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Serum zinc and copper in people with COVID-19 and zinc supplementation in parenteral nutrition

Arrieta et al., Nutrition, doi:10.1016/j.nut.2021.111467
Aug 2021  
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Zinc for COVID-19
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*, now known with p = 0.0000027 from 43 studies, recognized in 10 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
3,800+ studies for 60+ treatments.
Retrospective 35 COVID-19 patients on parenteral nutrition on Spain, showing serum zinc levels inversely associated with length of hospital stay. There was no significant association between zinc and mortality (p>0.1, actual results are not provided).
Arrieta et al., 31 Aug 2021, peer-reviewed, 13 authors.
This PaperZincAll
Serum zinc and copper in people with COVID-19 and zinc supplementation in parenteral nutrition
M.D Francisco Arrieta, Victoria Martinez-Vaello, Nuria Bengoa, Lucía Jiménez-Mendiguchia, M.D Marta Rosillo, Angélica De Pablo, M.D. d Cristina Voguel, Hilario Martinez-Barros, Rosario Pintor, M.D Amaya Belanger-Quintana, Ph.D. f Raquel Mateo, M.D. d , Jos Angel Candela, José I Botella-Carretero
Nutrition, doi:10.1016/j.nut.2021.111467
Zinc and copper are important to protect cells from oxidative stress and to enhance immunity. An association between low zinc levels and the severity of acute respiratory distress syndrome has been shown for people with COVID-19. We aimed to study serum zinc and copper concentrations in people with severe COVID-19 and zinc supplementation in parenteral nutrition (PN). Methods: Thirty-five people with COVID-19 in need of PN were studied in a retrospective design. Serum samples were collected at three time points: at the start of PN, between 3 and 7 d after, and at the end of PN. Results: Participants were on PN for a mean of 14 d, with a mean ( § SD) daily supplemental zinc of 14.8 § 3.7 mg/d. Serum zinc increased during PN administration from 98.8 § 22.8 to 114.1 § 23.3 mg/dL (Wilks' l = 0.751, F = 5.459, P = 0.009). Conversely, serum copper did not vary from baseline (107.9 § 34.2 mg/dL) to the end of the study (104.5 § 37.4 mg/dL, Wilks' l = 0.919, F = 1.453, P = 0.248). Serum zinc within the first week after starting PN and at the end of PN inversely correlated with total hospital stay (r = À0.413, P = 0.014, and r = À0.386, P = 0.022, respectively). Participants in critical condition presented lower serum copper (z = 2.615, P = 0.007). Mortality was not associated with supplemental zinc or with serum zinc or copper concentrations at any time of the study (P > 0.1 for all analyses). Conclusions: Serum zinc concentrations during PN support were inversely associated with length of hospital stay but not with mortality. Serum copper concentrations were lower in participants in critical condition but not associated with prognosis.
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