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Comparative study between the therapeutic effect of remdesivir versus hydroxychloroquine in COVID-19 hospitalized patients
Eldeen et al., Microbes and Infectious Diseases, doi:10.21608/mid.2021.85877.1177
Eldeen et al., Comparative study between the therapeutic effect of remdesivir versus hydroxychloroquine in COVID-19.., Microbes and Infectious Diseases, doi:10.21608/mid.2021.85877.1177
Aug 2021   Source   PDF  
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Small study comparing 25 HCQ and 25 remdesivir hospitalized patients, reporting faster viral clearance with remdesivir. The article proof is missing the results for the HCQ group. Confounding by time is likely - remdesivir patients were after HCQ patients in time, and treatment protocols improved over the period of the study.
[Gérard, Wu, Zhou] show significantly increased risk of acute kidney injury with remdesivir.
This study includes remdesivir and HCQ.
Eldeen et al., 16 Aug 2021, peer-reviewed, 5 authors.
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Comparative study between the therapeutic effect of Remdesivir versus Hydroxychloroquine in Covid-19 hospitalized patients.
Maii A Shams Eldeen, Mohamed S Abdelghafar, Hoda A Ibrahim, Alshimaa Aboalsoud, Marwa S Taha
Microbes and Infectious Diseases, doi:10.21608/mid.2021.85877.1177
announced infections and about 4000 deaths were reported in more than 100 countries [1, 2] . In Egypt, the officially reported COVID-19 confirmed cases were 94,316 with 4,834 deaths on August 2020 [3] .
Conflict of interest: no conflict of interest. Authors' Contribution All authors contributed equally to this work. Financial disclosure This study was done as a part of the outbreak investigation conducted at Tanta University Hospitals, Egypt and supported by the Ministry of Higher Education (MHE). Patients with laboratory-confirmed SARS-CoV-2 infection, who were admitted to Tanta University Isolation Hospital ICU between June and September, 2020 were included. Shankar
References
-Ali, Ali, Ahmed, Wy, Characteristics, and predictive factors of disease severity in hospitalized patients with SARS-COV-2 in Fayoum governorate, Egypt: a multicenter study, Microbes and Infectious Diseases
-Wu, Mcgoogan, Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72 314 cases from the Chinese Center for Disease Control and Prevention, Jama
-Yang, Islam, Wang, Li, Chen, Traditional Chinese medicine in the treatment of patients infected with 2019-new coronavirus (SARS-CoV-2): a review and perspective, International journal of biological sciences
Abena, Decloedt, Bottieau, Suleman, Adejumo et al., Chloroquine and hydroxychloroquine for the prevention or treatment of COVID-19 in Africa: caution for inappropriate off-label use in healthcare settings, The American journal of tropical medicine and hygiene
Corman, Landt, Kaiser, Molenkamp, Meijer et al., Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR, Eurosurveillance
Devaux, Rolain, Colson, Raoult, None
Nas, Ali, Azu, Abdallah, Yusuf, Epidemiology of novel COVID-19 in Nigeria, Microbes and Infectious Diseases
Late treatment
is less effective
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