Early Hydroxychloroquine Is Associated with an Increase of Survival in COVID-19 Patients: An Observational Study
Francisco Javier Membrillo, Germán Ramírez-Olivencia, Miriam Estébanez, Begoña De Dios, María Dolores Herrero, Tatiana Mata, Alberto M Borobia, Carlos Gutiérrez, María Simón, Ana Ochoa, Yolanda Martínez, Alejandro Aguirre, Francisco De Asís Alcántara, Pablo Fernández-González, Elena López, Paula Valle, Sergio Campos, María Navarro, Lucía Elena Ballester
doi:10.20944/preprints202005.0057.v2
Hydroxychloroquine has shown in vitro activity against SARS-CoV-2. Here we present an observational study. We analysed data from 164 patients admitted to our hospital diagnosed with COVID-19. Hydroxychloroquine treatment was associated with an increase in the mean cumulative survival.
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doi:10.1182/bloodadvances.2020001907{ 'indexed': {'date-parts': [[2024, 3, 3]], 'date-time': '2024-03-03T11:38:36Z', 'timestamp': 1709465916640},
'posted': {'date-parts': [[2020, 5, 5]]},
'group-title': 'MEDICINE & PHARMACOLOGY',
'reference-count': 0,
'publisher': 'MDPI AG',
'license': [ { 'start': { 'date-parts': [[2020, 5, 5]],
'date-time': '2020-05-05T00:00:00Z',
'timestamp': 1588636800000},
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'abstract': '<jats:p>Background: There is no treatment proven effective against COVID-19. Several drugs '
'with in vitro potential against SARS-CoV-2 virus have been proposed. Hydroxychloroquine has '
'in vitro anti-viral and immunomodulatory activity, but there is no current clinical evidence '
'of its effectiveness changing the outcome of the disease. Methods: We enrolled all 18-85 '
'years old inpatients from Central Defense Hospital &ldquo;G&oacute;mez '
'Ulla&rdquo;, Madrid, Spain, who were hospitalised for COVID-19 and had a definitive '
'outcome (dead or discharged). We used a statistical survival analysis to detect treatment '
'differences associated with in-hospital death. Results: We analysed first 220 medical '
'records. 166 patients met the inclusion criteria. 48,8 % of patients not treated with HCQ '
'died, 22% of those treated with hydroxychloroquine (p=0,002). According to clinical picture '
'at admission, hydroxychloroquine increased the mean cumulative survival in all groups from '
'1,4 to 1,8 times. This difference was statistically significant in the mild group. '
'Conclusions: in a cohort of 166 patients from 18 to 85 years hospitalised with COVID-19, '
'hydroxychloroquine treatment with 800mg added loading dose increased survival when patients '
'were admitted in early stages of the disease. There was a non-statistically significant trend '
'towards survival in all groups, which will have to be clarified in subsequent '
'studies.</jats:p>',
'DOI': '10.20944/preprints202005.0057.v1',
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'source': 'Crossref',
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'title': 'Early Hydroxychloroquine Is Associated with an Increase of Survival in COVID-19 Patients: An '
'Observational Study',
'prefix': '10.20944',
'author': [ { 'given': 'Francisco Javier',
'family': 'Membrillo de Novales',
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{'given': 'Germán', 'family': 'Ramírez-Olivencia', 'sequence': 'additional', 'affiliation': []},
{'given': 'Miriam', 'family': 'Estébanez', 'sequence': 'additional', 'affiliation': []},
{'given': 'Begoña', 'family': 'de Dios', 'sequence': 'additional', 'affiliation': []},
{'given': 'María Dolores', 'family': 'Herrero', 'sequence': 'additional', 'affiliation': []},
{'given': 'Tatiana', 'family': 'Mata', 'sequence': 'additional', 'affiliation': []},
{'given': 'Alberto M.', 'family': 'Borobia', 'sequence': 'additional', 'affiliation': []},
{'given': 'Carlos', 'family': 'Gutiérrez', 'sequence': 'additional', 'affiliation': []},
{'given': 'María', 'family': 'Simón', 'sequence': 'additional', 'affiliation': []},
{'given': 'Ana', 'family': 'Ochoa', 'sequence': 'additional', 'affiliation': []},
{'given': 'Yolanda', 'family': 'Martínez', 'sequence': 'additional', 'affiliation': []},
{'given': 'Alejandro', 'family': 'Aguirre', 'sequence': 'additional', 'affiliation': []},
{ 'given': 'Francisco de Asís',
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{'given': 'Pablo', 'family': 'Fernández-González', 'sequence': 'additional', 'affiliation': []},
{'given': 'Elena', 'family': 'López', 'sequence': 'additional', 'affiliation': []},
{'given': 'Sergio', 'family': 'Campos', 'sequence': 'additional', 'affiliation': []},
{'given': 'María', 'family': 'Navarro', 'sequence': 'additional', 'affiliation': []},
{'given': 'Lucía Elena', 'family': 'Ballester', 'sequence': 'additional', 'affiliation': []}],
'member': '1968',
'container-title': [],
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'deposited': { 'date-parts': [[2020, 5, 11]],
'date-time': '2020-05-11T10:44:34Z',
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