Efficacy of antiseptic mouthrinses against SARS-CoV-2: A prospective randomized placebo-controlled pilot study
Fantozzi et al.
, Efficacy of antiseptic mouthrinses against SARS-CoV-2: A prospective randomized placebo-controlled pilot study
, American Journal of Otolaryngology, doi:10.1016/j.amjoto.2022.103549
Mouthrinse RCT in Italy comparing short-term viral load after a single 60 second treatment with povidone-iodine, hydrogen peroxide, chlorhexidine, and saline. The greatest efficacy was seen with povidone-iodine, especially for patients with low viral load at baseline.
relative viral load, 57.5% better, RR 0.43, treatment 8, control 11, T2, relative fraction of median baseline viral load remaining.
relative viral load, 100% better, RR < 0.001, treatment 8, control 11, T1, relative fraction of median baseline viral load remaining.
risk of no viral clearance, 31.2% lower, RR 0.69, p = 0.26, treatment 5 of 8 (62.5%), control 10 of 11 (90.9%), NNT 3.5, T2.
risk of no viral clearance, 58.7% lower, RR 0.41, p = 0.04, treatment 3 of 8 (37.5%), control 10 of 11 (90.9%), NNT 1.9, T1.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Fantozzi et al., 28 Jul 2022, Randomized Controlled Trial, Italy, peer-reviewed, 14 authors, study period December 2020 - May 2021, this trial compares with another treatment - results may be better when compared to placebo.
Abstract: Journal Pre-proof
Efficacy of antiseptic mouthrinses against SARS-CoV-2: A
prospective randomized placebo-controlled pilot study
Paolo Junior Fantozzi, Emanuele Pampena, Alessandra
Pierangeli, Giuseppe Oliveto, Leonardo Sorrentino, Domenico Di
Vanna, Riccardo Pampena, Alessandro Lazzaro, Elio Gentilini,
Claudio Maria Mastroianni, Gabriella D'Ettorre, Antonella
Polimeni, Umberto Romeo, Alessandro Villa
To appear in:
American Journal of Otolaryngology--Head and Neck Medicine and
5 June 2022
Please cite this article as: P.J. Fantozzi, E. Pampena, A. Pierangeli, et al., Efficacy of
antiseptic mouthrinses against SARS-CoV-2: A prospective randomized placebocontrolled pilot study, American Journal of Otolaryngology--Head and Neck Medicine and
Surgery (2022), https://doi.org/10.1016/j.amjoto.2022.103549
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© 2022 Published by Elsevier Inc.
Title: Efficacy of antiseptic mouthrinses against SARS-CoV-2: a prospective randomized placebo-controlled
Authors: Paolo Junior Fantozzi, DDSa*; Emanuele Pampena, DDSa*; Alessandra Pierangeli, PhDb; Giuseppe
Oliveto PhDb; Leonardo Sorrentino, PhDb, Domenico Di Vanna, MDc; Riccardo Pampena, MDd; Alessandro
Lazzaro, MDe; Elio Gentilini, MDe; Claudio Maria Mastroianni, MDe; Gabriella D’Ettorre, MDe; Antonella
Polimeni, DDS, MDa; Umberto Romeo, DDSa, Alessandro Villa, DDS, PhD, MPHf.
*Equally contributed to the manuscript.
Department of Oral and Maxillofacial Sciences, Sapienza University of Rome, Rome, Italy.
Laboratory of Microbiology and Virology, Department of Molecular Medicine, Sapienza University of Rome,
Department of Emergency Medicine, Umberto I Polyclinic Hospital, Sapienza University of Rome, Rome,
Centro Oncologico ad Alta Tecnologia Diagnostica, Azienda Unità Sanitaria Locale - IRCCS di Reggio Emilia,
Infectious Diseases Unit, Department of Public Health and Infectious Diseases, Sapienza University of Rome,
Reggio Emilia, Italy
Department of Orofacial Sciences, University of California San Francisco, San Francisco, CA, USA.
Manuscript Word Count: 3631
Abstract word count: 217
Umberto Romeo, DDS
Department of Oral and Maxillofacial Sciences
Sapienza University of Rome
Via Caserta 6, 00187
Coronavirus-disease-19 (COVID-19) continues to affect millions of individuals worldwide. Antiviral activity of
mouthrinses remains an important research area as the oral cavity is a site of SARS-CoV-2 initial replication.
The aim of this study was to assess the effectiveness of three different mouthrinses in reducing..
is less effective
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