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Remdesivir-ivermectin combination displays synergistic interaction with improved in vitro activity against SARS-CoV-2
Jeffreys et al., International Journal of Antimicrobial Agents, doi:10.1016/j.ijantimicag.2022.106542 (date from earlier preprint) (In Vitro)
Jeffreys et al., Remdesivir-ivermectin combination displays synergistic interaction with improved in vitro activity against.., International Journal of Antimicrobial Agents, doi:10.1016/j.ijantimicag.2022.106542 (date from earlier preprint) (In Vitro)
Dec 2020   Source   PDF  
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In Vitro study showing enhanced antiviral activity of ivermectin and remdesivir in combination.
[Gérard, Wu, Zhou] show significantly increased risk of acute kidney injury with remdesivir.
3 In Vitro studies support the efficacy of remdesivir [De Forni, Delandre, Jeffreys].
This study includes ivermectin and remdesivir.
Jeffreys et al., 24 Dec 2020, peer-reviewed, 17 authors.
In Vitro studies are an important part of preclinical research, however results may be very different in vivo.
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This PaperRemdesivirAll
Remdesivir–ivermectin combination displays synergistic interaction with improved in vitro activity against SARS-CoV-2
Laura N Jeffreys, Shaun H Pennington, Jack Duggan, Claire H Caygill, Rose C Lopeman, Alastair F Breen, Jessica B Jinks, Alison Ardrey, Samantha Donnellan, Edward I Patterson, Grant L Hughes, David W Hong, Paul M O'neill, Ghaith Aljayyoussi, Andrew Owen, Stephen A Ward, Giancarlo A Biagini
International Journal of Antimicrobial Agents, doi:10.1016/j.ijantimicag.2022.106542
This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
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Klotz, Ogbuokiri, Okonkwo, Ivermectin binds avidly to plasma proteins, Eur J Clin Pharmacol
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