', 'DOI': '10.1007/s12291-020-00950-1'}, { 'key': '3124_CR26', 'doi-asserted-by': 'publisher', 'unstructured': 'Dharmalingam K, Birdi A, Tomo S, et al (2021) Trace elements as ' 'immunoregulators in SARS-CoV-2 and other viral infections. Indian J Clin ' 'Biochem IJCB 1–11. https://doi.org/10.1007/s12291-021-00961-6', 'DOI': '10.1007/s12291-021-00961-6'}, { 'key': '3124_CR27', 'doi-asserted-by': 'publisher', 'first-page': '2475', 'DOI': '10.1007/s12011-020-02377-4', 'volume': '199', 'author': 'M Taheri', 'year': '2021', 'unstructured': 'Taheri M, Bahrami A, Habibi P, Nouri F (2021) A review on the serum ' 'electrolytes and trace elements role in the pathophysiology of COVID-19. ' 'Biol Trace Elem Res 199:2475–2481. ' 'https://doi.org/10.1007/s12011-020-02377-4', 'journal-title': 'Biol Trace Elem Res'}, { 'key': '3124_CR28', 'doi-asserted-by': 'publisher', 'first-page': '45', 'DOI': '10.1186/s40249-020-00662-x', 'volume': '9', 'author': 'M-Y Li', 'year': '2020', 'unstructured': 'Li M-Y, Li L, Zhang Y, Wang X-S (2020) Expression of the SARS-CoV-2 cell ' 'receptor gene ACE2 in a wide variety of human tissues. Infect Dis ' 'Poverty 9:45. https://doi.org/10.1186/s40249-020-00662-x', 'journal-title': 'Infect Dis Poverty'}, { 'key': '3124_CR29', 'doi-asserted-by': 'publisher', 'first-page': '343', 'DOI': '10.1016/j.ijid.2020.09.014', 'volume': '100', 'author': 'D Jothimani', 'year': '2020', 'unstructured': 'Jothimani D, Kailasam E, Danielraj S et al (2020) COVID-19: poor ' 'outcomes in patients with zinc deficiency. Int J Infect Dis IJID Off ' 'Publ Int Soc Infect Dis 100:343–349. ' 'https://doi.org/10.1016/j.ijid.2020.09.014', 'journal-title': 'Int J Infect Dis IJID Off Publ Int Soc Infect Dis'}, { 'key': '3124_CR30', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.nut.2021.111467', 'volume': '91–92', 'author': 'F Arrieta', 'year': '2021', 'unstructured': 'Arrieta F, Martinez-Vaello V, Bengoa N et al (2021) Serum zinc and ' 'copper in people with COVID-19 and zinc supplementation in parenteral ' 'nutrition. Nutrition 91–92:111467. ' 'https://doi.org/10.1016/j.nut.2021.111467', 'journal-title': 'Nutrition'}, { 'key': '3124_CR31', 'doi-asserted-by': 'publisher', 'first-page': '3608', 'DOI': '10.1007/s12011-020-02496-y', 'volume': '199', 'author': 'AT Anuk', 'year': '2021', 'unstructured': 'Anuk AT, Polat N, Akdas S et al (2021) The relation between trace ' 'element status (zinc, copper, magnesium) and clinical outcomes in ' 'COVID-19 infection during pregnancy. Biol Trace Elem Res 199:3608–3617. ' 'https://doi.org/10.1007/s12011-020-02496-y', 'journal-title': 'Biol Trace Elem Res'}, { 'key': '3124_CR32', 'doi-asserted-by': 'publisher', 'first-page': '1228', 'DOI': '10.1099/jmm.0.001250', 'volume': '69', 'author': 'PM Carlucci', 'year': '2020', 'unstructured': 'Carlucci PM, Ahuja T, Petrilli C et al (2020) Zinc sulfate in ' 'combination with a zinc ionophore may improve outcomes in hospitalized ' 'COVID-19 patients. J Med Microbiol 69:1228–1234. ' 'https://doi.org/10.1099/jmm.0.001250', 'journal-title': 'J Med Microbiol'}, { 'key': '3124_CR33', 'doi-asserted-by': 'publisher', 'unstructured': 'Muhammad Y, Kani YA, Iliya S, et al (2021) Deficiency of antioxidants ' 'and increased oxidative stress in COVID-19 patients: a cross-sectional ' 'comparative study in Jigawa, Northwestern Nigeria. SAGE Open Med ' '9:2050312121991246. https://doi.org/10.1177/2050312121991246', 'DOI': '10.1177/2050312121991246'}, { 'key': '3124_CR34', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.envres.2020.110670', 'volume': '194', 'author': 'H-L Zeng', 'year': '2021', 'unstructured': 'Zeng H-L, Zhang B, Wang X et al (2021) Urinary trace elements in ' 'association with disease severity and outcome in patients with COVID-19. ' 'Environ Res 194:110670. https://doi.org/10.1016/j.envres.2020.110670', 'journal-title': 'Environ Res'}, { 'key': '3124_CR35', 'doi-asserted-by': 'publisher', 'first-page': '22', 'DOI': '10.1007/s12011-017-1039-6', 'volume': '181', 'author': 'X Chen', 'year': '2018', 'unstructured': 'Chen X, Li Y, Zhang T et al (2018) Association of serum trace elements ' 'with schizophrenia and effects of antipsychotic treatment. Biol Trace ' 'Elem Res 181:22–30. https://doi.org/10.1007/s12011-017-1039-6', 'journal-title': 'Biol Trace Elem Res'}, { 'key': '3124_CR36', 'doi-asserted-by': 'publisher', 'first-page': '1684', 'DOI': '10.1128/IAI.03015-14', 'volume': '83', 'author': 'MDL Johnson', 'year': '2015', 'unstructured': 'Johnson MDL, Kehl-Fie TE, Klein R et al (2015) Role of copper efflux in ' 'pneumococcal pathogenesis and resistance to macrophage-mediated immune ' 'clearance. Infect Immun 83:1684–1694. ' 'https://doi.org/10.1128/IAI.03015-14', 'journal-title': 'Infect Immun'}, { 'key': '3124_CR37', 'doi-asserted-by': 'publisher', 'first-page': '90', 'DOI': '10.1016/j.clnesp.2020.09.022', 'volume': '40', 'author': 'S Fooladi', 'year': '2020', 'unstructured': 'Fooladi S, Matin S, Mahmoodpoor A (2020) Copper as a potential adjunct ' 'therapy for critically ill COVID-19 patients. Clin Nutr ESPEN 40:90–91. ' 'https://doi.org/10.1016/j.clnesp.2020.09.022', 'journal-title': 'Clin Nutr ESPEN'}, { 'key': '3124_CR38', 'doi-asserted-by': 'publisher', 'first-page': '1898', 'DOI': '10.3390/nu13061898', 'volume': '13', 'author': 'J Hackler', 'year': '2021', 'unstructured': 'Hackler J, Heller RA, Sun Q et al (2021) Relation of serum copper status ' 'to survival in COVID-19. Nutrients 13:1898. ' 'https://doi.org/10.3390/nu13061898', 'journal-title': 'Nutrients'}, { 'key': '3124_CR39', 'doi-asserted-by': 'publisher', 'first-page': '1149', 'DOI': '10.1007/s10654-020-00644-1', 'volume': '35', 'author': 'JT Laine', 'year': '2020', 'unstructured': 'Laine JT, Tuomainen T-P, Salonen JT, Virtanen JK (2020) Serum ' 'copper-to-zinc-ratio and risk of incident infection in men: the Kuopio ' 'Ischaemic Heart Disease Risk Factor Study. Eur J Epidemiol 35:1149–1156. ' 'https://doi.org/10.1007/s10654-020-00644-1', 'journal-title': 'Eur J Epidemiol'}, { 'key': '3124_CR40', 'doi-asserted-by': 'publisher', 'first-page': '37', 'DOI': '10.1016/j.semcdb.2020.11.002', 'volume': '115', 'author': 'JA Maier', 'year': '2021', 'unstructured': 'Maier JA, Castiglioni S, Locatelli L et al (2021) Magnesium and ' 'inflammation: advances and perspectives. Semin Cell Dev Biol 115:37–44. ' 'https://doi.org/10.1016/j.semcdb.2020.11.002', 'journal-title': 'Semin Cell Dev Biol'}, { 'key': '3124_CR41', 'doi-asserted-by': 'publisher', 'first-page': '21', 'DOI': '10.1684/mrh.2020.0465', 'volume': '33', 'author': 'S Iotti', 'year': '2020', 'unstructured': 'Iotti S, Wolf F, Mazur A, Maier JA (2020) The COVID-19 pandemic: is ' 'there a role for magnesium? Hypotheses and perspectives. Magnes Res ' '33:21–27. https://doi.org/10.1684/mrh.2020.0465', 'journal-title': 'Magnes Res'}, { 'key': '3124_CR42', 'doi-asserted-by': 'publisher', 'DOI': '10.1096/fj.202002346RR', 'volume': '35', 'author': 'H-L Zeng', 'year': '2021', 'unstructured': 'Zeng H-L, Yang Q, Yuan P et al (2021) Associations of essential and ' 'toxic metals/metalloids in whole blood with both disease severity and ' 'mortality in patients with COVID-19. FASEB J Off Publ Fed Am Soc Exp ' 'Biol 35:e21392. https://doi.org/10.1096/fj.202002346RR', 'journal-title': 'FASEB J Off Publ Fed Am Soc Exp Biol'}, { 'key': '3124_CR43', 'doi-asserted-by': 'publisher', 'first-page': '230', 'DOI': '10.1016/j.ijid.2020.09.008', 'volume': '100', 'author': 'Y Yasui', 'year': '2020', 'unstructured': 'Yasui Y, Yasui H, Suzuki K et al (2020) Analysis of the predictive ' 'factors for a critical illness of COVID-19 during treatment - ' 'relationship between serum zinc level and critical illness of COVID-19. ' 'Int J Infect Dis IJID Off Publ Int Soc Infect Dis 100:230–236. ' 'https://doi.org/10.1016/j.ijid.2020.09.008', 'journal-title': 'Int J Infect Dis IJID Off Publ Int Soc Infect Dis'}, { 'key': '3124_CR44', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.redox.2020.101764', 'volume': '38', 'author': 'RA Heller', 'year': '2021', 'unstructured': 'Heller RA, Sun Q, Hackler J et al (2021) Prediction of survival odds in ' 'COVID-19 by zinc, age and selenoprotein P as composite biomarker. Redox ' 'Biol 38:101764. https://doi.org/10.1016/j.redox.2020.101764', 'journal-title': 'Redox Biol'}], 'container-title': ['Biological Trace Element Research'], 'original-title': [], 'language': 'en', 'link': [ { 'URL': 'https://link.springer.com/content/pdf/10.1007/s12011-022-03124-7.pdf', 'content-type': 'application/pdf', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': 'https://link.springer.com/article/10.1007/s12011-022-03124-7/fulltext.html', 'content-type': 'text/html', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': 'https://link.springer.com/content/pdf/10.1007/s12011-022-03124-7.pdf', 'content-type': 'application/pdf', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'deposited': { 'date-parts': [[2022, 1, 22]], 'date-time': '2022-01-22T06:48:41Z', 'timestamp': 1642834121000}, 'score': 1, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2022, 1, 22]]}, 'references-count': 44, 'alternative-id': ['3124'], 'URL': 'http://dx.doi.org/10.1007/s12011-022-03124-7', 'relation': {}, 'ISSN': ['0163-4984', '1559-0720'], 'issn-type': [{'value': '0163-4984', 'type': 'print'}, {'value': '1559-0720', 'type': 'electronic'}], 'subject': [ 'Biochemistry (medical)', 'Inorganic Chemistry', 'Clinical Biochemistry', 'General Medicine', 'Biochemistry', 'Endocrinology, Diabetes and Metabolism'], 'published': {'date-parts': [[2022, 1, 22]]}, 'assertion': [ { 'value': '21 December 2021', 'order': 1, 'name': 'received', 'label': 'Received', 'group': {'name': 'ArticleHistory', 'label': 'Article History'}}, { 'value': '17 January 2022', 'order': 2, 'name': 'accepted', 'label': 'Accepted', 'group': {'name': 'ArticleHistory', 'label': 'Article History'}}, { 'value': '22 January 2022', 'order': 3, 'name': 'first_online', 'label': 'First Online', 'group': {'name': 'ArticleHistory', 'label': 'Article History'}}, {'order': 1, 'name': 'Ethics', 'group': {'name': 'EthicsHeading', 'label': 'Declarations'}}, { 'value': 'This study was performed in line with the principles of the Declaration of ' 'Helsinki. Approval was granted by the institutional ethics committee.', 'order': 2, 'name': 'Ethics', 'group': {'name': 'EthicsHeading', 'label': 'Ethics Approval'}}, { 'value': 'All participants has freely given informed consent to participate in the study.', 'order': 3, 'name': 'Ethics', 'group': {'name': 'EthicsHeading', 'label': 'Consent to Participate'}}, { 'value': 'The authors declare no competing interests.', 'order': 4, 'name': 'Ethics', 'group': {'name': 'EthicsHeading', 'label': 'Competing Interests'}}, { 'value': 'This content has been made available to all.', 'name': 'free', 'label': 'Free to read'}]}