Effect of the povidone iodine, hypertonic alkaline solution and saline nasal lavage on nasopharyngeal viral load in COVID-19

DOI record: { "DOI": "10.22541/au.166675335.56566797/v1", "URL": "http://dx.doi.org/10.22541/au.166675335.56566797/v1", "abstract": "<jats:p id=\"p1\">Objective: The causative virus of COVID-19 is SARS-CoV-2. The aim of the\npresent study was to invastigate the in vivo virucidal activity of nasal\nirrigation with saline, nasal irrigation with Povidone-iodine (PVP-I)\n1%, nasal irrigation with hypertonic alkaline and nasal irrigation with\nPVP-I 1% against SARS CoV- 2. Design: The present study was a\nprospective randomized clinical trial. Setting: A multicenter study\ninvolving tertiary care centers. Participants: The study included adult\noutpatients whose qualitative SARS-CoV-2 RT-PCR tests in nasopharyngeal\nswabs were positive. One hundred twenty patients divided into four equal\ngroups. Standard COVID-19 treatment was given to group 1 (n=30), nasal\nirrigation containing isotonic solution was added to patients’ treatment\nin group 2 (n=30), nasal irrigation containing 1% PVP solution was\nadded to patients’ treatment in group 3(n=30), and nasal irrigation\ncontaining 1% PVP solution and nasal irrigation containing hypertonic\nalkaline solution was added to patients’ treatment in group 4 (n=30).\nMain outcome measures: On the first day of diagnosis (day 0),\nnasopharyngeal swab samples were taken, on the 3rd and 5th days the\nnasopharyngeal viral load reduction in quantitative RT-PCR tests were\ncalculated. Results: Between the 0-3rd Day and 0-5th days, the\nnasopharyngeal viral load reduction was significant in all groups\n(p&lt; .05). In paired comparisons of groups, the nasopharyngeal\nviral load decrease in group 4 in first 3 days was significantly lower\nthan all groups (p &lt; .05). The nasopharyngeal viral load\ndegrease in groups 3 and 4 in the first 5 days were significantly lower\nthan group 1 (p &lt; .05). Conclussion: This study was reveal\nthat the use of hypertonic alkaline nasal irrigation together with 1%\npovidone-iodine was more effective in reducing viral load in the early\nperiod. The decreased nasopharyngeal viral load may reduce the carriage\nof infectious SARS-CoV-2 in patients. Our results suggest that 1%\npovidone-iodine and hypertonic alkaline nasal irrigation may be\npromising modality to prevent the COVID-19 epidemic.</jats:p>", "accepted": { "date-parts": [ [ 2022, 10, 26 ] ] }, "author": [ { "ORCID": "http://orcid.org/0000-0002-8620-4375", "affiliation": [ { "name": "Istanbul University" } ], "authenticated-orcid": true, "family": "Karaaltin", "given": "Aysegul", "sequence": "first" }, { "affiliation": [ { "name": "istanbul education and research hospital" } ], "family": "yigit", "given": "ozgur", "sequence": "additional" }, { "affiliation": [ { "name": "Istanbul University-Cerrahpasa" } ], "family": "cakan", "given": "dogan", "sequence": "additional" }, { "affiliation": [ { "name": "Istanbul Aydin Universitesi" } ], "family": "akgül", "given": "özer", "sequence": "additional" }, { "affiliation": [ { "name": "Istanbul Teaching and Research Hospital" } ], "family": "Yiğit", "given": "Enes", "sequence": "additional" }, { "affiliation": [ { "name": "İstanbul Üniversitesi-Cerrahpaşa" } ], "family": "yılmaz", "given": "yetkin zeki", "sequence": "additional" }, { "affiliation": [ { "name": "Istanbul Universitesi-Cerrahpasa" } ], "family": "Çakır", "given": "Kays Burak", "sequence": "additional" }, { "affiliation": [ { "name": "İstanbul Üniversitesi-Cerrahpaşa" } ], "family": "çiftçi", "given": "gamze", "sequence": "additional" }, { "affiliation": [ { "name": "Istanbul Teaching and Research Hospital" } ], "family": "Seden", "given": "Nihal", "sequence": "additional" }, { "affiliation": [ { "name": "Istanbul Teaching and Research Hospital" } ], "family": "çağlıyan", "given": "abdurrahman", "sequence": "additional" }, { "affiliation": [ { "name": "Istanbul Teaching and Research Hospital" } ], "family": "Can", "given": "Efe", "sequence": "additional" }, { "affiliation": [ { "name": "Istanbul Education Research Hospital" } ], "family": "dikme", "given": "özgür", "sequence": "additional" }, { "affiliation": [ { "name": "Istanbul Teaching and Research Hospital" } ], "family": "hacıoğlu", "given": "yalçın", "sequence": "additional" }, { "affiliation": [ { "name": "İstanbul Üniversitesi-Cerrahpaşa" } ], "family": "balkan", "given": "ilker inanç", "sequence": "additional" }, { "affiliation": [ { "name": "Istanbul Aydin Universitesi" } ], "family": "enver", "given": "özgün", "sequence": "additional" }, { "affiliation": [ { "name": "Istanbul University Cerrahpasa Medical Faculty" } ], "family": "Ozdogan", "given": "Ahmet", "sequence": "additional" } ], "container-title": [], "content-domain": { "crossmark-restriction": false, "domain": [] }, "created": { "date-parts": [ [ 2022, 10, 26 ] ], "date-time": "2022-10-26T03:02:41Z", "timestamp": 1666753361000 }, "deposited": { "date-parts": [ [ 2022, 10, 26 ] ], "date-time": "2022-10-26T03:02:42Z", "timestamp": 1666753362000 }, "group-title": "Preprints", "indexed": { "date-parts": [ [ 2022, 10, 27 ] ], "date-time": "2022-10-27T05:09:14Z", "timestamp": 1666847354285 }, "institution": [ { "name": "Authorea, Inc." } ], "is-referenced-by-count": 0, "issued": { "date-parts": [ [ 2022, 10, 26 ] ] }, "member": "9829", "original-title": [], "posted": { "date-parts": [ [ 2022, 10, 26 ] ] }, "prefix": "10.22541", "published": { "date-parts": [ [ 2022, 10, 26 ] ] }, "publisher": "Authorea, Inc.", "reference-count": 0, "references-count": 0, "relation": {}, "resource": { "primary": { "URL": "https://www.authorea.com/users/337860/articles/592062-effect-of-the-povidone-iodine-hypertonic-alkaline-solution-and-saline-nasal-lavage-on-nasopharyngeal-viral-load-in-covid-19?commit=bcb03d2ad8d86742ebd473271b70f5ab7211094d" } }, "score": 1, "short-title": [], "source": "Crossref", "subtitle": [], "subtype": "preprint", "title": "EFFECT OF THE POVIDONE IODINE, HYPERTONIC ALKALINE SOLUTION AND SALINE NASAL LAVAGE ON NASOPHARYNGEAL VIRAL LOAD IN COVID-19", "type": "posted-content" }