A Prospective, Randomized, Open-Label Trial of Early versus Late Favipiravir Therapy in Hospitalized Patients with COVID-19

{ 'indexed': {'date-parts': [[2022, 9, 6]], 'date-time': '2022-09-06T09:28:14Z', 'timestamp': 1662456494270}, 'reference-count': 12, 'publisher': 'American Society for Microbiology', 'issue': '12', 'license': [ { 'start': { 'date-parts': [[2020, 11, 17]], 'date-time': '2020-11-17T00:00:00Z', 'timestamp': 1605571200000}, 'content-version': 'vor', 'delay-in-days': 0, 'URL': 'https://creativecommons.org/licenses/by/4.0/'}, { 'start': { 'date-parts': [[2020, 11, 17]], 'date-time': '2020-11-17T00:00:00Z', 'timestamp': 1605571200000}, 'content-version': 'tdm', 'delay-in-days': 0, 'URL': 'https://journals.asm.org/non-commercial-tdm-license'}], 'funder': [ { 'DOI': '10.13039/100009619', 'name': 'Japan Agency for Medical Research and Development', 'doi-asserted-by': 'publisher', 'award': ['JP19fk0108150']}], 'content-domain': {'domain': ['journals.asm.org'], 'crossmark-restriction': True}, 'published-print': {'date-parts': [[2020, 11, 17]]}, 'abstract': '<jats:p>Favipiravir is an oral broad-spectrum inhibitor of viral RNA-dependent RNA polymerase ' 'that is approved for treatment of influenza in Japan. We conducted a prospective, randomized, ' 'open-label, multicenter trial of favipiravir for the treatment of COVID-19 at 25 hospitals ' 'across Japan. Eligible patients were adolescents and adults admitted with COVID-19 who were ' 'asymptomatic or mildly ill and had an Eastern Cooperative Oncology Group (ECOG) performance ' 'status of 0 or 1. Patients were randomly assigned at a 1:1 ratio to early or late favipiravir ' 'therapy (in the latter case, the same regimen starting on day 6 instead of day 1).</jats:p>', 'DOI': '10.1128/aac.01897-20', 'type': 'journal-article', 'created': {'date-parts': [[2020, 9, 22]], 'date-time': '2020-09-22T13:47:51Z', 'timestamp': 1600782471000}, 'update-policy': 'http://dx.doi.org/10.1128/asmj-crossmark-policy-page', 'source': 'Crossref', 'is-referenced-by-count': 110, 'title': 'A Prospective, Randomized, Open-Label Trial of Early versus Late Favipiravir Therapy in ' 'Hospitalized Patients with COVID-19', 'prefix': '10.1128', 'volume': '64', 'author': [ { 'ORCID': 'http://orcid.org/0000-0002-9620-2525', 'authenticated-orcid': False, 'given': 'Yohei', 'family': 'Doi', 'sequence': 'first', 'affiliation': [ { 'name': 'Departments of Microbiology and Infectious Diseases, Fujita ' 'Health University School of Medicine, Toyoake, Aichi, Japan'}, { 'name': 'Division of Infectious Diseases, University of Pittsburgh School ' 'of Medicine, Pittsburgh, Pennsylvania, USA'}]}, { 'given': 'Masaya', 'family': 'Hibino', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Emergency and General Internal Medicine, Fujita ' 'Health University School of Medicine, Toyoake, Aichi, Japan'}]}, { 'given': 'Ryota', 'family': 'Hase', 'sequence': 'additional', 'affiliation': [ { 'name': 'Departments of Microbiology and Infectious Diseases, Fujita ' 'Health University School of Medicine, Toyoake, Aichi, Japan'}, { 'name': 'Department of Infectious Diseases, Japanese Red Cross Narita ' 'Hospital, Narita, Chiba, Japan'}]}, { 'given': 'Michiko', 'family': 'Yamamoto', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Respiratory Medicine, Sagamihara Kyodo Hospital, ' 'Sagamihara, Kanagawa, Japan'}]}, { 'given': 'Yu', 'family': 'Kasamatsu', 'sequence': 'additional', 'affiliation': [ { 'name': 'Infection Control and Clinical Laboratory, Kyoto Prefectural ' 'University of Medicine, Kyoto, Kyoto, Japan'}]}, { 'given': 'Masahiro', 'family': 'Hirose', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Respiratory Medicine, Fujita Health University ' 'Bantane Hospital, Nagoya, Aichi, Japan'}]}, { 'ORCID': 'http://orcid.org/0000-0002-7368-3004', 'authenticated-orcid': False, 'given': 'Yoshikazu', 'family': 'Mutoh', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Infectious Diseases, Tosei General Hospital, Seto, ' 'Aichi, Japan'}]}, { 'given': 'Yoshito', 'family': 'Homma', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Respiratory Medicine, Ehime Prefectural Central ' 'Hospital, Matsuyama, Ehime, Japan'}]}, { 'given': 'Masaki', 'family': 'Terada', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Respiratory Medicine, Saiseikai Niigata Hospital, ' 'Niigata, Niigata, Japan'}]}, { 'given': 'Taku', 'family': 'Ogawa', 'sequence': 'additional', 'affiliation': [ { 'name': 'Center for Infectious Diseases, Nara Medical University, ' 'Kashihara, Nara, Japan'}]}, { 'given': 'Fumihiro', 'family': 'Kashizaki', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Respiratory Medicine, Isehara Kyodo Hospital, ' 'Isehara, Kanagawa, Japan'}]}, { 'given': 'Toshihiko', 'family': 'Yokoyama', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Respiratory Medicine, Japanese Red Cross Nagoya ' 'Daiichi Hospital, Nagoya, Aichi, Japan'}]}, { 'given': 'Hayato', 'family': 'Koba', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Respiratory Medicine, Komatsu Municipal Hospital, ' 'Komatsu, Ishikawa, Japan'}]}, { 'given': 'Hideki', 'family': 'Kasahara', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Rheumatology, NTT East Sapporo Hospital, Sapporo, ' 'Hokkaido, Japan'}]}, { 'given': 'Kazuhisa', 'family': 'Yokota', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Infectious Diseases, Tokyo Metropolitan Health and ' 'Medical Corporation Ebara Hospital, Ohta, Tokyo, Japan'}]}, { 'given': 'Hideaki', 'family': 'Kato', 'sequence': 'additional', 'affiliation': [ { 'name': 'Infection Prevention and Control Department, Yokohama City ' 'University Hospital, Yokohama, Kanagawa, Japan'}]}, { 'given': 'Junichi', 'family': 'Yoshida', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Chest Surgery, Shimonoseki City Hospital, ' 'Shimonoseki, Yamaguchi, Japan'}]}, { 'given': 'Toshiyuki', 'family': 'Kita', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Respiratory Medicine, National Hospital ' 'Organization Kanazawa Medical Center, Kanazawa, Ishikawa, ' 'Japan'}]}, { 'given': 'Yasuyuki', 'family': 'Kato', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Infectious Diseases, International University of ' 'Health and Welfare Narita Hospital, Narita, Chiba, Japan'}]}, { 'given': 'Tadashi', 'family': 'Kamio', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Intensive Care, Shonan Kamakura General Hospital, ' 'Kamakura, Kanagawa, Japan'}]}, { 'given': 'Nobuhiro', 'family': 'Kodama', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of General Internal Medicine, Fukuoka Tokushukai ' 'Hospital, Kasuga, Fukuoka, Japan'}]}, { 'given': 'Yujiro', 'family': 'Uchida', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of General Medicine, Kitakyushu Municipal Medical ' 'Center, Kitakyushu, Fukuoka, Japan'}]}, { 'given': 'Nobuhiro', 'family': 'Ikeda', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of General Internal Medicine, Eiju General Hospital, ' 'Taito, Tokyo, Japan'}]}, { 'given': 'Masahiro', 'family': 'Shinoda', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Respiratory Medicine, Tokyo Shinagawa Hospital, ' 'Shinagawa, Tokyo, Japan'}]}, { 'given': 'Atsushi', 'family': 'Nakagawa', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Respiratory Medicine, Kobe City Medical Center ' 'General Hospital, Kobe, Hyogo, Japan'}]}, { 'given': 'Hiroki', 'family': 'Nakatsumi', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Respiratory Medicine, Ishikawa Prefectural Central ' 'Hospital, Kanazawa, Ishikawa, Japan'}]}, { 'given': 'Tomoya', 'family': 'Horiguchi', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Respiratory Medicine, Fujita Health University ' 'School of Medicine, Toyoake, Aichi, Japan'}]}, { 'given': 'Mitsunaga', 'family': 'Iwata', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Emergency and General Internal Medicine, Fujita ' 'Health University School of Medicine, Toyoake, Aichi, Japan'}]}, { 'given': 'Akifumi', 'family': 'Matsuyama', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Regenerative Medicine and Stem Cell Biology, ' 'Fujita Health University School of Medicine, Toyoake, Aichi, ' 'Japan'}]}, { 'given': 'Sumi', 'family': 'Banno', 'sequence': 'additional', 'affiliation': [ { 'name': 'Center for Clinical Trial and Research Support, Fujita Health ' 'University School of Medicine, Toyoake, Aichi, Japan'}]}, { 'given': 'Takenao', 'family': 'Koseki', 'sequence': 'additional', 'affiliation': [ { 'name': 'Center for Clinical Trial and Research Support, Fujita Health ' 'University School of Medicine, Toyoake, Aichi, Japan'}, { 'name': 'Department of Clinical Pharmacy, Fujita Health University School ' 'of Medicine, Toyoake, Aichi, Japan'}]}, { 'given': 'Mayumi', 'family': 'Teramachi', 'sequence': 'additional', 'affiliation': [ { 'name': 'Center for Clinical Trial and Research Support, Fujita Health ' 'University School of Medicine, Toyoake, Aichi, Japan'}]}, { 'given': 'Masami', 'family': 'Miyata', 'sequence': 'additional', 'affiliation': [ { 'name': 'Center for Clinical Trial and Research Support, Fujita Health ' 'University School of Medicine, Toyoake, Aichi, Japan'}]}, { 'given': 'Shigeru', 'family': 'Tajima', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Virology I, National Institute of Infectious ' 'Diseases, Shinjuku, Tokyo, Japan'}]}, { 'given': 'Takahiro', 'family': 'Maeki', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Virology I, National Institute of Infectious ' 'Diseases, Shinjuku, Tokyo, Japan'}]}, { 'given': 'Eri', 'family': 'Nakayama', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Virology I, National Institute of Infectious ' 'Diseases, Shinjuku, Tokyo, Japan'}]}, { 'given': 'Satoshi', 'family': 'Taniguchi', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Virology I, National Institute of Infectious ' 'Diseases, Shinjuku, Tokyo, Japan'}]}, { 'given': 'Chang Kweng', 'family': 'Lim', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Virology I, National Institute of Infectious ' 'Diseases, Shinjuku, Tokyo, Japan'}]}, { 'ORCID': 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Medical Statistics, Osaka City University Graduate ' 'School of Medicine, Osaka, Osaka, Japan'}]}, { 'given': 'Yukio', 'family': 'Yuzawa', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Nephrology, Fujita Health University School of ' 'Medicine, Toyoake, Aichi, Japan'}]}, { 'given': 'Masashi', 'family': 'Kondo', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Respiratory Medicine, Fujita Health University ' 'School of Medicine, Toyoake, Aichi, Japan'}, { 'name': 'Center for Clinical Trial and Research Support, Fujita Health ' 'University School of Medicine, Toyoake, Aichi, Japan'}]}], 'member': '235', 'reference': [ {'key': 'e_1_3_3_2_2', 'doi-asserted-by': 'publisher', 'DOI': '10.1001/jama.2020.2648'}, { 'key': 'e_1_3_3_3_2', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.antiviral.2018.03.003'}, { 'key': 'e_1_3_3_4_2', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.antiviral.2013.09.015'}, { 'key': 'e_1_3_3_5_2', 'doi-asserted-by': 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