Analgesics
Antiandrogens
Azvudine
Bromhexine
Budesonide
Colchicine
Conv. Plasma
Curcumin
Famotidine
Favipiravir
Fluvoxamine
Hydroxychlor..
Ivermectin
Lifestyle
Melatonin
Metformin
Minerals
Molnupiravir
Monoclonals
Naso/orophar..
Nigella Sativa
Nitazoxanide
Paxlovid
Quercetin
Remdesivir
Thermotherapy
Vitamins
More

Other
Feedback
Home
Top
Abstract
All zinc studies
Meta analysis
 
Feedback
Home
next
study
previous
study
c19early.org COVID-19 treatment researchZincZinc (more..)
Melatonin Meta
Metformin Meta
Azvudine Meta
Bromhexine Meta Molnupiravir Meta
Budesonide Meta
Colchicine Meta
Conv. Plasma Meta Nigella Sativa Meta
Curcumin Meta Nitazoxanide Meta
Famotidine Meta Paxlovid Meta
Favipiravir Meta Quercetin Meta
Fluvoxamine Meta Remdesivir Meta
Hydroxychlor.. Meta Thermotherapy Meta
Ivermectin Meta

All Studies   Meta Analysis    Recent:   

Serum zinc and copper in people with COVID-19 and zinc supplementation in parenteral nutrition

Arrieta et al., Nutrition, doi:10.1016/j.nut.2021.111467
Aug 2021  
  Post
  Facebook
Share
  Source   PDF   All Studies   Meta AnalysisMeta
Zinc for COVID-19
2nd treatment shown to reduce risk in July 2020
 
*, now known with p = 0.0000027 from 43 studies, recognized in 10 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
3,800+ studies for 60+ treatments. c19early.org
Retrospective 35 COVID-19 patients on parenteral nutrition on Spain, showing serum zinc levels inversely associated with length of hospital stay. There was no significant association between zinc and mortality (p>0.1, actual results are not provided).
Arrieta et al., 31 Aug 2021, peer-reviewed, 13 authors.
This PaperZincAll
Serum zinc and copper in people with COVID-19 and zinc supplementation in parenteral nutrition
M.D Francisco Arrieta, Victoria Martinez-Vaello, Nuria Bengoa, Lucía Jiménez-Mendiguchia, M.D Marta Rosillo, Angélica De Pablo, M.D. d Cristina Voguel, Hilario Martinez-Barros, Rosario Pintor, M.D Amaya Belanger-Quintana, Ph.D. f Raquel Mateo, M.D. d , Jos Angel Candela, José I Botella-Carretero
Nutrition, doi:10.1016/j.nut.2021.111467
Zinc and copper are important to protect cells from oxidative stress and to enhance immunity. An association between low zinc levels and the severity of acute respiratory distress syndrome has been shown for people with COVID-19. We aimed to study serum zinc and copper concentrations in people with severe COVID-19 and zinc supplementation in parenteral nutrition (PN). Methods: Thirty-five people with COVID-19 in need of PN were studied in a retrospective design. Serum samples were collected at three time points: at the start of PN, between 3 and 7 d after, and at the end of PN. Results: Participants were on PN for a mean of 14 d, with a mean ( § SD) daily supplemental zinc of 14.8 § 3.7 mg/d. Serum zinc increased during PN administration from 98.8 § 22.8 to 114.1 § 23.3 mg/dL (Wilks' l = 0.751, F = 5.459, P = 0.009). Conversely, serum copper did not vary from baseline (107.9 § 34.2 mg/dL) to the end of the study (104.5 § 37.4 mg/dL, Wilks' l = 0.919, F = 1.453, P = 0.248). Serum zinc within the first week after starting PN and at the end of PN inversely correlated with total hospital stay (r = À0.413, P = 0.014, and r = À0.386, P = 0.022, respectively). Participants in critical condition presented lower serum copper (z = 2.615, P = 0.007). Mortality was not associated with supplemental zinc or with serum zinc or copper concentrations at any time of the study (P > 0.1 for all analyses). Conclusions: Serum zinc concentrations during PN support were inversely associated with length of hospital stay but not with mortality. Serum copper concentrations were lower in participants in critical condition but not associated with prognosis.
References
Alexander, Tinkov, Strand, Alehagen, Skalny et al., Early nutritional interventions with zinc, selenium and vitamin D for raising anti-viral resistance against progressive COVID-19, Nutrients
Berger, Baines, Raffoul, Benathan, Chiolero et al., Trace element supplementation after major burns modulates antioxidant status and clinical course by way of increased tissue trace element concentrations, Am J Clin Nutr
Berger, Binnert, Chiolero, Taylor, Raffoul et al., Trace element supplementation after major burns increases burned skin trace element concentrations and modulates local protein metabolism but not whole-body substrate metabolism, Am J Clin Nutr
Besecker, Exline, Hollyfield, Phillips, Disilvestro et al., A comparison of zinc metabolism, inflammation, and disease severity in critically ill infected and noninfected adults early after intensive care unit admission, Am J Clin Nutr
Cvijanovich, King, Flori, Gildengorin, Wong, Zinc homeostasis in pediatric critical illness, Pediatr Crit Care Med
Florea, Molina-Lopez, Hogstrand, Lengyel, De La Cruz et al., Changes in zinc status and zinc transporters expression in whole blood of patients with Systemic Inflammatory Response Syndrome (SIRS), J Trace Elem Med Biol
Fooladi, Matin, Mahmoodpoor, Copper as a potential adjunct therapy for critically ill COVID-19 patients, Clin Nutr ESPEN
Gonçalves, Gonçalves, Guarnieri, Risegato, Guimarães et al., Association between low zinc levels and severity of acute respiratory distress syndrome by new coronavirus (SARS-CoV-2), Nutr Clin Pract
Hellman, Gitlin, Ceruloplasmin metabolism and function, Annu Rev Nutr
Heyland, Jones, Cvijanovich, Wong, Zinc supplementation in critically ill patients: a key pharmaconutrient?, JPEN J Parenter Enteral Nutr
Kachur, Koch, Biaglow, Mechanism of copper-catalyzed oxidation of glutathione, Free Radic Res
Kerns, Zigo, Sutovsky, Zinc: a necessary ion for mammalian sperm fertilization competency, Int J Mol Sci
Kvamme, Gronli, Jacobsen, Florholmen, Risk of malnutrition and zinc deficiency in community-living elderly men and women: the Tromso Study, Public Health Nutr
Laviano, Koverech, Zanetti, Nutrition support in the time of SARS-CoV-2 (COVID-19), Nutrition
Lee, Bang, Lee, Lee, Kang et al., Serum concentrations of trace elements zinc, copper, selenium, and manganese in critically ill patients, Biol Trace Elem Res
Lee, Critical role of zinc as either an antioxidant or a prooxidant in cellular systems, Oxid Med Cell Longev
Lichten, Cousins, Mammalian zinc transporters: nutritional and physiologic regulation, Annu Rev Nutr
Linko, Karlsson, Pettila, Varpula, Okkonen et al., Serum zinc in critically ill adult patients with acute respiratory failure, Acta Anaesthesiol Scand
Madjid, Safavi-Naeini, Solomon, Vardeny, Potential effects of coronaviruses on the cardiovascular system: a review, JAMA Cardiol
Mossink, Zinc as nutritional intervention and prevention measure for COVID-19 disease, BMJ Nutr Prev Health
Razzaque, COVID-19 pandemic: can zinc supplementation provide an additional shield against the infection?, Comput Struct Biotechnol J
Read, Obeid, Ahlenstiel, Ahlenstiel, The role of zinc in antiviral immunity, Adv Nutr
Rech, To, Tovbin, Smoot, Mlynarek, Heavy metal in the intensive care unit: a review of current literature on trace element supplementation in critically ill patients, Nutr Clin Pract
Ruocco, Cechinatti, Barbosa, Navarro, Zinc and selenium status in critically ill patients according to severity stratification, Nutrition
Singer, Blaser, Berger, Alhazzani, Calder et al., ESPEN guideline on clinical nutrition in the intensive care unit, Clin Nutr
Stefanowicz, Gashut, Talwar, Duncan, Beulshausen et al., Assessment of plasma and red cell trace element concentrations, disease severity, and outcome in patients with critical illness, J Crit Care
Wang, Hu, Hu, Zhu, Liu et al., Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China, JAMA
Zhou, Yu, Du, Fan, Liu et al., Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study, Lancet
Late treatment
is less effective
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Vaccines and treatments are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment, vaccine, or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop   
Submit