Efficacy of antiseptic mouthrinses against SARS-CoV-2: A prospective randomized placebo-controlled pilot study
et al., American Journal of Otolaryngology, doi:10.1016/j.amjoto.2022.103549
, Efficacy of antiseptic mouthrinses against SARS-CoV-2: A prospective randomized placebo-controlled pilot study, American Journal of Otolaryngology, doi:10.1016/j.amjoto.2022.103549
Mouthrinse RCT in Italy comparing short-term viral load after a single 60 second treatment with povidone-iodine, hydrogen peroxide, chlorhexidine, and saline. The greatest efficacy was seen with povidone-iodine, especially for patients with low viral load at baseline.
|
relative viral load, 57.5% better, RR 0.43, treatment 8, control 11, T2, relative fraction of median baseline viral load remaining.
|
|
relative viral load, 100% better, RR < 0.001, treatment 8, control 11, T1, relative fraction of median baseline viral load remaining.
|
|
risk of no viral clearance, 31.2% lower, RR 0.69, p = 0.26, treatment 5 of 8 (62.5%), control 10 of 11 (90.9%), NNT 3.5, T2.
|
|
risk of no viral clearance, 58.7% lower, RR 0.41, p = 0.04, treatment 3 of 8 (37.5%), control 10 of 11 (90.9%), NNT 1.9, T1.
|
| Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates |
Fantozzi et al., 28 Jul 2022, Randomized Controlled Trial, Italy, peer-reviewed, 14 authors, study period December 2020 - May 2021, this trial compares with another treatment - results may be better when compared to placebo.
Contact:
umberto.romeo@uniroma1.it.
Abstract: Journal Pre-proof
Efficacy of antiseptic mouthrinses against SARS-CoV-2: A
prospective randomized placebo-controlled pilot study
Paolo Junior Fantozzi, Emanuele Pampena, Alessandra
Pierangeli, Giuseppe Oliveto, Leonardo Sorrentino, Domenico Di
Vanna, Riccardo Pampena, Alessandro Lazzaro, Elio Gentilini,
Claudio Maria Mastroianni, Gabriella D'Ettorre, Antonella
Polimeni, Umberto Romeo, Alessandro Villa
PII:
S0196-0709(22)00176-4
DOI:
https://doi.org/10.1016/j.amjoto.2022.103549
Reference:
YAJOT 103549
To appear in:
American Journal of Otolaryngology--Head and Neck Medicine and
Surgery
Received
date:
5 June 2022
Please cite this article as: P.J. Fantozzi, E. Pampena, A. Pierangeli, et al., Efficacy of
antiseptic mouthrinses against SARS-CoV-2: A prospective randomized placebocontrolled pilot study, American Journal of Otolaryngology--Head and Neck Medicine and
Surgery (2022), https://doi.org/10.1016/j.amjoto.2022.103549
This is a PDF file of an article that has undergone enhancements after acceptance, such
as the addition of a cover page and metadata, and formatting for readability, but it is
not yet the definitive version of record. This version will undergo additional copyediting,
typesetting and review before it is published in its final form, but we are providing this
version to give early visibility of the article. Please note that, during the production
process, errors may be discovered which could affect the content, and all legal disclaimers
that apply to the journal pertain.
© 2022 Published by Elsevier Inc.
Journal Pre-proof
Title: Efficacy of antiseptic mouthrinses against SARS-CoV-2: a prospective randomized placebo-controlled
pilot study
Authors: Paolo Junior Fantozzi, DDSa*; Emanuele Pampena, DDSa*; Alessandra Pierangeli, PhDb; Giuseppe
Oliveto PhDb; Leonardo Sorrentino, PhDb, Domenico Di Vanna, MDc; Riccardo Pampena, MDd; Alessandro
Lazzaro, MDe; Elio Gentilini, MDe; Claudio Maria Mastroianni, MDe; Gabriella D’Ettorre, MDe; Antonella
Polimeni, DDS, MDa; Umberto Romeo, DDSa, Alessandro Villa, DDS, PhD, MPHf.
of
*Equally contributed to the manuscript.
Department of Oral and Maxillofacial Sciences, Sapienza University of Rome, Rome, Italy.
-p
a
ro
Institutional Affiliations:
b
re
Laboratory of Microbiology and Virology, Department of Molecular Medicine, Sapienza University of Rome,
Rome, Italy.
Department of Emergency Medicine, Umberto I Polyclinic Hospital, Sapienza University of Rome, Rome,
lP
c
na
Italy.
d
Centro Oncologico ad Alta Tecnologia Diagnostica, Azienda Unità Sanitaria Locale - IRCCS di Reggio Emilia,
Infectious Diseases Unit, Department of Public Health and Infectious Diseases, Sapienza University of Rome,
Rome, Italy.
f
Jo
e
ur
Reggio Emilia, Italy
Department of Orofacial Sciences, University of California San Francisco, San Francisco, CA, USA.
Manuscript Word Count: 3631
Abstract word count: 217
Journal Pre-proof
Corresponding Author:
Umberto Romeo, DDS
Department of Oral and Maxillofacial Sciences
Sapienza University of Rome
Via Caserta 6, 00187
Rome, Italy.
-p
ro
of
Email: umberto.romeo@uniroma1.it
re
Abstract
lP
Objectives:
Coronavirus-disease-19 (COVID-19) continues to affect millions of individuals worldwide. Antiviral activity of
na
mouthrinses remains an important research area as the oral cavity is a site of SARS-CoV-2 initial replication.
The aim of this study was to assess the effectiveness of three different mouthrinses in reducing..
Late treatment
is less effective
is less effective
Please send us corrections, updates, or comments. Vaccines and
treatments are complementary. All practical, effective, and safe means should
be used based on risk/benefit analysis. No treatment, vaccine, or intervention
is 100% available and effective for all current and future variants. We do not
provide medical advice. Before taking any medication, consult a qualified
physician who can provide personalized advice and details of risks and
benefits based on your medical history and situation. FLCCC and WCH
provide treatment protocols.