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0 0.5 1 1.5 2+ Viral load 57% no CI Improvement Relative Risk Viral load (b) 100% no CI Viral clearance 31% Viral clearance (b) 59% c19early.org/p Fantozzi et al. Povidone-Iodine for COVID-19 RCT LATE Does late treatment with povidone-iodine reduce short-term viral load? RCT 38 patients in Italy (December 2020 - May 2021) Trial compares with saline, results vs. placebo may differ Improved viral clearance with povidone-iodine (not stat. sig., p=0.26) Fantozzi et al., American J. Otolaryngology, doi:10.1016/j.amjoto.2022.103549 Favors povidone-iodine Favors saline
Efficacy of antiseptic mouthrinses against SARS-CoV-2: A prospective randomized placebo-controlled pilot study
Fantozzi et al., American Journal of Otolaryngology, doi:10.1016/j.amjoto.2022.103549
Fantozzi et al., Efficacy of antiseptic mouthrinses against SARS-CoV-2: A prospective randomized placebo-controlled pilot study, American Journal of Otolaryngology, doi:10.1016/j.amjoto.2022.103549
Jul 2022   Source   PDF  
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Mouthrinse RCT in Italy comparing short-term viral load after a single 60 second treatment with povidone-iodine, hydrogen peroxide, chlorhexidine, and saline. The greatest efficacy was seen with povidone-iodine, especially for patients with low viral load at baseline.
relative viral load, 57.5% better, RR 0.43, treatment 8, control 11, T2, relative fraction of median baseline viral load remaining.
relative viral load, 100% better, RR < 0.001, treatment 8, control 11, T1, relative fraction of median baseline viral load remaining.
risk of no viral clearance, 31.2% lower, RR 0.69, p = 0.26, treatment 5 of 8 (62.5%), control 10 of 11 (90.9%), NNT 3.5, T2.
risk of no viral clearance, 58.7% lower, RR 0.41, p = 0.04, treatment 3 of 8 (37.5%), control 10 of 11 (90.9%), NNT 1.9, T1.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Fantozzi et al., 28 Jul 2022, Randomized Controlled Trial, Italy, peer-reviewed, 14 authors, study period December 2020 - May 2021, this trial compares with another treatment - results may be better when compared to placebo.
Contact: umberto.romeo@uniroma1.it.
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Abstract: Journal Pre-proof Efficacy of antiseptic mouthrinses against SARS-CoV-2: A prospective randomized placebo-controlled pilot study Paolo Junior Fantozzi, Emanuele Pampena, Alessandra Pierangeli, Giuseppe Oliveto, Leonardo Sorrentino, Domenico Di Vanna, Riccardo Pampena, Alessandro Lazzaro, Elio Gentilini, Claudio Maria Mastroianni, Gabriella D'Ettorre, Antonella Polimeni, Umberto Romeo, Alessandro Villa PII: S0196-0709(22)00176-4 DOI: https://doi.org/10.1016/j.amjoto.2022.103549 Reference: YAJOT 103549 To appear in: American Journal of Otolaryngology--Head and Neck Medicine and Surgery Received date: 5 June 2022 Please cite this article as: P.J. Fantozzi, E. Pampena, A. Pierangeli, et al., Efficacy of antiseptic mouthrinses against SARS-CoV-2: A prospective randomized placebocontrolled pilot study, American Journal of Otolaryngology--Head and Neck Medicine and Surgery (2022), https://doi.org/10.1016/j.amjoto.2022.103549 This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. © 2022 Published by Elsevier Inc. Journal Pre-proof Title: Efficacy of antiseptic mouthrinses against SARS-CoV-2: a prospective randomized placebo-controlled pilot study Authors: Paolo Junior Fantozzi, DDSa*; Emanuele Pampena, DDSa*; Alessandra Pierangeli, PhDb; Giuseppe Oliveto PhDb; Leonardo Sorrentino, PhDb, Domenico Di Vanna, MDc; Riccardo Pampena, MDd; Alessandro Lazzaro, MDe; Elio Gentilini, MDe; Claudio Maria Mastroianni, MDe; Gabriella D’Ettorre, MDe; Antonella Polimeni, DDS, MDa; Umberto Romeo, DDSa, Alessandro Villa, DDS, PhD, MPHf. of *Equally contributed to the manuscript. Department of Oral and Maxillofacial Sciences, Sapienza University of Rome, Rome, Italy. -p a ro Institutional Affiliations: b re Laboratory of Microbiology and Virology, Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy. Department of Emergency Medicine, Umberto I Polyclinic Hospital, Sapienza University of Rome, Rome, lP c na Italy. d Centro Oncologico ad Alta Tecnologia Diagnostica, Azienda Unità Sanitaria Locale - IRCCS di Reggio Emilia, Infectious Diseases Unit, Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy. f Jo e ur Reggio Emilia, Italy Department of Orofacial Sciences, University of California San Francisco, San Francisco, CA, USA. Manuscript Word Count: 3631 Abstract word count: 217 Journal Pre-proof Corresponding Author: Umberto Romeo, DDS Department of Oral and Maxillofacial Sciences Sapienza University of Rome Via Caserta 6, 00187 Rome, Italy. -p ro of Email: umberto.romeo@uniroma1.it re Abstract lP Objectives: Coronavirus-disease-19 (COVID-19) continues to affect millions of individuals worldwide. Antiviral activity of na mouthrinses remains an important research area as the oral cavity is a site of SARS-CoV-2 initial replication. The aim of this study was to assess the effectiveness of three different mouthrinses in reducing..
Late treatment
is less effective
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