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All Studies   Meta Analysis    Recent:   

Effect of the povidone iodine, hypertonic alkaline solution and saline nasal lavage on nasopharyngeal viral load in COVID-19

Karaaltin et al., Authorea, Inc., doi:10.22541/au.166675335.56566797/v1
Oct 2022  
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Viral load, day 5 83% Improvement Relative Risk Viral load, day 5 (b) 86% Viral load, day 3 82% Viral load, day 3 (b) 91% Povidone-Iodine  Karaaltin et al.  EARLY TREATMENT  RCT Is early treatment with povidone-iodine beneficial for COVID-19? RCT 60 patients in Turkey (September - October 2021) Improved viral load with povidone-iodine (p=0.007) c19early.org Karaaltin et al., Authorea, Inc., October 2022 Favorspovidone-iodine Favorscontrol 0 0.5 1 1.5 2+
PVP-I for COVID-19
13th treatment shown to reduce risk in February 2021
 
*, now with p = 0.000000004 from 21 studies.
Lower risk for mortality, cases, and viral clearance.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,400+ studies for 79 treatments. c19early.org
RCT 120 outpatients in Turkey, showing improved reduction in viral load with PVP-I nasal irrigation.
PVP-I prepared with hypertonic alkaline solution had better results.1 show that SARS-CoV-2 requires acidic pH to infect cells, therefore alkalinization may add additional benefits.
All patients received favipiravir. PVP-I 1% 4 times per day.
Targeted administration to the respiratory tract provides treatment directly to the typical source of initial SARS-CoV-2 infection and replication, and allows for rapid onset of action, higher local drug concentration, and reduced systemic side effects.
viral load, 83.1% lower, relative load 0.17, p = 0.007, treatment 30, control 30, relative change in viral load, PVP-I vs. control, day 5.
viral load, 85.5% lower, relative load 0.14, p = 0.001, treatment 30, control 30, relative change in viral load, PVP-I + HANI vs. control, day 5.
viral load, 82.1% lower, relative load 0.18, p = 0.14, treatment 30, control 30, relative change in viral load, PVP-I vs. control, day 3.
viral load, 90.8% lower, relative load 0.09, p < 0.001, treatment 30, control 30, relative change in viral load, PVP-I + HANI vs. control, day 3.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Karaaltin et al., 26 Oct 2022, Randomized Controlled Trial, Turkey, preprint, 16 authors, study period September 2021 - October 2021.
This PaperPovidone-Iod..All
EFFECT OF THE POVIDONE IODINE, HYPERTONIC ALKALINE SOLUTION AND SALINE NASAL LAVAGE ON NASOPHARYNGEAL VIRAL LOAD IN COVID-19
Aysegul Karaaltin, Ozgur Yigit, Dogan Cakan, Özer Akgül, Enes Yiğit, Yetkin Zeki Yılmaz, Kays Burak Çakır, Gamze Çiftçi, Nihal Seden, Abdurrahman Çağlıyan, Efe Can, Özgür Dikme, Yalçın Hacıoğlu, Ilker Inanç Balkan, Özgün Enver, Ahmet Ozdogan
doi:10.22541/au.166675335.56566797/v1
Objective: The causative virus of COVID-19 is SARS-CoV-2. The aim of the present study was to invastigate the in vivo virucidal activity of nasal irrigation with saline, nasal irrigation with Povidone-iodine (PVP-I) 1%, nasal irrigation with hypertonic alkaline and nasal irrigation with PVP-I 1% against SARS CoV-2. Design: The present study was a prospective randomized clinical trial. Setting: A multicenter study involving tertiary care centers. Participants: The study included adult outpatients whose qualitative SARS-CoV-2 RT-PCR tests in nasopharyngeal swabs were positive. One hundred twenty patients divided into four equal groups. Standard COVID-19 treatment was given to group 1 (n=30), nasal irrigation containing isotonic solution was added to patients' treatment in group 2 (n=30), nasal irrigation containing 1% PVP solution was added to patients' treatment in group 3(n=30), and nasal irrigation containing 1% PVP solution and nasal irrigation containing hypertonic alkaline solution was added to patients' treatment in group 4 (n=30). Main outcome measures: On the first day of diagnosis (day 0), nasopharyngeal swab samples were taken, on the 3rd and 5th days the nasopharyngeal viral load reduction in quantitative RT-PCR tests were calculated. Results: Between the 0-3rd Day and 0-5th days, the nasopharyngeal viral load reduction was significant in all groups (p< .05). In paired comparisons of groups, the nasopharyngeal viral load decrease in group 4 in first 3 days was significantly lower than all groups (p < .05). The nasopharyngeal viral load degrease in groups 3 and 4 in the first 5 days were significantly lower than group 1 (p < .05). Conclussion: This study was reveal that the use of hypertonic alkaline nasal irrigation together with 1% povidone-iodine was more effective in reducing viral load in the early period. The decreased nasopharyngeal viral load may reduce the carriage of infectious SARS-CoV-2 in patients. Our results suggest that 1% povidone-iodine and hypertonic alkaline nasal irrigation may be promising modality to prevent the COVID-19 epidemic.
alkaline-solution-and-saline-nasal-lavage-on-nasopharyngeal-viral-load-in-covid-19 Hosted file table 1.docx available at https://authorea.com/users/337860/articles/592062-effect-of-thepovidone-iodine-hypertonic-alkaline-solution-and-saline-nasal-lavage-on-nasopharyngealviral-load-in-covid-19 Hosted file
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Participants: The study included adult\n' 'outpatients whose qualitative SARS-CoV-2 RT-PCR tests in nasopharyngeal\n' 'swabs were positive. One hundred twenty patients divided into four equal\n' 'groups. Standard COVID-19 treatment was given to group 1 (n=30), nasal\n' 'irrigation containing isotonic solution was added to patients’ treatment\n' 'in group 2 (n=30), nasal irrigation containing 1% PVP solution was\n' 'added to patients’ treatment in group 3(n=30), and nasal irrigation\n' 'containing 1% PVP solution and nasal irrigation containing hypertonic\n' 'alkaline solution was added to patients’ treatment in group 4 (n=30).\n' 'Main outcome measures: On the first day of diagnosis (day 0),\n' 'nasopharyngeal swab samples were taken, on the 3rd and 5th days the\n' 'nasopharyngeal viral load reduction in quantitative RT-PCR tests were\n' 'calculated. Results: Between the 0-3rd Day and 0-5th days, the\n' 'nasopharyngeal viral load reduction was significant in all groups\n' '(p&lt; .05). In paired comparisons of groups, the nasopharyngeal\n' 'viral load decrease in group 4 in first 3 days was significantly lower\n' 'than all groups (p &lt; .05). The nasopharyngeal viral load\n' 'degrease in groups 3 and 4 in the first 5 days were significantly lower\n' 'than group 1 (p &lt; .05). Conclussion: This study was reveal\n' 'that the use of hypertonic alkaline nasal irrigation together with 1%\n' 'povidone-iodine was more effective in reducing viral load in the early\n' 'period. The decreased nasopharyngeal viral load may reduce the carriage\n' 'of infectious SARS-CoV-2 in patients. 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