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All Studies   Meta Analysis    Recent:   

Androgen Deprivation Therapy in Men with Prostate Cancer Does Not Affect Risk of Infection with SARS-CoV-2

Klein et al., Journal of Urology, doi:10.1097/JU.0000000000001338
Feb 2021  
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Mortality -124% Improvement Relative Risk Case 7% Antiandrogens for COVID-19  Klein et al.  Prophylaxis Is prophylaxis with antiandrogens beneficial for COVID-19? Retrospective 1,779 patients in the USA (March - June 2020) Higher mortality with antiandrogens (not stat. sig., p=0.12) c19early.org Klein et al., J. Urology, February 2021 Favorsvarious Favorscontrol 0 0.5 1 1.5 2+
7th treatment shown to reduce risk in September 2020
 
*, now with p = 0.000000056 from 49 studies.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,500+ studies for 81 treatments. c19early.org
Retrospective 1,779 prostate cancer patients, showing no significant differences in COVID-19 outcomes with ADT.
risk of death, 123.9% higher, RR 2.24, p = 0.12, treatment 6 of 304 (2.0%), control 13 of 1,475 (0.9%).
risk of case, 6.6% lower, RR 0.93, p = 0.80, treatment 17 of 304 (5.6%), control 85 of 1,475 (5.8%), NNT 586, adjusted per study, odds ratio converted to relative risk, multivariable.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Klein et al., 1 Feb 2021, retrospective, USA, peer-reviewed, 7 authors, study period 12 March, 2020 - 10 June, 2020.
This PaperAntiandrogensAll
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