Association of serum vitamin D concentration with the final course of hospitalization in patients with COVID-19
Klaudia Konikowska, Katarzyna Kiliś-Pstrusińska, Agnieszka Matera-Witkiewicz, Krzysztof Kujawa, Barbara Adamik, Adrian Doroszko, Krzysztof Kaliszewski, Michał Pomorski, Marcin Protasiewicz, Janusz Sokołowski, Katarzyna Madziarska, Ewa Anita Jankowska
Frontiers in Immunology, doi:10.3389/fimmu.2023.1231813
Background: Vitamin D deficiency is a substantial public health problem. The present study evaluated the association between vitamin D concentration and hospitalization and mortality risk in patients with coronavirus disease 19 . Methods: This study used the COronavirus in LOwer Silesia (COLOS) dataset collected between February 2020 and June 2021. The medical records of 474 patients with confirmed severe acute respiratory syndrome 2 (SARS-CoV-2) infection, and whose vitamin D concentration was measured, were analyzed. Results: We determined a significant difference in vitamin D concentration between discharged patients and those who died during hospitalization (p = 0.0096). We also found an effect of vitamin D concentration on the risk of death in patients hospitalized due to COVID-19. As vitamin D concentration increased, the odds ratio (OR) for death slightly decreased (OR = 0.978; 95% confidence interval [CI] = 0.540-0.669). The vitamin D concentration cutoff point was 15.40 ng/ml. In addition, patients with COVID-19 and serum 25-hydroxyvitamin D (25 (OH)D) concentrations < 30 ng/ml had a lower survival rate than those with Frontiers in Immunology frontiersin.org 01
Ethics statement The studies involving humans were approved by The Institutional Review Board and Bioethics Committee of Wroclaw Medical University, Poland (No: KB-444/2021). The studies were conducted in accordance with the local legislation and institutional requirements. Written informed consent for participation was not required from the participants or the participants' legal guardians/ next of kin because The data were collected retrospectively, and written informed consent to participate in the study was not required. The Bioethics Committee approved the publication of anonymized data.
Author contributions KK-P and KKo contributed to the conception and design of the study. KK-P, KKo, and KKu contributed to the methodology of the study. KKu performed the statistical analysis. KKo, KK-P, AM-W, KKu, BA, AD, KKa, MPo, MPr, JS, KM, and EJ conducted research, investigation process, and data curation of the study. KKo and KK-P wrote the first draft of the manuscript. KKu and AM-W wrote sections of the manuscript. KM and EJ supervised the study. All authors contributed to the article and approved the submitted version.
Conflict of interest The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Publisher's note All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or..
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