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All Studies   Meta Analysis   Recent: 
0 0.5 1 1.5 2+ Viral load, day 5 83% Improvement Relative Risk Viral load, day 5 (b) 86% Viral load, day 3 82% Viral load, day 3 (b) 91% c19early.org/p Karaaltin et al. Povidone-Iod.. for COVID-19 RCT EARLY Favors povidone-iodine Favors control
Effect of the povidone iodine, hypertonic alkaline solution and saline nasal lavage on nasopharyngeal viral load in COVID-19
Karaaltin et al., Authorea, Inc., doi:10.22541/au.166675335.56566797/v1 (Preprint)
26 Oct 2022    Source   PDF   Share   Tweet
RCT 120 outpatients in Turkey, showing improved reduction in viral load with PVP-I nasal irrigation.
PVP-I prepared with hypertonic alkaline solution had better results, consistent with [Kreutzberger], showing that SARS-CoV-2 requires acidic pH to infect cells.
All patients received favipiravir. PVP-I 1% 4 times per day.
viral load, 83.1% lower, relative load 0.17, p = 0.007, treatment 30, control 30, relative change in viral load, PVP-I vs. control, day 5.
viral load, 85.5% lower, relative load 0.14, p = 0.001, treatment 30, control 30, relative change in viral load, PVP-I + HANI vs. control, day 5.
viral load, 82.1% lower, relative load 0.18, p = 0.14, treatment 30, control 30, relative change in viral load, PVP-I vs. control, day 3.
viral load, 90.8% lower, relative load 0.09, p < 0.001, treatment 30, control 30, relative change in viral load, PVP-I + HANI vs. control, day 3.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Karaaltin et al., 26 Oct 2022, Randomized Controlled Trial, Turkey, preprint, 16 authors, study period September 2021 - October 2021.
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